says Nicholas Grassly, an epidemiologist at Imperial College London, but implementing it will be difficult.""There are some big ifs as to
Although remedial courses have been available for physicians for more than a decade#with many returning to medicine to forge successful careers#Dubois says that Repair is the first such programme for researchers.
But the lead plaintiff on the case, James Sherley of the Boston Biomedical Research Institute in Watertown, Massachusetts, says that the decision will not end his efforts"to emancipate human embryos from research slavery sponsored by the NIH.
"What a great day for science, says Amy Comstock Rick, president of the Coalition for the Advancement of Medical Research in WASHINGTON DC, an umbrella group of organizations that advocate for the research.
parallel universe of unexplored RNAS, says Nikolaus Rajewsky, the lead author of one of the studies and a systems biologist at the Max Delbr#ck Center for Molecular Medicine in Berlin.
called ATP IV, has been drawn up by an expert panel of 15#cardiologists appointed by the institute.
says Harlan Krumholz, a cardiologist at Yale university in New haven, Connecticut.""We ve been burned so many times in the past decade by that assumption.
says Joseph Drozda, a cardiologist and director of outcomes research at Mercy Health in Chesterfield, Missouri."
and strokes, says Richard Cooper, an epidemiologist at the Loyola University of Chicago Stritch School of medicine in Illinois,
says committee chairman Neil Stone, a cardiologist at Northwestern University School of medicine in Chicago. If so, Krumholz argues,
says Robert Vogel, a cardiologist at the University of Colorado, Denver.""Short people have a higher risk of heart disease,
Jay Cohn, a cardiologist at the University of Minnesota Medical school in Minneapolis, also worries that the focus on LDL levels offers up the wrong patients for statin therapy.
Not all cardiologists want to abolish LDL targets. Indeed, Seth Martin, a fellow in cardiology at Johns hopkins university School of medicine in Baltimore, Maryland, believes that ATP IV should reduce LDL targets further.
The simplicity of targets has helped to deliver an important public-health message, he says, and motivated many patients to get the statin therapy that he believes they need."
the researchers played soft voices to premature babies while they were asleep in their incubators a few days after birth,
including premature babies. The team's results appear in Proceedings of the National Academy of Sciences1.
cultivate a network of surgeons who can implant the device and recruit hospitals to offer it.
To date surgeons have implanted Retina Implant prosthetics in 36 patients through two clinical trials over six years.
but not substitute for, traditional epidemiological surveillance networks.""It is hard to think today that one can provide disease surveillance without existing systems,
says Alain-Jacques Valleron, an epidemiologist at the Pierre and Marie Curie University in Paris,
says John Brownstein, an epidemiologist at Harvard Medical school in Boston, Massachusetts.""You need to recalibrate them every year.
an oncologist at Pennsylvania State university in Hershey and lead author of the study, which is published today in Science Translational Medicine1.
says Andrew Thorburn, an oncologist at the University of Colorado Denver, who co-authored a review on the subject last year4."
Many large biomedical research groups have shelved their TRAIL-based drugs L
#Europe bets on drug discovery Two sites shuttered by the pharmaceutical giant Merck, one in Scotland and one in The netherlands, will soon be humming again with the work of drug discovery.
is sponsored by the Europe s Innovative Medicine Initiative. The European commission s Seventh Framework Programme is contributing##80#million to the venture,
"What needs to be done is to convince oncologists and cancer biologists that this new kind of immunotherapy can work,
Oncologist Renier Brentjens, also at Memorial Sloan-Kettering Cancer Center, remembers the day that he had to tell one of the patients in the trial that the weeks of high-dose chemotherapy the 58-year-old man had endured had worked not after all."
which will be touting for customers at a meeting of the American College of Medical Genetics and Genomics in Phoenix, Arizona, on 19-23 march.
But one of the biggest questions will be how deeply analysis companies can reach into medical settings,
but it would require surgery and would cover only a small fraction of the brain.
