which is known to trigger melanoma (a type of skin cancer that can develop from abnormal moles).
imagined for people with late-stage dementia who are unable to speak but require constant physical touch.
so you don forget medicine at the store, to connect to your digital wallet and stop you before you overspend.
According to the World Heart Federation, stroke is the second leading cause of disability worldwide. It affects 15 million people each year,
and experience paralysis and confusion. According to the President of the ORBI foundation, Daria Lisichenko, nable to speak,
but with increasing advances in technology, science and medicine, perhaps it isn so unrealistic to think that someday mobile apps like this one will help bridge the gap between patients who lost the capacity to speak,
and Sunburn With This Smart Bikini Spinali Design brings wearable technologies to the beach (where skin cancer runs rampant) The french are credited with creating the modern bikini,
According to UK cancer research, new cases of malignant melanoma, the most dangerous form of skin cancer, have become the fifth most common cancer.
In many cases, the time of infection must be at least three months prior for detection.
many therapies can reverse its harmful effects and allow the afflicted to live normal lives.
infection must be detected and confirmed as early as possible. In the countries today where AIDS numbers are still on the rise,
a shift in public opinion about the disease is happening. The rise in the number infected is not immediately
Stigma surrounding the disease keep high-risk individuals in hiding because of fear of judgement. A do-at home kit can remove the stress
and the threat of discrimination a trip to the clinic can bring. At press time
the Biosure HIV Self Test kit is for sale at £29. 95 (US$46. 80) in the U k
and individuals who get a positive result should undergo a confirmatory test at a clinic i
One of the patients trialing the new implants, Gummi Olafsson, lost his right foot and lower leg years after a childhood traffic accident.
He said the implants allowed him to control his bionic leg and foot almost instantly."
which develops medical technology for use in patients. Olafsson said his body continues to adapt to his prosthetic limb more each day
Orthopedic surgeon and Ossur's director of research and development, Thorvaldur Ingvarsson implanted the sensors in the two patients involved in the trial himself
who require monitoring without having to see her doctor.""It connects me a lot more with the fetus,
I also won't have to be dependent on a doctor, at any given time I'll be able to connect,
like pre-term labor like preeclampsia and more and we will be able to intervene in the right time,
"said Varda Shalev, a medical informatics expert and active care primary physician. She is an external consultant to the Tel aviv-based Nuvo Group.
Nuvo Group's advisory board member Professor Simcha Yagel, who also heads the division of obstetrics and gynecology at Hadassah,
Hebrew University Medical centers, said the electrocardiogram (ECG) provides the added value to the device.""I think the new achievement of Nuvo is in the field of detection of the ECG traces of the fetus,
Oz said doctors would appreciate not having to use traditional heavy machinery, such as the cardiotocography (CTG) or electronic fetal monitor (EFM) machines to trace the fetal heartbeat.
"The immediate impact, the immediate benefit to doctors is that we are replacing the bulky CTG machines
and reduce anxiety. They recently launched a Kickstarter campaign to turn their prototypes in to consumer-ready models,
#Glasses that make cancer glow When Sandy Sagitto was diagnosed with breast cancer she was devastated.""First thought is that
when her doctors said they needed to remove the cancer forming in her body. Sagitto, 53, a neurosurgery nurse for the past 25 years,
was open to the idea of participating in a clinical trial to test out a new technology that gives surgeons the ability to visualize cancer cells in real time
while they operate.""Wow, we have headed into the Superman realm. You have the x-ray vision,
It's better than x-ray vision, according to Dr. Samuel Achilefu, a professor of radiology at Washington University,
a procedure to remove a portion of the breast to treat cancer, surgeons rely on scans taken before the operation to decide how much tissue to remove.
He says differentiating between healthy cells and cancer cells is hard, which is why surgeons remove an excess amount of healthy tissue when operating,
and even when erring on the side of caution, up to 25 percent of patients need a repeat procedure to remove more cancerous tissue."
