"said Orlin Velev, INVISTA Professor of Chemical and Biomolecular engineering at NC State and the corresponding author of the paper."
research assistant professor of chemical and biomolecular engineering at NC State and first author of the paper.
2015 IEEE International Conference on Robotics and Biomimetics-December 6-9, 2015, Zhuhai, China July 19th, 2015groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015govt.
biomimetic membranes may aid water filtration August 1st, 2015take a trip through the brain July 30th, 2015sol-gel capacitor dielectric offers record-high energy storage July 30th,
#Milestone single-biomolecule imaging technique may advance drug design Abstract: The first nanometer resolved image of individual tobacco mosaic virions shows the potential of low energy electron holography for imaging biomolecules at a single particle level--a milestone in structural biology and a potential new tool
for drug design. Knowing the detailed shape of biomolecules such as proteins is essential for biological studies and drug discovery.
Modern structural biology relies on techniques such as nuclear magnetic resonance (NMR), X-ray crystallography and cryo-electron microscopy to discover the tiny structural details of biomolecules.
All these methods, however, require averaging over a large number of molecules and thus structural details of an individual biomolecule are lost often.
Now researchers from the University of Zurich Switzerland have made a breakthrough by obtaining the first nanometer (one billionth of a meter) resolved image of individual tobacco mosaic virions,
a rod-shaped RNA VIRUS that infects a wide range of plants, especially tobacco. The work demonstrates the potential of low energy electron holography as a non-destructive,
single-particle imaging technique for structural biology. The researchers describe their work in a paper published this week on the cover of the journal Applied Physics Letters, from AIP Publishing."
"The virions are imaged with one nanometer resolution exhibiting details of the helical structure of the virus. Our technique would be the first non-destructive imaging tool for structural biology at the truly single molecule level."
"Longchamp noted the technique would also open the door for"rational drug design,"an inventive process of finding new medications based on the knowledge of a biological target.
Second, low energy electrons are harmless to biomolecules, "Longchamp said. In many conventional techniques such as transmission electron microscopy, the possible resolution is limited by high-energy electrons'radiation damage to biological samples.
Individual biomolecules are destroyed long before an image of high enough quality can be acquired. In other words, the low permissible electron dose in conventional microscopies is not sufficient to obtain high-resolution images from a single biomolecule.
However in low energy electron holography, the employed electron doses can be much higher--even after exposing fragile molecules like DNA or proteins to a electron dose more than five orders of magnitude higher
than the critical dose in transmission electron microscopy, no radiation damage could be observed. Sufficient electron dose in low energy electron holography makes imaging individual biomolecules at a nanometer resolution possible.
In Longchamp's experiment, the tobacco mosaic virions were deposited on a freestanding, ultraclean graphene, an atomically thin layer of carbon atoms arranged in a honeycomb lattice.
Nagoya, Japan-Yutaro Saito, Yasutomo Segawa and Professor Kenichiro Itami at the Institute of Transformative Biomolecules (ITBM
"As altering the para position has been a common approach in biology and materials science for creating benzene-containing functional molecules,
"says Kenichiro Itami, the Director of the Institute of Transformative Biomolecules.""Since starting this research in 2009,
#Millions of liters of juice from 1 grapefruit (Nanowerk News) The Austrian Centre of Industrial biotechnology (acib) uses the positive aspects of synthetic biology for the ecofriendly production of a natural compound("Production of the sesquiterpenoid
"The challenge of the biotechnologists Tamara Wriessnegger and Harald Pichler in Graz was to produce Nootkatone in large quantities.
as a biopharmaceutical component or as a natural insect repellent.""We have installed new genetic information in the yeast Pichia pastoris,
so that our cells are able to produce Nootkatone from sugar, "says acib researcher Tamara Wriessnegger.
The genome of the yeast cells has been extended with four foreign genes derived from the cress Arabidopsis thaliana, the Egyptian henbane Hyoscyamus muticus, the Nootka cypress Xanthocyparis nootkatensis and from baker's yeast Saccharomyces cerevisiae.
