and used a nanoscale vehicle made of DNA to deliver a CRISPR-Cas9 gene-editing tool into cells in both cell culture and an animal model.
To examine just how some inhaled anesthetic drugs affect viral and bacterial infections, Krishnan Chakravarthy, M d.,Ph d.,a faculty member at the Johns Hopkins Institute of Nanobiotechnology and a resident physician in the department of anesthesiology and critical
#Lab-on-a-chip Cuts Costs of Sophisticated Lab Tests Engineers at Rutgers University have designed a three-inch long,
#New Nanoparticles Clean the Environment, Drinking water Nanoparticles are between 1 and 100 nanometers in size.
With the help of nanoparticles and UV LIGHT removal of these toxins could be less expensive and time-consuming than current methods.
How it works The nanoparticles are prepared from molecules (synthetic macromolecules commonly called plastics) that have a protective,
When this happens on a nanoparticle, its protecting corona is removed and only the hydrophobic core remains.
with more than 95 percent of the nanoparticles removed from the water. When the nanoparticle loses its protective layer,
polymers are released into the water. While the polymer released (polyethylene glycol) is recognized as safe and used in various food, pharmaceutical and cosmetics products,
Bertrand nanoparticles have compared benefits with current purification processes. Some current techniques rely on chemical degradation of pollutants,
the nanoparticles float passively in the fluid until we precipitate them. Current water purification infrastructures have UV irradiation systems optimized to kill bacteria,
this irradiation is more than sufficient to precipitate our nanoparticles, Bertrand explained. Bertrand told Laboutlook that one fundamental observation from this work is that small molecules passively absorb on the surface of the nanoparticle,
and that the amounts absorbed correlate with the surface-to-volume ratio, meaning more absorption occurs on small nanoparticles. his is an important consideration for drug delivery
because it could explain what happens with nanoparticles with high drug encapsulation and extensive burst release.
Harnessing nanoparticles in Africa Theresa Dankovich uses nanotechnology to purify drinking water in Africa. By filtering water through paper embedded with silver or copper nanoparticles,
99.9 percent water purity is achievable. She calls it he Drinkable Book. Silver nanoparticles eliminate a wide variety of microorganisms,
including bacteria and some viruses . While some silver and copper will seep from the nanoparticle-coated paper,
the amount is said minimal, Dankovich, and is well below limits for metals put in place by the Environmental protection agency and World health organization.
Dankovich nonprofit company page Drinking Paper, works together with the nonprofit WATERISLIFE to produce a book of this nanoparticle-embedded paper,
which is put in a special holding device that water is filtered then through. One page can filter 26 gallons of drinking water;
Drug delivery and beyond The power of nanoparticles is also being harnessed to fight life-threatening lung diseases, such as cystic fibrosis.
Researchers at Johns hopkins university School of medicine, Johns hopkins university Department of Chemical and Biomolecular engineering and Federal University of Rio de janeiro in Brazil conducted a proof-of-concept study that found DNA-loaded nanoparticles could successfully pass through the hard-to-breach mucus barrier
Other attempts to penetrate the barrier with nanoparticles were unsuccessful because they possessed a positive charge that caused them to be tickyand adhere to the negatively charged mucus covering the airways.
To circumvent this problem the team developed a simple method to densely coat the nanoparticles with a nonsticky polymer called PEG,
or drugs inside a man-made biodegradable nanoparticle rapperthat patients inhale could penetrate the mucus barrier
a biomedical engineer and faculty member at the Center for Nanomedicine at the Wilmer Eye Institute at Johns Hopkins. Researchers funded by the National Institute of Biomedical Imaging and Bioengineering meanwhile,
stopped brain cancer in rats by delivering gene therapy through nanoparticles. The nanoparticles deliver genes for an enzyme that converts a prodrug called ganciclovir into a glioma cell killer.
There is no reliable treatment for glioma which has a 5-year survival rate of 12 percent.
Although their nanoparticle technology is solid, some challenges remain before it can be implemented in an industrial application.
