were checked out at a hospital and cleared to go back to work following the July 1 collision,
24, from the Intel Clinic. It is fitted with sensors that monitor brainwaves, eye movement, oxygen levels and the wearer's body temperature before sending this information to an app on their connected phone.
This is done using Bright light Therapy which artificially triggers the light sensors in a person's eyes to make their brain believe the sun is coming up.
The therapy can be used to rouse people gently so that they feel more refreshed and less tired
and with light therapy it can manage the production of sleep hormone in the brain.'
when he was struggling to sleep during his exams at a medical university. He said:'
Breakthrough could lead to better treatment for brain disorders Scientists have created super-intelligent mice by altering a single gene.
but it also meant the they were less likely to feel anxiety or recall fear, researchers found.
They hope the discovery may help the search for treatments for disorders such as Alzheimer's, schizophrenia and post traumatic stress disorder (PTSD.
The experiments also showed that PDE4B-inhibited mice suffered less anxiety, choosing to spend more time in open, brightly lit spaces than normal mice,
whether the findings could have implications for Alzheimer's disease or other dementias.''We'd need to see how this gene could influence memory
'There is currently a lack of effective treatments for dementia and understanding the effect of genes can be a key early step on the road to developing new drugs.'
'With so many people affected by dementia, it is important that there is research into a wide array of treatment approaches to have the best chance of helping people sooner
trapped, frozen or absorbed in some material-from the surface that is triggered by tidal stress on the moon.
and fibres will prove to be a valuable research tool for non-animal testing of new drugs and investigating brain disorders such as Alzheimer's.
'We've struggled for a long time trying to solve complex brain disease problems that cause tremendous pain and suffering.'
and develop therapeutics other than rodents.''To build the replica brain, the team transformed adult skin cells into induced pluripotent stem (ips) cells by altering their genes.'
Already the scientists have gone on to create brain organoid models of Alzheimer's and Parkinson's disease, and autism, in a dish.
With the addition of a blood circulation, which is currently lacking, they also hope to use the model to study stroke therapies.
Military applications include research on Gulf war syndrome, traumatic brain injury, and posttraumatic stress disorder. r
#Royal Navy could soon be using remote-controlled warships with'see-through'hulls Sleek and stealthy, it resembles something from Star wars. In fact,
this is what British warships could look like in as little as 35 years. With RAF jets already being replaced by drones piloted by men sitting at computer screens many miles away,
the Royal Navy is now investigating how technology will change the fleet. The answer, it seems,
and prevent fatal injuries Fatal shootings by police and other law enforcement agencies could soon be avoided thanks to a device that acts like an'airbag'for a bullet.'
effectively slowing it down to result in less injury. Scroll down for video It is hoped the'airbag for a bullet'could reduce the number of civilians killed by police officers in potentially lethal situations.
but less injury to a body than a conventional bullet. In this way, it is'less lethal'than a regular bullet
#Scientists brew cannabis chemical THC for better drugs for cancer sufferers An active ingredient typically found in cannabis has been engineered genetically in the lab for the first time.
They believe the breakthrough will lead to more effective and easier-to-manufacture cancer and HIV drugs
THE BENEFITS OF THC There's already evidence to suggest certain compounds in marijuana might be helpful for certain medical conditions.
It's often used to treat nausea associated with HIV or cancer therapies but this new process could offer a less expensive,
There's already evidence to suggest certain compounds in marijuana might be helpful for certain medical conditions.
It's often used to treat nausea associated with HIV or cancer therapies, but this new process could offer a less expensive,
to provide disease resistance, or even to introduce novel traits that are not found in humans.'
But it continues to attract controversy as critics fear DNA alterations could create unforeseen health problems that would be passed down from generation to generation of the population.
which involved the injection of enzymes, and attempted to edit the DNA in 86 on-viablehuman embryos from local fertility clinics.
Nonviable embryos are those which cannot result in a live birth. The genes only changed in 28 cases,
is precisely the type of knowledge medicine needs if we are to improve IVF methods.
It could also help doctors understand how infections spread. But in the short-term, the thought that we are enveloped each in millions of bugs is likely to terrify hygiene obsessives.
Chair gives drivers a relaxing massage or a blast of air to focus their attention From sitting in traffic jams to speeding along monotonous motorways at night,
or is caused under stress by road rage or similar. It then responds by offering a suitable massage and blowing air through its ventilation system.