The common biotech variant via Valencene and a chemical synthesis step is less ecofriendly, more difficult and expensive.
"Synthetic biology could be of vital importance to humanity, as Artemisinin shows. Thanks to this substance malaria is curable.
said the papers senior author, Mark Saltzman, the Goizueta Foundation Professor of Biomedical engineering. Nanoparticles are large enough to keep from going through the skins surface,
including Lohitash Karumbaiah of the University of Georgia Regenerative Bioscience Center, has developed a brain-friendly extracellular matrix environment of neuronal cells that contain very little foreign material.
and is chair of the Wallace H. Coulter Department of Biomedical engineering at the Georgia Institute of technology and Emory University,
Kit could one day Be led by widely available Professor Jeffrey Bode of the Institute of Transformative Biomolecules at Nagoya University in Japan,
"said Percival Zhang, a professor in the Department of Biological Systems Engineering, which is in both the College of Agriculture and Life sciences and the College of Engineering.
Typically in biological conversions, these two sugars can only be used sequentially, not simultaneously which adds time and money to the process.
the most common building block today for biosynthesis."We believe our system is a revolutionary leap forward in the field of artificial photosynthesis,
"Our system represents an emerging alliance between the fields of materials sciences and biology, where opportunities to make new functional devices can mix
"says Michelle Chang, an expert in biosynthesis."For example, the morphology of the nanowire array protects the bacteria like Easter eggs buried in tall grass
MIT biological engineers have devised a new mix-and-match system to genetically engineer viruses that target specific bacteria.
says Timothy Lu, an associate professor of electrical engineering and computer science and biological engineering. Arrayarray"We'd like to be able to remove specific members of the bacterial population
Also, each family of bacteriophages can have a different genome organization and life cycle, making it difficult to engineer them
the researchers combed through databases of phage genomes looking for sequences that appear to code for the key tail fiber section, known as gp17.
they had to create a new system for performing the genetic engineering. Existing techniques for editing viral genomes are fairly laborious
so the researchers came up with an efficient approach in which they insert the phage genome into a yeast cell,
where it exists as an"artificial chromosome"separate from the yeast cell's own genome.
During this process the researchers can easily swap genes in and out of the phage genome."
"Once we had that method, it allowed us very easily to identify the genes that code for the tails
the most common building block today for biosynthesis. e believe our system is a revolutionary leap forward in the field of artificial photosynthesis,
solar-powered green chemistry using sequestered carbon dioxide. ur system represents an emerging alliance between the fields of materials sciences and biology,
says Michelle Chang, an expert in biosynthesis. or example, the morphology of the nanowire array protects the bacteria like Easter eggs buried in tall grass
#USDA Scientists, International Colleagues Sequence Upland cotton Genome U s. Department of agriculture (USDA) scientists and their partners have sequenced the genome of the world most widely cultivated and genetically complex species of cotton,
The results were published today in two Nature Biotechnology reports. Sequencing the genome of Upland cotton (Gossypium hirsutum) will help breeders develop varieties of cotton that are equipped better to combat the pests,
diseases and higher temperatures and droughts expected to accompany climate change. Cotton growers have experienced a plateau in yields since the early 1990s
The two teams sequenced the genome of the genetic standard of Upland cotton, Texas Marker-1,
a professor of physics at NYU and chair of the Chemical and Bioengineering Department at NYU Polytechnic School of engineering. ur research shows that this be done
#A fast cell sorter shrinks to cell phone size Commercially available cell sorters can rapidly and accurately aid medical diagnosis and biological research,
but also other cellular features such as gene expression, post translational modification, and cell function, said Huang. he acoustic power intensity
and biological research. ecause the device is built on a lab-on-a chip system, it is both compact and inexpensive about the size and cost of a cell phone in its current configuration.
Lung and Blood Institute of the National institutes of health, published their work in a recent issue of Lab on a Chip. ell sorting is used widely in many areas of biology to characterize
Microfluidic cell sorting is revolutionary for the fields of cell biology and immunology, as well as other fields in biology, in concomitantly overcoming all of these obstacles.
