the senior author of the new study, Trever Bivona, MD, Phd, assistant professor of medicine and member of the UCSF Helen Diller Family Comprehensive Cancer Center (HDFCCC).
partly because patients with late-stage lung cancer rarely undergo surgery, leaving scientists with few drug-resistant tumors to use in research.
cardiovascular disease or neurodegenerative conditions, have a much more complex genetic component. Many different variations in the genome sequence can affect your risk of disease
Known as deep brain stimulation, it is a therapeutic procedure that is already used in some parts of the world to treat various neurological conditions such as tremors or Dystonia,
a professor of medicine and cellular biology at Northwestern University who was not part of the research team.
Dr. David Schiff of the U. Va. Department of Neurology said the results of the trial have come as a eal shocker to the field,
including surgery and chemotherapy.)Forty-three percent of device wearers survived two years; only 29 percent of those who didn wear the device lived that long.
A major challenge of ASD diagnosis and treatment is that the neurological condition which affects 1 in 68 children in the United states,
The researchers combined prospective fmri measurements of neural systemsresponse to speech in children at the earliest ages at which risk of ASD can be detected clinically in a general pediatric population (at approximately ages 1-2 years
Reported online in Nature Medicine, these novel findings suggest a promising new way to fight cancerarticularly cancers that are aggressive
HMS professor of medicine and director of translational therapeutics in the Cancer Research Institute at Beth Israel Deaconess. in1 is a common key regulator in many types of cancer
In this new work, co-senior author Xiao Zhen Zhou, HMS assistant professor of medicine and an investigator in the Division of Translational Therapeutics at Beth Israel Deaconess, decided to take a different
added co-author Pier Paolo Pandolfi, the HMS George C. Reisman Professor of Medicine and director of the Cancer Genetics Program at Beth Israel Deaconess,
such as targeting medicines more specifically into cancer cells and driving charge separation potentially for harvesting energy for batteries.
said Jean Chin of the National institutes of health National Institute of General Medical sciences, which funded the work through grants to several of the paper co-authors. he highly collaborative team used its deep knowledge of the structures,
and medicine. e envision that this protein can create an electrochemical gradient using things like ph,
Complications from this disease can lead to emergency cesarean sections early in pregnancies to save the lives of the infants and mothers.
2015 online issue of Cell Reports, the researchers, under the direction of senior investigator Gabriele Bergers, Phd, UCSF professor of neurological surgery,
The novel knowledge is the result of longstanding research in the field of cell surface receptor proteins at the Department of Biomedicine at Aarhus University. ur studies have shown that the protein megalin is almost always detectable in malignant melanomas,
says Associate professor Mette Madsen from the Department of Biomedicine at Aarhus University. With the new knowledge, the hope is that pathologists
and oncologists at an early stage will be able unlike today to predict whether a patient should expect spreading
which patients the most, says Henrik Schmidt, consultant at the Department of Oncology at Aarhus University Hospital,
either medicine affecting the protein and its function thereby inhibiting the proliferation of the cancer cells and their survival,
#Fruit fly studies shed light on adaptability of nerve cells An international team of researchers at German Center for Neurodegenerative Diseases (DZNE)
little was known about the signalling underlying such ynaptic plasticity Now, investigations of fruit flies by researchers at the German Center for Neurodegenerative Diseases (DZNE), Tokyo Tech, the National Institute of Genetics in Japan,
Future work may investigate how modifying the Wnt signal can be used to manipulate synaptic plasticity, with possible therapeutic applications for neurodegenerative or mental diseases n
of Regeneration Medicine and Stem Cell Research at UCSF. The finding was published online on March 16
2015 in Nature Medicine. All mammals, including humans, have two types of fat with completely opposite functions:
That medical mystery is just one of the questions that Ruth Montgomery, associate professor of medicine at Yale School of medicine, seeks to explore with the use of a transformational tool for translational research.
It called Cytof, which stands for cytometry by time-of-flight, and it gives researchers greater insight into the intricacies of immune cells than ever before.
It akin to the difference between looking at the stars with a standard telescope versus an observatory-quality refractor telescope, according to Yale chair of neurology, Dr. David Hafler, who worked with Montgomery to bring Cytof to Yale. t allows
Head of Oral and Maxillofacial Surgery at the Faculty of dentistry, Lam research initially focused on cancers of the head and neck,
In his study, Lam, who is appointed jointly as a Consultant Surgeon at the Princess Margaret Cancer Centre
Shapiro, Canada Research Chair in Transplantation Surgery and Regenerative medicine in the University of Alberta Faculty of medicine & Dentistry,
we have successfully and reliably reversed diabetes in our preclinical models. This approach is new
tested in preclinical models, is an evolution of the Edmonton Protocol, which Shapiro developed in the late 1990s to treat Type 1 diabetes.
