#MEDPRIN 3d prints world first biological meningioma Redura for use in brain surgery While 3d bioprinting innovations sound lifesaving and revolutionary, most are still years away from impacting ordinary
people in regular hospitals. However, one Chinese company is already implementing a bioprinted product on a large scale across the world.
Called MEDPRIN, they have developed the world first 3d printed biological meningioma called Redura a replica of tissue covering the brain
and are already applying it in surgical rooms across the world. MEDPRIN is based in Guangzhou,
China and was founded by a team of biomedical scientists in 2008 as a developer of regenerative medical materials and devices.
Since then they have grown out to become a global leader in the field of implantable medical devices,
and the Redura is just one of the many products they have released. It full name is the Redura Biomimetic-Synthetic-Absorbable Dural Substitute,
and has received already a number of medical certificates, including from CE and CFDA. It has also reportedly been applied on tens of thousands of cases across the world
and it is believed also to be applied the first bioprinted product to come out of China. So what exactly is the Redura?
With a thickness of only 0. 2 mm, it looks like ordinary tissue paper, but is in fact a tissue with extraordinary qualities.
Usually, when patients undergo brain surgery, doctor first need to cut through a layer of protective tissue between the skull and the brain.
When patching everything up, they'paste'an artificial Meningioma layer on the area in question and sew everything together.
While these have already been widely and successfully used in brain surgeries everywhere, they are not biological
and have a tendency to disrupt a patient life-as most artificial meningioma layers contain metal parts
and will often case security alarms to beep. Fortunately this 3d printed biological Redura doesn suffer from these problems,
but instead closely resembles the existing membrane and a patient autologous cells. It also features an excellent repair effect.
While dry, it resembles a white paper, but when wet it begins to resemble a thin rubber surface perfect for use in surgical rooms.
Yuan Yuyu, the chairman of MEDPRIN, explained how they developed this 3d printed material. They begin by taking meninges tissue out of patients themselves to analyze the fiber structure.
They will subsequently use 3d printing technology to create artificial meninges structures. Upon implantation the brain blood vessels crawl into the structures.
Over a course of up to three months, a completely new Meningioma beings to grow, while the artificial structure naturally degrades.
It has already been applied very successfully to thousands of patients, Professor Xu Tao from Tsinghua University,
and has been used in world renowned hospitals such as Cambridge university Hospital. So far, no reports of adverse reactions have been made
he said. he core membrane adopts the most advanced 3d printing based bio-regenerative medical platform,
when Xu Tao was still a Phd student in the US at the team of Thomas Boland the father of 3d bioprinted organs.
In 2009, Xu Tao teamed up with Yuan Yuyu from Clemson University to found the first bioprinting company in China.
the key difference between bio 3d printing and traditional printing is in the printhead used. here are two kinds of printhead used in bio 3d printing:
When printing out membranes, he says, the machine sprays out a fiber-like ink onto biological paper that simulates the collagen structures found in body.
Forming hundreds or even thousands of layers of molecular membrane, the result can be adapted to a human environment.
Key is the use of a patient own autologous cells to prevent immune reactions. In time, this will allow on-demand organ printing to take place.
In case of the Redura membrane they only produce tissue of up to 0. 2 mm in thickness,
According to the company, doctors could just use Redura on the defect areas and sow it together. edura is hydrophobic with a more than 90 contact angle that acts as a watertight barrier for the prevention of cerebrospinal fluid (CSF) leakage,
which has been tested extensively to prove the biocompatibility and non-toxicity. uan Yuyu further stated that the Redura is absorbed eventually into the body. imply put Redura provides the bracket in
which cells and tissue can grow. About two months after a meningeal tissue has grown, the Redura begins to slowly degrade into toxic-free carbon dioxide and water,
'he says. edura is degraded fully and absorbed, leaving no foreign body in-situ and is replaced by regenerated dura tissue.
a tensionless urethral sling, a hernia repair piece, and artificial skin, blood vessels and ligament, many of which rely on the exact same 3d printing technique.
According to Xu Tao, the availability of 3d printed medical tissues could widely change over the coming years. issue repair is a complex human organ regeneration process,
he said. he plan is to develop more than 10 kinds of implantable medical devices products within the next 5 years.
we are leading the establishment of Guangzhou Research Institute of regenerative medical industry, seeking to integrate global and domestic regenerative medical technology
and clinical resources to push 3d printing from biological tissue reconstruction all the way up to 3d printing of organ regeneration.
