#Spherical nucleic acids set stage for new paradigm in nanomedicine drug development A research team led by Northwestern University nanomedicine expert Chad A. Mirkin
and Sergei Gryaznov of Aurasense Therapeutics is the first to show spherical nucleic acids (SNAS) can be used as potent drugs to effectively train the immune system to fight disease,
"The ability to selectively trigger the immune response with spherical nucleic acids presents a whole new way of thinking about drug development,
additional cells are trained to behave the same way as the initial cells. This gives you a catalytic effect that grows into a systemic search for cells that look for example, like lymphoma cells."
but also in other major industries such as automotive and aviation. Joseph M. Desimone, professor of chemistry at UNC-Chapel hill and of chemical engineering at N c. State, is currently CEO of Carbon3d where he co-invented the method with colleagues Alex Ermoshkin, chief technology officer
Its findings could change the way medical professionals treat fractured bones that experience difficulty in healing
On route to self-powered smart suits s
#Breakthrough in nonlinear optics research A method to selectively enhance or inhibit optical nonlinearities in a chip-scale device has been developed by scientists,
which strongly effects the propagation of light, in the same way that semiconductors control the flow of electrons.
and get multiple stickers to respond in the same way at the same time, as part of an adaptive camouflage system.
He's also working on ways to make the stickers more versatile. The current version reflects near-infrared light.
The new technology may hold promise for many applications such as for jewelry, automotive interior trim, aviation, signage, colored keypads, electronics and wearable displays s
and improve the way in which it simulates the human hand. This will involve modelling hand movement patterns
Each pick-up and release with conventional gripping systems involves the risk of either contamination of the surfaces with residues from transportation adhesives,
and release large components and heavy materials in an energy-efficient way. Furthermore the development group works on the gripping of objects with curved surfaces without leaving residues.
and is always on the lookout for new ways to build more efficient coolers. So, after years of working with magnetocaloric refrigeration system modeling and design,
"The team's future work will focus on ways to load the material to increase its resistance to fatigue,
researchers are finding ways to combine living organisms with nonliving machinery to solve a variety of problems.
Removing salt and other minerals from our biggest available source of water--seawater--may help satisfy a growing global population thirsty for fresh water for drinking, farming, transportation, heating, cooling and industry.
who co-led the study with Ivan Vlassiouk in ORNL's Energy and Transportation Science Division."
The membrane allowed rapid transport of water through the membrane and rejected nearly 100 percent of the salt ions, e g.,
which the scientists used to correlate the porosity of the graphene membrane with transport properties.
Chemists from Brown University have come up with a way to make new nanomaterials from a silicon-based compound.
if we could find a way to target FL2 in humans, we might have a new way to promote wound healing,
said Dr. Sharp. Dr. Sharp and project co-leader Joshua Nosanchuk, M d.,professor of medicine at Einstein and attending physician, infectious diseases at Montefiore Medical center, developed a wound-healing therapy that uses
To find a way to deliver sirnas for curbing FL2, Dr. Sharp collaborated with Joel Friedman, M d.,Ph d.,professor of physiology & biophysics and of medicine at Einstein,
The nanoparticles with their sirna cargoes were tested then by topically applying them to mice with either skin excisions or burns.
"There might be ways to enhance light emission even further. But, so far, we have shown successfully that it's indeed possible to increase light emission from a very thin material
Photons are wave packets that vibrate in a specific plane the direction of polarization. The state of the qdots determines the direction of polarization of the photon."
we were able to read out the ion that was excited in this way, "explains Prof. Khl."
This success is an important step on the still long and rocky road to a quantum computer.
In an experiment, recently published in Science("Probing Johnson noise and ballistic transport in normal metals with a single-spin qubit),
Planes are modelled on birds and many drugs have their origins in plants. Researchers at the Department of Mechanical and Process Engineering have taken it a step further:
dry material in such a way that their temperature-sensitive properties are preserved, "he recounts. The scientists achieved their objective by growing the cells in a medium containing tiny tubes of carbon.
and expanded in a plane when a voltage is applied between electrodes. In contrast to actuators based on rigid materials such as silicon, dielectric elastomers can reach a very large extent of stretch, often exceeding 100 percent elongation while not breaking,
but this time it comfortably held a tringof water molecules. he continuous one-dimensional ater chaintrapped by the molecules is indispensable for mediating water transport across a lipid membrane,
whether a proton gradient could induce water transport. We were surprised very to find that it could.
