and brain signaling with the potential to transform our understanding of how the brain worksnd how to treat its most devastating diseases.
This could get around a lot of serious health problems in neurodegenerative diseases in the future.""These disorders, such as Parkinson's, that involve malfunctioning nerve cells can lead to difficulty with the most mundane and essential movements that most of us take for granted:
This inability to see what's happening in the body's command center hinders the development of effective treatments for diseases that stem from it.
which are affected in some neurodegenerative diseases. And it's at this level where the promise of Lieber's most recent work enters the picture.
#Supercomputers reveal strange stress-induced transformations in world's thinnest materials (Phys. org) Interested in an ultra-fast unbreakable and flexible smart phone that recharges in a matter of seconds?
and break under stress. Fortunately researchers have pinpointed now the breaking mechanism of several monolayer materials hundreds of times stronger than steel with exotic properties that could revolutionize everything from armor to electronics.
In this study DFT calculations revealed the materials'atomic structures stress values vibrational properties and whether they acted as metals semiconductors or insulators under strain.
These toxic liquid solvents raise many issues for concern including environmental pollution, high cost of disposal, health problems and poisoning during the disposal process.
or DNA sequence from one animal into the genome of another plays a critical role in a wide range of medical researchncluding cancer, Alzheimer's disease, and diabetes.
and repel DNALLOWING injections to occur with a tiny, electrically conductive lance,"explained Brian Jensen, associate professor in the Department of Mechanical engineering at Brigham Young University."
This ability to inject DNA into cells without causing cell death leads to"more efficient injections,
"This may enable future automation of the injections, without requiring manual injection, "Jensen says. It may also mean that injections can be performed in animals with cloudy or opaque embryos."
"Such animals, including many interesting larger ones like pigs, would be attractive for a variety of transgenic technologies,
"said Jensen.""We believe nanoinjection may open new fields of discovery in these animals.""As a next step, Jensen and colleagues are performing injections into cells in a cell culture using an array of lances that can inject hundreds of thousands of cells at once."
"We expect the lance array may enable gene therapy using a culture of a patient's own cells,
In the future such a clone could be a source of stem cells for super-personalized therapies made from people's own DNA.
You also fail to mention just how many advances in modern medicine we were given by the Germans.
And yes a lot of medical breakthroughs came from the horrible experiments done by the Nazi's
-which might not actually manage to develop into a human even under the right conditions-than of individuals who suffer daily with crippling diseases that were thrust upon them by chance
Stem cell research is an incredibly valuable source of information concerning real diseases that real humans are really suffering from right at this very moment.
Stem cell-derived organs might in future provide accurate disease models for screening of pharmaceutical compounds reducing the requirement for animal testing
and potentially getting new medicines to the people who need them more rapidly. Not to mention the potential applications of stem cell-derived organs in toxicology screens for new pharmaceutical compounds
in order to reduce the chances of severe side effects manifesting further down the line in real living people.
'there is enormous medical potential here and I think that to deny such potential for the individuals who will most benefit from it in future
and while many of these are beneficial, some can cause disease. For example, some reports have linked Crohn disease to the presence of certain strains of E coli. e like to be able to remove specific members of the bacterial population
and see what their function is in the microbiome, Lu says. n the longer term you could design a specific phage that kills that bug
but more information about the microbiome is needed to effectively design such therapies. he paper lead author is Hiroki Ando, an MIT research scientist.
but efforts to harness them for medical use have been hampered because isolating useful phages from soil
so that simplifies that workflow in the lab. he new approach also overcomes an important hurdle in using bacteriophages to treat disease,
which makes it difficult to choose the right phage for the right infection, if such a phage is available at all,
who was involved not in the research. his is a big step in the development of phage therapies with predictable outcomes and a good demonstration of
what synthetic biology approaches will bring to medicine in the near future. targeted strikein this study, the researchers engineered phages that can target pathogenic Yersinia and Klebsiella bacteria,
and gastrointestinal infections, including pneumonia, sepsis, gastritis, and Legionnairesdisease. One advantage of the engineered phages is that unlike many antibiotics,
Lu says. e aim to create effective and narrow-spectrum methods for targeting pathogens. u
as well as treating human disease. Another advantage of this approach is that all of the phages are based on an identical genetic scaffold,
Digital imaging is expected to enable many emerging fields including wearable devices, sensor networks, smart environments, personalized medicine,
#New synthetic technology for medicines and fine chemicals A University of Tokyo research group has succeeded in synthesizing (R)- and (S)- rolipram, the active component of a medicine,
in high yield with high selectivity by an innovative catalyzed flow fine synthesis instead of the traditional batch method used in the production of 99%of medicines.
the active components of medicines as well as other fine chemicals are synthesized by a repeated batch reaction method, in
Professor Kobayashi says"This new technology can be applied to not only other gamma aminobutyric-acids acids and medicines but also various chemicals such as flavors, agricultural chemicals,
Medical devices designed to reside in the stomach have a variety of applications, including prolonged drug delivery, electronic monitoring,
However, these devices, often created with nondegradable elastic polymers, bear an inherent risk of intestinal obstruction as a result of accidental fracture or migration.