Led by Amy Kistler at the Novartis Institutes for Biomedical Research in Emeryville California, the team responded to an outbreak of Theiler's disease at a farm in
or for discovering of signaling pathways associated to brain function and/or dysfunction or as a tool for virtual neurosurgery.
which could revolutionize drug discovery and personalized medicine. In a laboratory first, Duke researchers have grown human skeletal muscle that contracts
showing the lab-grown muscle was giving a truly human response. ne of our goals is to use this method to provide personalized medicine to patients,
and William Krauss, professor of biomedical engineering, medicine and nursing at Duke university. The research was supported by NIH Grants R01ar055226 and R01ar065873 from the National Institute of Arthritis and Musculoskeletal and Skin disease and UH2TR000505 from the NIH Common Fund for the Microphysiological Systems Initiative.
and toxicology screening and development of novel therapeutics for muscle-related disorders. ioengineered human myobundles mimic clinical responses of skeletal muscle to drugsby Lauran Madden, Mark Juhas, William
Now, as part of a joint international project, a team of young researchers at the Center for Medical Physics and Biomedical engineering at Meduni Vienna has succeeded in identifying the mechanisms the spinal cord uses to control this muscle activity.
explains study author Simon Danner, from the Center for Medical Physics and Biomedical engineering of Meduni Vienna.
that too much protein synthesis downstream of mglur5 activation gives rise to many of the psychiatric and neurological symptoms of fragile X. Bear lab tested this idea in mice,
Biomedical Research, the UCSF Diabetes Center Obesity Pilot program, and the National institutes of health b
#New ALS Gene and Signaling Pathways Identified Using advanced DNA sequencing methods, researchers have identified a new gene that is associated with sporadic amyotrophic lateral sclerosis (ALS),
ALS is a devastating neurodegenerative disorder that results in the loss of all voluntary movement
especially in the context of precision medicine and whole-genome sequencing.""Industry and academia often do things together,
where the gene is thought to play a role in tumor-cell survival. his is a great example of the potential of precision medicine,
and director of Columbia university-wide precision medicine initiative. t now seems clear that future ALS treatments will not be equally effective for all patients because of the disease genetic diversity.
senior researcher at the Department of Medical Biochemistry and Biophysics. ut in recent years wee developed much more sensitive methods of analysis that allow us to see which genes are active in individual cells.
The study was carried out by Sten Linnarsson and Jens Hjerling-Leffler research groups at the department of medical biochemistry and biophysics, in particular by Amit Zeisel and Ana Muños Manchado.
It also involved researchers from Karolinska Institutet Department of Oncology-Pathology, and Uppsala University. The study was financed with grants from several bodies,
the EU Seventh Framework Programme, the Swedish Society of Medicine, the Swedish Brain Fund, Karolinska Institutet strategic programme for neuroscience (Stratneuro), the Human Frontier Science Program
which is involved with a number of neurodegenerative disorders, including Parkinson disease (PD) and AD. These findings provide novel insight into Alzheimer neurodegeneration,
possibly opening the door for improved clinical diagnosis and treatment. The findings are published in the February 18 online issue of Molecular Psychiatry.
Alzheimer disease, which afflicts an estimated 5 million Americans, is characterized typically by progressive decline in cognitive skills, such as memory and language and behavioral changes.
In comparison, a number of studies have found a strong association between MAPT and other neurodegenerative disorders,
Phd, research fellow and radiology resident at the UC San diego School of medicine and the study first author.
Tom Deerinck, NCMIR, UC San diego. In the new Molecular Psychiatry paper, conducted with collaborators across the country and world,
and progression of the disease, said Gerard Schellenberg, Phd, professor of pathology and laboratory medicine at the University of Pennsylvania,
Thanks to our collaborators from the Consortium, the International Parkinson Disease Genetics Consortium, the Genetic and Environmental Risk in Alzheimer Disease, the Cohorts for Heart and Aging research in Genomic Epidemiology, decode Genetics and the Demgene cohort,
professor of biological psychiatry at the University of Oslo and a senior co-author. Sudha Seshadri, MD, professor of neurology at the Boston University School of medicine, the principal investigator of the Neurology Working group within the Cohorts for Heart and Aging research in Genomic Epidemiology consortium and a study co-author added:
lthough it has been known since Alois Alzheimer time that both plaques (with amyloid) and tangles (of tau) are key features of Alzheimer pathology,
These findings underscore the importance of using a multi-modal and multi-disciplinary approach to evaluating Alzheimer neurodegeneration. hese findings suggest that the combination of genetic,
said Anders M. Dale, Phd, professor of neurosciences and radiology and director of the Center for Translational Imaging and Precision Medicine at UC San diego and the study senior author e
Teaming up with Alfredo Quinones-Hinojosa, M d.,a professor of neurosurgery at Johns Hopkins, the researchers examined NHE9 in tumor cells from several patients.
the National Institute of General Medical sciences (GM62142), the American Heart Association (11post7380034), the Johns Hopkins Post-Baccalaureate Research Education Program, the International Fulbright Science and Technology Award,
and deliver medicines to specific locations. Yes, creepy but also undeniably cool. At the ICRA 2015 conference in Seattle, researchers from MIT and TU Munich presented just such a creation in a presentation titled (cleverly) n Untethered Miniature Origami Robot That Self-folds, Walks, Swims,
of the MGH Department of Surgery and the Center for Regenerative medicine and senior author of the research paper,
In a study published this week in the journal Pediatrics, the researchers suggest that the technology can indeed help with accurate pain level assessment.