It is quite easy to envision applications for this technology in diverse environments from a family doctor office to field studies in limnology. n future work,
#Researchers Smash Records with Pig-to-Primate Organ transplants With the financial aid of a biotechnology executive whose daughter may need a lung transplant,
Virginia, by Revivicor, a division of the biotechnology company United Therapeutics. That company founder and co-CEO, Martine Rothblatt, is noted a futurist who four years ago began spending millions to supply researchers with pig organs
and difficult to get them to function correctly. ou try to put all your genes into one parcel so they go to one place in the genome,
who leads a German consortium developing transgenic pigs. t very cumbersome. Creating a good pig is really like winning the lottery. n the United states,
Since last year, some of the genetic engineering has been carried out in collaboration with Synthetic Genomics, a California company started by DNA sequencing entrepreneur J. Craig Venter.
who runs the mammalian synthetic biology program for Synthetic Genomics. o one is so naïve as to think, h,
The organs he used before had three genetic alterations, but the next ones will have seven. f they survive,
The team found a similar gene expression profile to that of kidneys of first-trimester human fetuses, for example,
States Professor Joseph Perry, School of Chemistry and Biochemistry at Georgia Tech,"sol-gels...such as phosphonic acids are well known...
For the water to reach the households in a clean state via the distribution network a team headed by microbiologist Ursula Obst who directs the partial project for water processing and water quality assurance developed methods for the central semi
and metal--and also suppressed biofilm formation in a study reported in Nature Biotechnology. But that's not All the team implanted medical-grade tubing
Ingber is also the Judah Folkman Professor of Vascular Biology at Harvard Medical school and Boston Children's Hospital as well as professor of bioengineering at Harvard School of engineering and Applied sciences (SEAS.
and designed said Peng Yin senior author of the paper Wyss Core Faculty member and Assistant professor of Systems Biology at Harvard Medical school.
and Biophysics led by Mark Bathe senior co-author of the paper. The paper's findings describe a significant advance in DNA NANOTECHNOLOGY as well as in inorganic nanoparticle synthesis Yin said.
#Smallest world record has ndless possibilitiesfor bionanotechnology Scientists from the University of Leeds have taken a crucial step forward in bionanotechnology a field that uses biology to develop new tools for science technology and medicine.
demonstrates how stable'lipid membranes'--the thin'skin'that surrounds all biological cells--can be applied to synthetic surfaces.
Importantly, the new technique can use these lipid membranes to'draw'--akin to using them like a biological ink--with a resolution of 6 nanometres (6 billionths of a meter
and promises the ability to position functional biological molecules--such as those involved in taste, smell,
and other sensory roles--with high precision, to create novel hybrid bioelectronic devices, "said Professor Steve Evans,
"explained Evans. Aside from biological applications, this area of research could revolutionise renewable energy production. Working in collaboration with researchers at the University of Sheffield,
the researchers will be able to arbitrarily swap out the biological units and replace them with synthetic components to create a new generation of solar cells.
"This is part of the emerging field of synthetic biology, whereby engineering principles are being applied to biological parts
--whether it is for energy capture, or to create artificial noses for the early detection of disease
'A new method developed at the Centre for Plant Biotechnology and Genomics (CBGP UPM-INIA) has shown that by the contact of a plant with a strain of the Colletotrichum tofieldiae microorganism previously isolated this plant can increase the number size
or weight of its seeds fruits and flower. This discovery has been protected by patent and its implementation could lead to cost savings
pageac=patente. jsp&idpatente=812) and there is an exclusive commercial patent license agreement with Plant Response Biotech S l. a spin-off company from the Universidad Politécnica de Madrid created in 2008 that focuses its work on the development
Linden is working closely with project co-investigators Professor R. Scott Summers of environmental engineering and Professor Alan Weimer chemical and biological engineering and a team of postdoctoral fellows professionals graduate students undergraduates
Tittel is the J. S. Abercrombie Professor in Electrical and Computer engineering and a professor of bioengineering.
