tumor growth, metastasis, recurrence and drug resistance. In epithelial cancers cancers of the breast, ovaries, prostate, skin and bladder,
and delivery of anticancer drugs by the same nanoparticles that have attached sirna to their outsides,
and to resist being killed by an antimicrobial molecule. The researchers demonstrated that their set of genetic tools
the treatment doesn carry the risk of side effects that are associated often with drug treatments. he pioneering study,
and as a drug-screening tool to make pregnancies safer. In experiments published in the journal Nature Communications, the researchers used biochemical and biophysical cues to prompt stem cells to differentiate
a senior investigator at the Gladstone Institute of Cardiovascular disease and a professor of medical genetics and cellular and molecular pharmacology at UC San francisco. his technology could help us quickly screen for drugs likely to generate cardiac birth defects,
which drugs are dangerous during pregnancy. Screening for drug toxicity To test the potential of the system as a drug-screening tool,
the researchers exposed the differentiating cells to thalidomide, a drug known to cause severe birth defects.
They found that at normal therapeutic doses the drug led to abnormal development of microchambers, including decreased size,
problems with muscle contraction and lower beat rates compared with heart tissue that had not been exposed to thalidomide. e chose drug cardiac developmental toxicity screening to demonstrate a clinically relevant application of the cardiac microchambers,
as many as 280,000 pregnant women are exposed to drugs with evidence of potential fetal risk. The most commonly reported birth defects involve the heart,
and the potential for generating cardiac defects is of utmost concern in determining drug safety during pregnancy.
and other UC Berkeley researchers publicly debuted a system of beating human heart cells on a chip that could be used to screen for drug toxicity.
Morgan Alexander, professor of biomedical surfaces in the School of Pharmacy at the University of Nottingham
it may be possible to improve the success rate of treatment by giving patients an antiviral medication as well as an antiparasite medication.
These were gathered through a project on drug resistance, funded by the European commission and led by co-author Jean-Claude Dujardin, Ph d.,of the Institute of Tropical Medicine, Antwerp, Belgium. n Peru,
in Peru and Bolivia, they receive a class of drugs called pentavalent antimonials. The modes of action of the two treatments are very different, according to Beverley. n the studies,
and antiviral medications for patients with virus-infected parasites, improving the chances of successful treatment.
and doctors together online, applying massive computing power to analyze DNA and even developing ingestible"smart"pills for detecting cancer.
Once enrolled, iphone owners use the apps to submit data on a daily basis, by answering a few survey questions
or taken medication that day.""I'm a Latina woman and there's a high rate of asthma in my community,
"None of the apps test experimental drugs or surgeries. Instead, they're designed to explore such questions as how diseases develop
or reminders about exercise and medication. In the future, researchers might be able to incorporate data from participants'hospital records,
as scientists have shown that using drugs to block PD-1 coaxes T cells to attack tumors.
and Jonathan Weissman, Ph d.,professor of cellular and molecular pharmacology at UCSF and a Howard hughes medical institute (HHMI) investigator.
and a drug for multiple sclerosis to control immune response in the brain. Under the two approaches, immune cells from outside the brain were found to travel in greater numbers through the blood into the brain.
an FDA-approved drug used for the treatment of multiple sclerosis; the drug has been shown to foster the migration of white blood cells from the bloodstream to the brain.
A third group received both treatments. All three groups experienced a substantial decrease in Alzheimer's-like pathology and symptoms.
and whether drugs could be developed to stop it from happening. North West Cancer Research (NWCR) has funded the research as part of a collaborative project between the University of Warwick and the University of Liverpool,
one of the authors of the study and Professor of Biotechnology and Therapeutics at the Graduate school of Pharmaceutical Sciences at Osaka University. ecause the new patch is so easy to use,
#"Pill On A String"Could Help Spot Early Signs Of Cancer Of The Gullet, University of Cambridge Study A ill on a stringdeveloped by researchers at the University of Cambridge could help doctors detect oesophageal cancer cancer of the gullet at an early stage,
The ytospongesits within a pill which, when swallowed, dissolves to reveal a sponge that scrapes off cells when withdrawn up the gullet.
and active pre-loaded, light-sensitive drugs only in that area
#First Artificial Ribosome Designed, University of Illinois Researchers Reveal Researchers at the University of Illinois at Chicago
The engineered ribosome may enable the production of new drugs and next-generation biomaterials and lead to a better understanding of how ribosomes function.
