Cancer cachexia impairs quality of life and response to therapy, which increases morbidity and mortality of cancer patients.
Currently, there is no approved treatment for muscle wasting but a new study from the Research Institute of the Mcgill University Health Centre (RI-MUHC) and University of Alberta could be a game changer for patients, improving both quality of life and longevity.
The research team discovered a new gene involved in muscle wasting that could be a good target for drug development.
In all of these chronic conditions, muscle wasting predicts earlier death.""Cancer patients often present with muscle wasting even prior to their initial cancer diagnosis,
not only can we potentially improve the quality of life of patients, but also allow them to better tolerate their oncological treatments, to stay at home for a longer period of time,
The quantum lab on tour through Austria Currrently, a light version of the virtual lab can be experienced as an interactive exhibit in the special exhibition"Das Wissen der Dinge"in the Natural history Museum Vienna.
-H in cell lines, primary neuron cultures and zebrafish using molecular genetics, protein biochemistry and high speed imaging.
#Novel role of mitochondria identified in immune function Scientists at The Scripps Research Institute (TSRI) have discovered a new role for an enzyme involved in cell death.
Talking to the Immune system Previous studies have shown RIPK3 controls the induction of a type of programmed cell death, called necroptosis,
Patricia A. Martin-Deleon, a reproductive biologist at the University of Delaware, has witnessed this behavior many times in her studies of fertility in mice, the closest genetic model to humans (and with a much faster reproductive cycle.
The research, supported by the National institutes of health-National Institute of Child Health and Human Development and the Delaware INBRE program, is published in the Journal of Biological Chemistry.
disappointing reality that they can't have a child of their own. Even when the process works, a high sperm-to-egg ratio is required, the opposite of
"That gives us hope they can be used as vehicles for improving fertility and the chances of producing healthy embryos and offspring."
-H in cell lines, primary neuron cultures and zebrafish using molecular genetics, protein biochemistry and high speed imaging.
and then trigger a specific response, such as cell death. This system can be customized to detect any DNA sequence in a mammalian cell
and then produce transcription factors that would activate the cells'own programmed cell death pathways. Research tool The researchers are now adapting this system to detect latent HIV proviruses
Cells that did not receive the new gene could be induced to undergo cell death creating a pure population of the desired cells.
The Canadian Diabetes Association reports that more than 20 Canadians are diagnosed newly with the disease every hour of every day.
It is also the seventh leading cause of death in Canada, with associated health-care costs estimated at nearly $9 billion a year.
"Without access to this critical tissue through the Alberta Diabetes Institute Isletcore and the generosity of organ donors and their families, we would not have been able to carry out this study,
an aging population and heightened awareness of the disease stemming from the 2011 death of Apple Inc. cofounder Steve jobs. Zajac-Kaye's group discovered that a single protein is behind the process that allows pancreatic neuroendocrine tumors to thrive.
and induced the death of pancreatic cancer cells. Researchers then tested its effectiveness on human pancreatic cells that had been implanted in mouse models.
Metastases cause the vast majority of cancer deaths, but their tiny seeds are so difficult to track that few researchers have managed to study them.
despite the fact that it causes virtually all breast cancer deaths. Previous work by Werb's group had found a subset of cells at the edges of breast cancer tumors that seemed primed to metastasize.
undifferentiated state and relatively immune to cell death, which the researchers surmised might help metastatic colonies survive in new and hostile environments.
Also, each family of bacteriophages can have a different genome organization and life cycle, making it difficult to engineer them
The MIT team began with a phage from the T7 family that naturally kills Escherichia coli.
and characterization of atomically thin 2d hybrid perovskites and introduces a new family of 2d solution-processed semiconductors for nanoscale optoelectronic devices, such as field effect transistors and photodetectors."
The application of the CRISPR-Cas9 system for mammalian genome editing was reported first in 2013, by Zhang and separately by George Church at Harvard.
or death in the cabozantinib arm as compared with the everolimus arm. Regaining tumour control after prior targeted therapy may reduce symptoms related to kidney cancer
Bakir's group has demonstrated the fabrication of copper vias that would run through the silicon columns that are part of the cooling structure fabricated on the FPGAS.
fabricated high aspect ratio copper vias through the silicon columns, reducing the capacitance of the connections that would carry signals between chips in an array."
"The findings are particularly significant in the light of improving life expectancies and the associated increase in cases of ARMD.