French car seat manufacturer Faurecia claims its concept seat unveiled at the IAA show in Frankfurt, is a world first.'
and we derive stress and energy level from that,'Olaf Biedermann, director of innovation at Faurecia said.'
so in case you are stressed you get a relaxation massage, in case you have low energy levels you get a very energising massage.'
'The seat has taken five years to develop and the team's aim was to make drivers feel better after their journey than
they will receive a massage with a warming or cooling sensation to either relax or energise them.
and whether someone is having a heart attack. The idea is that if higher than usual heart activity is detected,
Research has shown that drivers suffering from cardiovascular disease are 23 per cent more likely to be involved in a road accident
rising to 52 per cent for drivers suffering from angina-chest pains caused by the heart.
Ford's car seat may in some cases detect increased heart activity before the driver notices they are having a heart attack,
and dangerous situations by robotic medics under proposals put forward by a senior army doctor. The off-road robots,
Major general Steve Jones, commander of the Army Medical Department Centre and chief of the US ARMY Medical Corps
Speaking at a medical conference sponsored by the Association of the US ARMY near the Pentagon in Arlington County, Virginia,
he said the robots could also link doctors to frontline units for on the spot diagnosis and advice.
Major general Jones said they could also provide a vital'telemedicine'link between front-line units and experienced medical staff back at base or even at home in the US.
'What happens when a member of the team comes down with cellulitis or pneumonia? We have got to use telemedicine to tele-mentor them on the diagnosis and treatment.
Drone aircraft could also be used to deliver antibiotics or blood to front-line units to keep them in the fight,
#HIV breakthrough could lead to a CURE as markers on immune cells identified The way a patient's immune system responds to HIV infection could offer clues as to
'Normally, if someone is being treated for HIV infection and they stop their medication, the virus can be detected back in the blood stream within days.'
and ultimately a cure for HIV infection.''He added:''Our work has identified that there are certain markers on the immune cells of patients
which seem to predict who can stop therapy and stay well.''Interestingly, some of these markers have also been shown to be good targets for therapy in some cancers.'
'We hope now to find out more about these markers -and others-to discover if new strategies for treating
'Working with researchers at the University of New south wales, the team at Oxford analysed data from a patient trial where anti-retroviral therapy was interrupted at 48 weeks.
Anti-retroviral therapy has improved dramatically life-expectancy for people with HIV. Recent studies have advised patients should start the treatment
and the therapy is delayed until a patient's viral load reaches a certain level. But the drug treatment is not a cure.
The infection persists in latent cells,'hidden'reservoirs, from where they can re-emerge. Destroying these reservoirs remains one of the'Holy grails'of HIV research.
For some patients whose anti-retroviral treatment was started at an early stage, they have gone on to experience'remission'periods of 10 years or more,
after stopping the therapy. Dr Frater and his team analysed the data from a study of patients with primary HIV infection involved in the SPARTAC trial.
They compared the T-cells-a type of white blood cell that forms part of the body's immune system-of 154 patients in Europe, Brazil and Australia,
The researchers found that in patients where high levels of these three biomarkers attached to'exhausted'T-cells prior to patients beginning anti-retroviral therapy,
Professor Rodney Phillips, a former Oxford don and now dean of medicine at the University of New south wales, played an instrumental role.
'Focusing on the exhaustion markers was an important step as it has given us vital clues as to why some people are able to better control the virus after therapy has been interrupted.'
'We want to be able to predict how the virus will behave before we take patients of anti-retroviral therapy to test drug therapies aimed at eradicating HIV,
Immune cells with the PD1 biomarker have already been identified as a target for drugs to treat stage-four melanoma
or end stage cancer. Researchers are now considering how to manipulate immune cells with the PD1 marker in their HIV research.
and from fluorine poisoning after the fissure eruptions ceased. Around 80%of sheep, 50%of cattle,
Scientists discovered for the first time that people left in agony by arthritis develop more receptors in the brain that respond to opiate pain relief.
They found that arthritis patients who had suffered more recent severe pain had more opiate receptors.
a patient who suffers chronic pain from osteoarthritis, said she was xtremely interestedin the research. feel
the brain is still susceptible to injuries from impacts. The 6d helmet contains a foam liner inside
which can cause the brain to spin inside the skull and lead to brain injuries. Bob Weber, cofounder of 6d helmets, said the combination of the suspension system
they created an easy way to tweak the genetic information in a cell nucleus. This has implications for medicine and agriculture.
and thus curb infectious disease. Plant and animal breeders may find it useful, too, for creating new strains of crops and livestock.