with a possible focus on filtering biological contaminants from groundwater to make it safe to drink. There are already a number of filters on the market that can do this,
The system is equipped also to treat the biological contaminants that Wright initially thought she be treating,
It is common for these so-called chiral molecules to exist in just one form in biological systems,
The chirality of these biomolecules also strongly affects the way in which they interact with other molecules,
#Where the bio-rubber meets the road My posts about biotechnology as it relates to agriculture tend to draw impassioned naysayers,
but surely here's a biotech application with which they can relate: a renewable fermentation process that seeks to act as a partial replacement for the an oil-based processes that goes into making synthetic rubber.
Biotech company Genencor, which is a division of Danisco, is more than one year into testing the commercial applications for
The only difference is that we are using biology to make it, and we are using renewable raw materials.
If you can have a simpler mechanism that doesn't require anatomical changes that's pretty darn good says Daniel Voytas director of the Center for Genome Engineering at the University of Minnesota.
Maureen Hansen a professor of molecular biology and genetics at Cornell says the advances won't be seen in commercially grown food crops for at least five or 10 years.
and making sure the genes are stable says Dean Price a professor of medicine biology and environment at Australian National University.
The mobile platform has been tested successfully in a clinical microbiology laboratory, comparing 571 patient samples to FDA-approved samples of mumps, measles,
professor of bioengineering and one of the researchers on the team. t is quite important to have these kinds of mobile devices,
physics and astronomy, to bioengineering, pathology and laboratory medicine. The Californa Nanosystems Institute and the Johnsson Comprehensive Cancer Center also contributed, with support from the National Science Foundation and the Howard hughes medical institute.
The research spearheaded by Aydogan Ozcan, associate director of the California Nanosystems Institute, Dino Di Carlo, professor of bioengineering,
and Omai Garner, associate director of clinical microbiology for the UCLA Health System, and written by UCLA undergraduate Brandon Berg (the study first author) manages to shrink this work down to the size
The FDA-approved well-plate readers used in clinical labs today were compared with the team handheld smartphone diagnostic in a UCLA clinical microbiology laboratory.
Some of the examples comprise materials that deliver biomolecules, rotate light, or control the flow of energy.
The team employed cryo-electron microscopy, also known as CRYO EM, to observe the particles and origami frames. This work was headed by Huilin Li, Brookhaven Lab and Stony Brook University biologist,
and Tong Wang, the other lead co-author of the paper and who also works with Li in the Biosciences department of Brookhaven.
In order to view the varied density components individually, the researchers need to subtract the data from the images
CRYO EM preserves samples in their near-native states and provides close to nanometer resolution. We show that CRYO EM can be applied successfully to probe the 3d structure of DNA NANOPARTICLE clusters,
Wang said. The DOE Office of Science supported the study. DOE Office of Science supports the Brookhaven National Laboratory.
#Polymer Nanobrushes Grab Selected Bacteria for Pathogen Detection A Texas A&m Agrilife Research engineer and a Florida colleague have developed a biosensor that can detect listeria bacterial contamination within two
"said Dr. Carmen Gomes, Agrilife Research engineer with the Texas A&m University department of biological and agricultural engineering, College Station.
The biosensor she is working on is still in the prototype stage of development, but in a few years she envisions a hand-held device that will require hardly any training to use.
"I do the biological and polymer engineering; he does the electrochemistry and nanostructures, "she said.
As for the biological component, Gomes said she is using"nanobrushes"specially designed to grab particular bacteria.
"The selection process the polymers use to select for specific bacteria in the listeria biosensor is very similar to the squid's cilia.
"Currently, the listeria biosensor is about the size of a postage stamp, with two wires leading to two etched conductive areas.
Also in the works is a disposable paper-based biosensor that can be disposed of after one use.