Nurses might only check on a pediatric patient every few hours whereas a facial recognition system could provide constant monitoring.
New findings published in the journal Future Medicine suggest that we may have another way forward.
A medical research team at Florida International University in Miami injected 20 billion nanoparticles into the brains of mice
Karachi hospitals have treated nearly 80,000 people for the effects of heatstroke and dehydration, according to medical officials.
edible barcodes that can be planted right onto medicine to verify that the pills and tablets you might consume are the real deal.
According to Wuh, a medical doctor, this kind of wider recognition is an indication that these bite-size barcodes could play a role in a tech revolution sweeping through medicine. t (Trutag) is really a game-changer
missing just one case of latent syphilis, the team reports online today in Science Translational Medicine.
and 27"other contacts"are under medical surveillance. None of those quarantined or under surveillance in Hong kong and China have showed any signs of illness so far.
says neurologist Dena Dubal of the University of California, San francisco (UCSF), who was involved not in the study. he importance of this work cannot be underestimated as the world population is aging rapidly. ultiple groups of scientists have shown that adding the blood of older mice to younger animalsbodies makes them sluggish, weaker,
nearly as good as young animals at completing the water maze, for instance, the scientists report online today in Nature Medicine.
and surgeons sometimes replace the lens. But now, a team of scientists and ophthalmologists has tested a solution in dogs that may be able to dissolve the cataract right out of the eye lens.
And the solution is itself a solution: a steroid-based eye drop. Though scientists don fully understand how cataracts form,
Coming up with a solution other than surgery has been tough. Scientists have been hunting for years for mutations in crystallin proteins that might offer new insights
This helps medical technicians localise and examine tissues inside your body but requires bulky equipment.
You'll see new applications in the ER in surgery with telehealth in remote communities and even in ambulances.
#Mini robot space surgeon to climb inside astronauts It could one day answer the prayers of astronauts who need surgery in deep space.
The miniature surgeon slides into the body through an incision in the belly button. Once inside the abdominal cavity which has been filled with inert gas to make room for it to work the robot can remove an ailing appendix, cut pieces from a diseased colon or repair a perforated gastric ulcer.
the surgery bot will perform a set of exercises to demonstrate its dexterity, such as manipulating rubber bands and other inanimate objects.
if you would consider surgery in space, "says team member Shane Farritor at the University of Nebraska-Lincoln.
Medical emergency For now, the only humans in space venture no further than the International space station.
Surgery in space would be extremely difficult. Without gravity, it is easy for bodily fluids like blood to float free
so medical tools need to be relatively light but capable of handling many kinds of situations."
The feed relays to a control station, where a human surgeon operates it using joysticks.
Space surgeons Prototypes have performed several dozen procedures in pigs. The team says the next step is to work in human cadavers
"You could imagine situations in the future where you can actually dial in a surgery from the ground
This article will appear in print under the headline"Surgery bot fits in astronaut's gut a
They will also run medical and technical tests and broadcast a science lesson to Chinese students from orbit.
Additionally more than 60 research organizations across the globe are using the system on management social psychology medicine computer science and physical therapy among other things.
They envision that this stable erasable and easy-to-retrieve memory will be suited well for applications such as sensors for environmental and medical monitoring.
for Medical Engineering and Science (IMES). This center is built around a bold idea: to accelerate our progress toward a world in
which was established at MIT in 2012 to tackle some of the world s biggest health challenges through interdisciplinary approaches at the intersection of engineering science and clinical medicine.
Collaboration between academic investigators and real-world clinicians is vital to the center s purpose according to Xavier who also serves as the Kurt Isselbacher Professor of Medicine at Harvard Medical school.
Microbiome-based medicine is poised to revolutionize patient care for IBD and many other diseases in the gastrointestinal tract he says.
or medical interventions based on reprogramming an individual s immune system. We need to develop a toolkit for engineering the human microbiome Alm says.
These tumors known as metastases are treated usually with surgery followed by chemotherapy but the cancer often returns.
and a member of the Koch Institute the Institute for Medical Engineering and Science (IMES and the Department of Chemical engineering and Henry Brem a professor of neurosurgery at Johns Hopkins. The lead author is Urvashi Upadhyay previously a neurosurgeon
at Brigham and Women s Hospital and now an assistant professor of neurosurgery at the University of Massachusetts Medical school.