With this knowledge in hand, researchers have opened a new world for designer proteins and investigations into nanotechnology
#Pseudo-platelet Drug Delivery System Targets Cancer Researchers are using patients own platelet membranes to coat drugs and use as nanovehicles for anticancer treatments.
comparted to about six hours for nanoscale vehicles without the coating. his combination of features means that the drugs can
which are placed then in a solution with a nanoscale gel containing the anticancer drug doxorubicin (Dox).
and creates nanoscale spheres that consist of platelet membranes with Dox-gel cores. The surface of the spheres are coated then with the anticancer drug TRAIL,
and circulating tumor cells than using the drugs in a nanogel delivery system without the platelet membrane. e like to do additional preclinical testing on this technique,
more expensive devices The Minion is a handheld DNA-sequencing device developed by Oxford Nanopore,
It works by detecting individual DNA bases that pass through a nanopore a tiny hole in a membrane.
which incorporates nanoparticles into polymers through a technique called electrospinning, was developed by a team from the University of North Texas System College of Pharmacy,
The team managed to synthesize a thin film made of densely packed aluminum oxide nanorods blended with molecules of a thrombolytic enzyme (urokinase-type plasminogen activator.
and Professor Nam-Trung Nguyen (Queensland Micro-and Nanotechnology Centre) collaborated with Dr Jenny Ekberg (Queensland University of Technology) and scientists in Spain."
US researchers have developed a new low-cost lab-on-a-chip device to aid analysis of sputum from patients with pulmonary diseases such as tuberculosis and asthma.
"said paper co-author Alexis Vallée-Belisle, a University of Montreal chemistry professor and the Canada Research Chair in bioengineering and bionanotechnology."
The folks at Berkeley Lab have been all over S. ovata for artificial photosynthesis (our bad for missing their April 16 press release) through a connection with UC Berkeley Kavli Energy Nanosciences Institute.
The new process starts by harvesting sunlight with a nanostructure of wires made from silicon and titanium:
photo-excited electron#hole pairs are generated in the silicon and titanium oxide nanowires, which absorb different regions of the solar spectrum.
We were able to uniformly populate our nanowire array with S. ovata using buffered brackish water with trace vitamins as the only organic component.
In this regard they point toward employing nanoprint lithography a common technique for producing nanometer scale patterns in larger quantities to produce silica overlays.
Nanoengineers at the University of California, San diego, have designed enzyme-functionalized micromotors that rapidly zoom around in water,
led by distinguished nanoengineering professor and chair Joseph Wang, published the work this month in the journal Angewandte Chemie."
In their experiments, nanoengineers demonstrated that the micromotors rapidly decarbonated water solutions that were saturated with carbon dioxide.
Measuring just 50 nanometres across, the aluminium yolk is surrounded by a shell of titanium dioxide of just three or four nanometres thick.
When these nanoparticles are used as the anode in a lithium ion battery, the researchers found it had a storage capacity of 1. 2 ampere-hours per gram.
A lithium ion battery using graphite has a storage capacity of 0. 35 ampere-hours per gram. The researchers also found they could achieve very fast charging times with the'yolk and shell'battery
Putting pressure on the skin squeezes the nanotubes closer together and enables them to conduct electricity.
This Nifty Toothbrush Scrubs Teeth Clean With Nanotech. If you think about it, toothpaste is pretty gnarly stuff.
Now, thanks to the wonders of nanotechnology, we can. A group of Japanese techies have designed a toothbrush that uses super skinny nylon bristles wrapped in nano-size mineral ions to scrub teeth squeaky clean.
and then it must be degraded--the components are recycled then basically,"added Marth, also director of UCSB's Center for Nanomedicine and a professor in the campus's Department of Molecular, Cellular, and Developmental biology."
"said lead author Won Ho Yang, Ph d.,a postdoctoral associate at SBP and at UCSB's Center for Nanomedicine."