Velev, INVISTA Professor of Chemical and Biomolecular engineering at NC State. The nanoparticles infused with silver ions were utilized to attack Pseudomonas aeruginosa, disease-causing bacteria;
and Ralstonia, a genus of bacteria that contains various soil-borne pathogens. All these bacteria were destroyed by the newly developed nanoparticles.
The findings, published in Nature Chemical Biology, raise promise for medicine but also concerns about"home-brewed"illegal drugs.
Dr John Dueber, a bioengineer at the university, said:""What you really want to do from a fermentation perspective is to be feed able to the yeast glucose,
Prof Paul Freemont, one of the directors of the Centre for Synthetic biology and Innovation at Imperial College London, said:"
Lead researcher Aydogan Ozcan, Howard hughes medical institute chancellor professor at UCLA, sat down with Bioscience Technology to talk about this advancement and its implications for resource-poor labs,
-and Nanophotonics Laboratory at UCLA Electrical engineering and Bioengineering Departments, said. To scan the DNA researchers developed a computational interface
and potentially decide on a drug choice based on some of the genetic testing copy number variations of certain genes that you would find in the sample taken from the patient. he technology also removes barriers to testing that cities
said Warren Ruder, an assistant professor of biological systems engineering in both the College of Agriculture and Life sciences and the College of Engineering."
For future experiments, Ruder is building real-world robots that will have the ability to read bacterial gene expression levels in E coli using miniature fluorescent microscopes.
understanding the biochemical sensing between organisms could have far reaching implications in ecology, biology, and robotics.
engineered gene circuits in E coli, microfluid bioreactors, and robot movement. The bacteria in the mathematical experiment exhibited their genetic circuitry by either turning green or red, according to
Ruder conducted his research in collaboration with biomedical engineering doctoral student Keith Heyde, of Wilton, Connecticut, who studies phyto-engineering for biofuel synthesis. e hope to help democratize the field of synthetic biology for students and researchers all over the world with this model,
said Ruder. n the future, rudimentary robots and E coli that are used already commonly separately in classrooms could be linked with this model to teach students from elementary school through the Ph d.-level about bacterial relationships with other organisms. ource:
along with Dino Di Carlo, professor of bioengineering, and Omai Garner, associate director of clinical microbiology for the UCLA Health System.
UCLA undergraduate Brandon Berg was the study first author, and two other undergraduates also contributed to the research. t is quite important to have these kinds of mobile devices,
and Bioengineering. his mobile platform can be used for point-of-care testing, screening populations for particular diseases,
This mobile platform was compared with the standard FDA-approved well-plate readers in a UCLA clinical microbiology laboratory.
The UCLA team included researchers from electrical engineering, physics and astronomy, bioengineering, pathology and laboratory medicine,
and Michael Lewinski, an adjunct faculty in UCLA bioengineering department. This research was supported by the National Science Foundation and the Howard hughes medical institute h
#Biodiesel production from Sugarcane A multi-institutional team led by plant biology professor Stephen P. Long from the University of Illinois reports that it can increase sugarcane's geographic range boost its photosynthetic rate by 30 percent
Using genetic engineering the researchers increased photosynthetic efficiency in sugarcane and sorghum by 30 percent Long said.
Long is an affiliate of the Institute for Genomic Biology at the University of Illinois s
Industrial biotechnology continues to enable solutions to energy challenges and building a biobased economy is key to reducing dependence on foreign oil enhancing our nation economic and energy security.
Last week, the U s. Navy signed an agreement with biotech company Biodico to collaborate on developing advanced biofuels and bioenergy refineries throughout the globe for the U s. military.
spent two years using a PCC store as a iving laboratory to understand how food waste is created in a retail grocery environment. n 2010 the WISERG teamith the help of biologists, computer programmers and engineerseveloped a solution:
That finding dispels concerns that the genetic material will quickly degrade in rain and sunlight. In the proof-of-principle study researchers wanted to answer
Geneticists have used the technique to silence specific genes examine what functions are lost and hence learn that gene purpose.