"The primary goal of the technology is to make sure that the surgeon does not operate in the blind,
The system works by first injecting the patient with a cancer-targeting dye that attaches to abnormal cells.
which allows a surgeon wearing specialized glasses to see cancer cells glowing.""What this does is conserve the healthy tissue
Currently the cancer glasses are being tested on skin and breast cancer patients, but Dr. Achilefu says they could be used to visualize
and remove a wide range of cancers. He says lighting up cancer means a brighter future for people diagnosed with the deadly disease e
#Chimaera device paves way for wireless pain relief The hand-held device, called Chimaera, could revolutionize the delivery of miniaturized neurostimulators to specific nerves,
whether that's pain from a broken leg or pain from a headache. So by putting an electrical signal directly into target nerves-in a known way,
Chimaera is designed to make implanting neuromodulators to nerves much easier by integrating surgical sensing and implant delivery functions in one intelligent device.
enabling surgeons to identify critical structures, such as nerves and blood vessels. This combines with the intraoperative data from Chimaera's sensing technology to guide the surgeon to the precise location of a procedure,
helping to ensure the surgical device stays on a predetermined safe pathway. The real-time data generation is designed to be used in conjunction with optical wearable technology, such as Google glass.
This means a surgeon can literally'see'exactly where they are within the body at any point during an operation.
Once the target nerve has been reached the sensors also let the surgeon know, and the implant can then be deployed down the device.
Karger said their aim was to figure out how neuromodulators-measuring less than a centimeter in length-could be implanted as simply and quickly as possible.
Chimaera, he said, could allow doctors around the world perform a procedure that can currently only be carried out by a handful of people."
"With Chimaera, what we've done is we've combined smart sensing technology, preoperative planning,
we've taken small implant form-factors; and we've combined both implant delivery with surgical tool to provide a completely connected,
unified surgical system that has the potential to take a surgery that maybe only four
or five people in the world can carry out today and make it accessible to a broad cross-section of general surgeons.
By doing that we make it accessible to a much, much broader patient population, "he said.
while most of today's surgical tools are largely passive, offering surgeons little feedback, Chimaera opens the door to a new generation of neurostimulation implant procedures.
It could they say, enable more surgeons to carry out complex operations at lower risk and with better results for patients.
While it may be some time before a device like Chimaera is in surgeons'hands, Karger said it could pave the way for wireless pain management for patients using, for example, their mobile phone:"
"Imagine a migraine sufferer who literally as they feel the onset of their migraine, can reach for their cell phone
That is a life-changing therapy for that patient. And crucially what it does is it changes that patient from a patient into a consumer;
"Developers Cambridge Consultants say Chimaera is the equivalent of a'concept car'that demonstrates their vision for the next generation of surgery.
and they are now looking for partners to lead a product development cycle to turn it into a medical device ready for market t
#Scientists control mouse brain by remote control The tiny implant, smaller than the width of a human hair, let the scientists determine the path a mouse walks using a remote control to inject drugs
of which require surgery that can damage the brain and restrict an animal's natural movements.
The test subjects were made to stay on one side of a cage by remotely making the implant shine pulses of light on the specific cells.
could lead to the development of more minimally invasive probes to treat neurological disorders including stress, depression, addiction,
it can be a source for triggering cancer, for example, said study co-author Dr Gilles Hickson from the University of Montreal, Canada.
and to certain diseases, Dr Hickson said. In fact, all cancers are characterized by unchecked cell division, and the underpinning processes are potential targets for therapeutic interventions that prevent cancer onset
and spread. ut before we get there, we must continue to expand our knowledge about the basic processes
and signals involved in normal cell division to understand how they can go awry, or how they can be exploited.
this could help the rational design of more specific therapies to inhibit the division of cancer cells,
#Clinical Trial Demonstrates Noninvasive Expulsion Of Kidney stones At the 2015 American Urological Association annual meeting in New orleans,
Harper and colleagues in the Department of Urology and Applied Physics laboratory at the University of Washington have invented a new way to facilitate kidney stone passage
or kidney stone disease, than develop diabetes or heart disease. Kidney stones cause severe pain, obstruction of the urinary tract,
and loss of worker productivity. The use of ultrasound technology to move kidney stones is a major advance with broad clinical utility for people On earth."
"This clinical trial has been advanced with funding from the National Space Biomedical Research Institute (NSBRI.""During space flight, microgravity, dehydration,
Noninvasive approaches to move and ultimately expel kidney stones from the body provide medical capabilities needed by NASA and other international space agencies.
downstream complications such as infection and sepsis that could end space missions may be avoided d
#Telomerase Cancer cell Mutation Mystery Solved More than 500,000 people in the United states die each year of cancer-related causes
and a new study has identified the mechanism behind one of the most common mutations that help cancer cells replicate limitlessly.
