or too much stress but their underlying cause has remained a mystery. Now researchers have found that a migraine may be triggered by a protein deep in the brain that stimulates the neurons controlling facial sensations.
The discovery creates a potential new target for safer migraine medicines and adds weight to the theory that neurons,
they found that they could cause a headache or migraine about two hours later. Both peptides widen blood vessels,
which are known to trigger a headache. The pair measured the electrical activity of these neurons in anaesthetised rats
the neurons responsible for a headache no longer surged with activity. hese receptors could genuinely represent a new therapeutic target for migraine,
In need of relief New therapies are needed desperately. Triptans don work for half the people who try them,
#World first trial of stem cell therapy in the womb Their bones are so brittle that they fracture while in the womb.
Now a clinical trial of stem cell therapy in the womb aims to help babies born with brittle bone disease start life with stronger skeletons. o our knowledge,
Brittle bone disease or osteogenesis imperfecta, is caused by mutations in the gene for making collagen a tough,
and fix any fractures. hey home to any site of injury, says Anna David of University college London,
By comparing the number of fractures in each group, they should be able to determine
and new neurons grown by asthma drug IT as good as new. An asthma drug has rejuvenated rat brains,
making old rats perform as well as young ones in tests of memory and cognition. Our brains slowly degenerate as we age.
And age-related inflammation of the brain is implicated in many brain disorders. To tackle both problems in one go,
A drug called montelukast (Singulair), regularly prescribed for asthma and allergic rhinitis, blocks these receptors, so Aigner and his colleagues tested it on young and old rats.
The team used oral doses equivalent to those taken by people with asthma. The older animals were 20 months old perhaps between 65 and 75 in human years.
says James Nicoll, a neuropathologist at the University of Southampton, UK. Aigner agrees he will start by testing the drug in people with Parkinson disease,
he says p
#AI tool scours all the science on the web to find new knowledge It the proverbial needle in a haystack.
says Oren Etzioni, director of AI2. f youe a medical researcher, you could ask hat the latest on these drug interactions?
Or even a query in natural language like, hat are papers saying about middle-aged women with diabetes and this particular drug?'
or technique that they could use, in a medical case, to save somebody life. AI2 is not the only organisation intent on digitising
codenamed Big Mechanism, to read all the scientific papers on certain types of cancer and use that knowledge to identify potential treatments.
these modified yeast strains should make it much easier and cheaper to manufacture new painkilling medicine
and is designed to treat seizures in people suffering from epilepsy. It's a new version of a seizure medication that's been on the market for years."
"The FDA had approved previously medical devices made with 3-D printing. The company that makes Spritam says the 3-D-printed version of the drug allows it to dissolve more quickly,
these modified yeast strains should make it much easier and cheaper to manufacture new painkilling medicine
where there's a terrible shortage of pain medicine, Smolke says. Still, the genetically modified yeast strains have triggered a heated debate about how to regulate these organisms and the possibility of"home-brewing morphine.""
Doctors in Spain say this is the world's first 3-D-printed rib cage, made entirely from titanium.
And they've already implanted the device into the chest of a 54-year-old cancer patient.
The man lost his sternum and pieces of four ribs when doctors removed a large tumor.
The perforated center section of the implant is the prosthetic sternum. Four thin rods on the left mimic ribs.
The eight clamps on either side attach the implant to bone. Screws hold the clamps in place.
Surgeons at Salamanca University Hospital reported the man's case and how they made the prosthesis last month in the European Journal of Cardio-Thoracic Surgery.
Engineers at Anatomics in Melbourne, Australia, custom-designed the device using CT SCANS of the man's chest.
They manufactured the implant with a $1. 3 million metal printer at a government-run lab. The printer uses an electron beam to melt titanium powder,
"But for complex and customized implants, the cost to print them is more affordable and the time to produce it is shorter than with traditional manufacturing,"Crystal Ladiges,
so will printed 3-D implants. Surgeons typically use a combination of flat plates, bars and mesh to build an artificial rib cage and sternum for patients.
The 3-D printing technology allowed the surgeons to create an implant that"fitted like glove"in the man's chest, Dr. Jose Aranda
of Salamanca University Hospital, said in a statement. He and his colleagues hope the better fit will mean fewer complications in the long run.
