To accomplish that Duke university researchers used software they developed to predict a constantly-evolving infectious bacterium's countermoves to one of these new drugs ahead of time before the drug is tested even on patients.
When the researchers treated live bacteria with the new drug two of the genetic changes actually arose just as their algorithm predicted.
This gives us a window into the future to see what bacteria will do to evade drugs that we design before a drug is deployed said co-author Bruce Donald a professor of computer science and biochemistry at Duke.
and Amy Anderson at the University of Connecticut used a protein design algorithm they developed called OSPREY to identify DNA sequence changes in the bacteria that would enable the resulting protein to block the drug from binding
The researchers are now using their algorithm to predict resistance mutations to other drugs designed to combat pathogens like E coli and Enterococcus.
The software they developed called OSPREY is open-source and freely available for any researcher to use e
"The data from the studies have been shared with federal regulators, he added, with the aim of launching a clinical trial to test the system at UPMC this year."
#New laser for computer chips: International team of scientists constructs first germanium-tin semiconductor laser for silicon chips The transfer of data between multiple cores as well as between logic elements and memory cells is regarded as a bottleneck in the fast-developing computer technology.
Data transmission via light could be the answer to the call for a faster and more energy efficient data flow on computer chips as well as between different board components.
Signal transmission via copper wires limits the development of larger and faster computers due to the thermal load and the limited bandwidth of copper wires.
The clock signal alone synchronizing the circuits uses up to 30%of the energy--energy which can be saved through optical transmission explains Prof.
Some long-distance telecommunication networks and computing centres have been making use of optical connections for decades.
Through optical fibres signal propagation is almost lossless and possible across various wavelengths simultaneously: a speed advantage
Along with computer chips completely new applications that have not been pursued so far for financial reasons may
In the future cost-effective portable sensor technology--which may be integrated into a smart phone--could supply real-time data on the distribution of substances in the air
plasmids and other mobile genetic elements, says Rodolphe Barrangou, associate professor of food science at NC State and a co-corresponding author of the paper.
Conventional honeycomb structures are insular panels of repeating, often hexagonal-shaped cells in a range of sizes and configurations.
"said Zhenqiang Ma, the team leader and a professor of electrical and computer engineering at the UW-Madison."
but cellulose nanofibrillated fiber films have the potential to replace silicon wafers as electronic substrates in environmental friendly, low-cost, portable gadgets or devices of the future.
PLA is also one of the few plastics that are suitable for 3d printing. However, PLA is not yet a full alternative for petroleum-based plastics due to its cost.
In a paper published July 10 in the journal Physical Review Letters, Zongfu Yu, an assistant professor of electrical and computer engineering,
By simulating experiments in computers and observing the results, they were able to design actual chemistry experiments and reagents with much better performance than traditional trial-and-error approaches.
collaboration could lead to biodegradable computer chips Portable electronics typically made of nonrenewable, non-biodegradable and potentially toxic materials are discarded at an alarming rate in consumerspursuit of the next best electronic gadget.
In an effort to alleviate the environmental burden of electronic devices, a team of University of Wisconsin-Madison researchers has collaborated with researchers in the Madison-based U s. Department of agriculture Forest Products Laboratory (FPL) to develop a surprising solution:
A cellulose nanofibril (CNF) computer chip rests on a leaf. Image credit: Yei Hwan Jung, Wisconsin Nano Engineering Device Laboratory A cellulose nanofibril (CNF) computer chip rests on a leaf.
Image credit: Yei Hwan Jung, Wisconsin Nano Engineering Device Laboratory The research team, led by UW-Madison electrical
and computer engineering professor Zhenqiang ackma, described the new device in a paper published on May 26, 2015 by the journal Nature Communications.
or support layer, of a computer chip, with cellulose nanofibril (CNF), a flexible, biodegradable material made from wood. he majority of material in a chip is support.
Yei Hwan Jung, a graduate student in electrical and computer engineering and a co-author of the paper,
data storage hardware and advancing quantum computing. uow195685 o one in the scientific community believed silicene paper could be made
Dr Du said. hen we use two small robotic arms that we move with a hand-held video game controller to catch the atoms in the vacuum chamber
for context, only 108 mammals are listed in the National Center for Biotechnology Information database. ntil recently,
With advances in DNA sequencing technology and computer processing the process is now efficient and cost-effective enough to be useful in obtaining whole genome sequences of wildlife species, like bighorn sheep.
As a game species, the trophy status of a bighorn sheep ram is based largely on horn size.
Because the rams with the largest horns are often the ones targeted by hunters their removal from a population could then eliminate the genetic ability of animals in that population to grow large horns.
a chemical engineer with joint appointments at Berkeley Lab and UC Berkeley. he recyclable catalysts we developed are capable of converting sugarcane biomass into a new class of aviation fuel and lubricants with superior cold
The process developed at EBI can be used to selectively upgrade alkyl methyl ketones derived from sugarcane biomass into trimer condensates with better than 95-percent yields.
and additives for gasoline as Gokhale explains. ith some minimal modifications to both the catalysts
but hold that there still important incentives to encourage investments. ee shown in this study that biorefineries can use inexpensive catalysts to produce a suite of hydrocarbon fuels and lubricants,
and tested the results with advanced 3d printing technology. The new findings could serve as a basis for designing moveable components with especially natural mobile properties, for example for applications in robots.
To this end, they developed a computer simulation as well as tissue-like materials from a porous polymer in
The researchers were delighted also that the theoretical predictions from the computer simulation almost perfectly matched the results of their tests on synthesized porous polymer materials.
Only the amount of expansion was somewhat less in the experiment than in the virtual simulation. his means that wee able to design such materials on the computer
Scientists at Harvard university in Cambridge, USA, manufactured the material with the help of a multimaterial 3d printer.
air filtration systems and even your clothes. bbey Liebman 0 created a dress using conductive cotton threads capable of charging an iphone.
With ultrathin solar panels for trim and a USB charger tucked into the waist, the Southwest-inspired garment captured enough sunshine to charge cell phones
and other handheld devices allowing the wearer to stay plugged in. The technology may be embedded into shirts to measure heart rate
and environmentally benign method to combat bacteria by engineering nanoscale particles that add the antimicrobial potency of silver to a core of lignin,
The remaining particles degrade easily after disposal because of their biocompatible lignin core, limiting the risk to the environment. eople have been interested in using silver nanoparticles for antimicrobial purposes,
INVISTA Professor of Chemical and Biomolecular engineering at NC State and the paper corresponding author. e show here an inexpensive and environmentally responsible method to make effective antimicrobials with biomaterial cores. he researchers used the nanoparticles
#Processors do grow on trees: your next phone could be made of wood Engineers hunting for a way to make electronics more sustainable have hit on a novel invention-a semiconductor chip made almost entirely out of wood.
The idea is that instead of making chips from petroleum-based plastic, we'd be able to use cellulose nanofibril-a flexible,
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