Michael Lim an associate professor of neurosurgery at Johns Hopkins says the new approach seems like a promising way to expand the range of treatments available for brain tumors
The researchers are also working on using this approach to precisely deliver drugs to very small regions of the brain in hopes of developing better treatments for psychiatric and neurodegenerative disorders.
This opens up a whole new field of being personalized able to do oncology where you can model human mutations
The research was funded by the Howard hughes medical institute the Ludwig Center for Molecular Oncology at MIT and the National Cancer Institute u
In the mid-2000s, a urologist at Boston Children Hospital contacted Cima at the behest of Institute Professor Robert Langer with a plea:
and tested in clinical trials by Taris Biomedical, co-founded by Cima and Langer, a longtime collaborator and entrepreneur.
This type of technology can revolutionize how we do drug therapy in urology, says Cima,
Results of both trials were published in 2012 in the journal Science Translational Medicine. Last year, Taris began an ongoing focus study specifically on patients with Hunner lesions.
the Heinrich-Pette Institute and the Bernhard-Nocht Institute for Tropical Medicine in Hamburg Germany;
Now Stephanopoulos and colleagues at MIT and the Whitehead Institute for Biomedical Research have identified a new way to boost yeast tolerance to ethanol by simply altering the composition of the medium in
for Medical Engineering and Science and an author of the new paper. These fatty molecules have shown promise as delivery vehicles for RNA interference a process that allows disease-causing genes to be turned off with small strands of RNA.#
#Jeff Karp an associate professor of medicine at Harvard Medical school who was not part of the research team says this work is an excellent example of harnessing a multidisciplinary team to partner complementary technologies for the purpose of solving a unified problem.
The study which appears today in the journal Nature Medicine is based on an analysis of blood samples from 1500 people participating in long-term health studies.
The paper s other senior author is Brian Wolpin an assistant professor of medical oncology at Dana-Farber.
Wolpin a clinical epidemiologist assembled the patient sample from several large public-health studies. All patients had drawn their blood
It s based on a naturally occurring biomarker that does not require any biochemical processing of samples says Han one of the senior authors of a paper describing the technique in the Aug 31 issue of Nature Medicine.
Indeed a 2006 report from the Institute of Medicine found that 1. 5 million hospitalized patients in the United states experience medication errors every year due in part to drug-administration mistakes.
Medication verification is a pinnacle point of medical safety says Helgason a physician and product developer.
#RNA combination therapy for lung cancer offers promise for personalized medicine Small RNA molecules including micrornas (mirnas)
and is used often in preclinical trials. It was developed originally in the laboratory of Koch Institute Director#Tyler Jacks the#David H. Koch Professor of Biology#who is co-senior author of this paper.
They were developed in the laboratories of co-senior author Daniel G. Anderson the Samuel A. Goldblith Associate professor of Chemical engineering an affiliate of MIT's Institute of Medical Engineering and Science;
With the current version doctors would need to do a surgical biopsy to get enough tissue
The research was funded by the National Institute of General Medical sciences the National Institute of Environmental Health Sciences the National Science Foundation the National institutes of health and the Bill and Melinda Gates Foundation n
The work might enable new kinds of biomedical or microfluidic devices or solar panels that could automatically clean themselves of dust and grit.
and surgery but it's all invasive in the sense that you either have to put something in your eye wear something on your head
or undergo surgery. We have a different solution that basically puts the glasses on the display rather than on your head.
says Chris Dainty a professor at the University college London Institute of Ophthalmology and Moorfields Eye Hospital.
The Broad Institute today announced an unprecedented commitment of $650 million from philanthropist Ted Stanley aimed at galvanizing scientific research on psychiatric disorders and bringing new treatments based on molecular understanding to hundreds
The Stanley commitment the largest ever in psychiatric research and among the largest for scientific research in general will support research by a collaborative network of researchers within the Stanley Center for Psychiatric Research at the Broad Institute a biomedical research institution
Stanley s new commitment is the culmination of a 25-year personal mission to discover the biology of psychiatric disorders
Biomedical researchers have struggled for years to understand the molecular causes of serious ailments such as schizophrenia and bipolar disorder.
and assembled the world s largest collection of DNA samples in psychiatric research currently more than 175000 samples including schizophrenia bipolar disorder autism attention deficit hyperactivity disorder and healthy control samples.
He wanted to set psychiatric research on the same path. Scolnick vividly remembers the moment he and the Stanleys joined forces.
The Stanleys had given many small grants to support psychiatric research through their foundation but Scolnick argued for the importance of critical mass
Thus the Stanley Center for Psychiatric Research at the Broad was launched in 2007 with Scolnick as its founding director.