"That change is very tiny--as small as a few nanometers or less, "Tao says.""We have a way to track that change with great precision--down to a fraction of a nanometer."
"Further, the technique is compatible with simple optical microscopy, though techniques including phrase contrast imaging
With the gadget's unique design as inspiration, researchers now report in ACS Central Science the development of bottlebrush nanotags that can contain thousands of fluorophores,
so that a wide range of colors of these fluorescent nanotags can be obtained readily. The authors note that,
Jensen and her colleagues now report in the journal International Journal of Pharmaceutics that they have managed to use S. islandicus to construct a nanocapsule that can transport drugs safely through the stomach.
and graduate student Gopinath Rajadinakaran teamed up with UK-based Oxford Nanopore technologies to show that the company's Minion nanopore sequencer can sequence genes faster,
Oxford Nanopore, a company based in the UK released its new nanopore sequencer, and offered one to Graveley's lab. The nanopore sequencer,
called a Minion, works by feeding a single strand of DNA through a tiny pore.
The pore can only hold five DNA bases-the'letters'that spell out our genes-at a time.
Each combination creates a different electrical current in the nanopore. GGGGA makes a different current than AGGGG,
and then ran them through the Minion's nanopores. In this one experiment, they not only found 7,
"Graveley will speak about the research at the Oxford Nanopore Minion Community Meeting at the New york Genome Center on Dec 3.
In contrast to using advanced nanofabrication facilities based on chemical processing of materials, this flexible technique allows for rewritable'optical fabrication'of devices.
"In a way, the most exciting aspect of this work is that it should be applicable to a wide range of nanoscale materials such as complex oxides, graphene,
At one end of that plane there is a so-called quantum dot: a tiny trap for electrons, only a hundred nanometers wide, in which owing to quantum mechanics the electrons exist in well-defined energy states similar to those of an atom.
Such quantum dots are, therefore, also known as"artificial atoms"."At the other end, just a few micrometers away, a bent electrode acts as a curved mirror that reflects electrons
In their experiments, the physicists detect this wave nature by measuring the current flowing from the quantum dot to the curved mirror.
and thus couple coherently to the quantum dot",stresses Rössler, who developed the experiment in the group of ETH professor Klaus Ensslin.
Indeed, the researchers were able to show that the interaction between the electrons in the quantum dot
With the help of a resonator and a quantum dot simulating such an impurity, the physicists hope to be able to study the Kondo effect very precisely.
Efstathios Karathanasis, a biomedical engineer at Case School of engineering, has developed chainlike nanoparticles that can carry drugs across the blood-brain barrier that keeps standard medicines from reaching their target--a highly aggressive brain cancer called
Karathanasis'lab developed a short chain of magnetic nanoparticles made of iron oxide and modified the surfaces so one links to the next, much like Lego building blocks.
In addition to the grant money, the researchers will have access to the National Cancer Institute's Alliance for Nanotechnology in Cancer,
"Hasan's method, developed at the University's Nanoscience Centre, works by suspending tiny particles of graphene in a'carrier'solvent mixture,
semiconducting and insulating nanoparticles. Currently, printed conductive patterns use a combination of poorly conducting carbon with other materials, most commonly silver
Hasan and Phd students Guohua Hu, Richard Howe and Zongyin Yang of the Hybrid Nanomaterials Engineering group at CGC
researchers need to make it easier to manipulate light at the nanoscale. Researchers at the Harvard John A. Paulson School of engineering and Applied sciences (SEAS) have done just that,
bend, twist and reduce diameter of a beam from the macroscale to the nanoscale, "said Mazur."
and turnover,"said senior author Jamey Marth, director of UCSB's Center for Nanomedicine and a professor in the campus's Department of Molecular, Cellular, and Developmental biology."
"said lead author Won Ho Yang, a postdoctoral associate at UCSB's Center for Nanomedicine and SBP."
and Professor Nam-Trung Nguyen (Queensland Micro-and Nanotechnology Centre) collaborated with Dr Jenny Ekberg (Queensland University of Technology) and scientists in Spain."