Recent cancer research has shown that highly recurrent mutations in the promoter of the TERT gene are the most common genetic mutations in many cancers,
including adult glioblastoma and hepatocellular carcinoma. TERT stabilizes chromosomes by elongating the protective element at the end of each chromosome in a cell.
which these common mutations result in elevated TERT expression by using computational and experimental analyses to determine that the mechanism of increased TERT expression in tumor tissue relies on a specific transcription factor-a protein that binds specific DNA sequences
and binds the mutant TERT promoter in tumor cells from four different cancer types, underscoring that this is a common mechanism of TERT reactivation.
The identified transcription factor and its regulators have great potential for the development of new precision therapeutic interventions in cancers that harbor the TERT mutations.
#Could There Be An Asthma Cure Within Five Years? A recent study has revealed a breakthrough in asthma research might be on the horizon.
Following extensive research carried out across a number of institutions, it has been discovered that protein molecules-known as calcium-sensing receptors-have a vital role in asthma.
Although they have not previously been used to treat asthma, there is already medication available (calcilytics) that could be used to block these proteins.
In asthmatics, the immune system essentially misidentifies harmless substances, such as pollen for example, as a threat. The airways then restrict in an attempt to keep the armfulsubstances from entering the lungs leading to the body facing constricted airways and
Based on the study, the researchers concluded that this is one of the main reasons for the excessive inflammatory responses that occur in people with asthma.
This discovery has led the researchers to believe that new treatment options for asthma could be found some time in the near future.
or combination of treatments, that will help people to deal with asthma once and for all. When approached by our research team,
the medical experts of a UK healthcare provider expressed a sincere appreciation of the work carried out by researchers,
when talking about an asthma cure. hilst this study offers hope to over 5%of asthma sufferers who do not respond to any of the treatments currently available,
we would advise people to await the results of human trials before making claims of a potential cure.
Director of research and Policy at Asthma UK, was optimistic about the future potential this study has:
to tackle the underlying causes of asthma symptoms. 5%of people with asthma don respond to current treatments so research breakthroughs could be life changing for hundreds of thousands of people.
whether the use of calcilytics is a viable treatment method for asthma. There are a number of areas that large-scale clinical trials could help clear up.
Also, whilst the asthma sufferers who took part in this study had increased an number of receptors,
and whether the same is true for all people with asthma. However, the study does raise some hope of new asthma treatments in the future,
something that should give hope to millions of asthma sufferers worldwide. The study was published by researchers from Cardiff University, The Open university, the University of Manchester, the University of California
the San francisco School of medicine and King College, London. It was funded by Asthma UK, the Cardiff Partnership Fund, Marie Curie Initial Training Network, the Biotechnology and Biological sciences Research Council and the US National institutes of health t
#Microscopic Sonic Screwdriver Invented A team of engineers have created tiny acoustic vortices and used them to grip
#Targeted Treatment For Arthritis, Thanks To Stem Cell Discovery Researchers have identified individual stem cells that can regenerate tissue, cartilage and bone.
or joint tissue opening the way for improved treatment for arthritis. A team at the University of York isolated a rare subset of stem cells in bone marrow that
said, hile stem cell therapy is an exciting new development for the treatment for osteoarthritis,
It will help in the search to develop more targeted therapies for arthritis patients. o-Lead author Dr. James Fox said,
orking with colleagues across the Arthritis Research UK Tissue Engineering Centre will help to bring our discovery closer to patient treatment. irector of research at the charity Arthritis Research UK Dr Stephen
and disability caused by osteoarthritis. We are fighting to find better treatments and one day, a cure.
takes us a step closer to our aim of developing an injectable, safe, stem cell therapy for people with osteoarthritis. pcoming in Stem Cell Reports
Way To Disrupt Brain tumor Stem Cells Some brain tumors are notoriously difficult to treat. Whether surgically removed, zapped by radiation
The ability of many brain tumors to regenerate can be traced to cancer stem cells that evade treatment and spur the growth of new tumor cells.
