#CCNE1 Gene Turns Back Cellular Clock Yale researchers have discovered a gene that turns back the cellular clock,
and one day develop customized cell therapies for individual patients. The Yale team used a new form of transciptome analysis that allowed them to more fully explore impact of all types of RNA on cell reprogramming.
releasing a bit of stress, and making it easier for a second atom to climb out of a trough
a discovery that could have therapeutic potential for diabetes, obesity, and other metabolic diseases. Harvard Stem Cell Institute (HSCI) scientists have found a way to both make more energy-burning human brown fat cells
and make the cells themselves more active, a discovery that could have therapeutic potential for diabetes, obesity,
and other metabolic diseases. Unlike energy-storing white, or ad, fat cells, oodbrown fat cells make a protein called UCP1 that converts energy stored in glucose
and fatty acids into heat to keep the body warm. When active brown fat cells can also use energy stored by white fat cells,
and at Harvard-affiliated Joslin Diabetes Center and led by HSCI principal faculty member Yu-Hua Tseng,
The research was published online today in the journal Nature Medicine. Tseng collaborated with HSCI Lee Rubin and researchers at the National institutes of health, the Joslin, Boston University, Beth Israel Deaconess Hospital,
and Fudan University in China. Knowing which genes control UCP1 should help scientists develop therapies. e could take fat samples from patients undergoing liposuction
and we could purify this specific population of progenitor cells, keeping only those that would eventually make highly active brown fat cells,
Tseng hopes this technique could eventually replace invasive procedures such as liposuction and gastric bypass surgery.
Tseng believes cell therapy would be uch safer and much less invasive. ontrolling the genes might allow scientists to make mediocre brown fat cells work better.
This could potentially allow the brown fat cells to remove the high numbers of circulating glucose associated with type 2 diabetes
and circulating fatty acids and triglycerides that are the hallmark of metabolic syndrome. y further understanding how adipose cells become thermogenically active,
we may discover novel therapeutics for the treatment of obesity and metabolic disease, said Chad Cowan, an HSCI principal faculty member who, among other things,
also studies the therapeutic potential of brown fat cells. In 2014, Cowan identified two drugs with the potential to convert stem cells that make white fat into those that would make brown. his latest study gives us new tools and targets to use in the battle against obesity
Cowan said. Publication: Ruidan Xue, et al. lonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes, Nature Medicine, 2015;
doi: 10.1038/nm. 3881source: Hannah Robbins, Harvard Gazetteimage: Tseng Laboratory, Joslin Diabetes Cente T
#Deriving Power Directly from Evaporation Eva, the first evaporation-powered car, rolls along, thanks to a moisture mill a turbine engine driven by water evaporating from wet paper strips lining its walls.
Eva is one of the many devices created to harness evaporation energy. Credit: Sahin Laboratory, Columbia University An immensely powerful yet invisible force pulls water from the earth to the top of the tallest redwood
While conventional lithium-ion batteries are composed of brittle electrodes that can crack under stress the new formulation produces battery cells that can be bent,
-or right-handed form may have a multitude of practical applications, potentially leading to new and improved drugs, diagnosis methods, and pesticides.
The breakthrough could be important in developing effective molecules for use in a wide range of industries everything from the development of safer new drugs and disease diagnosis to less toxic pesticides.
for instance the well-known malformation of the limbs of infants of pregnant women taking the Thalidomide drug to relieve morning sickness that occurred around 1960.
In addition to the development of effective new drugs and diagnosis methods for diseases including cancer, it could potentially lead to new reenpesticides using pheromones tailored specifically to attract pollinators
and trees when under stress and detectors to identify concentrations in air samples could be used to monitor our changing ecology.
Such devices could be used to diagnose diseases, especially skin conditions, or to detect environmental pollutants and food conditions,
or analyzing tissue samples for biomedical research and diagnostics. Replacing that bulky optical equipment with quantum dots allowed the MIT team to shrink spectrometers to about the size of a U s. quarter,
The new technique harnesses the regenerative capacity of stem cells to generate an immune response to the virus. The findings were published today in the journal Molecular Therapy. e hope this approach could one day allow HIV-positive individuals to reduce
and a member of the Broad Stem Cell Research center. e also think this approach could possibly be extended to other diseases.
and an associate professor of medicine in the division of hematology and oncology at the David Geffen School of medicine at UCLA. Kitchen and his colleagues were the first to report the use of an engineered molecule called a chimeric antigen receptor,
In a healthy immune system, T cells can usually rid the body of viral or bacterial infection.
As a result, HIV infection causes disease similar to that in humans. The researchers found that the CAR-carrying blood stem cells successfully turned into functional T cells that could kill HIV-infected cells in the mice.