Published today in Science Translational Medicine journal, University researchers, working in collaboration with scientists at King College London
which could prove useful in biomedical applications, among other uses. i
#More power to the mitochondria: Cells'energy plant also plays key role in stem cell development Researchers at NYU Langone Medical center have discovered that mitochondria, the major energy source for most cells,
Indeed, Lehmann, who also serves as director of NYU Langone Skirball Institute of Biomolecular Medicine and chair of its Department of Cell biology,
Bishop is now cofounder and chief innovation officer of Qualaris Healthcare Solutions, a Pittsburgh-based medical-product development company.
Earlier this year, Advanced Tear Diagnostics, a medical-products company based in Birmingham, Alabama, licensed the same technology to improve
monitoring and treatment of a wide range of medical conditions, said Yash Vaishnav, Azte vice president of business development for life sciences. ekcapital is also a great partner.
the biomedical engineers outlined how they had reinforced soft hydrogels via a 3d printed scaffold. Professor Dietmar W. Hutmacher, from QUT Institute of Health and Biomedical Innovation, said nature often used fibre reinforcement to turn weak structures into outstanding mechanically robust ones. uch
is the case with articular cartilage tissue, which is formed by stiff and strong collagen fibres intertwined within a very weak gel matrix of proteoglycans,
Professor Thomas said the project progressed from animal studies to human investigations through collaborations with the Prince Charles Hospital in Brisbane. sing heart tissue from humans undergoing heart surgery
Professor Takeshi Iwatsubo, graduate students Kaoru Yamamoto and Zen-ichi Tanei, Assistant professor Tadafumi Hashimoto and Professor Haruhiko Bito at the University of Tokyo Graduate school of Medicine, Professor
As the spool pulls, the CNT ribbon is dragged between two surgical blades. While the blades appear straight to the naked eye
May 6) in the journal Science Translational Medicine. his research is addressing neglected tropical diseases, said Fletcher. t demonstrates
treatment with IVM can potentially lead to severe or fatal brain or other neurologic damage.
The results of the study were published in the Journal of Medicinal Chemistry. Surgery, associated with cardiovascular diseases, such as ischemia,
often require the implantation of vascular grafts artificial blood vessels, aimed at restoring the blood flow in a problematic part of the circulatory system.
which results in compulsory and lifelong intake of anticoagulants among patients and sometimes may even require an additional surgical intervention.
they actively release medicine into the blood. The lifetime of such grafts is determined often by the amount of drug stored within the graft
The same approach may be used for kidney or liver surgery but these are plans for the future,
however show that the PNAS we tested are suitable candidates for further preclinical studies, Stephan sums up.
a biomedical engineer and faculty member at the Center for Nanomedicine at the Wilmer Eye Institute at Johns Hopkins. A report on the work appeared in the Proceedings of the National Academy of Sciences on June 29.
including gene-based medicine, from reaching their target. His team experiments with human airway mucus and small animals,
a radiologist and director of the Center for Systems Biology lab at Massachusetts General Hospital who is familiar with the research. hatever you can do right then and there without any complicated testing,
Neurological tumors, for example, may arise from glial cells that develop from the crest. Researchers with the institute Medical Informatics Systems division say cancer types can be found
says John Essigmann, the William R. 1956) and Betsy P. Leitch Professor in Residence Professor of Chemistry, Toxicology and Biological engineering at MIT,
Motoharu Sakaue together with Maya Sieber-Blum, Professor of Stem Cell Sciences at the Institute of Genetic Medicine in Newcastle, investigated the possibility of making Schwann cells,
but I think this technology definitely has the potential to be transformative in medicine. h
of which took less than five days to convert sugar into one of two medicinal compounds: either thebaine,
this could broaden access to many plant-based medicines. For thousands of years, people have used yeast to ferment wine,
Now researchers at Stanford have engineered genetically yeast to make painkilling medicines, a breakthrough that heralds a faster and potentially less expensive way to produce many different types of plant-based medicines.