But the surgical team admits that such a complex prosthesis is probably helpful only for extreme cases,
when extensive reconstruction of the sternum and rib cage are needed e
#4-D laser printing: holograms and beyond Novel tech that manipulates light has applications beyond holograms,
The new imaging method could make future medical applications more cost-effective and space-efficient than is possible with today technologies.
The researchers say that their technology is articularly interesting for medical applications as it can distinguish between differences in tissue density.
Cancer tissue, for example, is less dense than healthy tissue. The method therefore opens up the prospect of detecting tumors that are less than 1mm in diameter in an early stage of growth before they spread through the body
and exert their lethal effect. For this purpose however, researchers must shorten the wavelength of the X-rays even further
in order to be able to diagnose diseases earlier, to find new active ingredients faster and more reliably,
The developers say the system can be used to identify biomarkers that are early indicators of a disease
or can predict the response to a therapy. The Fraunhofer FIT will make the first public demonstration of the system alongside its ZETA imaging software that is used in drug research at the forthcoming BIOTECHNICA expo in Hanover, Germany, between October 6 8, 2015.
the team led by Ghent Dries Van Thourhout suggests that electrical injection-a necessity for true photonic integration-could be achieved readily with the incorporation of a suitable blend of narrow-bandgap semiconductor material in the future.
Van Thourhout and colleagues outlined how these challenges could be met. he in-plane laser configuration employed makes it straightforward to adopt well-studied electrical injection schemes,
predicts the team. his also forms a route towards electrical injection for the device. Cutting data center power consumption They suggest that a wide range of applications stand to benefit from the kind of low-cost,
IMEC says that efforts are focused now on growing the more complex semiconductor layer stacks needed for electrical injection of the lasers and emission in the 1300 nm wavelength range d
#3d printed Pills Could Bring Bespoke Drugs to a Hospital Near You It a development that could spell the end of horse pills,
an existing anticonvulsant used to treat epilepsy that has been available as a generic in the U s. since 2008.
and shipped them to hospitals and for the first time this process means we can produce tablets much closer to the patient,
Today, most bespoke drugs are formulated at specialized compounding pharmacies that are frequently miles away from the hospitals and clinics in
which they are used. 3d printing could bring those capabilities into hospitals and clinics, cutting time off delivery and making custom pharmaceuticals easier to obtain b
#New uper-Tomatocan Fight Cancer, Heart disease, Diabetes and Alzheimer Scientists said that they have invented a uper-tomatowhich can fight cancer, heart disease, diabetes and Alzheimer.
The makers of this unique tomato said it has high quantities of disease-fighting antioxidant plant chemicals.
whereas genistein could help in prevention of some cancers, including breast cancer. The study published in the journal Nature Communications said that the super-tomatoes contain a protein called Atmyb12,
and potentially production of other products derived from aromatic amino acids Martin further said their work could be used effectively in a number of areas including plant and microbe engineering, medicinal plant natural products,
The researchers also hope that the similar technique can be used to manufacture other compounds that form the basis of many medicines a
For example, the material could be engineered to detect specific pollutants, toxins or pathogens, with the results instantly visible through color emission.
The findings could help identify ways to repair damaged neural connections in patients with spinal cord injuries or neurodegenerative diseases like amyotrophic lateral sclerosis (ALS), also known as Lou gehrig's disease.
That's a key finding for research on how to treat spinal cord injuries and ALS,
Integrated into an injection molding system, the device is capable of generating more than 1. 7 million bar code configurations on anything from cellphones to pills.
"While our system has been developed initially for products made from plastics or composites through injection molding,
produced using an injection molding process, into which 3d bar codes could be incorporated e
#Fiber Sensors Improve Robot Touch Sensitivity Fiber optic sensors could give robots the sensitivity needed to handle delicate objects and work safely alongside humans.
#UV Catheter Plugs Holes in Hearts With help from UV LIGHT, a new catheter device could provide a way to repair defects in hearts and other organs without surgery.
It was developed jointly by researchers from Boston Children's Hospital, Harvard university and Brigham and Women's Hospital."
"said Dr. Pedro del Nido, chief of cardiac surgery at Boston Children's Hospital. The catheter is inserted through a vein in the neck or groin and directed to the area of the defect.
As the glue cures, pressure from the balloons secures the patch it in place. Finally, both balloons are deflated
"This really is a completely new platform for closing wounds or holes anywhere in the body,"said Harvard professor Dr. Conor Walsh."