#Swedish researchers create a nanoscale 3d printed bunny using folded DNA Among some of the more exciting developments that wee been seeing in additive manufacturing involve the creation of structures that you can even see at all-in the form of nanoscale assemblies.
Whether its for medical use or for other scientific purposes, the ability to create custom objects using additive manufacturing methods at the nanoscale is allowing experts to manipulate objects at even the smallest levels.
The new results will help pave the way for DNA NANOTECHNOLOGY in medicine over the next 10 years.
The complex structures are less than 50 nanometres wide and have been produced as part of a new study published this week in the journal Nature.
it hasn been until recently where new methods have opened up different possibilities for fine-tuning the folding process through automation-an important step for the near future of nanoscale 3d printing. ee developed a new slim lined method to fold DNA
says Björn Högberg, a senior lecturer at the Karolinska Institute, Sweden, and head of the research group behind the new study. e use the same principles as 3d printing to design the DNA structure,
and most importantly we have shown that these designs work in real life, by developing some examples in the laboratory.
For the study, the researchers used design software to draw complex shapes including a bunny, a waving humanoid and a bottle.
the researchers then used custom algorithms to plan a DNA scaffolding that would ultimately form the designed 3d object-such as a bunny.
In order to actually rintthe DNA, researchers ran their algorithms and combined them with ideal temperature conditions that assembled the 3d objects.
the researchers used manufactured DNA from viruses as a building material. e take the paradigm of 3d printing to construct a method to go from a mesh designed in the computer,
and use a new algorithm to simulate a design in DNA that looks like this mesh,
which is where the algorithm really helps. The researchers chose a bunny shape (also known as the Stanford Bunny) to publicly demonstrate the technology because of its widespread use as a test model for various 3d technologies
said Högberg. t not just that we have a useful computer algorithm, but we have a real method to produce more complex DNA structures.
Among other applications for the automated DNA folding process include helping researchers develop nanoscale structures for targeted drug delivery
or for further learning about how cells communicate with each other in the body he cells in our bodies communicate by adding proteins onto their surfaces,
but instead of reading by dots, the cells read by these nanoscale protein clusters on neighbouring cells,
using similar DNA NANOSTRUCTURES presented in this research, and these structures will be a guide for developing future research,
#3d printed smartphone device reads ELISA diagnostic tests accurately and within one minute In remote or developing countries,
Unfortunately, many common diagnostic tools, such as enzyme-linked immunosorbant assay (ELISA), require large and expensive readout instruments that can only be found in well-equipped hospital labs. Now,
a team of researchers from the California Nanosystems Institute at UCLA have created a low-cost, smartphone-based device and app that is made with a 3d printer
and can read ELISA plates on-the-spot, with up to 99.6%accuracy for certain viruses. The new ELISA platform is made on a 3d printer.
Image via UCLATO conduct a traditional ELISA test, doctors place antigen samples from the patient onto a surface,
normally a small transparent plate resembling a honeycomb with 96 tiny wells. Specific antibodies are placed then into each well,
which can be analyzed by doctors to determine whether particular viruses are present. While that process may seem a bit complicated to us non-medical experts
these type of multiwall plate batched analysis are highly efficient, and dramatically reduce diagnosis costs per patient compared to nonbatched or nonstandard tests.
A traditional ELISA 96-well platewith the UCLA researcher new invention, the same steps are taken,
but with a small and low-cost 3d printed device that attaches to a smartphone. Known as a olorimtreic microplate reader, the attachment illuminates a 96-well plate with an LED array.
A custom-designed smartphone app then reads the resulting images and analyzes them using a machine-learning algorithm.
Perhaps most impressively the diagnostic results for the entire 96-well plate can be sent back to the phone within one minute, complete with a handy visualization for the user.