Writing today in Science, the Stanford engineers describe how they reprogrammed the genetic machinery of baker yeast
It can take more than a year to produce a batch of medicine, starting from the farms in Australia,
and refined into medicines. hen we started work a decade ago, many experts thought it would be impossible to engineer yeast to replace the entire farm-to-factory process,
400 gallons of bioengineered yeast to produce a single dose of pain relief the experiment proves that bioengineered yeast can make complex plant-based medicines. his is only the beginning,
infectious diseases and chronic conditions such as high blood pressure and arthritis. rom plant to test tubesmany medicines are derived from plants,
to reprogram the cells into custom chemical assembly lines to produce medicinal compounds. An important predecessor to the Stanford work has been the use of genetically engineered yeast to produce the antimalarial drug artemisinin.
the Stanford team had to fill in a missing link in the basic science of plant-based medicines.
Many plants, including opium poppies, produce (S)- reticuline, a molecule that is a precursor to active ingredients with medicinal properties.
Smolke said. e need options to help ensure that the bio-based production of medicinal compounds is developed in the most responsible way. molke said that in the United states,
where opioid medicines are already widely available, the focus is on potential misuse. But the World health organization estimates that 5. 5 billion people have little
and the techniques we developed show that it is possible to make important medicines from scratch using only yeast,
and fairly provide medicines to all who need
#Scientists pioneer method to track water flowing through glaciers Researchers for the first time have used seismic sensors to track meltwater flowing through glaciers and into the ocean,
. assistant professor of Orthopaedic Surgery and Rehabilitation. n certain instances it may help, but wee shown for sure that you don need it.
and orthopaedic surgery. t was unexpected totally that fibrin clearance is essential to prevent heterotopic ossification,
and plates used in orthopaedic surgeries, so that those devices don disrupt the ability of blood vessels to grow
He points out that some of the medications developed for cardiovascular medicine to prevent clotting may find new purposes in enhancing tissue repair and regeneration i
says endocrinologist Francesco Celi of the Virginia Commonwealth University Medical center, who was not involved with the study. mportantly,
Cleveland and was funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the National institutes of health.
Andreas Velten, a Morgridge medical engineering affiliate and scientist with the University of Wisconsin-Madison Laboratory for Optical and Computational Instrumentation (LOCI
Harvard Medical school associate professor of neurosurgery at Boston Children Hospital and senior author of the paper. he 3-D printed models allowed us to rehearse the cases beforehand
who co-directs the Cerebrovascular Surgery and Interventions Center at Boston Children. ou can physically hold the 3-D models,
and get tactile feedback. s described in the Journal of Neurosurgery: Pediatrics, the models were based on the children actual brain scans.
Data from the scans were used to program a 3-D printer that laid down synthetic resins layer by layer.
I practiced those steps ahead of time. he surgery went off without complications, and last month Adam had a clean one-year follow-up angiogram.
Darren Orbach, HMS associate professor of radiology and co-director of the Cerebrovascular Surgery and Interventions Center at Boston Children, treated a 2-month-old infant who had a rare vein of Galen malformation in
Orbach used an interventional radiology technique called embolization to seal off the malformed blood vessels from the inside. ven for a radiologist who is comfortable working with
surgeon and operating roomhose with 3-D models had their surgical time reduced by 30 minutes,
but hopefully it will lead to medical applications. This gives us new opportunities to look at cell structures
The device is expected to make a difference in medical treatments, preventive health care and sports p
and non-invasively saliva biomarkers holds considerable promise for many biomedical and fitness applications, said Wang.
as a collaboration with orthopedic surgeon Dr. Alex Mclaren and his team member and bioengineer Dr. Ryan Mclemore of Banner Good samaritan Medical center, Phoenix,
along with Dr. Mark Spangehl of the Mayo Clinic College of Medicine, Arizona. By most metrics the antibiotic-resistant and susceptible strains of Staphylococcus epidermidis are phenotypically identical,
an assistant professor in the School of Chemical & Biomolecular engineering at the Georgia Institute of technology. he information we can provide could one day help nutritional epidemiologists
#Brain cells get tweaked n the goresearchers from the MRC Centre for Developmental Neurobiology (MRC CDN) at the Institute of Psychiatry, Psychology & Neuroscience (Ioppn),
Tufts University biomedical engineers recently published the first report of a promising new way to induce human mesenchymal stem cells (or hmscs,
The biomedical engineers also showed that the exosomes contain mirnasiny pieces of RNA that regulate cell behavior
Xu work focuses on material science engineering, specifically nanoscience and its biomedical application: the development of new synthetic materials for the delivery of therapeutic proteins and genetic material.
#ab-on-a-Chiptechnology to cut costs of sophisticated tests for diseases and disorders Rutgers engineers have developed a breakthrough device that can significantly reduce the cost of sophisticated lab tests for medical disorders and diseases, such as HIV,
said Gargus, director of the Center for Autism Research & Translation and professor of pediatrics and physiology & biophysics. qually exciting,
Study results appear online in Translational Psychiatry, a Nature publication. Autism spectrum disorder is a range of complex neurodevelopmental disorders affecting 2 percent of U s. children.
such as the ER, are an emerging field in medicine, with several well-recognized neurological ailments linked to two other ones, the mitochondria and lysosomes.