Risk Factors for Cardiovascular disease Approximately 610,000 people die from heart disease every year in the United states--that's one of every four deaths.
These modifiable risk factors include high blood pressure, high cholesterol, obesity, physical inactivity, diabetes, unhealthy diets and smoking.
or the size and position of the fetus in a pregnant woman, to mention a few examples.
Trib1 is part of the protein family Tribbles which play diverse roles in cell signalling and development.
From River Besòs sediments, after three years'research, the researchers have obtained a stable bacterial culture
"The metamaterial consists of silicon pillar arrays embedded in a polymer matrix and clad in gold film.
"The chemical marriage between URMC-099 and antiretroviral drug nanoformulations could increase drug longevity, improve patient compliance,
Dr Fernández-Espejo added,"The ultimate aim is to use this information in targeted therapies that can drastically improve the quality of life of patients.
'Understanding how subtle changes in our genes may trigger brain cell death is one of the most promising avenues for the development of new treatments for Parkinson's.'
a man in the prime years of his life suffering from debilitating heart failure and a former NFL athlete crippled by end-stage heart failure were treated all successfully with a surgical approach pioneered by cardiac experts at University of California, San diego School of medicine.
and death for a person waiting for a transplant or suffering from advanced heart failure.""An LVAD relieves symptoms,
and increases mortality.""Pretorius said biventricular support is required for up to 30 percent of LVAD recipients.
If any of these associations are disrupted, the transcription factor is inhibited. In this study, Tsigelny and team aimed to disrupt the OLIG2 buddy system as a potential treatment for glioblastoma.
Cancer is a leading cause of death worldwide, accounting for over 8 million deaths per year,
and 70%of the world's cancer deaths occur in Africa, Asia and Central and South america.
The number of new cancer cases is expected to rise by 70%over the next two decades 1. With the help of his Research Associate Ana Isabel Barbosa,
which operates in a similar way to a pregnancy test, has already been used successfully by Dr Reis in a separate study that detected prostate cancer with the help of a smartphone camera.
"It's as simple as pregnancy tests, where the specific marker shows in a few seconds,"explains project coordinator Dr. Marco Antonio Rite Palomares, director of the Biotechnology Center of the Tec de Monterrey FEMSA.
natural cell death no longer functioned properly. According to the researchers, the apoptotic process is to be seen as completely independent of the uptake mechanism.
the cell shrinkage observed in programmed cell death no longer functions. This has nothing to do with the mechanism of medication uptake."
Previous work in this realm relied on"growing the cell cultures in a Petri dish, which tends to deform the structure,
"And, borrowing from previous cell culture work done by our group, our high-frequency ultrasound method detects changes within the stiffness of cells with high accuracy.
but can lead to severe adverse reactions. 150 deaths between 2004 and 2008 in the US were thought to be a result of drug manufacturers deliberately cutting heparin with OSCS to save money.
) USC biomedical engineer Dong Song, a member of the team, says that the group has tried the stimulation on a woman with epilepsy,
#This Robotic Hand Wired to a Brain Implant Restored a Paralyzed Man Sense of touch In the last few years,
In 2012, a man with one leg took the stairs all the way to the top of Chicago Willis Tower on a thought-controlled prosthetic limb.
Meanwhile, a paralyzed woman directed a robotic arm with her thoughts to bring a straw to her lips for a sip of soda.
The astronomers created a video explaining the slow death of the universe to illustrate the discovery.
Robohon was designed by renowned Japanese roboticist Tomotaka Takahashi, the man behind the similarly-styled Kirobo humanoid robot and several others.
That a useful feature for parents until the child figures out how to deactivate or hide it, presumably.
Hsieh specializes in male fertility and men health. He treats sexual dysfunction, including low testosterone, erectile dysfunction and Peyronie disease.
the senior author of the new study, Trever Bivona, MD, Phd, assistant professor of medicine and member of the UCSF Helen Diller Family Comprehensive Cancer Center (HDFCCC).
they could turn on a gener even families of genesy targeting enhancers at distant locations in the genomeomething that their previous gene activators could not do.
and fulfil their regular (adult) lifespan of around 22 months. The research was funded by the Lee kuan yew Research Fellowship
Studies have shown that perceived discrimination among minority adolescents leads to smoking, anger, alcohol use and abuse, depression or psychological distress,
According to the American Heart Association, African americans are at a higher risk than whites to die of heart disease.
but most of this research has been in adults. Goosby study is one of the first to examine the effects of discrimination in youth. e haven seen any studies that have been done in people this young before,
because there is a growing literature that shows discrimination is actually harmful for people health, particularly among African american adults,
#New transitional stem cells discovered Preeclampsia is a disease that affects 5 to 8 percent of pregnancies in America.
