Technology areas of interest include cloud applications, analytics, social media, mobile, materials, medical devices, digital health, healthcare IT, instruments and cloud software infrastructure.
The nanoparticles infused with silver ions were utilized to attack Pseudomonas aeruginosa, disease-causing bacteria; E coli, a bacterial species that cause food poisoning;
Staphylococcus epidermis, bacteria that form toxic biofilms on plastics such as catheters in the human body; and Ralstonia, a genus of bacteria that contains various soil-borne pathogens.
All these bacteria were destroyed by the newly developed nanoparticles. Using this latest technique, researchers can easily modify the nanoparticle recipe to target certain microbes.
The method released the stress in the laminate layer and avoided stress to build up between the two stacked layers.
Yet, more traditional approaches to thermocompression bonding come with long cycle times(>1 minute per die),
rapid, data-rich biomedical imaging. By merging data simultaneously collected by thousands of microlenses optical elements each smaller than the width of a human hair this new multispectral microscope is able to produce a continuous series of datasets that essentially reveal how much of multiple colors
Multispectral Imaging Color and Data Combinemultispectral imaging is used for a variety of scientific and medical research applications.
Medical researchers are able to study these frequencies to learn about the composition and chemical processes that are taking place within a biological sample.
This is essential for pharmaceutical research particularly cancer research--to observe how cells and tissues respond to specific chemicals and experimental drugs.
which find application in cancer treatment, pollution reduction, renewable energy collection. Scientists from Harvard, Boston, and Princeton universities have played also a role in the development of this innovative technique, called D Structure Identification of Nanoparticles by Graphene Liquid Cell EM (SINGLE),
and observe and study the biological and medical significance of RNA misregulation. Details will be published the week of July 20 in the journal Proceedings of the National Academy of Sciences (PNAS.
"Mirkin is the George B. Rathmann Professor of Chemistry in the Weinberg College of Arts and Sciences and professor of medicine, chemical and biological engineering, biomedical engineering and materials science and engineering.
which was the first genetic-based approach that is able to detect live circulating tumor cells out of the complex matrix that is human blood.
a start-up company, has developed a proprietary nano-polymer additive that protects against any microbial infection
or implant-associated infection, improve clinical outcomes and increase device longevity. The nano-polymer additive's unique features are that they are activated only upon contact,
Antimicrobial resistance (AMR) is considered to be the most urgent and important challenge of all medical fields.
"Unless we take significant actions to improve efforts to prevent infections. the implications will be devastating."
"1 NIH (National institutes of health) estimates that"Infectious diseases are the second cause of death worldwide, more than13 millions deaths per year (mostly due to bacteria.
More than 60%of microbial infections proceed with involvement of biofilms.""Prof. Ervin Weiss inventor and one of the developers of the nano-polymer additive technology adds,
and heavy metals, will revolutionize medical device industry. s
#Novel Method Utilizes Nanoparticles and UV LIGHT to Isolate, Extract Contaminants In a new paper published this week in Nature Communications,
for Integrative Cancer Research. Eliana Martins Lima, of the Federal University of Goiás, is the other co-author.
from environmental remediation to medical analysis. The polymers are synthesized at room temperature, and don need to be prepared specially to target specific compounds;
offering the example of a cheap testing kit for urine analysis of medical patients. The study also suggests the broader potential for adapting nanoscale drug-delivery techniques developed for use in environmental remediation. hat we can apply some of the highly sophisticated,
and an expert in nanoengineering for health care and medical applications. hen you think about field deployment,
including medicine, electronics and energy. Discovered only 11 years ago, graphene is one of the strongest materials in the world,
and someone with schizophrenia would be a leap in our understanding of how our brains shape who we are (or vice versa).
whether as result of accidents, injuries or illnesses, observes Huber. Under the motto he New Future of Old age the German Federal Ministry of Education and Research (BMBF) is sponsoring research projects for technical solutions such as akrobatik@home that help
while others suffer from hearing impairments. hese specific disabilities led to concrete ideas, explains Mizera. Three ideas were implemented by the researchers together with the thalidomide victims, Heidelberg University,
whether rotational, vertical or horizontal. hile users play, they unconsciously do recommended the exercises by therapists.
and stress would be too great. In a project funded by The swiss National Science Foundation (SNSF) Empa
and the University Hospital Zurich thus teamed up to develop the sensor Glucolight which gages the blood sugar level through the skin without taking any blood.