#Umbrella-shaped diamond nanostructures make efficient photon collectors Standard umbrellas come out when the sky turns dark,
but in the nanoworld, umbrella shapes may be the next creative way to enhance light emission. Inspired by recent work to enhance the luminescence from diamond nanopillar structures,
a team of researchers in Japan has discovered that"umbrella-shaped"diamond nanostructures with metal mirrors on the bottom are more efficient photon collectors than their diamond nanostructure"cousins"of other shapes.
By tweaking the shape of the diamond nanostructures into the form of tiny umbrellas, researchers from Tokyo Institute of technology experimentally showed that the fluorescence intensity of their structures was three to five times greater than that of bulk diamond.
They report their results in the journal Applied Physics Letters, from AIP Publishing. To get started, the team formed the umbrella-shaped diamond nanostructures by using an original"bottom-up"fabrication technique that relies on selective and anisotropic growth through holes in a metal mask.
The metal mask also serves as a mirror that is self-aligned to the diamond nanostructures."
"Our umbrella-shaped nanostructure has an effect similar to a solid immersion lens, which reduces the chance of total reflection on its upper surface
and focuses the emitted light toward the'upside'of the structure, "explained Mutsuko Hatano, a professor in the Graduate school of Science and Engineering's Department of Physical Electronics at Tokyo Institute of technology.
The self-aligned mirror goes a step further to enhance the efficiency of collecting this light by reflecting it at the lower surface area of the nanostructure."
The significance of the team's discovery is that they've shown that the brighter fluorescence intensity of umbrella-shaped diamond nanostructures can be achieved by improving the photon collection efficiency of the nitrogen vacancy centers,
In terms of applications, the team's nanostructures may find use in highly sensitive magnetic sensors for making biological observations or within the computational science realm for quantum computing and cryptographic communications.
Next, Hatano and colleagues plan to pursue better control of the nanostructures'shape, as well as target a smoother surface by optimizing chemical vapor deposition growth conditions."
"Our goal now is to improve the nanostructures'photon collection efficiency, "she said.""We also plan to demonstrate quantum sensors--in particular,
or a monolayer and be used in making nanoscale transistors in other electronics. The material was thought originally to be two-dimensional in nature because of the ease with
"What's unique about this paper is that we show not the use of metal particles, not the use of metal nanoparticles,
"Even particles on the nanoscale work only at the surface, he said.""There are so many atoms inside the nanoparticle that never do anything.
But in our process the atoms driving catalysis have no metal atoms next to them.
such as platinum-copper single atom alloy nanoparticles supported on an alumina substrate, and then tested them under industrial pressure and temperatures."
Funding for this study was provided by a Boston University Nanomedicine grant and NIH P50hl083801 to James Hamilton and by the Howard hughes medical institute and NIH CA158448 to the Roger Tsien group p
Advances in nanomaterials however, could make analysis of genetic material possible at a much lower cost.
if they could come up with a new paper device with such nanomaterials to test DNA without the use of high-tech facilities.
Cornelia Palivan, researchers from The swiss Nanoscience Institute have developed now a membrane gate that opens on demand.
This means that the enzymes inside a nanocapsule become active under exactly the right conditions
and substances from the surrounding area can enter the nanocapsule. In the resulting enzymatic reaction, the capsule's contents act on the incoming substrate
Palivan were able for the first time to integrate a modified membrane protein into an artificially produced nanocapsule, which opened only if it encountered corresponding ph values.
and The swiss Nanoscience Institute (SNI
#Chance effect of lab's fluorescent lights leads to discovery An accidental discovery of a"quantum Etch-a-Sketch"that may lead to the next generation of advanced computers
The new technique is more flexible than advanced nanofabrication facilities based on chemical processing because it allows for rewritable"optical fabrication"of the topological insulators."