Now, researchers at MIT Koch Institute for Integrative Cancer Research and Massachusetts General Hospital (MGH) have created a polymer gel that overcomes this safety concern
which is a medical emergency potentially requiring surgical intervention, says Koch Institute research affiliate Giovanni Traverso,
as there is a greater risk for fracture if a device is too large or too complex.
a professor of medical science and engineering at Brown University who was not involved with this study. his is a very smart approach. n particular,
patientsadherence to long-term therapies for chronic illnesses is only 50 percent in developed countries, with lower rates of adherence in developing nations.
Medication nonadherence costs the U s. an estimated $100 billion every year, the bulk of which comes in the form of unnecessary hospitalizations.
The researchers also say that single-administration delivery systems for the radical treatment of malaria
and other infections could significantly benefit from these technologies. In a March 2015 commentary piece in Nature, Traverso and Langer wrote that the GI TRACT is an area rife with opportunity for prolonged drug delivery in tackling this global health problem.
With this new material which can be used to create extended-release systems via swallowable ills,
they envision an emerging field of orally delivered devices that can maximize adherence and therapeutic efficacy.
#Bioadhesive Nanoparticles Help Protect Your Skin From the Sun Dermatologists from Yale university have developed a new sunscreen made with bioadhesive nanoparticles that doesn penetrate the skin,
Most commercial sunblocks are good at preventing sunburn, but they can go below the skin surface
the researchers tested their sunblock against direct ultraviolet rays and their ability to cause sunburn.
the researchersformulation protected equally well against sunburn. They also looked at an indirect and much less studied effect of UV LIGHT.
said co-author Michael Girardi, a professor of dermatology at Yale Medical school. n fact, the indirect damage was worse
and Julia Lewis, from the Department of Dermatology. Saltzman and Girardi are affiliated with the Yale Cancer Center.
Source: William Weir, Yale Universit C
#Tunnel Transistor May Meet Power Needs of Future Chips A new kind of transistor consumes 90 percent less power than conventional transistors,
medical devices and Internet of things devices anything that doesn require massive amounts of electricity. It will be launching on Kickstarter in one month for $99,
#3d printed Tadpole Endoscope device can improve cancer diagnoses Sep 15, 2015 By Kiratadpoles. Very recently, we reported on 3d printed icrofishrobots that can be injected directly into our blood to perform complex medical tasks.
Now, yet another aquatic creature has inspired scientists and 3d engineers within the medical community. A team from the Institute of Precision Engineering at the Chinese University of Hong kong as developed 3d printed tadpole-like devices that can improve diagnosis of various cancers by entering the patient stomach
and wirelessly transmitting images of what it sees. A traditional procedure for diagnosing cancers of the gastrointestinal (GI TRACT
which rank as the second most prevalent among all types of cancers in the world,
is endoscopy, wherein a long, flexible tube with a light and camera attached to its end passes through a person digestive system.
This can be done either through the mouth and back of the throat, as in gastropy,
doctors can get a firsthand view of the patient organs and assess the damage. While the procedure has been invaluable in diagnosing stomach, intestinal, esophagus and colon cancers
it requires a great deal of skill on behalf of the doctor, and can be uncomfortable, painful, and stressful for the patientot to mention prohibitively expensive.
and relatively noninvasive solution that could improve the very way we diagnose cancers. Developed to be swallowed just like a large pill (it is a bit bigger than a small coin),
which allows it to be guided deftly around the entire stomach by the doctor, and the ingeniously 3d printed shell,
when it comes to cancer diagnosis. Once the stomach has been checked thoroughly, the device wimsinto the lower GI TRACT aided by natural peristaltic actionhat is,
the doctor can view different parts of the stomachex vivo testing in a pig stomach.
and eventually be implemented successfully in medical applications. Posted in 3d printing Applications (adsbygoogle=window. adsbygoogle. push({}
Its applications range from medicine, advanced energy, electronics, aerospace design and many others. Despite these groundbreaking characteristics,
and delivering medicinal products to hard-to-reach places within the body. The leaders of this project, Professors Shoachen Chen and Joseph Wang, recognized that most microrobots that have already been produced are unable to perform more advanced tasks due to their simply-shaped designs and inorganic physical make-ups.