Glucolight spares the premature babies blood samples and enables the blood sugar level to be monitored permanently thanks to the sensor's novel measuring technology which comprises several parts:
A microdialysis measuring head which was developed at the University Hospital Zurich with a smart membrane developed at Empa;
The computer then uses these two different readings to calculate the premature baby's blood sugar level.
and the first clinical studies are scheduled at the University Hospital Zurich for 2015. However it could be years before the use of Glucolight becomes standard.
Empa and the University Hospital Zurich are currently in negotiations with partners for the industrial production of the sensor.
For the future the researchers also envisage the use of Glucolight in other fields such as diabetes s
The Saturas sensor provides accurate information for optimized irrigation to reduce water consumption with no stress to the plants and increases fruit production and quality.
--whose deregulation is associated with diseases ranging from diabetes to cancer to epilepsy--have gradually been brought to light.
No one doubts that this is an important pathway with implications for aging cancer and diabetes and we had figured out the core machinery of the pathway says Sabatini.
But the mystery has been what are the sensors? Now we've found what is likely the first nutrient sensor.
because hyperactivation of the pathway can lead to aberrant growth seen in cancer or metabolic abnormalities associated with diabetes.
Intriguingly because SLC38A9 activates the pathway it may represent a target for clinical situations in
In this case one could think about situations where you would want to increase protein synthesis perhaps to treat muscle atrophy and disease-related weight loss.
and medical care sectors to connect with general public and sub-health population. In particular wearable vital sign monitoring devices is set to revolutionize the healthcare and medical devices industry over the next few years.
In the hospital and home healthcare there are portable pulse oximeters that provide noninvasive continuous monitoring of individual's heart rate
and compared with a medical grade handheld pulse oximter. Human trial testing results shows that the accuracy of the wrist-worn pulse oximetry device closely agreed with the medical grade specifications said Jyh-Chern Chen President of Taiwan Biophotonic Co
. This report has been submitted to the journal of Biomedical Optics Express in Nov. 2014 for publication.
Founded by a team of experts from the Industrial Technology Research Institute (ITRI) the Taiwan Biophotonic Corporation has developed the world-leading noninvasive and wearable sensing technologies for healthcare
and medical devices said Ching-Yen Tsay Chairman of ITRI. This reflective pulse oximetry sensor is just the beginning of a line of wearable solutions that Taiwan Biophotonic Co. will be introducing this year.
and sales of medical and healthcare related products Headquartered from Hsin-chu Taiwan tbpc is dedicated to develop novel noninvasive sensing solutions that measure various physiological parameters for healthcare and medical care.
Danehorn and Holmström formed the company, Neosense Technology, with Lars Åke Brodin, a professor of medical engineering at KTH, with the hope of bringing their technology to market by 2018."
"When with severe inflammation of the stomach and intestines, infection and impaired lung function, bad blood oxygen control can be deadly,
Oxygenation at too high a level can cause damage to the retina, and blindness.""If we can contribute to better monitoring and stabilisation of oxygenation supply,
In the longer term, Neosense Technologies'technology could also be used for adults in intensive care and in cardiac and vascular surgery.
Neosense Technologies collaborates with both KTH, Karolinska University Hospital and Uppsala University Hospital s
#Portable, Autonomous Device Analyzes Trace elements in Water, Air and Upper atmosphere Researchers from Arizona State university School of Earth and Space exploration have combined their sensors,
since it is able to quantify pathogens, he doesn see it as a medical diagnostic tool. t designed for exploration,
he said. eing able to detect trace components, single molecules, autonomously and reliably, without the need for sample return or hardware consumables in a really tiny,
what our machine is all about. lthough there may be limited medical diagnostic applications, Youngbull envisions use of the device in homeland security, mass transit, public spaces, hospitals, schools, food production and combat theater analytics.
Autonomous, digital droplet PCR is useful for many aspects of science. The device might even one day be integrat ed into a rover,
and are under medical treatment because it will be an effective tool to know how many hours of sleep the patient is getting."
which via radio frequency sends"monitoring or results"to the doctor or specialist. He adds that as innovation is noninvasive,
The U s. Centers for Disease Control and Prevention have estimated that drug overdoses kill more than 44,000 Americans annually,
Concerned about these alarming statistics, experts at the Johns Hopkins Bloomberg School of Public health Center for Injury Research and Policy challenged a team of Johns Hopkins undergraduate mechanical engineers to design
said Kavi Bhalla, assistant professor at the university Bloomberg School of Public health and one of the team mentors for the project.