Zeng explains that the team olecular strawbeats the naturally occurring aquaporins in a number of ways.
#Nanoparticles provide novel way to apply drugs to dental plaque Therapeutic agents intended to reduce dental plaque
But a team of researchers has developed a way to keep the drugs from being washed away.
found a new way to deliver an antibacterial agent within the plaque, despite the presence of saliva.
Institute for Basic Science) By creating the alloy this way, the joints between the fused grains,
This new thermoelectric alloy paves the way for the future of modern TE devices s
With this fundamental understanding in fluid mechanics, our research will pave the way for future robots that require fast maneuvers to help us get close to something that moves fast
Their soft nanoparticles stick to the plane where oil and water meet, but do not stick to one another.
and Kathleen Stebe, also devised clever ways of measuring the properties of this unique system.
and the way they are attached to the central particle allows them to contort themselves so both sides are happy
revealed the characteristic ways in which light interacts with this nanometer scale object.""Interpreting a 2-D image,
"For instance, it could be used in manufacturing LEDS to optimize the way light is emitted, or in solar panels to improve the absorption of light by the active materials."
distribution and utilization in a wide range of applications ranging from heating to transport fuel.
and describes how the research team used nanotechnology to watch tumor stem cells respond to therapy. ee never been able to directly observe the actions of potential cancer treatments this way before,
#Electrical control of quantum bits in silicon paves the way to large quantum computers (Nanowerk News) A University of New south wales (UNSW)- led research team has encoded quantum information in silicon using simple electrical pulses for the first time,
and single-crystal structures of the ac (middle) and ab planes (bottom). Right: Output characteristics of FETS fabricated using the polycrystalline thin films as-coated (top)
#New ways to see light and store information (Nanowerk News) Reseachers from the University of Cologne,
ITBM, Nagoya University) Metal-catalyzed C-H borylation of aromatic rings is considered an efficient way to introduce functional groups to make functional molecules via a boryl moiety.
However, there has been no general way to do this up to now, "says Kenichiro Itami, the Director of the Institute of Transformative Biomolecules."
we have been trying to find ways to introduce functional groups at the para position of the benzene ring"says Yasutomo Segawa,
With the help of the new genes the yeast is capable to synthesize the high-prized, natural flavor (more than 4000 euros per kilo) in a cheap way and in useful quantities from sugar (one euro per kilo.
"With our method, the important and expensive terpenoid Nootkatone can be produced industrially in an environmentally friendly, economical and resource-saving way in useful quantities."
Because Sørensen's molecules work by way of a simple colour shift they give a very exact indication of quantity as well as location of oxygen in a tissue sample or inside a cell.
#Bio-inspired eye stabilizes robot's flight without need for an accelerometer Biorobotics researchers at the Institut des Sciences du Mouvement-Etienne-Jules Marey (CNRS/Aix-Marseille
All aircraft, from drones to the Ariane launcher, are equipped currently with an inertial measurement unit,
This allows these aircraft to stabilize their roll and pitch with respect to the horizon or rather with respect to its perpendicular:
An accelerometer measures all the accelerations of the aircraft including gravity, which is directed always toward the center of the Earth.
when driving along a motorway: the view in front is fairly stable, but looking out to either side,
By way of a brain, Beerotor has three feedback loops2, which act as three different reflexes that directly make use of the optic flow.
3) An inertial reference system is used an instrument in navigation that is able to process the measurements of a device's motion (acceleration and angular velocity) in order to estimate its orientation (angles of roll, pitch and heading.
Johns Hopkins Medicine researchers may have discovered a way to prevent rejection by using biodegradable nanoparticles that release needed medication into the eye after surgery.
Cataract and External Eye diseases at Johns Hopkins. About 60 to 80 percent of patients dont take medicine the way they are supposed to.