Viral infection is a serious threat to these microbes, and the natural job of both CRISPR-Cas9 and CRISPR-Cpf1 is to recognise viral genes
#A drug used to rid people of worms is a new weapon against malaria IVERMECTIN,
a drug employed for the treatment of worm infections, has a side effect. It has been known since the 1980s that it kills arthropods (lice, mites,
which transmit malaria. Preliminary studies suggested so. Mosquitoes do, indeed, get poisoned when they bite people who have taken the drug.
And, since ivermectin is deployed routinely en masse to deal with lymphatic filariasis (a nasty disease that can lead to extreme swelling of limbs and genitalia), river blindness and so on,
to this year meeting of the American Society of Tropical Medicine and Hygiene, in Philadelphia, has changed that.
Dr Foy and his colleagues ran a small clinical trial in Burkina faso that is the first to measure the effect of the drug on rates of malaria.
People in a comparison group of villages got just the first dosehich is the routine annual mass-treatment for worm diseases.
Dr Kobylinski and his colleagues fed mosquitoes malaria-infected human blood mixed with the drug.
In Thailand, a country well on its way to eliminating the scourge of malaria, one line of attack is mass-treatment with drugs that can clear the parasite from its human hosts.
since this is already a familiar treatment for common problems like scabies. The discoverers of ivermectin predecessor, avermectin, were among the winners of this year Nobel prize for medicine.
By an odd coincidence, the third winner was the inventor of artemisinin, which is now the most effective antimalarial drug around.
it will increase the chance that the disease can be knocked on the head once and for all r
#Why This Hearing Device Is Making Noise With Investors Ear surgeon Rodney Perkins has an impressive track record building companies around
The target Soundhawk customer doesn have severe hearing loss but rather a situational needhe inability to hear during a lecture or in a noisy restaurant,
Regarding customers with even minimal hearing loss, Kisch explains, ou want to motivate people to be able to do something about it very quickly.
potentially impacting the hundreds of millions of people experiencing hearing loss globally who do not qualify for existing solutions.
though you just walked out of a teeth-cleaning session at the dentist's, Misoka designers said in a recent interview.
In the areas of surgery and molecule detection, for example, they offer significant advantages compared to traditional, shorter-wavelength lasers.
Bloodless surgery and long-range molecule détection Two-micron spectral domain has potential applications in medicine, environmental sciences and industry.
In the realm of high precision surgery they can be used to target water molecules during an operation
What is more, the energy from the laser causes the blood to coagulate on the wound, which prevents bleeding.
the result is a potentially fatal arrhythmia. Now, a team of researchers from Oxford and Stony Brook universities has found a way to precisely control these waves-using light.
'When there is scar tissue in the heart or fibrosis, this can cause part of the wave to slow down.
This ideal therapy has remained in the realm of science fiction until now.''The team stresses that there are significant hurdles before this could offer new treatments-a key issue is being able to alter the heart to be light-sensitised
However, as gene therapy moves into the clinic and with miniaturization of optical devices, use of this all-optical technology may become possible.
Biomedical scientists at the Sanford-Burnham-Prebys Medical Discovery Institute (SBP) and UC Santa barbara (UCSB) have discovered now a mechanism by
and disease, appear today in the Proceedings of the National Academy of Sciences (PNAS).""This is a fundamental advance that is broadly applicable
and turnover,"said senior author Jamey Marth, Ph d.,professor in SBP's NCI-designated Cancer Center."
and thereby maintain health as well as contribute to various diseases.""This newly discovered mechanism encompasses multiple factors,
which we increasingly note is occurring at the interface of health and disease, "Marth explained."
"In retrospect from published literature and from studies in progress, we can now see how sepsis,
diabetes and inflammatory bowel disorders can arise by the targeted acceleration or deceleration of secreted protein aging and turnover."
"The discovery of this mechanism provides a unique window into disease origins and progression,"Marth added."
"It has been known that circulating glycosidase enzyme levels are altered in diseases such as sepsis, diabetes, cancer and various inflammatory conditions.
We are beginning to see previously unknown molecular pathways and connections in the onset and progression of disease
and Genistein, the compound found in soybean which has been suggested to play a role in prevention of steroid-hormone related cancers, particularly breast cancer.
The tomatoes themselves could potentially become the source of increased nutritional or medicinal benefit. Professor Cathie Martin said:"
Our work will be of interest to different research areas including fundamental research on plants, plant/microbe engineering, medicinal plant natural products,
"Medicinal plants with high value are often difficult to grow and manage, and need very long cultivation times to produce the desired compounds.