Andrea Gielen, director of the Johns Hopkins Center for Injury Research and Policy at the Bloomberg School of Public health and one of the team mentors, said she
#Scott & White Memorial Implants Miniaturized, Wireless Monitoring Sensor to Help Manage Heart failure Scott & White Memorial is one of six hospitals in Texas
and the first hospital in the Baylor Scott & White Health system to offer the device.
For more information watch this short video, click New Tech Helping Heart failure Patientse are always looking for new and innovative ways to treat our patient disease process
and improve outcomes for heart failure patients, said Robert Scott III, MD, Director for Advanced Heart failure at Scott & White Memorial. his device will give us the ability to anticipate problems with our patients before they occur,
decreasing their chance of being readmitted to the hospital, and improving their quality of life. emorial implemented the Cardiomems HF System
which is the first and only FDA-approved heart failure monitoring device proven to significantly reduce hospital admissions.
The device is a sensor that is implanted in the pulmonary artery (PA) during a minimally invasive procedure.
Once implanted, the device can measure and transmit PA pressure from the patient back to their healthcare team.
Elevation in PA pressure appears even before changes in weight and blood pressure in the patient,
which are used traditionally as indirect measures of worsening heart failure. The new system allows patients to transmit daily sensor readings from their homes to their health care providers allowing for personalized
and proactive management to reduce the likelihood of hospitalization and onset of debilitating symptoms. eart failure can rob patientsquality of life
and frequently results in repeated hospitalizations, said John Erwin III, MD, cardiologist at Scott & White Memorial. e think that we can provide significantly improved quality of life by partnering with the patient in acting preventatively as opposed to responding
when an adverse event occurs. eart failure occurs when the heart is unable to pump enough blood to meet the body demands.
According to the Centers for Disease Control and Prevention, more than 5. 1 million Americans have heart failure
Patients with heart failure are hospitalized frequently, have reduced a quality of life and face a higher risk of death.
#New Smart Insulin Patch May Replace Injections for Diabetics By Beth Ellisonthe mart insulin patchis a thin square a couple of millimetres large.
The research team found that the new patch could reduce blood glucose levels in a mouse model of type 1 diabetes for as long as nine hours.
with further preclinical tests and human clinical trials to come. The future potential of the device is highlighted by co-senior author Zhen Gu, Phd, a professor in the Joint UNC/NC State department of Biomedical engineering:"
"The whole system can be personalized to account for a diabetic's weight and sensitivity to insulin,
diabetes is maintained currently with frequent finger prick tests and insulin shots to control blood glucose levels.
"Injecting the wrong amount of medication can lead to significant complications like blindness and limb amputations,
or even more disastrous consequences such as diabetic comas and death.""This research team have removed the risk of human error by emulating the natural insulin generators of the body beta cells.
The team tested the patch on a mouse model of type 1 diabetes and compared it to injecting insulin as standard.
Regular insulin injections can cause blood glucose levels to plummet dangerously low the patch has been found not to pose this risk.
tell your dentist and even help you stop doing it. What more, the next version of the guard, currently under development, may be able to tell
when he was developing a set of dentures that alert the dentist to an improper fit
and can lead to damaged teeth, headaches, insomnia, and a sore jaw. Most people don even know they do it.
Wong thought the same thing. earing a mouth guard is less intrusive than spending time in a sleep clinic,
where a dentist or orthodontist can retrieve it, make a diagnosis and suggest treatment. hat kind of information has been unavailable until now,
Yoon said. The mouth guard is an improvement over traditional bruxism therapies, such as behavioral modification training during clinical sessions,
Wong said. he advantage is that the guard extends the treatment beyond the time spent in the clinic,
she said. his promises greater effectiveness and lower cost. Yoon said one population that could stand to benefit from the smart mouth guard is combat veterans with posttraumatic stress,
which can lead to bruxism. But the smart mouth guard potential extends beyond dentistry. The next iteration could be aimed at athletes.
which could give doctors early warning about the possibility of a concussion g
#Warwick Q-Eye Sensor Enables Rapid Identification of Materials in Terahertz Region A new type of sensor,
#DIRHA Prototype Enables People with Disabilities to use Voice as a Remote control to Access Home Devices Based on advanced voice recognition and audio signal processing technology,
The prototype was designed especially for people with disabilities and allows them to use their voice as a remote control to access services
#Researchers Report Completely Transparent Absorbers at Nonoperational Frequencies The manipulation of light has led to many applications that have revolutionized society through communications, medicine and entertainment.
real-time information about a patient, alerting medical professionals if there is a warning sign, for example high blood pressure or swelling.