The findings strongly suggest that stem cell-based gene therapy with a CAR may be a feasible and effective treatment for chronic HIV infection in humans.
This kills the T cells and weakens the immune system so much that the body can fight even a simple infection.
and millions more at risk of infection, do not have adequate access to prevention and treatment,
and there is still no practical cure, said Jerome Zack, professor of medicine and of microbiology,
immunology and molecular genetics in the UCLA David Geffen School of medicine and a co-author of the study. ith the CAR approach,
and is affiliated with UCLA Jonsson Comprehensive Cancer Center and a member of the Broad Stem Cell Research center.
The study first author was Anjie Zhen, a postdoctoral fellow at UCLA in the Division of Hematology/Oncology, the UCLA AIDS Institute and the Broad Stem Cell Research center.
IV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells, Molecular Therapy,(8 june 2015;
The robot body transitions from soft to hard, reducing the stress where the rigid electronic components join the body
Bobak Mosadegh of Weill Cornell Medical College; and, as noted, Whitesides of Harvard and the Wyss Institute.
#Yale Researchers Successfully Treat Eczema with Rheumatoid arthritis Drug A team of scientists at Yale university used a rheumatoid arthritis drug to successfully treated patients with moderate to severe eczema.
The same rheumatoid arthritis drug (tofacitinib citrate) has shown recently to reverse two other disfiguring skin conditions, vitiligo and alopecia areata.
The research findings are published early online in the Journal of the American Academy of Dermatology.
Eczema (atopic dermatitis) is a chronic condition that causes severe itching and leaves the skin red and thickened.
such as steroid creams and oral medicines, commonly fail to relieve symptoms in patients with moderate to severe eczema.
Based on current scientific models of eczema biology, assistant professor of dermatology Dr. Brett King. hypothesized that a drug approved for rheumatoid arthritis,
would interrupt the immune response that causes eczema. In the new study, King and his colleagues report that treatment with the drug led to dramatic improvement in six patients with moderate to severe eczema who had tried previously conventional therapies without success. During treatment all six
patients reported significant reduction in itch as well as improved sleep. The redness and thickening of the skin diminished
King and fellow Yale dermatologist Dr. Brittany Craiglow had shown previously that tofacitinib citrate regrows hair in patients with an autoimmune-related form of hair loss called alopecia areata.
They also published findings reporting the successful treatment of a patient with vitiligo, which can leave widespread irregular white patches all over the body.
The new study suggests that a change in the standard of care for eczema a condition for
which there is no targeted therapy may be on the horizon, say the researchers. czema affects millions of children
and adults in the United states, said King. hopeful we are entering a whole new era in treatment. he researchers note that further research is needed to confirm the treatment long-term efficacy and safety for eczema patients f
for Integrative Cancer Research. Eliana Martins Lima, of the Federal University of Goiás, is the other co-author.
from environmental remediation to medical analysis. The polymers are synthesized at room temperature, and don need to be prepared specially to target specific compounds;
offering the example of a cheap testing kit for urine analysis of medical patients. The study also suggests the broader potential for adapting nanoscale drug-delivery techniques developed for use in environmental remediation. hat we can apply some of the highly sophisticated,
and an expert in nanoengineering for health care and medical applications. hen you think about field deployment,
A multidisciplinary team at Yale, led by Yale Cancer Center members, has defined a subgroup of genetic mutations that are present in a significant number of melanoma skin cancer cases.
Their findings shed light on an important mutation in this deadly disease, and may lead to more targeted anticancer therapies.
The study is published in Nature Genetics. The role of mutations in numerous genes and genomic changes in the development of melanoma a skin cancer with over 70
000 new cases reported in the United states each year is established well and continues to be the focus of intense research.
Yet in approximately 30%of melanoma cases the genetic abnormalities are unclear. To deepen understanding of melanoma mutations,
the Yale team conducted a comprehensive analysis using whole-exome sequencing of more than 200 melanoma samples from patients with the disease.
The multidisciplinary team drawing on their expertise in genetics, cancer, computational biology, pharmacology, and other disciplines also tested the response of tumor cells with specific mutations to anticancer drugs.
The researchers confirmed that a gene known as NF1 is a ajor playerin the development of skin cancer. he key finding is that roughly 45%of melanomas that do not harbor the known BRAF or NRAS mutations display loss of NF1 function,
which leads to activation of the same cancer-causing pathway, said Dr. Michael Krauthammer, associate professor of pathology and the study corresponding author.
Additionally, researchers observed that melanoma patients with the NF1 mutation were had older and a greater number of mutations in the tumors.