But some brain tumor stem cells may have an Achilles'heel, scientists have found. The cancer stem cells'remarkable abilities have to be maintained,
and researchers at Washington University School of medicine in St louis have identified a key player in that maintenance process.
so is the spread of cancer.""This discovery may help us attack the root of some of the deadliest brain tumors,
"said senior author Albert H. Kim, MD, Phd, assistant professor of neurological surgery.""A successful brain cancer treatment will very likely require blocking the tumor stem cells'ability to survive
and replenish themselves. Kim studies glioblastoma, a deadly form of brain cancer that each year strikes about 18,000 people in the United states. The average length of survival after diagnosis is 15 months,
and only 30 percent of patients survive more than two years. Scientists have realized in recent years that some cancer cells in glioblastomas
and other tumors are more resistant to treatment than others. Those same, more defiant cells also are much better at reestablishing cancer after treatment."
"These tumor stem cells are really the kingpins of cancers--the cells that direct and drive much of the harm done by tumors,
"said Kim, who treats patients at Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of medicine.
Kim and his colleagues identified a protein, known as SOX2, that is active in brain tumor stem cells and in healthy stem cells in other parts of the body.
The researchers found that the tumor stem cells'ability to make SOX2 could be turned up or down via another protein, CDC20.
Increasing SOX2 by boosting levels of CDC20 also increased a tumor's ability to grow once transplanted into mice.
Eliminating CDC20 meanwhile, left tumor stem cells unable to make SOX2, reducing the tumor stem cells'ability to form tumors."
"The rate of growth in some tumors lacking CDC20 dropped by 95 percent compared with tumors with more typical levels of CDC20,
"Kim said. When the scientists analyzed human tumor samples, they found that a subset of patients with glioblastomas that had the highest CDC20 levels also had the shortest periods of survival after diagnosis. Kim's lab is exploring methods to block CDC20 in brain tumors,
including RNA interference, an approach in which the production of specific proteins is blocked. That general approach is in clinical trials as a therapy for other cancers, viral infections and other illnesses.
Citation: Mao DD, Gujar AD, Mahlokozera T, Chen I, Pan Y, Luo J, Brost T, Thompson EA, Turski A, Leuthardt EC, Dunn GP
, Chicoine MR, Rich KM, Dowling JL, Zipfel GJ, Dacey RG, Achilefu S, Tran DD, Yano H, Kim AH.
A CDC20-APC/SOX@signaling axis regulates human glioblastoma stem-like cells. Cell Reports, online June 11, 2015.
This research was supported by the National institutes of health (NIH), grants K08ns08110, K01ag033724 and P50ca094056; the American Cancer Society;
Voices Against Brain Cancer; the Elsa U. Pardee Foundation; the Concern Foundation; and the Duesenberg Research Fund d
#Metal-Organic Framework Compounds: Solar cell Made Of Highly Ordered Molecular Frameworks Researchers have developed a functioning organic solar cell consisting of a single component has been produced on the basis of metal-organic framework compounds (MOFS.
Currently, diagnosis of Ebola requires a full vial of venous blood to be shipped to a laboratory with a high level of biosafety and staff expertise for testing by real-time reverse transcription polymerase chain reaction (RT-PCR).
) This method poses substantial risks to the health care workers responsible for blood collection, transport, and testing,
and efforts to contain the Ebola epidemic in west Africa have been hampered by this slow and complex diagnostic test. aboratory results can sometimes take days to return.
explains Dr Nira Pollock, senior author and Associate Medical Director of the Infectious diseases Diagnostic Laboratory at the Boston Children Hospital. his new test,
In this study, the researchers compared the diagnostic accuracy of the new RDT against the benchmark RT-PCR test (altona Diagnostics) being used for clinical diagnosis in the field reference laboratory run by Public health England at Port
and infection control by reliably detecting patients well into their illness who are likely to be highly infectious.
and reducing the opportunity for infection of non-Ebola uspects Although the RDT requires refrigeration,
particularly those that store vaccines and other medical products. Published in The Lancet. This study was funded by a gift from the Abundance Foundation (Stephen Kahn.
#Eye disease Detected-Using A Smartphone Researchers at the Medical and Surgical Center for Retina have developed software that detects eye diseases such as diabetic macular edema using a smartphone.
The technology was designed for general physicians who support the health system in Mexico to detect certain abnormalities without an ophthalmologist
and send the patient to the specialist. It's obviously better and cheaper to prevent blindness rather than try to cure it so an app on a cellphone that just needs to focus on the eye is better in all ways.
This is especially important in rural communities where expertise areas such as ophthalmology won't be commonly available. The software was developed in collaboration with biomedical engineers from the ITESM
and uses the camera of the phone to detect any abnormality in the thickness of the retina."