"In a way, the most exciting aspect of this work is that it should be applicable to a wide range of nanoscale materials such as complex oxides, graphene,
Researchers grow nanocircuitry with semiconducting graphene nanoribbons In a development that could revolutionize electronic ciruitry, a research team from the University of Wisconsin at Madison (UW)
and this method provides a straightforward way to make semiconducting nanoscale circuits from graphene, a form of carbon only one atom thick.
it naturally forms nanoribbons with these very smooth, armchair edges,"said Michael Arnold, an associate professor of materials science and engineering at UW-Madison."
UW researchers went to Argonne staff scientists Brian Kiraly and Nathan Guisinger at the Center for Nanoscale Materials,
"We have some very unique capabilities here at the Center for Nanoscale Materials, "said Guisinger."
"What's even more interesting is that these nanoribbons can be made to grow in certain directions on one side of the germanium crystal,
#Researchers build nanoscale autonomous walking machine from DNA Researchers at The University of Texas at Austin have developed a nanoscale machine made of DNA that can randomly walk in any direction across bumpy surfaces.
The study by researchers Cheulhee Jung, Peter B. Allen and Andrew Ellington, published this week in the journal Nature Nanotechnology,
Previously, nanoparticle walkers were only able to walk on precise and programmed one-and two-dimensional paths.
"This is an important step forward in developing nanoscale nucleic acid machines that can autonomously act under a variety of conditions,
"DNA NANOTECHNOLOGY is especially interesting because it explores the world of'matter computers, 'where computations (including walking) are carried out by physical objects, rather than by electronic or magnetic shuttles.
There also may be implications for future delivery of nanoscale therapeutics. Although it may be a long march from diagnosing cancer to curing it,
The study demonstrated that as the nanoscale machine walked, it did not go over the same area twice e
Black silicon consists of clusters of microscopic vertical pillars, or nanowires. Incoming light bouncing between individual silicon nanowires cannot escape the complex structure,
making the material darker than dark. Rather than laying down layers of black silicon on top of a clear backdrop,
and etched silicon nanowires in the areas between aluminum rings. Then they seeped a polymer between the silicon nanowire pillars.
After the plastic support solidified they etched away the silicon backing, leaving bull's-eye patterned black silicon embedded in supple plastic.
Black silicon consists of clusters of microscopic vertical pillars, or nanowires. Incoming light bouncing between individual silicon nanowires cannot escape the complex structure,
making the material darker than dark. Rather than laying down layers of black silicon on top of a clear backdrop,
and etched silicon nanowires in the areas between aluminum rings. Then they seeped a polymer between the silicon nanowire pillars.
After the plastic support solidified they etched away the silicon backing, leaving bull's-eye patterned black silicon embedded in supple plastic.
#Accidental nanoparticles could let lithium ion batteries live another day A new study from MIT could keep lithium ion battery technology on the track for another few laps,
The breakthrough comes from an accidentally created synthetic metal nanoparticle that could solve some of the oldest problems for batteries.
Their testing shows that the nanoparticles could allow up to four times the charge retention after a long lifetime of use,
Researchers from MIT were attempting to address this problem with different treatments for aluminum nanoparticles
and that work led them to bathe nanoparticles in a mixture of sulfuric acid and titanium oxysulfate,
This resulted in an unforeseen egg-like nanoparticle design, in which a olkof aluminum is covered in a hellof titanium dioxide.
#New quantum dot could make quantum communications possible A new form of quantum dot has been developed by an international team of researchers that can produce identical photons at will,
So, unless youe less than one quantum dot range away from the person you want to talk to,
These techs include things like 3d printing, artificial intelligence, synthetic biology, infinite computing, networks, sensors, nanotechnology, and virtual realitynd is essentially a list of the most disruptive technologies ever invented.