While medical devices that remain in the body may be jostled out of place or fail to cover the hole as the body grows,
The adhesive was developed in the lab of Dr. Jeff Karp, a bioengineer at Brigham and Women's Hospital.
The french company Gecko Biomedical, of which Karp is a founder, plans to test the adhesive in humans later this year r
#Antibiotic-Resistant Bacteria Are No Match For Medieval Potion Bloodletting, mercury cures, holes drilled in the headany ancient medical remedies seem ill-advised based on our modern understanding of medicine.
But researchers recently found that a thousand-year-old Anglo-saxon treatment for eye infections works as an antibiotic against one of today most notorious bacteria, Methicillin-resistant Staphylococcus aureus (MRSA.
The british researchers will present their findings this week at an annual microbiology conference held in the United kingdom. Christina Lee,
and is one of the earliest known medical textbooks. The researchers prepared four batches of the recipe,
The researchers tested the concoction on cultures of MRSA bacteria in synthetic wounds as well as in rats.
Blind rats without the digital implants never achieved more than a 50 percent chance of guessing the correct branch.
they've developed software that can gauge the speed at which a typist is tapping the keyboard to help diagnose Parkinson disease.
(which slows all motor skills) and diseases that affect the central nervous system, including Parkinson. For the first version of this study, the researchers were looking at typing patterns that indicated
#Glowing Tumor Paint Shows Surgeons Where To Cut Brain surgery is complicated notoriously. Before surgeons go in to remove a tumor,
they study the size and location of the tumor. But once theye in, they have to rely on their fingers
and eyes to distinguish tumor cells from healthy brain cells. Now researchers have developed a"paint"that can be injected into a patient's veins to make tumor cells glow.
After a number of successful studies in mice and dogs, the paint is now being tested in humans in California.
The paint is made from two chemicals. The first is chlorotoxin a protein derived from scorpion venom,
which targets the chloride receptors on the surface of tumor cells. The protein carries a second,
Researchers injected the tumor paint into the patients'veins and it was successfully able to cross the blood-brain barrier,
The first few test subjects had tumors that were deep in the brain so the surgeons had to remove a piece of the tissue before shining a light on it.
T he question was, 'Does it glow?''And when we saw that it glows, it was just one of those moments...
Chirag Patil, one of the researchers behind the test at Cedars Sinai Medical center in Los angeles, told NPR.
The paint may also be used for other types of tumors in the future. Ideally, doctors wouldn be using surgery at all to eliminate tumors--it still a rudetechnique,
as one researcher said. But while surgery is still a standard treatment, tumor paint could help surgeons be much more precise m
#A 3d printed, Battery-Powered Rocket engine Nothing demonstrates engineering prowess and technical knowhow quite like rocket science.
Theres also nothing quite as expensive either. To launch even a lightweight rocket into space, the cost is easily upwards of $100 million
or fracture in the earth's crust. There are many different types of faults. A thrust fault, like the one that caused the earthquake Saturday,
or some combination of the three, not to mention the numerous people who desperately need medical care. Faced with scenes of such devastation
because people need malaria meds. You feel like you've spent time in these places after spending hours digitizing aerial imagery.
--but a transfusion of the wrong blood type can be fatal. For example, the immune system of a type O individual will launch a massive attack on the"invading cells"of a type A individual
They attempted to delete a gene for a blood disorder called beta thalassemia from the DNA of 86 nonviable embryos.
which causes Tay-sachs disease--a disease in which children develop normally for six months and then become progressively deaf, blind, unable to swallow, and paralytic,
before dying at four-will benefit future generations. We lose nothing by editing this gene out of the human lineage.
Of course, gene editing techniques are nowhere near ready to eradicate human diseases. The modifications are difficult to target
Liu hopes that his invention would one day be used to build shapeshifting robots to repair pipelines and delivery medicine inside blood vessels.
pitching coaches can do little to predict the injury. They look at certain metrics--throwing speed and pitch count--to guess
dubbed Tommy John surgery after the first player to get it, in 1974. Solution: During spring training this year, more than 10 MLB teams began using the Motus mthrow motion-tracking system to keep tabs on pitchersarm health.