Complications from this disease can lead to emergency cesarean sections early in pregnancies to save the lives of the infants and mothers.
meaning that all the cells in the culture are quite similar to each other in the way they express their genetic information. reviously,
During anti-angiogenic therapy, said Bergers, the Neill H. and Linda S. Brownstein Endowed Chair in Brain tumor Research and a member of the UCSF Helen Diller Family Comprehensive Cancer Center,
The innate neuronal property might be utilized to protect neurons from degeneration or cell death in the future.
we might be able to protect neurons from degeneration or cell death. Recent studies have suggested that changes in a region at the presynaptic membrane
Now that they have a reliable human beige fat cell culture system, Kajimura said, his team will be able to use the system as a screening platform to identify
what theye touching while gaming. The Hands Omni glove developed at Rice Oshman Engineering Design Kitchen will provide a way for gamers
and developed with sponsor Virtuix, a Houston gaming technology company, is intended to provide force feedback to the fingertips as players touch,
while pain treatment options are limited to opioid-family pharmaceuticals such as morphine. It was while conducting clinical research at the University of California San francisco
Lam and his fellow researchers followed up this observation by looking at different types of cancers with known pain associations for instance, certain breast and melanoma cell lines.
and amount of TMPRSS2 in these cancer cell cultures stood in exact correlation with the known level of pain each cancer causes. t was exactly
what we know clinically about pain association, adds Lam. A New Direction for Drug Research The startling discovery of TMPRSS2 role in triggering cancer pain may lead to the creation of targeted cancer pain therapies that effectively shut down the expression of this gene
and we look forward to working with them on other intellectual properties in the future. Diabetes is a chronic disease that occurs either
Police sources spoke of 1000 more deaths in the rural areas of Nepal. 50 more people were killed in northeastern India,
The total death toll for both quakes exceeded 5000. In 1934 Nepal and the neighboring Indian state of Bihar suffered severe damage when an 8. 2 quake struck.
Professor Thomas said. ut a common end result of this compensatory growth is eventual heart failure, a major cause of death in Australia. uring laboratory tests,
and using this new family of molecules. Furthermore, this discovery opens the way for the development of strategies to eliminate the viral reservoirs of individuals already infected.
but the research may potentially uncover several roles theca cells play in female fertility y
and are capable of rapidly penetrating human airway mucus freshly collected from patients visiting the Johns Hopkins Adult Cystic fibrosis Program directed by Michael Boyle,
said Wyss Core Faculty member George Church, Ph d, . who is a pioneer in the converging fields of synthetic biology, metabolic engineering, and genetics.
Church is the Robert Winthrop Professor of Genetics at Harvard Medical school and Professor of Health Sciences and Technology at Harvard and MIT.
Now, Wyss Institute researchers led by Church have developed a new suite of such sensors, reported in Nucleic acids Researchjournal,
said Church. ee trying to control biological processes and we need new ways to get our hands in at the molecular level wee now reaching in deeper than wee previously been able to,
says John Essigmann, the William R. 1956) and Betsy P. Leitch Professor in Residence Professor of Chemistry, Toxicology and Biological engineering at MIT,
the researchers isolated stem cells from adult skin and coaxed them into Schwann cells by exposing them to small molecules. e observed that the bulge,
CGL4, which usually leads to death in the patient teenage years. Many children presumably also die from this disease during their first week of life,
without any diagnosis other than udden infant death syndrome'says Karl Swärd and Catarina Rippe, researchers at Lund University.
In a recently published study in the journal PLOS ONE (1), the researchers at Lund University reveal that a family of so-called transcription factors called yocardin family coactivatorsregulate the formation of invaginations.
Conference on Artificial intelligence, organized by the Association for the Advancement of Artificial intelligence. A two-year seed grant from the UW-Madison Graduate school currently supports this work.
disability and death in the U s. Smokers who want to quit can turn to various pharmacological aids.