These include mutations in the same pathway, collectively known as RASOPATHY genes. Yet mutations in NF1 are not sufficient to cause skin cancer,
said Ruth Halaban, senior research scientist in dermatology, a member of Yale Cancer Center, and lead author of the study. oss of NF1 requires more accompanying changes to make a tumor,
she explained. ur study identified changes in about 100 genes that are present only in the malignant cells
and are likely to be causative. This panel of genes can now be used in precision medicine to diagnose malignant lesions
and can be applied to personalized cancer treatment. By testing the response of the melanoma samples to two cancer drugs,
the researchers also determined that, in addition to loss of NF1, multiple factors need to be tested to predict the response to the drugs. t opens the door to more research,
said Halaban, who is also principal investigator at Yale SPORE in Skin cancer. Other Yale authors include Yong Kong
Antonella Bacchiocchi, Perry Evans, Natapol Pornputtapong, en Wu, James P. Mccusker, Shuangge Ma, Elaine Cheng, Robert Straub, Merdan Serin, Dr
. arcus W. Bosenberg, Dr. Stephan Ariyan, Dr. Deepak Narayan, Dr. Mario Sznol, Dr. Harriet M. Kluger, Shrikant Mane, Joseph Schlessinger,
and Dr. Richard P. Lifton. The study was supported by the Yale SPORE in Skin cancer, funded by the National Cancer Institute, U s. National institutes of health, under award number 1 P50 CA121974;
the Melanoma Research Alliance; Gilead sciences, Inc.;the Howard hughes medical institute; the Department of Dermatology; and the Yale Comprehensive Cancer Center.
Publication: Michael Krauthammer, et al, xome sequencing identifies recurrent mutations in NF1 and RASOPATHY genes in sun-exposed melanomas, Nature Genetics, 2015;
doi: 10.1038/ng. 3361 Source: Ziba Kashef, Yale Universit
#First Direct evidence of the Formation Process of Brown dwarfs Using the Very Large Array, an international team of astronomers has discovered jets of material ejected by still-forming young brown dwarfs,
revealing the first direct evidence that brown dwarfs are produced by a scaled-down version of the same process that produces stars.
The astronomers studied a sample of still-forming brown dwarfs in a star-forming region some 450 light-years from Earth in the constellation Taurus,
Kenya has one of the highest HIV infection rates in the world at least 10 times that of most countries.
Kenya offers free Antiretroviral Therapy (ART) at clinics throughout the country, but the problem has been a lack of access.
A connection that saves lives Qualcomm is changing that by providing something that you won find in a typical medical bag:
Clinics have to track their drugs, generate tedious reports to get new supplies and deliver those reports to central facilities.
the clinic wouldn get the drugs it needed to treat its patients. The 3g technology has allowed clinics to computerize much of their administrative work,
streamlining the submission process and saving time. The time needed to prepare three monthly reports dropped from 11.6 hours to less than half an hour.
Projects run the gamut from health care and public safety to education and entrepreneurship. A project in India is helping to educate migrant children.
or used in medical treatments. Other cities using the system benefit from New york work and they can provide their own suggestions.
That same amount of money could provide them more permanent housing, comprehensive health care and employment services.""A considerable amount of public dollars is spent essentially maintaining people in a state of homelessness,"Dennis Culhane,
The formerly homeless can get mental health treatment counseling or other services to help them overcome their demons,
our health care to be patient-centric and our education to be student-centric, "O'sullivan explains of the growing market opportunity."
Luckily, experimental products that combat cute radiation syndrome (ARS) have already been tested in people and could be on the cusp of market approval, Nature Medicine reports.
Nearly a quarter-million KI doses (pictured) have been amassed by evacuation centers near the site. But while those guard against the long-term risks of thyroid cancer linked with chronic radiation exposure
they do little for plant workers and emergency personnel in the event of a meltdown.
the extreme radiation sickness associated with exposure to high doses of ionizing radiation over a short period of time.
their treatment options are limited to antibiotics, blood transfusions, and fluid supplements to deal with the symptoms of the disease.
Doctors also sometimes administer cancer drugs to help the immune system rebound. Now, however, several small biotech companies are racing to develop the first approved therapy for ARS,
using biologics and small molecules to halt radiation harmful effects in the field. Some block cell death and protect damaged tissue exposed to radiation;
others replace cells lost to exposure. CBLB502, developed by Cleveland Biolabs, binds an immune protein to activate a cell survival pathway.