"researchers looked into ways to alleviate the strain of adhering to a post-surgery treatment regimen that is sometimes hard to manage.
and our study illustrates a potentially better way. The steroid-loaded nanoparticle treatment group showed no signs of corneal transplant rejection.
and medicine to look further into better ways to treat eye diseases s
#Flexible sensors turn skin into a touch-sensitive interaction space for mobile devices (w/video) If a mobile phone rings during a meeting,
and could offer industry a way to automate the design and manufacture of synthetic DNA.
The way BASIC has been designed lends itself very well to automation and high throughput processes, which is the future of synthetic biology.
and then study it, over time, in a noninvasive way, without having to administer a contrast agent."
each letter stylized in different ways or saturated with oise In a process similar to how we humans pick our friends out from a crowd,
similar to the way human neural cells generate neural electrical signals. he memory state is stored as a specific concentration profile of defects that can be moved back and forth within the memristor,
said lead researcher Prezioso. his memristor-based technology relies on a completely different way inspired by biological brain to carry on computation.
Potential applications already exist for this emerging technology, such as medical imaging, the improvement of navigation systems or even for searches based on images rather than on text.
this brain would consist of trillions of these type of devices vertically integrated on top of each other. here are so many potential applications it definitely gives us a whole new way of thinking,
The development opens the way to building devices that focus and amplify electrons just as lenses focus light
A person taps the tablet to control where the beam of light appears on a floor. The swarm robots then roll toward the illumination,
A person taps the tablet to control where the beam of light appears on a floor. The swarm robots then roll toward the illumination,
Then the robots work together to determine the best ways to accomplish the job.""Egerstedt envisions a scenario in
any way you want me: Scientists curve nanoparticle sheets into complex forms (Nanowerk News) Scientists have been making nanoparticles for more than two decades in two-dimensional sheets, three-dimensional crystals and random clusters.
Now researchers from the University of Chicago, the University of Missouri and the U s. Department of energy's Argonne National Laboratory have found a simple way to do exactly that.
Xiao-Min Lin et al, taken using a scanning electron microscope at the University of Chicago) The findings open the way for scientists to design membranes with tunable electrical,
so they end up distributing themselves in a nonuniform way across the top and bottom layers of the nanoparticle sheet.
came up with an ingenious way to measure the molecular asymmetry, which at only six angstroms,
and his team will continue trying to find ways to outsmart or change the pinball setup of graphene to minimize electron scattering.
and more effective way to treat heart attack and stroke via nanotechnology. The research jointly lead by Professor Christoph Hagemeyer, Head of the Vascular Biotechnology Laboratory at Baker IDI Heart and Diabetes Institute and Professor Frank Caruso,
Engineers at MIT have now hit upon a way to impart more dexterity to simple robotic grippers:
in a cost-effective way, to perform more complex maneuvers. hasing the human hand is still a very valid direction in robotics,
Giving robotics a push Rodriguez is currently exploring multiple ways in which the environment may be exploited to increase the dexterity of simple robotic grippers.
his group is looking for ways in which a robot might use gravity to toss
MIT engineers have devised a way to give more dexterity to simple robotic grippers using the environment as a helping hand.
and a plane. The team measured the forces the robot exerted to maneuver the rod into the desired orientations,
Ultimately, Rodriguez sees extrinsic dexterity as an inexpensive way to make simple robots more nimble for a variety of uses:
saving any additional work of finding a way to attach metal leads. This new fabrication technique is a hyper-efficient way of utilizing the available Mote2 without any wasted or extraneous parts.
When asked about its potential for future use Professor Heejun Yang of SKKU said, here are many candidates for 2d semiconductors,
and industrial R&d in a wide spectrum of applications, from transport to medicine. The Laser Applications Centre of AIMEN is devoted to applied research in the field of laser materials processing,
and according to the authors, it's important that research identifies optimal ways to deal with the waste."
and controlling light in this way also could lead to improvement in the efficiency of solar energy cells,
"Information built up from the way focused light scatters off a complex molecule can be used to determine something about its composition
we have been keen to find a way to get past the problems it causes, such as in biochemical analysis,"said Dr Cortes. The discovery opens up the possibility for new equipment that can track individual biochemical reactions in over a period of time,
"But this is a new way to make ultradense, nonvolatile computer memory, "Tour said. Nonvolatile memories hold their data even
First, the control voltage mediates how electrons pass through a boundary that can flip from an ohmic (current flows in both directions) to a Schottky (current flows one way) contact and back.