The Pitch Bryan Christie Design After Tommy John surgery pitchers are out of rotation for an average of one year
It our single biggest health problem, affecting the lives of 100 million adults--more than heart disease, cancer,
and diabetes combined. And that figure, from a 2011 Institute of Medicine report, doesn even count kids in pain, veterans with devastating war injuries,
or people in nursing homes. Yet despite the fact that chronic pain is the primary reason Americans receive disability benefits, its one of the least understood afflictions.
Medical schools teach doctors almost nothing about it, spending a median of nine hours on the topic over four years.
The good news, finally, is that scientists from Massachusetts General Hospital (MGH) in Boston have unveiled a new brain-scanning method that allows doctors to see chronic pain in exquisite detail for the first time.
according to the Centers for Disease Control and Prevention The new method produced dramatic images showing how glial cells
MIT sees it as a potential system for hospitals or rescue work, and it easy to imagine the same robots that here dispense beer instead taking orders for water bottles and crackers at an emergency shelter.
like morphine or codeine, are important for medical purposes. The drugs have been around for millennia
Material that heals itself in the presence of water could extend the usability of biomedical implants
The researchers next plan to study how their technology could help heal wounds n
#Can You Catch Alzheimer? The gradual loss of memory and thinking skills caused by Alzheimer disease are debilitating.
Scientists aren quite sure what causes the condition, but have hypothesized long that the disease results from a combination of genetic, environmental,
and lifestyle factors. Now a team of British researchers might have discovered a new cause: transmissible clumps of proteins called prions.
but can sometimes cause disease. Unlike bacteria or viruses, prions don have any of their own DNA;
they cause disease when they become misfolded so that they can no longer function properly, and they propagate throughout the brain.
Many of the resulting diseases, such as Creutzfeldt-jakob disease (CJD), have long incubation periods but eventually lead to death.
as children, received a medical procedure that was later found to transmit prions. They all died of CJD between the ages of 36 and 51.
thought to be a driver of Alzheimer disease. In fact, four patients had uite substantial Alzheimer-like pathology,
says John Collinge, one of the authors of the study said in a press conference. n that age group you don really see this sort of pathology;
it only really seen in elderly individuals unless you have a genetic predisposition to it,
and none of these patients did suspected. he researchers that other prion diseases might increase the production of amyloid beta,
so they checked the records of 116 other patients with different types of prion disease.
But they note that medical procedures like surgery or blood transfusions could play a role in transmitting prions,
putting patients at a higher risk of developing Alzheimer. There is no evidence of this connection yetnd,
as a spokesperson from The british Department of health points out, a small study of eight patients isn yet cause for alarmut the researchers hope to investigate how prions could be transmitted in a medical setting in the near future e
#Nose-Like Biosensor Sniffs Out Stinky Drinking water Electronic noses can detect bugs, disease or even explosives.
paralyzed due to a spinal injury, was able to feel a physical sensation thanks to a hand prosthetic attached to his brain,
and Better Memory ST LOUIS By hardwiring into the brains of people with traumatic injuries, scientists have been able to restore the feeling of touch
could help people suffering from traumatic brain injury. The Defense department research wing shared both milestones last week at a conference called ait, What?
people who were undergoing brain surgery and volunteered to get electrode implants saw improvement in their scores on memory tests,
DARPA said. They received small electrode arrays placed in brain regions involved in the formation of declarative memory, according to DARPA.
which could help people with memory problems including those with traumatic brain injuries, Sanchez said. s the technology of these fully implantable devices improves,
and as we learn more about how to stimulate the brain ever more precisely to achieve the most therapeutic effects,
and others who today suffer from intractable neurological problems, he said u
#British Scientists Want Permission To Genetically Edit Viable Human Embryos Cas9, the enzyme used in the CRISPR/Cas9 genome-editing technique, employed on a stand of DNA.
and after Chinese researchers reported they had employed indeed successfully the CRISPR/Cas9 system on nonviable human embryos to remove a part of the gene that causes a genetic blood condition called beta thalassemia.
and even preventing certain diseases, if given the proper basic research. Niakan told The Guardian:
#FDA Approves Use Of Engineered Herpes virus To Treat Cancer Yesterday, the Food and Drug Administration (FDA) announced that it had approved the drug Imlygic to treat late-stage melanoma on the skin and lymph nodes.
The drug, which relies upon a genetically engineered herpes virus to attack and kill the cancerous cells,
And while malignant cancers often slip by the immune system, the viruspresence ignites the immune response. Combined, these reactions mean that virology can successfully treat even some late-stage cancers that are often resistant to other treatment methods.