"The idea is to detect and prevent diseases in general practice. We are not replacing the specialist,
we want to know which patients have a disease and make an early detection, "says Dr. Juan carlos Altamirano Vallejo, medical director of the Medical and Surgical Center for Retina."
"It will help those that when they go to the eye doctor are already blind, we needed to go a step back,
to know who is at risk and needs to go to a specialist. Not wait for a doctor."
"The Medical and Surgical Center for Retina is a small group with ten people dedicated to ophthalmology and retina special medical care.
It it also dedicated to biomedical and pharmaceutical research, to develop diagnostics and equipment, applicable to society.
They expect it to be marketed soon n
#New GHOST Technology Leaps Out Of The Screen Nothing will make you feel like Tony Stark more than being able to change the shape of displays with your hands,
pulling objects and data out of the screen and playing with them in mid-air.
A surgeon, for instance, will be able to work on a virtual brain physically, with the full tactile experience,
#Toward A Universal Flu Vaccine Flu vaccines can be shot a in the dark-they must be given yearly
New research suggests it may be possible to harness a previously unknown mechanism within the immune system to create more effective and efficient vaccines against this ever-mutating virus. In a Cell paper,
"While the conventional flu vaccine protects only against specific strains, usually three of them, our experiments show that by including modified antibodies within the vaccine it may be possible to elicit broad protection against many strains simultaneously,
"says senior study author Jeffrey Ravetch, professor of Molecular genetics and Immunology at Rockefeller University.""We believe these results may represent a preliminary step toward a universal flu vaccine,
one that is effective against a broad range of the flu viruses."It was known already that chemical modifications to antibodies'Fc region altered their interactions with immune cells,
namely the production of more potent antibodies against the flu virus. Every year in the United states, influenza is implicated in the deaths of thousands of people, mostly 65 and older,
and causes serious disease in many others. The virus makes for a difficult target for vaccines
because its strains are so diverse, and new ones are constantly emerging. Types A and B cause seasonal flu epidemics.
Influenza a viruses are broken further down into subtypes based in part on their surface proteins, which include hemagglutinin, the"H"in H1n1, for example.
most flu vaccines in the United states are formulated to target a total of three or four viral strains:
The strains are selected based on public health experts'predictions for the coming flu season. But sometimes they are wrong,
A universal flu vaccine has become something of a holy grail, and a number of strategies have been proposed to create it.
These regions go on form complexes with vaccine antigens, which then modulate the evolving vaccine response.
First, the researchers vaccinated healthy volunteers with a seasonal flu vaccine containing an inactivated strain of the H1n1 virus. They then tracked the volunteers'immune responses via blood samples,
keeping an eye out for chemical modifications to antibodies against the hemagglutinin protein. About seven days after the vaccination, they saw a spike in sialylated antibodies, meaning sialic acid,
an important signaling molecule, had been added at a specific spot on the Fc region. The greater the sialylation
the better a person's response to the vaccine. To tease apart how this chemical modification improves the immune response,
The result of the higher affinity was broad protection against H1 subtype influenza viruses. The researchers then used this knowledge to improve the vaccine itself.
They modified the H1n1 vaccine so it contained not only protein from the virus itself, but also sialylated antibodies against that protein."
which a vaccine containing sialylated antibodies elicits broadly protective antibodies, could potentially be harnessed to reduce the tremendous morbidity
and mortality caused by seasonal influenza virus infections, "Wang says.""We are now looking into applying this strategy toward improving existing vaccines;
ideally, this would result in a vaccine that provides life long immunity against flu infections. s
#Human Antibody Blocks Dengue virus In Mice Researchers have discovered that a human antibody specific to dengue virus serotype 2,
--and they suggest that the site where 2d22 binds to the virus could represent a potential vaccine target.
and there is currently no protective vaccine available. Recent phase 3 clinical trials of a potential vaccine candidate showed poor efficacy,
especially against dengue virus serotype 2. Guntur Fibriansah and colleagues found that 2d22 protects mice against dengue virus serotype 2,
or after the rodents are inoculated with the virus. This finding suggests that the antibody may act as both a preventative and a therapeutic agent.
To learn more, the researchers analyzed cryo-electron microscopy (CRYO EM) structures of 2d22 in complex with two different strains of viral serotype 2--the dengue serotype with the most dynamic surface--at 6. 5
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