#Novel Synthetic Biosensor Glows in Response to Conditions that Mimic TB Infection Robert Abramovitch, an MSU microbiologist,
a sulfa-based compound found in many prescription glaucoma drugs, actually turns off the bacterium's ability to invade the immune system.
"We found the compound reduces disease symptoms in mice.""According to Abramovitch, TB may not have eyes and ears,
One of these cues includes the infection's ability to detect ph -or acidity levels-which tells the disease it's being attacked by a host immune cell."
"The compound we found inhibits TB's ability to detect acidic environments, effectively blindfolding the bacterium
globally, carry the infection, but in most cases it lies dormant and the immune system is able to prevent it from spreading in the body."
"The immune system has difficulty clearing the infection and the TB bacterium is just waiting for the immune system to weaken."
"Abramovitch and his research team screened 273,000 different compounds in hopes of finding one that could possibly stop the disease.
By using a synthetic biosensor that glows green in response to conditions that mimic TB infection,
Yet, this elusive compound not only has the potential of preventing the disease from spreading, but Abramovitch suggests that it could help shorten the length of treatment
"Trying to kill TB bacteria isn't the only way of stopping the disease though, Abramovitch added."
disease using conventional X-ray mammography and ultrasound scans. The new ultrasound method will be safer and lower cost than currently-used screening techniques,
and end up at the clinic with health problems. In 2009, Indonesia passed a law banning fires on peat plantations.
US researchers have found that peat fires in the southern states during the summer of 2008 caused a spike in emergency room visits for heart failure and asthma-related respiratory complications.
Finer-grained particles are also harder to block with the simple surgical masks that many people in Asian cities have worn traditionally as protection against air pollution.
raise promise for medicine but also concerns about"home-brewed"illegal drugs. Experts have called for tight control of organisms genetically modified to produce narcotics.
and have the yeast do all the chemical steps required downstream to make your target therapeutic drug."
"Morphine plays a vital role in pain relief in many hospitals, but it requires a poppy harvest to manufacture.
The broad concept of using microscopic organisms to make drugs is not new in medicine.
Insulin for people with diabetes has been made in genetically modified bacteria for decades. But there are concerns these latest advances could allow a DIY drug lord to brew illegal narcotics in their home."
#Test unravels history of infection US researchers claim to have developed a single test that is able to identify past exposure to every known human virus infection,
The technique decodes the infection history imprinted in our immune response. The scientists hope that the test will eventually provide important insight into how viruses contribute to development of a range of diseases.
The work was published in the journal Science. During a virus infection, your immune system generates antibodies designed to fight the virus. Each antibody recognises a tiny fragment of the virus
and their interaction is very specific-they fit like a lock and key. Virus-specific antibodies can be long-lived;
often persisting many years after an infection has disappeared. So, your antibody repertoire represents a historical record of all of the viruses that have infected you.
so it allows you to discover connections between different populations or different diseases amongst groups of people."
The data showed that the number of virus infections detected in people increased during life.
The study also suggested that those living in the US were exposed to fewer infections than people living in South africa, Thailand or Peru."
the sensitivity of the population to infection or practices in the country",commented Prof Elledge.
The greatest number of virus infections that were detected in any single individual was around 25,
or HIV infection could be massaged up to very respectable levels, I'd be nervous about using it as a diagnostic test to see
if an individual patient has HIV infection.""However, it will be a fabulous tool for looking at virus-disease associations
which are speculative, or even currently unknown. For example, primary biliary cirrhosis (PBC) has been reported, controversially, to arise from viral infection,
so it would be great to compare the virome of PBC patients with those without the disease.
Maybe you'd identify a consistent pattern suggesting a specific viral cause.""Indeed any other disease of unknown aetiology-identifying specific virome reactivity could give a major clue as to a causative agent."
"And the technique might also shed light onto why new treatments-immunotherapies-that are being deployed in the fight against cancers work in some individuals and not in others.
Prof Elledge commented:""It's possible that the people that respond to therapy are responding
because they are taking advantage of existing immune responses to viruses, so we are looking at correlation in these patients to previous viral exposures to see
if exposure to a particular virus makes it more likely to respond
#Sweet source for aviation biofuel Researchers have identified a new way to produce aviation fuel from sugarcane biomass that could deliver substantial cuts in greenhouse gas emissions.