#New gene therapy could rewire the eye to help blind people see Scientists might be able to change the cells in blind people eyes,
Now, scientists hope that they can use gene therapy to transform nerves in the eye to replace those lost photoreceptors.
It is part of a new field called optogenetics which uses molecules from algae or other microorganisms that respond to light,
Optogenetics is a form of gene therapy and works by changing the makeup of the damaged cells.
it is not likely to cause the same kind of ethical and practical problems that blight work on other forms of gene therapy.
"Working with Shaoqin"Sarah"Gong, a UW-Madison professor of biomedical engineering, Cai's group addressed two key barriers to using wood-derived materials in an electronics setting:
"said Velev, INVISTA Professor of Chemical and Biomolecular engineering at NC State and the paper's corresponding author."
Ralstonia, a genus of bacteria containing numerous soil-borne pathogen species; and Staphylococcus epidermis, a bacterium that can cause harmful biofilms on plastics-like catheters-in the human body.
"said Velev, INVISTA Professor of Chemical and Biomolecular engineering at NC State and the paper's corresponding author."
Ralstonia, a genus of bacteria containing numerous soil-borne pathogen species; and Staphylococcus epidermis, a bacterium that can cause harmful biofilms on plastics-like catheters-in the human body.
The researchers, led by University of Illinois bioengineering professors Dipanjan Pan and Rohit Bhargava, report their findings in the journal Small."
"##The research team included faculty members in bioengineering, chemical and biomolecular engineering, chemistry, electrical and computer engineering and mechanical science and engineering;
4-D printing to advance chemistry, materials sciences and defense capabilities June 18th, 2015cancer First full genome of a living organism assembled using technology the size of smartphone June 15th,
and deposited onto a spinal cord lesion in Glial fibrillary acidic protein-luc Transgenic mices (GFAP-luc mice). Overexpression of GFAP is an indicator of astrogliosis/neuroinflammation in CNS injury.
2015newly-Developed Biosensor in Iran Detects Cocaine addiction June 23rd, 2015university of Tehran to Host 12th Int'l Confab on Membrane Science, Technology (MST2015) June 23rd,
2015newly-Developed Biosensor in Iran Detects Cocaine addiction June 23rd, 2015discoveries Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015sweeping lasers snap together nanoscale geometric grids:
2015newly-Developed Biosensor in Iran Detects Cocaine addiction June 23rd, 2015iranian Scientists Design Nano Device to Detect Cyanogen Toxic Gas June 23rd,
2015newly-Developed Biosensor in Iran Detects Cocaine addiction June 23rd, 2015university of Tehran to Host 12th Int'l Confab on Membrane Science, Technology (MST2015) June 23rd,
2015newly-Developed Biosensor in Iran Detects Cocaine addiction June 23rd, 2015iranian Scientists Design Nano Device to Detect Cyanogen Toxic Gas June 23rd, 2015materials/Metamaterials n-tech Research Issues Report on Smart Coatings Market
and the Environment June 24th, 2015newly-Developed Biosensor in Iran Detects Cocaine addiction June 23rd, 2015iranian Scientists Design Nano Device to Detect Cyanogen Toxic Gas June 23rd,
"said Velev, INVISTA Professor of Chemical and Biomolecular engineering at NC State and the paper's corresponding author."
Ralstonia, a genus of bacteria containing numerous soil-borne pathogen species; and Staphylococcus epidermis, a bacterium that can cause harmful biofilms on plastics-like catheters-in the human body.
"said Jihyun Kim, the team leader and a professor in the Department of Chemical and Biological engineering at Korea University."
the processing of the woolen fabric samples by using optimum amount of honeycomb nanocomposite such as N-Ag/Zno improves the biological, mechanical and hydrophilicity of the fabrics.
with a possible focus on filtering biological contaminants from groundwater to make it safe to drink. There are already a number of filters on the market that can do this,
The system is equipped also to treat the biological contaminants that Wright initially thought shed be treating,
Overtext Web Module V3.0 Alpha
Copyright Semantic-Knowledge, 1994-2011