The mobile platform has been tested successfully in a clinical microbiology laboratory, comparing 571 patient samples to FDA-approved samples of mumps, measles,
and herpes simplex viruses 1 and 2. The platform achieved an accuracy of 99.6 percent in diagnosing mumps, 98.6 percent for measles,
and 99.4 percent each for herpes simplex 1 and 2. Schematic overview and different perpsectives of the colorimetric readeraccording to the research paper,
published online in the journal ACS Nano, this cost-effective, hand-held platform could assist healthcare professionals perform disease screening
and vaccination tracking campaigns in resource-poor and field settings. In addition to serving low-resource or remote areas, the researchers noted that intrinsic wireless connectivity can serve epidemic-related studies,
generating real-time, spatiotemporal maps of disease prevalence and immunity. e are always looking toward the next innovation,
and are looking to adapt the basic design of this ELISA cellphone reader to create smartphone-based quantified readers for other important medical tests,
said Dino Di Carlo, professor of bioengineering and one of the researchers on the team. t is quite important to have these kinds of mobile devices,
especially for administering medical tests that are done usually in a hospital or clinical laboratory, added lead researcher Aydogan Ozcan. t fantastic for an undergraduate to be first author on the publication,
he said in reference to first author Brandon Berg and two other undergraduates on the research team.
Screenshots from the Colorimetric Plate Reader app. The app creates easy-to-read visualizations of the diagnostic test resultsalongside Berg, Di Carlo,
and Ozcan, the UCLA team was made up of an interdisciplinary group of researchers from the fields of electrical engineering,
physics and astronomy, to bioengineering, pathology and laboratory medicine. The Californa Nanosystems Institute and the Johnsson Comprehensive Cancer Center also contributed, with support from the National Science Foundation and the Howard hughes medical institute.
Since 3d printing technology is acknowledged already for being affordable and easily transportable to low-resource areas,
it is easy to imagine this kind of groundbreaking medical technology being used in remote, rural or developing countries, many
of which are at high risk for virus-related epidemics. And, given the incredibly high success rates of the clinical trials so far, it can only be hoped that this lifesaving device is put to good use as soon as humanly possible. a
#Surgeons turn to 3d printing to help perform world first pediatric bilateral hand transplant in USA Although wee previously heard about the many remarkable instances where 3d printing has helped improve the quality of life for an individual thanks to its increased usage and acceptance in the medical industry,
none of the scenarios involved a surgical procedure as complicated as a hand transplant. Yet, thanks to a team of surgeons in Philadelphia, an 8-year-old boy can now throw the football thanks to a recent hand transplant that was made possible thanks to the aide of 3d printing.
The 8-year-old Zion Harvey, sadly lost his hands and feet to an infection several years ago and has learned
since how to live without them. In order for doctors to perform the rare procedure, a total of four simultaneous operating teams were required;
while two were focused on the donor limbs, two were focused on Zion. In order to prepare for the procedure,
the team practiced for nearly a year and a half. Among other reasons, speed was of the utmost importance due to the ability to only have about five hours from the time they received the hands to the time they had to ensure that blood was flowing again.
Of course, finding the right hands to even transplant in the first place wasn without its challenges, too. In order to determine whether a set of donor hands would be the right size for Zion
Dr. L. Scott Levin and another member of Zion surgical team created sample hands on a 3d printer that were based on CT SCANS of Zion forearms.
In order to increase their chances, they made hands that were up to 20%larger and 20%smaller.
These 3d printed hands were used then by Dr. Levin when checking on potential donors. This week, it was announced by the Children's Hospital of Philadelphia that the surgery,
which occurred in early July, was a success and that Zion is both the first pediatric hand transplant patient in the U s as well as the world's first pediatric bilateral hand transplant patient.
In total the surgery took 10 hours and involved a team of 40 doctors and nurses from the Children's Hospital, Penn Medicine,
and Shriners Hospital for Children in Philadelphia. According to Dr. Benjamin Chang, a surgeon who was on Zion hand transplant team, the complicated surgery involved uniting 2 bones, 2 deep arteries, 4 veins, 10 nerves, and 22 tendons."(
"The challenge involved) bringing everything together so that they not only looked like hands, but also functioned as hands,
"explained Dr. Chang. Thanks to the thorough preparations performed by the surgical team in advance of the actual surgery,
Zion recovery was limited to just a week in the hospital intensive care unit. Currently, he is undergoing intensive hand therapy several times a day
in order to improve his hand function. As for throwing a football, Zion has a few months before football season gets underway in the US-but there no rush, of course. s
#Eastman, taulman 3d, Aleph Objects Partner for New n-vent 3d printing Filament Eastman Chemical Company has been making its Amphora plastic available to filament manufacturers to take advantage of the material
properties in order to produce unique 3d printing materials. Namely, colorfabb has created a BPA-free copolyester material, as well as their powerful carbon fiber filament, using the material.