CLT-008 from Cellerant Therapeutics replaces blood stem cells lost due to exposure. Those blood progenitor cells form mature infection-fighting
and clotting blood cells when infused by intravenous drip. Prochymal from Osiris Therapeutics is a stem cell therapy derived from adult bone marrow to treat organ damage due to radiation exposure.
AEOL-10150 of Aeolus Pharmaceuticals is a small molecule that reduces inflammation associated with radiation exposure.
and the Pandemic and All-Hazard Preparedness Act (signed into law 2 years later) allotted billions of dollars in funding for research into medical countermeasures to be used in the case of nuclear, chemical,
It's possible to use CO2 to fracture shale rock formations, but it's expensive, particularly in large-scale operations.
reuse the CO2 to fracture rock formations and then capture it again to use on the next well.#
Citizens Health care Working group (CHCWG:##Under the direction of Health and human services, CHCWG commissioned by Congress to enlist citizens to provide input to review health care system.
Grant Thorton reports that a collaborative solution was up and running in less than one month.##
and Case Western Reserve's work applying high-definition multipoint video conferencing to telemedicine. Sue Spradley also pointed out that U s. Ignite is seeking not only to incubate new applications
and the Great RSS Gold rush of 2013 is reaching fever pitch. Bloomberg Businessweek reports. An RSS reader pulls in feeds of articles from various websites.
As next-generation genome sequencing heads into the clinic and public health, it ll be targeted at people who don t necessarily fully understand these issues.
which caused an outbreak of food poisoning in Germany last year. And the winner? Well, each platform has strengths
Basically, that inhibits the ability to do good public health analyses of bacterial genomes. The work was published in Nature Biotechnology this week.
the Obama Administration has been pushing EHRS as the solution to all that ails health care. The idea is that the data they collect can drive change,
This was proven for me today, through an interview with Paul Hensler (above), CEO of the Kern Medical center in Bakersfield, California.
Kern, a county hospital, has needed an EHR for some time. But getting a commercial system meant writing a Request for Proposal (RFP) for a consultant who would write an RFP for a system,
A lot of our doctors did their training at the VA. We knew we could download it
We can create personalized medical information. Anywhere there is data and there is interest. Our hope is to be able to do something for the 2010 census
and It'll Heal Your Wounds in 15 Seconds Flat Bloomberg News reports on an incredible new invention that astounding people across the world and across the web.
which was to use a polymer to seal up a wound very quickly. In the beginning I wasn expecting that the polymer itself would be able to quickly stop bleeds.
This is how his invention manages to seal wounds so quickly d
#Smart Highway: Solar power Bike path Opens In Netherlands This Week On November 12, 2014, The netherlands will proudly open up the world first public solar powered road.
Their setup resembled a fever thermometer, where the length of the mercury column in a capillary is controlled by the thermal expansion of the mercury in a reservoir connected to the capillary.
#Monitor Diabetes From Your Smart Watch My son, Evan, was diagnosed with type 1 diabetes in August 2012.
Type 1 diabetes is an autoimmune disease that attacks the pancreas and prevents insulin production. The body needs insulin to transport glucose from the blood to the cells.
Synthetic insulin is used to manage type 1 diabetes, but it doesn work as quickly as human insulin.
Determining the right dose of insulin for a given meal carbohydrate content becomes an all-consuming balancing act.
The shock of the diagnosis continued to set in over the next few months as my wife, Laura,
I wanted usaura, the school nurse, and meo be able to see his glucose level at any moment
as it allowed Evan some freedom from the typical type 1 diabetes regimen at day care.
because his life is disrupted far less by the demands of diabetes. We can mitigate most hyper
what we lost that day in August 2012 and blessed to know that my little boy diabetes has helped so many others.
This article originally appeared in print as IY Diabetes Remote Monitoring.
#Cheap Earthquake Warning Systems While predicting earthquakes remains a dream, scientists have developed early warning-systems systems that give people precious seconds to run out of buildings
#Diabetes Has a New Enemy: Robo-Pancreas The first great wonder drug was insulin, the blood-sugar-regulating hormone that was isolated in Canada nearly a century ago.
so those with the disease must work hard to mimic that organ function. If blood sugar goes too low,
and adjust the injection of insulin to account for it All the burden of self management goes on night and day.
and closed-loop systems that take over more of the diabetes management are in trials. Finally, everybody in the field agrees that a solution is nigh.
and nights in a controlled setting, surrounded by doctors and engineers. e used a Dexcom continuous glucose sensor,
(although technically he is supposed to recheck the numbers with a finger stick before an injection).
there a lot we can do to affect disease management. For instance, doctors could mine the data for patterns in which patients suffer from low blood sugar,
then adjust diet or insulin dosage accordingly. The information can also be used to prove to insurers that the money they spend on health care is producing results. ealth care providers are more and more being paid for outcomes,
Valdes says. ayers want patients to stay on the system; now they can make sure that patients do.