The artificial ribosome, called Ribo-T, was created in the laboratories of Alexander Mankin, director of the UIC College of Pharmacy's Center for Biomolecular Sciences
#Eisai launches In-house anticancer agent in Japan Japan's leading pharmaceutical company Eisai Co. Ltd. has launched its in-house developed novel anticancer agent Lenvima Capsule 4 mg
Discovered at Eisai's Tsukuba Research Laboratories and developed in-house, Lenvima is administered an orally molecular targeted agent that selectively inhibits the activities of several different molecules including VEGFR,
#Re-engineered antibiotic could fight drug-resistant bacteria The US scientists have created a promising second-generation antibiotic to fight against the bacteria that commonly cause respiratory and other infections,
have developed the antibiotics by changing the chemical structure of Spectinomycin, an old and weak antibiotic
"The rising problem of drug-resistant bacteria has created an urgent need for the new antibiotics that would help in mechanization use for the treatment of adults
which are resistant to commonly used antibiotics. The second-generation Spectinomycins demonstrated an increased in antibacterial activity against several other commonly caused respiratory infections such as Haemophilus influenza and Moraxella catarrhalis.
The Spectinomycin versions were also more effective against the bacteria which are mostly responsible for the cases like Legionnaires'disease and other sexually transmitted diseases such as gonorrhea and chlamydia.
#Approval for AIDS Vaccine at Canadian University The Food and Drug Administration has given Canadian researchers approval to test a vaccine for HIV/AIDS on humans.
#A Better Way to Make Unnatural Amino acids Discovered by Yu Certain amino acids that are not found in nature are highly sought after by pharmaceutical manufacturers.
and researchers expect that many of these nnaturalamino acids will be medically useful. his new technique offers a very quick way to prepare drug candidates
or building blocks for peptide drugs, explains Jin-Quan Yu, chemistry professor at The Scripps Research Institute (TSRI),
Proposed applications include anticancer drugs, antibiotics that are not susceptible to bacterial resistance, and drugs that inhibit the formation of amyloid aggregates seen in Alzheimer, Parkinson and other diseases.
An unnatural amino acid can be made by taking a natural amino acid or a closely related molecule and chemically modifying it.
and the pharmaceutical giant Bristol-myers squibb. nder this agreement we are putting the new methods to work to discover novel drug candidates,
we expect that these new developments will greatly expand the scope of research on unnatural amino acids as potential drugs or drug building-blocks. g
A recent article suggests that only one out of every 12 drugs that enters clinical trials succeeds
and the cost of a drug successfully reaching the market now exceeds an average of $5 billion
The risks and challenges associated with drug development will continue to be there for the foreseeable future.
I have noticed a promising trend the rise of open source drug R&d consortia that include large biotech
minimize failures and shorten the timeline to approval for new drugs helping bring treatments to the patients who need them the most.
In Sweden, Astrazeneca have followed this path, but interest in the concept has spread further down the discovery chain,
U s. economic leadership is being challenged by international competitors who are increasingly competing on the basis of technological innovation and scientific talent.
A recent study, commissioned by the Pharmaceutical Research and Manufacturers of America (Phrma) and undertaken by Battelle Technology Partnership Practice,
Bayer developed an entire website page dedicated to bee care. It holds general information on bees and
what Bayer is doing through research to improve bee health. You can find here information on how Monsanto is helping the honey bees keep on buzzinand the work the company is doing to restore habitats for the monarch butterfly.
For instance, there is an e-pill in trial that can be swallowed by livestock that can access respiration,
heart rates and help determine the health of the animals to prevent the spread of illnesswithout the use of antibiotics.
The basis of this led to the production of the sensor cap for milk cartons.
The US Food and Drug Administration (FDA) approved RFID chips for human implantation in 2004.
and doctors together online, applying massive computing power to analyze DNA and even developing ingestible"smart"pills for detecting cancer.
Once enrolled, iphone owners use the apps to submit data on a daily basis, by answering a few survey questions
or taken medication that day.""I'm a Latina woman and there's a high rate of asthma in my community,
"None of the apps test experimental drugs or surgeries. Instead, they're designed to explore such questions as how diseases develop
or reminders about exercise and medication i
#India's Largest Bank Commits $12. 5 Billion For Renewable energy Funding Private sector project developers in India rapidly growing renewable energy would be happy to have the backing of the country largest bank
The press release notes that the company new partnership program promotes sharing of profits as a basis for investors to take part
and demonstrate that wind propulsion technology has verifiable five-percent fuel savings on a yearly basis,
#Latest drug technology could help reduce cost of carbon capture A novel class of materials that enable a safer cheaper
Microcapsules have been used in a variety of applications--for example in pharmaceuticals food flavouring cosmetics and agriculture--for controlled delivery and release but this is one of the first demonstrations of this approach for controlled capture says Jennifer A. Lewis the Hansj rg Wyss Professor of Biologically Inspired Engineering at the Harvard School of engineering
and testing new medications in a safe setting outside the human body, said the team, led by Nenad Bursac, Duke university associate professor of biomedical engineering,
"We are working to test drugs'efficacy and safety without jeopardising a patient's health."