The IP3R controls the release of calcium from the ER. In the brain, calcium is used to communicate information within and between neurons
which would enhance the effectiveness of medical interventions. The key breakthrough underlying this new technology came by chance. hile working on the first generation of these DNA-base tests,
and the inaugural director of the Joint Center for Cancer Precision Medicine at the Dana-Farber Cancer Institute, Brigham and Women Hospital,
which would enhance the effectiveness of medical interventions. The key breakthrough underlying this new technology came by chance. hile working on the first generation of these DNA-base tests,
Detailed in a paper published in Genome Medicine on September 28th this technology could prove highly useful in settings where lab equipment
and medical infrastructure is in short supply. While most other commercially available diagnostic tests target specific pathogens, the method used in the study,
which has been published in the Journal of the American College of Cardiology (JACC), looked at the health records of 4. 1 million adults in the UK who were initially free of diabetes and cardiovascular disease and found:
and TRAIL in a nanogel delivery system without the platelet membrane. e like to do additional preclinical testing on this technique,
In turn, it could model how a specific treatment would interact with the patient. heyl be the Microsofts and Googles of biomedicine,
fast, individualized and precise biomedical care. he REACH project is applied to cancer biology, but we have an even bigger vision than that,
the Ruth L. Siteman Professor of Pediatrics. t casts a broad net and can efficiently detect viruses that are present at very low levels.
an instructor of pediatrics. light genetic variations among viruses often can be distinguished by currently available tests
or other drugs, said co-author Kristine Wylie, Phd, assistant professor of pediatrics. In the meantime, the technology can be used by scientists to study viruses in a research setting.
whether an individual cancer patient will benefit from a specific type of medicine. This is a very effective method
said John Guy, M d.,professor of ophthalmology and director of the ocular gene therapy laboratory at the Bascom Palmer Eye Institute, University of Miami Miller School of medicine.
UV LIGHT enabled catheter fixes holes in the heart without invasive surgery Researchers from Boston Children Hospital, the Wyss Institute for Biologically Inspired Engineering at Harvard university,
As the team reports in Science Translational Medicine, the catheter has been used successfully in animal studies to facilitate hole closure without the need for open heart surgery.
Chief of Cardiac Surgery at Boston Children and contributing author on the study, says the device represents a radical change in the way these kinds of cardiac defects are repaired. n addition to avoiding open heart surgery,
because wee just gluing something to it. atheterizations are preferable to open heart surgery because they don require stopping the heart,
the unique adhesive patch was published in Science Translational Medicine. This represented a large step forward in the quest to reduce complications associated with heart defect repair.
however, the Boston Children/Wyss/SEAS/Brigham and Women research team sought a way to deliver the patch without open heart surgery.
Jeff Karp, Ph d.,a bioengineer at Brigham and Women Hospital and a cofounder of Gecko Biomedical, developed the glue product in his lab at Brigham and Women Hospital.
Gecko Biomedical will be testing the glue product in humans later this year. ur collaboration across hospitals
lack of link to autism New research finds no evidence that thimerosal-containing vaccines cause negative behaviors or result in neuropathology in infant primates,
In the study, infant rhesus macaques received several pediatric vaccines containing thimerosal, a mercury-based preservative,
the administration of vaccines to rhesus macaques did not result in neuropathological abnormalities or aberrant behaviors such as those often observed in autism.
and in partnership with Trajan Scientific and Medical and the Federal government. ASTECH Training Centre Researcher Professor Michael Breadmore said the design
A team led by Dr. Mark Deboer of the U. Va. Department of Pediatrics and Matthew Gurka of West virginia University School of Public health developed the new diagnostic test.
The research has been described in articles in the Journal of the American College of Cardiology and the journal Diabetologia.
#New microscopy technology augments surgeon view for greater accuracy Researchers at the University of Arizona (UA) have developed a prototype of a new microscope technology that could help surgeons work with a greater degree
and Surgery was published today in the Journal of Biomedical Optics, published by SPIE, the international society for optics and photonics.