Our research provides a fantastic platform to quickly produce these valuable medicinal compounds in tomatoes.
which are the major groups of medicinal compounds from plants
#Wood instead of petroleum: Producing chemical substances solely from renewable resources Petroleum might well be replaced by wood soon
The German research team led by Professor Till Opatz at JGU's Institute of Organic chemistry participates in the interdisciplinary research consortium Chemical Biomedicine (Chembiomed) funded by the Carl Zeiss Foundation
and works on the synthesis of substances that can inhibit tumor cell growth. The US research group under Professor Anthony J. Arduengo III is interested particularly in developing industrially applicable methods for using materials derived from wood biomass for the sustainable manufacture of a broad array of basic chemicals such as, for example,
and young adults with rare blood disorders Hematology researchers have safely and effectively treated children and young adults for autoimmune blood disorders in a multicenter clinical trial.
In children with one of those conditions, autoimmune lymphoproliferative syndrome (ALPS), all the patients showed a durable, complete response, with normal blood cell counts and rapid improvements,
""Patients with ALPS and similar autoimmune disorders have had few long-term treatment options for managing their disease,
"said study leader David T. Teachey, M d.,a physician-researcher in hematology and oncology at The Children's Hospital of Philadelphia (CHOP)."
Collaborators from 15 medical centers contributed to the research; Teachey and Bride had study co-authors from four institutions.
ALPS is one of the autoimmune cytopenias, a group of diseases in which the immune system inappropriately destroys blood cells.
Patients may suffer anemia, uncontrolled bleeding and vulnerability to infections. Parents often see their children struggle with swollen lymph nodes, painful enlarged spleens, fatigue and anxiety.
Because autoimmune cytopenias are relatively rare, families often experience a"diagnostic odyssey"--years of testing,
bleeding and unsuccessful treatments before receiving an accurate diagnosis. Conventional treatment for autoimmune cytopenias uses corticosteroids to suppress the immune system.
Moreover, over the long term, corticosteroids increase the risk of osteoporosis and vulnerability to infection. The current study builds on preliminary results published by Teachey
and 12 others had caused secondary cytopenias by other underlying autoimmune diseases. All were intolerant of or resistant to corticosteroids.
Patients also had improvements in spleen and lymph node abnormalities. All 12 patients were able to discontinue steroids
Sirolimus, an immunosuppressant also known as rapamycin, has long been used to prevent rejection after a solid organ transplant.
Based on the new findings, the study team recommended that doctors should consider using sirolimus early in the management of patients with autoimmune blood disorders that require ongoing treatment.
#UT Southwestern researchers identify an enzyme as a major culprit of autoimmune diseases Activating an enzyme that sounds an alarm for the body's innate immune system causes two lethal autoimmune diseases in mice,
while inhibiting the same enzyme rescues them, UT Southwestern Medical center researchers report. The findings, published in the Oct 20 issue of the Proceedings of the National Academy of Sciences (PNAS),
could someday lead to new therapies for autoimmune diseases.""These results suggest that inhibition of the enzyme cgas may be an effective therapy for autoimmune diseases such as Aicardi-Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE),
which are linked to the same inflammatory pathway, "said senior author Dr. Zhijian"James"Chen, Professor of Molecular biology and a Howard hughes medical institute (HHMI) investigator at UT Southwestern.
In autoimmune diseases, the immune system turns against the body instead of protecting it. AGS is a rare genetic disorder that mainly affects the brain,
while SLE can affect the skin, joints, kidneys, brain, and other organs. Neither disease has a cure
only treatments to control symptoms. Dr. Chen said cgas is likely amenable to inhibition by small-molecule drugs
The same elegant system can trigger autoimmune disease when self-DNA is inappropriately present in the cytoplasm,
"Even deletion of just one of the two genes for cgas largely rescued the mice from the autoimmune disease,
#New finding offers clues for blocking cancer gene A new study suggests a potential new way to block one of the most common cancer-causing genes, without causing severe side effects.
The Notch gene plays a role in many types of cancer. It's the most common cancer-causing gene in T-cell acute lymphoblastic leukemia.
About 60 percent of children and adults with T-cell leukemia harbor a Notch mutation. But drugs designed to block Notch have caused serious side effects such as severe diarrhea or skin cancers.
Now a team from the University of Michigan Comprehensive Cancer Center offers a potential new target to block Notch without the toxic effects.
Researchers found that a protein called Zmiz1 sticks to Notch triggering the gene to turn on its cancer function.