Now, two popular US companies are taking advantage of Amphora with taulman 3d n-vent filament,
and high tensile strength. Thomas Martzall, owner of taulman 3d, says of the quality that Eastman Amphora brings,
along with Eastman Amphora (TM) 3d polymer bonding abilities, will ensure multipart designs accomplish the desired goal. he material will be available this summer in a variety of colors,
made with Eastman Amphora (TM) 3d polymer, will rank among the best premium materials on the market. hough the quality of both Lulzbot
These two companies are key leaders in this market from a hardware and filament perspective and collaborating with them allows us to bring Eastman Amphora (TM) 3d polymer to a broader audience in the right way. t the same time as this speaks of the firm foundation that Aleph Objects
and taulman 3d have in the 3d printing market, it also speaks to the growing presence of large companies in the space.
While GE, Autodesk, HP, Intel, and Microsoft look to dominate the software and hardware of 3d printing, Eastman, Mistubishi,
and Natureworks are looking at the materials side of the industry. It my personal opinion that the open source community will win out in the long term and
with Eastman picking partners already valued by the DIY and open source communities, I think theye placed the appropriate bets p
#The Focus 3d printer Is multifaceted Portable , & Delicious? At the end of last year, Davide reported that a company called 3d By Flow was going to be releasing a 3d printer with all of the fixings for portability.
that the printer would also be equipped to handle viscous materials, like food. Now that printer has hit Kickstarter revealing its specs, pricing, name and All the printer from 3d By Flow,
called Focus, is indeed portable and, more than that, it designed to use a wide variety of materials,
and ABS, but it can print silicon, ceramic, rubber, and more. With an added end-stop, the Focus can more easily integrate these different print heads,
which include a filament extruder, a paste extruder, and a granulate extruder that is still in development.
The printer is designed to fold into a suitcase, weighing only 7 kg. The unfolding and setup process is meant only to take 20 seconds, with printing ready in just two minutes.
This is possible due to a lack of leveling or calibration as the printbed is fixed completely. An SD card reader allows for untethered printing,
though a USB capable allows for printing from a computer as well. The Focus also has bed a heat that can reach up to 100°C. And,
once you get printing, you should be able to achieve Z-axis resolutions of 5 microns, according to the company.
You can see the full specifications below: 3dbyflow has constructed already 20 printers and field tested them in various locations,
including the Albert Hejin supermarket, as previously noted. With a solid Kickstarter campaign, the company plans to both construct the Focus for all of their backers, before eventually launching a second printer for the healthcare industry, the MKB printer measuring at 50x50x50cm,
and a third specifically for chocolate. The early bird packages for the printer start at around $2,
200, increasing to about $2, 400 after that. Not a bad price for a compact and capable printer,
if it delivers on all of its promised specifications. I don like getting my hopes up in this industry anymore
but I definitely hopeful about this compact and versatile printer. Check out the Kickstarter page for more information and watch the video below c
While Autodesk is leading thugged Sprite UAV Guided to Kickstarter Thanks to 3d printing At the end of last year,
we covered an interesting take on the DIY drone market, a 3d printed drone for scouting hiking trails from above.
After successfully completing their 3d printed prototype thharebot Voyager DLP 3d printer Officially For sale As they head to the reatest Show
Due to the precision and castabilitytereolabs Launches ZED 3d Camera for Long-range Depth Sensing Every day on 3dpi, we report on developments in 3d printing, scanning, reality computing, and more.
The ubiquitous and democratizing nature of 3d printing continues to obo Turtle Receives Species1st 3d printed Jaw Implant 3d printing has had its fair share of heartwarming stories
and toes to interact with our environment. Without a limb, our ability to hold a hot cup of coffee is taken away
so have myoelectric and sensor technologies. Lü Siyi and her team of researchers at Nankai University, in the northern city of Tianjin, China, have used 3d printing to develop a prototype bionic arm that feels.
It doesn restore all the tactile qualities of skin but it does restore an important one.
It can relay basic feedback about how hot an object is to the user nerves and muscles.
It not only helps save the user from burning skin but also prevents possible damage to the materials the bionic arm is made of.
One of the fingers of the bionic arm has embedded an temperature sensor that is connected to miniature control panels
Whenever the sensor records an object to be oo hotor greater than a threshold temperature (relative to body temperature) it sends a signal via the control panel to the servos
or shock to the user muscles and nerves, allowing them to eelthe excessive temperature. The sensor would help a user avoid gripping a hot object
and also inform him as to how hot it is. Just like the normal physiological reaction our fingers would have.