Importantly, the structures are stable enough to be used to make microscopic biomedical contraptions. The research is published in the journal Nature."
L'oreal currently grows skin samples from tissues donated by plastic surgery patients. It produces more than 100
"said Adam Friedmann, a consultant dermatologist at the Harley Street dermatology clinic.""I can understand why you would do it for severe burns or trauma but
"But printed skin has more value in a medical scenario, he thinks.""It would be a great thing to have stores of spare skins for burn victims
#Bionic eye implant world first Surgeons in Manchester have performed the first bionic eye implant in a patient with the most common cause of sight loss in the developed world.
Mr Flynn said he was delighted"with the implant and hoped in time it would improve his vision sufficiently to help him with day-to-day tasks like gardening and shopping.
The Argus II implant manufactured by the US firm Second sight, has previously been used to restore some vision to patients who are blind as a result of a rare condition known as retinitis pigmentosa.
The operation, at Manchester Royal Eye Hospital, is the first time it has been implanted in a patient with age-related macular degeneration (AMD)
which affects at least half a million people in the UK to some extent. I met Ray Flynn last month,
on the morning of his surgery and he explained that although his retained his peripheral vision,
and was led by Paulo Stanga, consultant ophthalmologist and vitreo-retinal surgeon at Manchester Royal Eye Hospital and professor of ophthalmology and retinal regeneration at the University of Manchester.
In a test, two weeks after surgery, Mr Flynn was able to detect the pattern of horizontal,
vertical and diagonal lines on a computer screen using the implant. He kept his eyes closed during the test
so that the medical team could be sure that the visual information was coming via the camera on his glasses and the implant.
"The implant cannot provide any highly detailed vision -but previous studies have shown it can help patients to detect distinct patterns such as door frames and shapes.
Mr Flynn should learn how to interpret the images from the implant more effectively. Four more patients with dry AMD will receive the implant at Manchester Royal Eye Hospital,
as part of a clinical trial. Prof Stanga said:""We hope these patients will develop some central visual function
Gregoire Cosendai of Second sight Medical Products, described the AMD study as"totally groundbreaking research"."The trial is being held in the Manchester Clinical Research Facility-funded by the National Institute for Health Research and Wellcome Trust,
which aims to bring new drugs and medical devices to patients. Cathy Yelf, of the Macular Society, said:"
and analyse our genes/DNA hold the potential for new and personalised medical treatments. But copying the huge amounts of information involved backwards
#Missing link found between brain, immune system--with major disease implications Vessels directly connecting brain, lymphatic system exist despite decades of doctrine that they don't.
and treatment of neurological diseases ranging from autism to Alzheimer's disease to multiple sclerosis.""Instead of asking,'How do we study the immune response of the brain?''
''Why do multiple sclerosis patients have the immune attacks?''now we can approach this mechanistically. Because the brain is like every other tissue connected to the peripheral immune system through meningeal lymphatic vessels,
Kipnis also saluted the"phenomenal"surgical skills of Igor Smirnov, a research associate in the Kipnis lab whose work was critical to the imaging success of the study.
Alzheimer's, Autism, MS and Beyond The unexpected presence of the lymphatic vessels raises a tremendous number of questions that now need answers, both about the workings of the brain and the diseases that plague it.
take Alzheimer's disease.""In Alzheimer's, there are accumulations of big protein chunks in the brain, "Kipnis said."
And there's an enormous array of other neurological diseases, from autism to multiple sclerosis, that must be reconsidered in light of the presence of something science insisted did not exist t
as well as lifestyle diseases such as obesity, cancer and mental disorders. The circadian rhythm is also related to seasonal reproduction,
which may overcome various circadian-related diseases and control reproductive activity in animals to provide solutions for food production.
and worked closely with the biologists at ITBM to synthesize molecules for studying structure-activity relationships (SARS)."Through SAR studies on the molecular derivatives of KL001,
which will surely contribute to medical applications, food production and advances in clock research. This has been a wonderful experience for
The relationship between genes and specific traits is complicated more than simple one-to-one relationships between genes and diseases.
but scientists are just beginning to explore how, specifically, genetic variations affect health and disease. Two major statistical challenges to finding these connections involve analysing associations between many different genetic variants and multiple traits,
"But the simple models we use to do this are too simplistic to uncover the complex dependencies between sets of genetic variants and disease phenotypes."
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