will be able to serve as both a detoxification device and a toxin sensor too, and, hopefully,
and detoxification is monitored easily due to the red light that is emitted on the device when nanoparticles are introduced to the particular toxins.
helping medical professionals gather their diagnosis from swimming throughout the body with these microfish. 3d printing enthusiasts are amazed oftentimes by
Researchers in professor Margaret Frey lab create fibers hundreds of times thinner than a human hair that can capture toxic chemicals and pathogens.
processes done in a medical testing lab for example, purifying samples, mixing ingredients, capturing bacteria can be done with material about the size of a deck of cards.
and will diagnose diseases without requiring specialized laboratories particularly useful in regions with limited access to doctors and hospitals.
and allows it to time-release. y allowing rapid detection of disease and preventing agricultural chemical release into the environment,
#Nanoporous Gold Sponge Detects Pathogens Faster This novel technique enables sensitive DNA detection in compound biological samples e g.,
According to UC Davis researchers, these sponge-like nanoporous gold hold the potential for enabling new devices to detect agents responsible for causing disease in both plants
It almost like a natural sieve. arly identification of disease biomarkers and pathogenic microbes is possible with the swift and sensitive detection of nucleic acids.
Going forward, the team anticipates that their research will be useful in the progress of mini point-of-care diagnostic systems for clinical and agricultural applications. he applications of the sensor are quite broad ranging from detection of plant pathogens to disease biomarkers,
For instance, in human sepsis cases, the illness can be detected early on, thereby preventing any needless treatments as doctors can now establish bacterial contamination much more rapidly than ever before.
Similarly in agriculture, without the occurrence of any symptoms researchers can still detect if pathogens are present.
Pallavi Daggumati, Zimple Matharu, and Ling Wang in the Department of Electrical and Computer engineering at UC Davis were the other authors of the papers.
#Nanoporous Gold Sponge Detects Pathogens Faster This novel technique enables sensitive DNA detection in compound biological samples e g.,
According to UC Davis researchers, these sponge-like nanoporous gold hold the potential for enabling new devices to detect agents responsible for causing disease in both plants
It almost like a natural sieve. arly identification of disease biomarkers and pathogenic microbes is possible with the swift and sensitive detection of nucleic acids.
Going forward, the team anticipates that their research will be useful in the progress of mini point-of-care diagnostic systems for clinical and agricultural applications. he applications of the sensor are quite broad ranging from detection of plant pathogens to disease biomarkers,
For instance, in human sepsis cases, the illness can be detected early on, thereby preventing any needless treatments as doctors can now establish bacterial contamination much more rapidly than ever before.
Similarly in agriculture, without the occurrence of any symptoms researchers can still detect if pathogens are present.
Pallavi Daggumati, Zimple Matharu, and Ling Wang in the Department of Electrical and Computer engineering at UC Davis were the other authors of the papers.
a make-or-break figure for those who are struggling with stunted production and less or no profit due to the disease. uring the past 15 years,
The disease starves the tree of nutrients damages its roots and the tree produces fruits that are green and misshapen, unsuitable for sale as fresh fruit or, for the most part, juice.
and the disease has affected already millions of citrus trees in North america. It has recently been found twice in California.
to combat disease for filtering fresh drinking water, and much more. Now, researchers from MIT and the Federal University of Goias in Brazil have developed a new technique that uses ultraviolet (UV LIGHT to extract man-made pollutants from soil and water.
Lead author Nicolas Bertrand, a former professor at MIT Koch Institute for Integrative Cancer Research, told Laboutlook that he
Drug delivery and beyondthe power of nanoparticles is also being harnessed to fight life-threatening lung diseases, such as cystic fibrosis.
and bacterianfortunately prevents targeted therapies from reaching the lungs. Other attempts to penetrate the barrier with nanoparticles were unsuccessful
a biomedical engineer and faculty member at the Center for Nanomedicine at the Wilmer Eye Institute at Johns Hopkins. Researchers funded by the National Institute of Biomedical Imaging and Bioengineering meanwhile,
stopped brain cancer in rats by delivering gene therapy through nanoparticles. The nanoparticles deliver genes for an enzyme that converts a prodrug called ganciclovir into a glioma cell killer.
There is no reliable treatment for glioma which has a 5-year survival rate of 12 percent.
As in cystic fibrosis, a current delivery method of gene therapy relies on using a virus, which can pose significant safety risks.