Surgical microscopes are specialized highly stereomicroscopes installed on articulated mounts and provide a long working distance and functional enhancements,
and are used widely in certain delicate operations, notably neurosurgery. Within the last decade, surgical microscopes have been combined with near-infrared (NIR) fluorescence imaging, in
which contrast agents are injected into tissue and their fluorescence detected in NIR scans. The scans may reveal patterns of blood flow,
For example, some microscopes used in complex vascular surgeries switch between two different views: the fully optical bright-field (real) view and the computer-processed projection of NIR fluorescence.
and on its own lacks the spatial cues that would help the surgeon identify anatomical points of reference.
So the surgeon must visualize how the fluorescence in the NIR image lines up with the respective anatomical structures shown in the bright-field view.
Real-time overlay of bright-field and near-infrared fluorescence imagesdescribes their prototype of an augmented stereomicroscope that presents a simultaneous view of real objects in the surgical field and computer-processed images
By displaying information through the surgical scope itself, the surgeon then sees the information with his or her own eyes.
Pogue said he sees the work being important in advancing the translation of research into clinical practice. here are very few papers on this idea of augmenting the surgical field of view that the surgeon sees,
yet this is a high-interest topic, he said. his article presents a very practical idea and innovative implementation
It also retains the imaging environment familiar to surgeons, including key features of surgical microscopes such as real-time magnification and focus adjustments, camera mounting,
and multiuser access. One possible application for this augmented microscope is laser surgery. In the past, surgeons could not see the laser beam through the standard stereomicroscope, nor anatomical details in the NIR images.
The researchers also suggest that this technology will be useful in the surgical treatment of brain tumors.
Surgeons aggressively removing a tumor run the risk of damaging normal brain tissue and impairing the patient brain functions;
on the other hand, incomplete removal of a tumor results in immediate relapse in 90%of patients. Being able to simultaneously see the surgical field
and the contrast agent identifying cancerous tissue within the augmented microscope may allow surgeons to remove these challenging tumors more accurately
#Medical diagnosis: Will brain palpation soon be possible? If there is one technique used by the physician to explore the human body during every medical examination
something that greatly complicates the work of neurosurgeons. On the other hand, the brain is the seat of natural vibrations created by the blood pulsating in the arteries and the circulating cerebrospinal fluid.
such as for analysing the development of neurodegenerative processes, the impact of a lesion from a trauma or tumour, response to treatment, etc e
Aiming for the clinic The development of LRA is the product of a collaboration led by Tripathi and Dr. Rami Kantor, associate professor of medicine in the Warren Alpert Medical school.
assistant professor of medicine and a co-author on the paper. he next steps are to continue the development of LRA
said David H. Sachs, director of the TBRC Laboratories at Massachusetts General Hospital, the Paul S. Russell Professor of Surgery Emeritus at HMS and professor of surgical sciences at Columbia
Professor Gavin Giovannoni, Chair of Neurology at QMUL Blizard Institute, said: he phase III ocrelizumab results for both PPMS and RMS,
from the Cambridge Institute of Medical Research at the University of Cambridge, said: e are starting to find that many forms of blood cancer can be traced back to defects in the basic housekeeping processes in our cellsmaturation.
the Selma and Herman Seldin Professor of Medicine. t does something that other components don do,
Holtzman and lead author Yong Zhang, Phd, an instructor in pulmonary medicine, suspect that the researchersone-two punch against the virus may explain the large difference in survival rates between control mice
He is now an assistant professor of medicine in the Division of Nephrology at the University of Washington and a UW Medicine researcher. nswering this question
The hydrogel may be most useful for surgeries particularly for patients who take anticoagulant drugs to thin their blood. t interesting that you can take something so deadly
This is important because surgical bleeding in patients taking heparin can be a serious problem. The use of batroxobin allows us to get around this problem
The substance used for medicine is produced by genetically modified bacteria and then purified, avoiding the risk of other contaminant toxins.
What we did was combine it with the hydrogel wee been working on for a long time. e think SB50 has great potential to stop surgical bleeding, particularly in difficult cases in
Dr. Albert J. Becker from the Institute of Neuropathology of the University of Bonn. The hippocampus, located in the temporal lobe, is a central switching station in the brain.
together with scientists from the departments of Experimental Epileptology and Neuroradiology of the University of Bonn Hospital as well as from the Hebrew University in Jerusalem (Israel), have decoded now a signaling pathway
Dr. Susanne Schoch from the department of Neuropathology at the University of Bonn. The researchers also see a possible potential in this new technology for novel diagnostic approaches in humans.
Hooks said. t the deadliest gynecologic cancer. Most women with ovarian cancer will have their tumors come back. ithin two years,
reviews over five years worth of research on RGS10 and was published in Future Medicinal Chemistry.
Hooks and Murph tested cells to see how they would react to common chemotherapy medicines.
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