Before taking that post Hyman a psychiatrist had served as head of NIMH from 1996 to 2001.
When Hyman left the NIMH in 2001 to become provost of Harvard he had lost almost completely hope that true progress could be made in his lifetime in elucidating the mechanisms of psychiatric illness.
and Harvard in 2004 and over time became encouraged by the Broad s progress in the molecular understanding of psychiatric disorders.
Ten years ago finding the biological causes of psychiatric disorders was like trying to climb a wall with no footholds says Hyman who Is distinguished also the Service Professor of Stem Cell and Regenerative Biology at Harvard.
Formally founded in 2004 to fulfill the promise of the Human genome Project by facilitating collaborative biomedical research across disciplines
The future of psychiatric research The Stanley Center engages a community of more than 150 scientists at the Broad Institute and its partner institutions.
Complete the list of all genes that play roles in severe psychiatric disorders including schizophrenia bipolar disorder autism and others.
when and how these genes act in human brain cells and how in psychiatric patients those processes may go awry.
In contrast to researchers studying cancer or diabetes researchers studying psychiatric disorders have been unable to identify animal models that correctly capture important biological aspects of the disorders
Now with growing knowledge of the genes underlying psychiatric disorders Broad researchers plan to create cellular models in the laboratory
and screen hundreds of thousands of compounds to identify molecules that can powerfully and precisely influence specific biological pathways relevant to psychiatric disorders.
I d be bold enough to say that in five years all the drug companies that got out of psychiatric research will be getting back in.
The coming decades of psychiatric research will yield new science and a needed parallel effort to increase resources for services that can help patients and their families.
About the Stanley Center for Psychiatric Research The mission of the Stanley Center for Psychiatric Research at the Broad Institute is to reduce the burden of serious mental illness through research.
Stanley Center researchers focus on schizophrenia bipolar disorder autism attention deficit hyperactivity disorder and other neuropsychiatric disorders.
Situated within the Broad Institute of MIT and Harvard the Stanley Center aims to exploit the most advanced technologies for human genetic analysis to study these psychiatric disorders
About the Broad Institute of MIT and Harvardthe Eli and Edythe L. Broad Institute of MIT and Harvard was launched in 2004 to empower this generation of creative scientists to transform medicine.
and students from throughout the MIT and Harvard biomedical research communities and beyond with collaborations spanning more than 100 private and public institutions in more than 40 countries worldwide e
or of neurodegenerative disorders, during which the implant can interact with brain physiology. In addition, it is difficult to perform long-term studies of chronic diseases with these implants.
says Garret Stuber, an assistant professor of psychiatry and cell biology and physiology at the University of North carolina at Chapel hill. n animals with larger brains,
Working with researchers at the Friedrich Miescher Institute for Biomedical Research in Switzerland, the MIT team also tested Jaws ability to restore the light sensitivity of retinal cells called cones.
similarly the return of motor function in patients with neurological damage could be identified by its unique grammar.
says Daniel Anderson, the Samuel A. Goldblith Associate professor of Chemical engineering, a member of MIT Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science,
Masanori Aikawa, an associate professor of medicine at Harvard Medical school, describes the new technology as monumental contributionthat should help researchers develop new treatments
which was funded by a National Defense Science and Engineering Fellowship, the National Science Foundation, MIT Presidential Fellowships, the National institutes of health, the Stop and Shop Pediatric Brain tumor Fund,
the Pediatric Brain Tumour Fund, the Deutsche Forschungsgemeinschaft, Alnylam, and the Center for RNA Therapeutics and Biology e
Scientists have identified also links between DNA repair and neurological, developmental, and immunological disorders, but useful predictive DNA-repair-based tests have not been developed,
and customize says Anderson who is also a member of MIT s Institute for Medical Engineering and Science.
Lai Fellowship, an Astrazeneca Distinguished Graduate student Fellowship, the National Institute of General Medical sciences, and the National institutes of health M
a professor of radiation oncology at Harvard Medical school and Massachusetts General Hospital. ur knowledge about the abundance of extracellular matrix proteins in tumors has been limited.
and colonoscopy used in the developed world are too costly to be implemented in settings with little medical infrastructure.
and Institute for Medical Engineering and Science is the senior author of a paper describing the particles in the Proceedings of the National Academy of Sciences the week of Feb 24.
The research was funded by a National Science Foundation Graduate Research Fellowship a Mazumdar-Shaw International Oncology Fellowship the Ruth L. Kirschstein National Research Service Award from the National institutes of health
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