Only about 15 to 30 percent of smokers who try them are able to stop smoking for longer than one year.
members of a family of painkilling drugs sourced from the opium poppy. It can take more than a year to produce a batch of medicine, starting from the farms in Australia,
as such big injuries of an incredibly vascular structure inevitably require a clot in order not to bleed to death,
One-third of patients diagnosed with breast cancer eventually develop metastases in distant organs, with an increased risk of death.
and diversification of the species. or each robot child, there is a unique enomemade up of a combination of between one and five different genes,
which contains all of the information about the child shape, construction and motor commands. As in nature, evolution in robots takes place through utation where components of one gene are modified
each child was tested on how far it travelled from its starting position in a given amount of time.
each child took the robot about 10 minutes to design, build and test. According to Iida, in future they might use a computer simulation to pre-select the most promising candidates,
Now they report in the journal Advanced Materials that they have discovered a new family of gel-like materials
Reversible conversion of a hybrid gel subject to physical and chemical stimuli his makes this family of hybrid gels highly tuneable,
Katherine Cohen, Boston Childrengreater precision, greater safetythe life-sized and enlarged 3-D models, based on brain magnetic resonance and magnetic resonance arteriography data from each child
without putting a child at risk. y
#Flexible, biodegradable device can generate power from touch Longstanding concerns about portable electronics include the devicesshort battery life and their contribution to e waste.
Sixty healthy adults had scanned their brains using diffusion spectrum imaging which provided a picture of the orientation of moving water molecules.
And, multi-shell imaging was used on 78 healthy adults to get similar images using different imaging parameters.
using them to measure activity in the larger culture population, which can include as many as a million cells. ecause we have all those electrodes,
and then compare the amount of activity being expressed by the culture to a target rate,
The optoclamp can be used to control cell cultures grown atop electrode arrays as well as in living animal models in
allowing experiments to focus stimulation on specific areas of the brain or brain cell cultures. The light signals now affect an entire culture
or brain region. e want to precisely control where photons are being sent to activate different cells, Newman said. ptogenetics allows genetic specification
Each silicon stump, or pillar has an elliptical cross section, and by carefully varying the diameters of each pillar
and rotating them around their axes, the scientists were able to simultaneously manipulate the phase and polarization of passing light.
the researchers etched micrometer scale pillars into a silicon surface using photolithography and deep reactive-ion etching,
and then created nanoscale textures on the pillars by wet etching. They then infused the nanotextures with a layer of lubricant that completely coated the nanostructures,
Mooney who is also the Robert P. Pinkas Family Professor of Bioengineering at the Harvard John A. Paulson School of engineering
As of now, transplanted cell death remains a major challenge. To improve the therapeutic ability of transplanted stem cells,
but hotspots are regions of volcanic activity at Earth surface that show no obvious association with plate boundaries.
but have extensive association with microglia (mobile cells that surround and protect neurons) instead. Scientists found a different application for Scales too.
this 3d analysis showed that association with active microglial cells occurs early in plaque development,
which has proven to be extremely safe for health monitoring, even during various stages of pregnancy.
given our previous finding in PLOS Pathogens where we found that this family of proteins generally affects the lipid property of cell membrane
The application of the CRISPR-Cas9 system for mammalian genome editing was reported first in 2013, by Zhang and separately by George Church at Harvard university.
and the Chikungunya virus in a man who was asymptomatic at the time, but eventually reported having a fever and joint pains a
looked at the health records of 4. 1 million adults in the UK who were initially free of diabetes and cardiovascular disease and found:
overweight and obese individuals The relative association between blood pressure and diabetes decreased as body mass index (BMI)
Last flu season, H3n2 contributed to some 36,000 deaths in the United states. And in some patients particularly young children
older adults and people with weakened immune systems knowing that the H3n2 strain is present may alter treatment.
Kristine Wylie investigates the viruses that set up residence in and on the human body, collectively known as the virome.
that will be eventually be able to treat countless patients. he findings are particularly significant in the light of improving life expectancies and the associated increase in cases of ARMD.
Approximately 610,000 people die from heart disease every year in the United states oughly one of every four deaths
These risk factors include high blood pressure, high cholesterol, obesity, physical inactivity, diabetes, unhealthy diets and smoking.
There is also a website available for calculating a child metabolic syndrome severity score using clinical measures e
or the size and position of the foetus in a pregnant woman, to mention a few examples.