Siyi, a Computer & Control engineering student at Nankai University, explains, his way, people with disabilities will be able to feel the relative temperature level of an object.
The higher the temperature of the objects, the stronger the cautionary electrical impulse sent from the micro control panel is.
Several students and I designed this emperature-sensitive prosthetic handto bring increased safety and authenticity of experience for persons with disabilities using a prosthetic.
It will help them live better independently and reduce the burden on family care. eng,
project instructor and Associate professor of Computer & Control engineering at Nankai, concurred, s far as people with disabilities are concerned,
they have a great wish to be able to live as normal healthy people. The design concept is clear, of great significance,
and will help create a better, safer future for those with disabilities. he design is currently undergoing commissioning and testing, according to Siyi.
The work restores an important feature that will hopefully broaden the scope of bionic limbs
and although the sense of touch isn just about temperature, research to help sense pressure, texture, or humidity surely can be far behind h
they dreamed of the video phone holographic systems will become commonplace within a couple of decades or even sooner.
Along with Microsoft Hololens, the first of them might be the Holus system, which Vancouver, Canada-based H+is launching on Kickstarter,
the Holus holographic tabletop platform can connect to smartphones, tablets or computers, turning 2d content into a 3d hologram.
where users can learn, collaborate, and have fun through immersive displays. It is easy to see the potential gaming applications of such a device
and H+itself points out that it could be used to visualize 3d models before starting a print job.
As is becoming a common policy even in hardware development, the Holus will be offered in two varieties:
The first is intended as a family entertainment and education device. It will come equipped with two smartphone charging docks
and will work as a 3d visualization system, with applications available via App stores, such as Google Play and itunes. The latter includes an HDMI port and SDK tool, with support for both Unity and Unreal, two of the most powerful and used video game engines on the market.
It is intended to allow developers to create new applications, with particular focus on 3d printing or 3d character development and visualization for animation.
The systems will also support professional and business uses such as holographic teleconferencing and holographic business presentations. ur vision with Holus was to create an open platform that was accessible to absolutely everybody,
Along with the accessible price point starting at $550, Holus will come equipped with a wide range of features that make it seem like a very realistic product,
It can of course be viewed at 360°and supports 3d sensors such as Kinect, Leap Motion, the Emotive Brain Sensor and the Occipital Structure 3d scanner.
It has something to do with rats, fetal pigs, frogs and fish. There 3d printing and complex 3d modeling involved.
It about transforming traditional hands-on education. More than anything though, Necropsynth is about saving lab animals from tyranny in the name of education,
from being sacrificed, year after year, at the altar of dissection in classrooms and laboratories across the world.
Before you think saving these animals is not as imperative as it sounds, consider that 6-12 million animals are killed every single year for the sake of education.
That dissection of these unfortunately chosen animals is a learning tool used by 84 percent of those imparting pre-college education.
That these animals are made to suffer and are killed just so we can learn a little bit about how their body parts are arranged.
All this for every one of thirty students in a class for every one of 300-500 students in a grade, in every school or university, every year.
But Necropsynth intends to change all this, and they can because 3d printing can. So what exactly is Necropsynth?
It is devoted a tartup to production of 3-d designed and printed, macroscopically accurate, anatomical models for scientific and education purposes.
The team at Necropsynth essentially aims to create synthetic animal dissection models that will make scientific education more affordable,
ethical and more widespread by removing the socioeconomic barriers in higher education. The first animal model they are working on is the rat.
This project is named ynthdawleyafter the Sprague Dawley rat the most commonly used rat in biomedical research.
It is our intention to change the face of anatomy education in the United states and the world.
They have a progress report on their website that tracks the various stages of the project and their development.
Their next project will model a frog the most commonly dissected organism in the classroom,
and in the long term, they will also develop models for fetal pigs, fish, cats, dogs,
as well as for specific pathological abnormalities and diseases. Perhaps eventually, they could extend their work to plant dissection as well.
To print these models, they will use 3d printers from Printrbot because of its affordability and emphatic commitment to education values that Necropsynth also shares. f Printrbot believes they can put a printer in every school in the US,
Necropsynth can put anatomical science education in the hands of every student in the USAS a starter.
And the difference Necropsynth can make with such projects is captured best by them in one simple comparison. 8, ethically questionable, preserved rat. $2, humane, safe, synthetic rat.
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