Challenges remainbertrand and other lead author Ferdinand Brandl both left MIT to join pharmacy schools in Quebec city, Canada and Regensburg, Germany, respectively.
Researchers propose to do by making the plants better at handling stress. Now I know what you might be thinking tress limate changeit sounds like it time to call the plant acupuncturist.
when the plant detects stress. Beneath this superficially crude mechanism lie untold layers of regulatory nuance.
the device could have applications in voice-command electronics, medical sensing devices that use waves, like ultrasound,
and hearing aids and cochlear implants. The proof-of-concept device looks a bit like a thick, plastic, pie-shaped honeycomb split into dozens of slices.
you could build the tissue right at the surgery time to be whatever size that you require,
Surgeons could then graft the scaffold onto the patient's heart, and after a few months the patient would be left with a repaired heart (and no scaffold,
#Tadpole-like endoscope swims through gastrointestinal tract in search of cancer Endoscopes are essential tools for the medical examination of many organs of the human body,
With cancers of the gastrointestinal (GI TRACT such as esophageal cancer, stomach cancer, and colon cancer, being some of the most commmon of all cancers in the world,
a range of procedures are necessary to physically examine all parts of the GI for maximum diagnostic effect.
Of these, gastroscopy is used to help diagnose esophageal and stomach cancer, whilst intestinal and coleorectal cancers can be determined with the use of capsule endoscopy and colonoscopy, respectively.
Unfortunately, all of these procedures are costly to perform and can place a great deal of stress on someone who may already be quite ill.
The new Tadpole Endoscope (TE on the other hand, is a relatively noninvasive device that is simply swallowed like a large pill
and then remotely guided around inside the patient's stomach by a doctor. Created by engineers from the Institute of Precision Engineering at the Chinese University of Hong kong,
the device has a soft-tail that it uses to maneuver about, a 3d printed shell that contains the control electronics,
After the TE has been used in the initial diagnosis of the stomach natural peristaltic action (the"squeezing"motion of muscles that ordinarily move food down the GI) will push it into the lower GI TRACT.
and record subsequent images which a medical professional can then download and add to the complete diagnostic data Set in testing thus far,
the researchers believe that the feasibility of the propulsion model will move their creation toward the next set of experiments and onward to eventual deployment in working medical applications.
and function after a heart attack Though sufferers of heart attacks may survive the initial event, they cause permanent damage to the organ in the form of scar tissue,
which affects its ability to pump blood. Scientists around the world are working on this problem, with hydrogels,
they then went on to develop a therapeutic patch made from collagen that incorporated this compound.
In pigs that had suffered from a heart attack, blood pumped out of the left ventricle was reduced from the normal 50 percent to 30 percent.
He envisioned a mog Free Towerthat would operate using the same air purifying technology hospitals do.
Biochemical engineer Christina Smolke and colleagues had been working on the problem of synthesizing opioids and other plant-based medicines in the lab for about a decade.
the lab-based manufacturing approach wouldn't be vulnerable to weather and disease, the way poppy crops are--allowing millions of people around the world who do not have sufficient access to painkilling drugs to get the medications they need.
that it would require thousands of gallons of yeast to make a single dose of medicine."
would need to be addressed for engineered yeast to ever realize home-brew biosynthesis of medicinal opiates at meaningful yields."
While noting that the work will need still refinement before it becomes a public health threat, he marveled at how quickly developments had been unfolding in bioengineering--for morphine synthesis
Tandon is a scientist, biomedical engineer, TED Senior Fellow and co-author of Super Cells: Building with Biology (TED Conferences, 2014.
If you've lost a healthy bone to an accident or illness, or if you were born with bones that aren't the right shape,
what it sees as a foreign object, leading to infections or defective transplants after these operations.
the late American film critic who lost his jawbone to cancer, is autograft. This is basically a euphemism for cutting a piece of bone out of one part of the body
Though it is surgeons'current best option, it still isn't that great. The surgery is invasive and destructive.
It can leave patients with a whole host of new issues, including the need for multiple surgeries.
Roger Ebert because doctors cut bone out of his hip and shoulder, suffered a limp for the rest of his life.
And with children who need the procedure, autografts are an even worse option; there's often quite simply not enough bone to go around.
One emerging technology for skeletal reconstruction is printed 3d synthetic implants made to match the anatomical shape of a patient's defects,
Others are developing stem-cell therapies, such as those from Stempeutics, Novadip or Bonus Biogroup. In this method
This is an implant that the patient's body hopefully won't reject because it's made from his or her own cells.
we might also adapt cells to groundbreaking new uses in other realms of medicine, or even entirely different fields, such as architecture, art and fashion.
problem-prone bone transplants are statistics from the past. Countless patients, present and future, hope so too.
but applying these chemicals to the surface of wounds has its limits. To best stem blood loss, those chemicals need to be able to find their way deep into a wound.