But now, in a landmark study by George Church and his team at the Wyss Institute for Biologically Inspired Engineering at Harvard university and Harvard Medical school, the gene editing system known as CRISPRAS9 has been used to genetically engineer pig DNA
Church is the Robert Winthrop Professor of Genetics at Harvard Medical school and a Wyss core faculty member.
The advance, reported by Church and his team, including the study lead author, Luhan Yang, a research fellow at HMS and the Wyss, was published in the October 11 issue of Science.
or PERVSROUGHT more than a billion dollarsworth of pharmaceutical industry investments in developing xenotransplant methods to a standstill by the early 2000s, said Church.
Church and his team have inactivated all 62 repetitive genes containing a PERV in pig DNA,
and is currently collaborating with Church on further genetic modifications of his pigs. f Church and his team are able to produce pigs from genetically engineered embryos lacking PERVS by the use of CRISPR-Cas9,
When the offspring became adults, the researchers examined their response to stress, just as they had done in their 2013 study. he results mapped right onto
Then scientists placed the cells into culture conditions containing certain cytokines and soon saw that their efforts were continued successful cells to divide as stem cells instead of undergoing differentiation into B-cells.
In a culture without these cytokines the cells differentiated into various immune cells. Team wanted to test
First, the receptors are not usually present in normal adult tissues which means that any drug therapy will likely have few side effects.
which is the leading cause of serious long-term disability in adults. The five-year study, performed in an animal model,
The carbonic anhydrase would be immobilized with solvent inside a reactor vessel that serves as a large purification column.
Their sensors have been used to monitor premature babies, pregnant women, patients in Intensive care units and patients suffering from sleep disorders.
The disease affects more than four million Americans and causes over 750,000 hospitalizations and 130,000 deaths per year in the United states alone.
disease and cell death. eat shock genes and their heat shock proteins are expressed highly during stress and are very critical to protect cells;
and assess male fertility at low cost Scientists have developed a new paper device that analyzes DNA
It also could determine the DNA integrity of sperm a predictor of fertility from semen samples as accurately as current clinical methods t
He used his research to launch three biotech companies centered on forensic science, fertility assessment and contraception methods.
The difference is that Ovastasis plans to use those protein biomarkers as targets for a novel female birth control medication. he identification of drug targets that are selective to the egg
or to the sperm gives you opportunities to create small-molecule drugs for female and male contraception, contraceptive vaccines,
Currently approved female birth control medications work by manipulating the female body estrogen and progesterone levels. While effective, these drugs are steroids
Ovastasis is developing a new form of birth control that will interact only with a woman reproductive cells to arrest their development.
and release the drug payload, triggering changes that result in cell death within a few days.
The same biomarkers that will help limit the area of impact for Ovastasis birth control will also help Neoantigenics confine the toxic effects of cancer treatment to growing egg and tumor cells.
and want to preserve fertility, Herr said. While Neoantigenicsmedication would have to attack growing egg cells in order to kill similar cancer cells,
it would leave a woman reserve of dormant primordial eggs untouched. Only egg cells that are growing in the ovary in preparation for ovulation carry the SAS1B protein.
he CPM+LPCS that we have derived from human ipscs can be transferred from one medium to another for continuous culture
or death, can take as little as two weeks. That may not leave enough time for the immune system to mount an effective response.
and smuggle cancer signals their neighbors New research in The FASEB Journal suggests that an in vitro co-culture system robustly quantifies the transfer of fluorescent proteins between cells
they have to survive on their own without family protection. To ensure successful colonization by these vulnerable creatures,
Frommer and his lab have worked extensively on the family of SWEET sugar transporters, which play several key roles in plants,
A Los angeles woman who got a pig liver in 1992 died within 34 hours. The last time a doctor transplanted a pig heart into a person, in India in 1996,
Harvard university scientist George Church and his former student, Farren Isaacs, of Yale, held a press conference to announce a breakthrough of their own.
Isaacs and Church described how, in separate experiments, they created what they called a enomically reordered organism, or GRO.
Church and Isaacs recently announced they had formed a Boston-based company, enevolv, to supply such GROS for use by industry to,
Church declared that e are aiming at modifying plant and animal cells, and maybe plants and animals. potential objection to the technology is already apparent:
Church likewise argues that his GROS are safe because they depend upon unnatural amino acids that are supplied only in the lab. Withhold these and the bacteria die.
Both Romesberg and Church reported a tiny fraction of the bacteria managed to slip the genetic handcuffs via mutation.
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