when a hospital-based experiment proved, in principle, that it was possible to achieve near-normal blood-sugar control.
rather than through frequent injections. Soon after, a hospital system called Biostator GCIIS was released in Germany;
says Francine R. Kaufmann, the company chief medical officer and a practicing endocrinologist. Why the long delay between the proof of concept and routine use?
so the insulin can get to the liver more quickly. ut youe talking about surgery, Haidar says. f you have a 2-year-old daughter,
a medical geneticist who heads artificial pancreas research for the JDRF. A third kind of algorithm tries to model human physiology, for instance by considering how quickly food passes through your system
People with diabetes often carry a special pen charged with glucagon for others to use on them
But at a diabetes technology conference held in Paris this past February, funding organizations appeared to have doubled down on the simpler one-hormone system in the hope that it will get approved more easily.
As the millions of people with type 1 diabetes work out the kinks in the new technology,
it will spread to the hundreds of millions with type 2 diabetes, many of whom would also benefit from insulin
Erik had no qualms about signing up for brain surgery, but his mother wasn happy about it. he was just being a mom,
the surgery gave Sorto superhuman abilities. In the experiments, Sorto simply imagines reaching out to grab an object
To prepare for Sorto surgery in April 2013 the researchers first used functional magnetic resonance imaging to identify two precise regions of his parietal cortex that activated when he imagined reaching and grasping motions.
The surgeons implanted two tiny microelectrode arrays, each with 96 electrodes that could record the electrical activity of single neurons.
Within one month of surgery, Sorto was ready to get to work. The researchers connected cables to the pedestals, bringing the neural signals to a computer that analyzed them and sent commands to the robot arm.
Most of the prior studies in which paralyzed people used implanted BCIS were conducted by John Donoghue, director of Brown University Institute for Brain science and a pioneer in the use of implants in the motor cortex.
More than two years after his surgery, his electrodes are still functioning and his enthusiasm is undimmed.
#Doctors Can Now Successfully 3d Print A Knee joint While this footage isn as exciting as
Essentially, doctors at the Columbia University Medical center have been able to print a knee meniscus using a degradable plastic scaffold and a protein growth system.
there little that orthopedists can do to regenerate a torn knee meniscus, said study leader Jeremy Mao in a release. ome small tears can be sewn back in place,
which greatly increases the risk of arthritis. The scaffold isn just a plastic shell, however.
and shipping the scaffolds to patients and their doctors s
#Why It s Right To Report On The Sony Hack o one private life can totally withstand public scrutiny,
But more importantly, employees dealing with sensitive information seem not to understand that email is not a place where an HR employee needs to be detailing a child medical treatment,
or which child medical claims were being denied. The media has reported, however, that is the kind of information these documents contain.
a care management platform designed to help low-income Utah residents suffering from mental health issues.
Doctors prescribe antidepressants in the Beehive state at nearly twice the average rate in the U s. Speculation as to
Utah Smartcare partners with three local mental health authorities and 2 community health clinics in Utah.
one of the local mental health authorities participating in the Utah Smartcare initiative. his data will allow us to better assess how our clients are doing between appointments
Ginger. io is working separately on projects with UC San francisco, Partners Healthcare (Massachusetts General Hospital, Brigham and Women Hospital,
and Mclean Hospital), Duke university, UC Davis and University of Nebraska Medical center i
#TV s Disruption On Display As Netflix And Amazon Go Head-To-Head At Golden Globes More proof that good television doesn have to be developed by traditional industry players:
#Kinsa Raises $9. 6m Series A For A Smart Thermometer That Tracks The Spread Of Illness Kinsa the company behind the world s first app-enabled FDA-approved smart thermometer
which lets Kinsa track the spread of illness at schools and in other small communities.
#It s the most ubiquitous medical device in the world and we re simply piggybacking off of and improving regular behavior.#
Having a record of fever with a feature to take notes on prescriptions and symptoms that are dated automatically gives doctors valuable information
when diagnosing and treating issues. And when you add in social functionality parents can start to differentiate between a common cold (that may not require an immediate doctor visit) and strep throat.
Kinsa s Fluency program begins with a campaign that lets schools sign up to receive free Kinsa thermometer kits for each family.
The Kinsa costs $29. 99 and alongside hardware sales the company is considering how they can be a communications layer for other companies working on telemedicine prescription delivery and other startups in the health ecosystem.
Overtext Web Module V3.0 Alpha
Copyright Semantic-Knowledge, 1994-2011