and a way to control the size of the nanopores s
#Bioengineers identify the key genes and functions for sustaining microbial life (Nanowerk News) A new study led by bioengineers at the University of California,
we can begin to realize new ways to engineer a cell to optimize production of a desired product without sacrificing the cell's health,
Hubbard has developed a way to reduce the off-target DNA binding of a class of gene editing proteins known as transcription activator-like effector nucleases (TALENS).
the team first looked for a way to measure the robots center of pressure, or weight distribution,
But perhaps more important than just a way to control a robot in the absence of knowing how to do it autonomously is being able to observe and collect data from the robot.
so were optimistic that this could be scaled up in a cost-effective way, Zhu says s
because one of the best ways to learn how our solar system evolved is to look to younger star systems in the earlier phase of development.
What makes 51 Eridani particularly interesting is that it also harbours dust and ice in the planetary system,"explains Professor Metchev.
it signifies that this planet is well on its way to becoming a cousin of our own familiar Jupiter,
of ways. It's a major step forward in creating a quantum computer to solve problems such as designing new drugs
that can sandwich 2-D sheets of elements that otherwise couldn't be combined in a stable way.
because it represents a new way of combining elemental materials to form the building blocks of energy storage technology--such as batteries, capacitors and supercapacitors,
Mastering Materials Combining two-dimensional sheets of elements in an organized way to produce new materials has been the goal of Drexel nanomaterials researchers for more than a decade.
"But Drexel researchers came up with a clever way to circumvent this chemistry challenge. It starts with a material called a MAX phase,
An Elemental Impasse Four years later, the researchers have worked their way through the section of the Periodic table with elements called"transition metals"
and manipulate them in a flexible way. They were able to organise the tiny particles into new structures with the utmost precision
#New research could help build computers from DNA Scientists have found a way to'switch'the structure of DNA using copper salts
Superconductivity occurs as the result of pairs of electrons binding together in such a way that they act as a single quasiparticle.
Yet not all superconductors behave this way. In unconventional superconductors that do not fit the conventional model,
"If one of the fiber-optic cables under the ocean breaks, the only way to fix it is to replace it,
if we could promote wound healing this way so that is where I'm going to focus now
This paves the way to wearable displays in clothing providing users with feedback. Wearable devices such as healthcare monitors and activity trackers are now a part of everyday life for many people.
#New, ultrathin optical devices shape light in exotic ways Caltech engineers have created flat devices capable of manipulating light in ways that are very difficult
a metasurface device could manipulate light in novel ways that are very hard and sometimes impossible to do using current setups.
In addition, the Faraon lab current is investigating ways to combine different metasurfaces to create functioning optical systems
#Biodiesel made easier and cleaner with waste-recycling catalyst Researchers at Cardiff University have devised a way of increasing the yield of biodiesel by using the waste left over from its production process.
It is believed this new process will have significant environmental benefits by improving the yield of biodiesel in a sustainable way that doesn't require the use of additional fossil fuels
By 2020, the EU aims to have 10 per cent of the transport fuel of every EU country come from renewable sources such as biofuels.
In their study, the researchers, from the Cardiff Catalysis Institute, developed a way of turning the crude glycerol back into methanol,
and potentially cheaper, way, by converting an undesired by-product into a valuable chemical that can be reused in the process."
"We set out to establish ways in which the waste product glycerol could be used to form other useful compounds,
"This research has the potential to transform the way in which waste is dealt with, and seriously improve the quality of life by reducing carbon emissions from fossil fuels
and Xin decided to use existing data to train computer algorithms to make predictions of new materials,
an extremely useful chemical in industry for making plastics. his study opens a new way for designing metal-based catalysts with complexities, for example, geometry and composition, promoters and poisons, defects,
heat transport and strength. The Rice team is laying a theoretical foundation for such structures by analyzing how the blocksjunctions influence the properties of the desired materials.
the way the atoms are arranged can influence all those properties. ome labs are actively trying to make these materials or measure properties like the strength of single nanotubes and graphene sheets,
Layered sheets of graphene keep their properties in-plane, but exhibit little stiffness or thermal conductance from sheet to sheet,
with the atoms arranged in a non-regular way.""There are many types of metallic glass, with the most popular ones based on zirconium, palladium, magnesium, titanium or copper.
in order to test ways the process could be disrupted or restored. In addition, platelets generated ex vivo could be used to help healing in regenerative medicine
tend to lack that ability for precise control. hat we wanted to do was to figure out a way to bridge those two worlds,
and finding a way to chemically modify its surface to give it the desired tunability.