Before it was approved, Imlygic was tested in more than 400 patients with metastatic melanoma, which kills about 10,000 people per year in the United states,
which had caused lesions in patientsskin or lymph nodes. When the drug was injected into the cancerous sites over the course of six months,
more than 16 percent of patients saw their lesions shrink. So far, virology treatments haven worked as well in cancers in tissues deeper in the bodyhe drug has to be injected directly into the tumor site
or the immune system will launch its attack too early, according to Nature News. But a number of drugs using different viruses
and to treat several types of cancer are already in clinical trials. Now that the first virology cancer treatment has been approved,
researchers hope that many more are to follow e
#This Flexible Electronic Sticks To Your Skin And Can Measure Your Blood Flow The blood coursing through your arteries
and veins bring necessary nutrients to organs throughout the body as well as take waste away. But conditions such as diabetes, kidney disease,
and certain types of inflammation can limit blood flow to various parts of the body
and monitor various medical conditions that may alter blood flow w
#Open-source Soil Sensors: Vinduino As California fourth straight year of drought forces farmers to cut back on water use,
when the sensing of light overlaps within these conesnchroma glasses allow wearers with red-green color blindness to see color again.
the MCA Chicago is making a move that might inspire other museums to increase accessibility for visitors with color blindness h
Compasses and GPS help people without disabilities find their destinations every day, but are of less use to the visually impaired,
The device is designed to detect syphilis, gonorrhoea, chlamydia and trichomoniasis, the most common in the category,
In these type of tests, reagents bond to specific proteins formed by the body under attack from an infection.
and recommends nearby doctors and facilities for treatment. Although shrinking the chemistry can be easy,
when testing for HIV infection and herpes. Other STDS are tested by confirming virus or bacterial presence in swabs or sample tissue from the patient.
Because it tests for antibodies, which is a bodily response, there is timeframe for false negatives.
overall minimizing the possibility of an undetected infection. The startup team is headed by Kazakhstani Damel Mektepbayeva,
a biotechnologist who has helped developed stem cell-based treatments for ischemic diseases. The Hoope idea originated from a NASA camp where Damel team bested 80 other scientists in developing an impactful product.
Farmedhere produce is grown indoors in urban facilities, away from the bugs, diseases, pesticides, and weather that impact most produce today.
The area in which Park has established herself as an expert is the field of study related to the creation and monitoring of delivery vehicles that carry medicine to specific locations within the body.
when she saw the side effects of cancer and how the drugs used to kill cancer cells also killed other parts of the body.
In doing this, the medical treatment would be more effective and the patient could remain stronger during treatment.
or risk to doctors who are trying to reach that locale with medicine. Two areas that have been of particular interest to her are spinal discs and places within the eyeball, both
Preliminary testing of the drug delivery procedure is being performed at the Laboratory Animal Medical Services (LAMS) facility on UC's East Campus. Currently Park is in the preclinical phase,
new ways to deliver medicines and other applications. Most commercial robots are made stiff of hard plastics and metal parts.
#Gene on-off switch works like backpack strap A research team based in Houston Texas Medical center has found that the proteins that turn genes on by forming loops in human chromosomes work like the sliding plastic adjusters on a grade-schooler backpack.
This discovery could provide new clues about genetic diseases and allow researchers to reprogram cells by directly modifying the loops in genomes.
The multi-institutional group includes researchers from Baylor College of Medicine Rice Univ.,Stanford Univ. and the Broad Institute.
Rao likened the result to a new form of genome surgery: a procedure that can modify how a genome is folded by design
An abnormally high or low white blood count, for instance, might indicate a bone marrow pathology or AIDS.
The rupturing of white blood cells might be the sign of an underlying microbial or viral infection.
Strangely shaped cells often indicate cancer. While this old, simple technique may seem a quaint throwback in the age of high-technology health care tools like genetic sequencing,
flow cytometry and fluorescent tagging, the high cost and infrastructure requirements of these techniques largely limit them to laboratory settingsomething point-of-care diagnostics aims to fix.
Her research today involves translating molecular imaging research to point-of-care diagnosticsescribes the fluorescence microscope system this week in a paper published in Biomedical Optics Express, from The Optical Society.
Overtext Web Module V3.0 Alpha
Copyright Semantic-Knowledge, 1994-2011