The work showed that adding a nanometers-thick layer of titanium dioxide (Tio2) material found in white paint
The new system uses such a 62.5-nanometer-thick Tio2 layer to effectively prevent corrosion
active catalyst by adding a 2-nanometer-thick layer of nickel to the surface of the Tio2.
a senior researcher at Caltech and first author of the study published in Nature Nanotechnology. e can take any incoming light
The tiny lab-on-a-chip device requires 90 percent less sample fluid than conventional tests. great deal of research has been hindered
The special feature of the alloy is that these individual crystals are tinyhis is referred to as a nanocrystalline material. lthough nanocrystalline materials have many desirable properties,
Applying voltage to a 250-nanometer-thick sandwich of graphene, tantalum, nanoporous tantalum oxide, and platinum creates addressable bits where the layers meet.
The combined effect of those patterns led to final images with 62-nanometer resolutionuch better than standard SIM and a threefold improvement over the limits imposed by the wavelength of light."
H-infinity, track-follow controllers that place the head within 6 nanometers; allowing a track density of 181,300 tracks per inch.
The findings of this work have recently been published in the journal Nature Nanotechnology h
#IBM's Watson does some culinary computing for its first cookbook These days, it seems like every celebrity comes out with a cookbook at some point,
#World's highest-performance single-molecule diode created As electronics miniaturization heads towards a theoretical physical limit in the tens of nanometers,
Operating at this nanoscale, though, such devices may emulate their macro counterparts, but that behavior is merely a simulation;
"The combined Berkeley Lab-Columbia University research team is convinced that the way they have managed to produce a single-molecule diode sets the benchmark for future nonlinear nanoscale device tuning and development, with applications above and beyond just
and energy flow at the nanoscale. What is exciting to me about this field is its multidisciplinary nature the need for both physics and chemistry and the strong beneficial coupling between experiment and theory.
"The results of this research were published recently in the journal Nature Nanotechnology
#Acer's Cloudbooks offer Windows 10 from just $169 Acer has announced a pair of new laptops that are set to provide access to Windows 10 at a very reasonable price point.
#New blood clot-busting nanocapsule promises immediate care for heart attacks When blood clots form in the aftermath of a heart attack or stroke,
A team of Australian scientists has developed a new approach that sees the drugs carried safely inside a nanocapsule, opening up the treatment to more patients and lessening the chance of side effects.
It sees an already approved clot-busting medication called urokinase (upa) loaded into a newly-developed type of nanocapsule.
which involved loading the drug into nanoparticles to improve the speed at which is destroys clots.
Metal-oxide nanosheets were arranged on a single plane using a magnetic field. The nanosheets were fixed then in place using a process called light-triggered in-situ vinyl polymerization
where the light helped to stick them together within the polymer. The nanosheets create electrostatic resistance in one direction,
but not the other. The polymer"legs"not only lengthened and contracted at pace, allowing it to move forward,
#Aluminum"yolk"nanoparticles deliver high-capacity battery recipe Researchers at MIT and Tsinghua University in China have found a way to more than triple the capacity of the anodes,
-and-shell"nanoparticles, is reportedly simple to manufacture and is especially promising for high-power applications.
They have done so by creating nanoparticles with a solid titanium outer shell and an inner aluminum"yolk"that can freely expand
To produce these nanostructures the researchers began by placing aluminum particles about 50 nanometers in diameter in a solution of sulfuric acid and titanium oxysulfate,
a process that coated the nanoparticles in a hard shell three to four nanometers thick.
After a few hours in the acid, the aluminum particles shrank down to about 30 nanometers while leaving the outer shell unchanged.
This gave the aluminum nanoparticles enough room to collect lithium ions and expand considerably as needed, without damaging the electric contacts of the cell.
In testing, the team found that the outer shells became slightly thicker after 500 charge cycles
Each of its pages is made from a thick sheet of paper impregnated with silver and copper nanoparticles,
much like that suggested for use in certain shape-shifting nanoprobes. After the TE has been used in the initial diagnosis of the stomach
and will be published in the journal Nanomedicine. They state that the biodegradable material could be used to heal bones in hundreds of thousands of patients requiring bone replacement
"The biodegradable polymer is reinforced with montmorillonite clay nanoparticles (we've seen nanoparticles used in other ways to heal bones) for strength,
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