By finding a way to make this material tunable in the same ways as molecular catalysts
which occur on such fast time scales that physicists have sought multiple ways to measure their durations and intensities.
a George Holmes University Professor of physics. ou don have to do this on the fly. aving a way to know what youe inputting into an unknown situation is important.
with the second rotating the opposite way. These orientations dictate whether the resulting spiral pattern appears to swirl left or right
#Darwin on a chip Researchers of the MESA+Institute for Nanotechnology and the CTIT Institute for ICT Research at the University of Twente in The netherlands have demonstrated working electronic circuits that have been produced in a radically new way,
which can solve complex problems in an energy-efficient way. Nature exploits complex networks that can execute many tasks in parallel.
Powerful and energy-efficient It is the first time that scientists have succeeded in this way in realizing robust electronics with dimensions that can compete with commercial technology.
Not only would this provide a more accurate way of delivering drugs, but the cages themselves could be used therapeutically."
and deliver their cargo, they could break down into additional therapeutic agents. We can now design two things into one."
an IMES postdoc and the paper lead author. his is used in many ways, but not so much for detection.
Learning more about such viruses could help scientists find ways to permanently eliminate them. atent HIV provirus is pretty much the final barrier to curing AIDS
and there aren any ways to eradicate it, Slomovic says. While treating diseases using this system is likely many years away,
whether two genes located far from each other on a chromosome fold in such a way that they end up next to each other,
producing the material in a different way to allow it to remain fatigue-free through thousands of cycles s
which will guide how scientists and engineers build aircraft components, for example. The research, led by Jianwei (John) Miao,
because different arrangements of atoms cause electrons to interact in different ways. However scanning transmission electron microscopes only produce two-dimensional images.
and find their way onto a detector, creating a diffraction pattern. By analyzing that pattern,
One of the easiest ways to speed up the drug development process is to simply perform it outside of the living body (e g.,
#Pioneering research develops new way to capture light-for the computers of tomorrow The key breakthrough will allow large quantities of data to be stored directly on an integrated optical chip,
a nanoscale integrated optical memory that could open up the route towards ultra-fast data processing and storage.
the scaffolds have the potential to be used as a way to deliver medication to a specific area in the body with high precision
This way, researchers were able to compress the inner core, creating the intense internal electric field.
which opens the way towards optical memories and smart pixel new devices. The new material could also lead to optical sensors that are highly sensitive to the electrical field in the environment on the nanometer scale e
or PEG, that releases its cargo only in targeted immune cells. The nanocarrier degrades when it encounters the acidic part of these cells,
Traces of the sunscreen chemical administered in a conventional way were found to have soaked deep within the skin.
the development of new, lighter and stronger materials spanning consumer electronics to aircraft; and faster information searching through large databases s
preferring to transport certain ions over others through the graphene layer. hat we see is that there is a lot of diversity in the transport properties of these pores,
and Sean Oern from MIT and Juan-carlos Idrobo from Oak ridge National Laboratory, publish their results today in the journal Nature Nanotechnology("Heterogeneous sub-continuum ionic transport in statistically isolated graphene nanopores").
and in understanding transport through these really small pores in ultrathin materials, Karnik says. Meni Wanunu, an assistant professor of physics at Northeastern University, says the group work with graphene membranes may significantly improve on commercial membranes used for water purification,
detail this new way to directly measure magnetic moments and how it may be used to break fundamental limits of spatial resolution that are imposed in purely optical magnetic measurements.
and in this way we can measure the resistance at different positions in a skyrmionsays Christian Hanneken, a Phd student in the group of Prof.
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