But Zmiz1 does not impact normal healthy Notch functions.""Notch controls the genes that cause cancer,
but it's also important for normal health. The challenge is to knock out the cancer function of Notch
but preserve its normal function,"says Mark Chiang, M d.,Ph d.,assistant professor of internal medicine at the University of Michigan Medical school."
"If you unstick Zmiz1 from Notch, the cancer cells die. And Zmiz1 seems to be selective in turning on the cancer functions of Notch,
"Chiang adds. The researchers found mice lived longer when Zmiz1 was deleted. The mice had normal body weight and no severe side effects from blocking Zmiz1.
We think this would block the Notch cancer pathway without causing toxic side effects, like we see with current Notch inhibitors,
While the majority of kids with T-cell leukemia are cured, about 20 percent will relapse. Those kids face a grim prognosis.
To date, no targeted therapies exist for these kids.""We need to develop therapies against Notch to help kids with relapsed cancer
and to cure kids with fewer toxicities or long-term effects, "Chiang says.""Our current treatments may often be curative,
the brushes also could someday deliver cancer therapeutics s
#Researchers want to turn acid-loving microbes into safe drug-carriers Usually the microbe S. islandicus is found in hot and acidic volcanic springs,
This is relevant for different drugs as growth hormones, vaccines and insulin. Many diabetics need to daily inject insulin directly into their body,
and they would benefit greatly by taking insulin in a tablet instead. Not only is it easier to take a tablet than inject;
vaccines, etc. What did the researchers do in the lab? S. islandicus was grown for four days at 75 degrees Celsius.
they chose the most complex one known, Down syndrome cell adhesion molecule 1 (Dscam1), which controls the wiring of the brain in fruit flies.
#Researcher develops vaccine for fatal disease Over 200 million people in 74 countries suffer from schistosomiasis
and four times that many are at risk for the disease since they do not have access to clean water.
A recent discovery in the Texas Tech University Health Sciences Center (TTUHSC) research laboratory may make it possible to reduce the number of infections from this disease.
Afzal A. Siddiqui, Ph d.,has tested his new vaccine in animals and is now planning human trials.
Siddiqui, a Grover E. Murray Distinguished Professor at the TTUHSC School of medicine, received a patent from the U s. Patent and Trademark Office for his schistosomiasis vaccine.
The vaccine""Schistoshield"potentially can impact up to one billion people. The Bill & Melinda Gates Foundation and the National institutes of health have supported Siddiqui's research."
"We worked to get the patent to deter others from making money off this vaccine,
"This way, it can be made for $1 per vaccination and distributed to those in need.
An effective schistosomiasis vaccine has the potential to impact one billion people.""Praziquantel, a drug developed over 40 years ago,
is the only effective treatment available for schistosomiasis. However, re-infection frequently occurs following drug treatment.
An effective vaccine is critical toward providing long-term treatment. This schistosomiasis vaccine offers unique opportunities for organizations to market it as a method for completely eliminating this disease.
The vaccine's advantages make it easy to sell because it eliminates the instances of re-infection common with the current chemotherapeutic drug,
is easier and less expensive to distribute and can be administered with current chemotherapy regimen. Long-term vaccine efficacy will effectively reduce the transmission of schistosomiasis in endemic areas.
According to the World health organization there are no commercially available vaccines against schistosomiasis, which afflicts people in countries primarily in Asia, Africa and South america.
Symptomatic schistosomiasis can result in increased susceptibility to sexually transmitted infections including HIV, which is prevalent in many countries plagued by schistosomiasis.
A person gets a schistosoma infection through contact with contaminated water. The parasite swims freely in open bodies of water.
Once contact is made with humans, the parasite burrows into the skin, matures into another stage,
and then migrates to the lungs and liver, where it matures into the adult form.
Siddiqui said detection of calcified schistosome eggs in Egyptian mummies from the 20th dynasty (1250 to1000 BC) tells us that schistosomiasis is an ancient disease."
"Major pathology of schistosomiasis is due to immunological reactions to schistosome eggs trapped in tissues, "Siddiqui said."
"Continuing infection causes enlargement of the liver and blood in urine. We see pictures of children from Africa with bulging bellies because of this disease."
"Despite mass treatment with drugs, infection rates continue to rise. An additional 800 million people are at risk of contracting schistosomiasis.
Durable and sustained reduction in the disease spectrum and transmission can only be obtained by long-term protection through vaccination.
Siddiqui has studied schistosomiasis for over 20 years working to develop this vaccine n
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