There may now be a solution, however, and it comes in the unlikely form of fizz, reports Wired.
propelling them deep into a wound as they pop. The new concoction is composed of powdered marble, tranexamic acid
Water from the blood is the catalysis that sets it fizzing. f you can get the particles in the general area of the wound,
a biomedical engineer at the University of British columbia. t similar to when a grenade goes off
all the way to the damaged internal blood vessels feeding the wound. By clotting so deep into the lesion, the clot was shown to be more stable.
Right now the fizzing agent is a bit messy. While chemicals do get deeper into the wound,
they pop off in every other direction too. Eventually researchers hope to make the delivery process more efficient,
Paramedics equipped with these fizzy bandages could prolong the lives of patients during transit to the hospital, for instance
Proof-of-concept study conducted in mice a key step toward better treatments for lung diseases August 3rd,
The detection process is exactly opposite to the spin wave injection: a spin wave collides at the interface between YIG and platinum,
and charge to some part of another molecule--such as the binding site of a human protein involved in some physiological process that goes awry in a given disease.
2015efforts to Improve Properties of Body Implants Using Nanocoatings Yield Positive Results September 28th, 2015cheap Nanomembrane, New Option for High-temperature Fuel cells September 26th,
2015efforts to Improve Properties of Body Implants Using Nanocoatings Yield Positive Results September 28th, 2015scientists Apply Graphene quantum dots in Production of Azo dyes September 26th, 2015discoveries Zenyatta Ventures Ltd.
2015efforts to Improve Properties of Body Implants Using Nanocoatings Yield Positive Results September 28th, 2015a different type of 2-D semiconductor:
2015efforts to Improve Properties of Body Implants Using Nanocoatings Yield Positive Results September 28th, 2015a different type of 2-D semiconductor:
2015efforts to Improve Properties of Body Implants Using Nanocoatings Yield Positive Results September 28th, 2015simulation of chiral edge states in a quantum system September 26th, 2015a different type of 2-D semiconductor:
Orbital angular momentum of neutron waves can be controlled September 25th, 2015liquid crystals show potential for detection of neurodegenerative disease September 24th, 201 0
He worries more about gremlins that plague today's reverse osmosis membranes--growths on membrane surfaces that clog them (called"biofouling)
leading to the rapid synthesis of drug derivatives for treating Parkinson's disease. Nagoya, Japan-Yutaro Saito, Yasutomo Segawa and Professor Kenichiro Itami at the Institute of Transformative Biomolecules (ITBM
"displays the development of a powerful synthetic method that enables rapid access to para-functionalized benzene derivatives to construct libraries of bioactive compounds that are useful in medicinal chemistry.
which is an anticholinergic drug used in the treatment of Parkinson's disease.''Parachuting'boron onto the para-position of a benzene ring by a bulky iridium catalyst.
Caramiphen, an anticholinergic agent used for the treatment of Parkinson's disease contains a monosubstituted benzene moiety along with ester and amine groups.
In the medical field, the substance has shown activity against cancer cell lines. In cosmetics, people appreciate the good smell, in soft drinks a fine, subtle taste.
Thanks to this substance malaria is curable. Unfortunately, it could be found only in tiny quantities in the sweet wormwood-until the US researcher Jay Keasling was able to transfer the appropriate production route from the plant in bacteria.
#A new sunblock that doesn't penetrate the skin Most commercial sunblocks are good at preventing sunburn,
the researchers tested their sunblock against direct ultraviolet rays and their ability to cause sunburn.
the researchers formulation protected equally well against sunburn. They also looked at an indirect and much less studied effect of UV LIGHT.
said co-author Michael Girardi, a professor of dermatology at Yale Medical school. In fact, the indirect damage was worse
#Brain Friendly Interface Could Change the Way People with Spinal cord Injuries Lead Their Lives Recent research published in the journal Microsystems
and spinal cord injury lead their lives. Instead of using neural prosthetic deviceshich suffer from immune-system rejection
helping people living with limb loss and spinal cord injury become more independent. However not only do neural prosthetic devices suffer from immune-system rejection,
this same methodology could then be applied in getting these extracellular matrix derived electrodes to be the next wave of brain implants,
There is a significant burden in cost of care and quality of life for people suffering from this disability.
Further, it rendered the implants sufficiently rigid for penetration into the target brain region and allowed them subsequently to soften to match the elastic modulus of brain tissue upon exposure to physiological conditions,
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