The team also demonstrated that the effect of drugs on the lab-grown tissue matched the effect seen in human patients.
They tested a variety of pharmaceuticals, such as statins, which are used to lower cholesterol, and clenbuterol, an off-label athletic performance enhancer.
This could allow future physicians to tailor pharmaceutical treatments to individual patients.""One of our goals is to use this method to provide personalised medicine to patients,
and experiment to see which drugs would work best for each person.""The team is already working towards this goal--as well as towards growing the muscle tissue, not from a biopsy,
Meanwhile a fluidic microchannel in the implant delivers neurotransmitting drugs to reanimate the nerve cells beneath the injured tissue.
#Electronic pill that helps you slim by tricking your tummy An electronic pill that tricks the brain into thinking the stomach is full could help tackle obesity.
The experimental pill works in the same way as gastric pacemakers to suppress appetite. A gastric pacemaker is an implant that is surgically placed in the stomach and wired to the vagus nerve.
This mesh stops the pill passing out of the stomach into the bowel. A powerful magnetic patch is applied then to the skin to draw the pill into position over the site where the vagus nerve runs through the abdomen-near the top of the stomach just under the breastbone.
This magnetic patch is worn round the clock and holds the smart pill in place. When it senses muscle contractions that tell it food is entering the stomach,
the pill begins to transmit signals along the nerve to the brain to dampen down appetite.
The pill is designed to disintegrate after three to four weeks. Powerful acid in the stomach dissolves the mesh
and the shell housing the tiny electronics, which then pass harmlessly out of the body as waste.
The patient can be given more pills if they still need to lose weight. The device is expected to enter clinical trials in the next year or so.
even when medication is known to be effective. v
#Mutebutton can train your brain to ignore tinnitus By Roger Dobson for the Daily mail Published:
although treatments such as maskers (ear-plugs that generate white noise to try to block out tinnitus noise), antidepressants,
'Current methods for testing ICP require procedures to be carried out under sedation or anaesthetic, which means they are limited to the most severe cases
A basis for'normal'was determined using a large database of test results. By comparison 20/40 vision means the test subject sees at 20ft what a'normal'person sees at 40ft.
paedophiles and drug dealers in the online underworld The deep web is a hive of illegal activity,
for example, help catalog the vast amounts of data NASA spacecraft deliver on a daily basis.'We're developing next-generation search technologies that understand people, places,
when the FBI made a series of raids on Silk road-an online marketplace described as the'ebay for illegal drugs'.
and patients have to take powerful immunosuppressant drugs -which weaken the immune system to prevent the rejection of a transplant-for life.
then it could be enhanced or supressed with the use of drugs. Dr Poon said: rogrammed cell death occurs throughout life in essentially all tissues in the human body as part of the normal process of development and death,
'Importantly we've also discovered drugs that affect this process so, once we know more,
But despite the drug's legal status in many parts of the world, the debate rages as to
And weaker evidence still that the drug eased nausea and vomiting in chemotherapy patients, sleep disorders,
And there was very-low quality evidence the drug eased anxiety. In addition, Dr Whiting and her team found weak evidence to support the claim that medicinal cannabis has no effect on psychosis,
Meanwhile, the drug was linked with several adverse effects. Notably, cannabinoids were found to cause dizziness, dry mouth, nausea, fatigue, euphoria, vomiting, disorientation, drowsiness, confusion, a loss of balance and hallucination.
needs to be handled on a case-by-case basis . But Oblivion would speed up this process and confirm the validity of the claims within seconds.'
needs to be handled on a case-by-case basis'As of now, these technical means consist of a web form that requires a user to manually identify all relevant links herself upfront
#Scientists crack morphine gene in poppies amid homebrew drugs fears Scientists have identified a key gene used by poppies to make morphine.
The discovery paves the way for better methods of producing the medically important drug, potentially without the need for cultivating poppy fields.
The latest finding follows recent success in engineering brewer's yeast to synthesise opiates such as morphine and codeine from a common sugar, boosting the prospect of'home-brew'drug supply.
But whether making morphine in bubbling vats of yeast will be commercially viable-either for drug companies
or criminal gangs-is far from certain, since poppies are very efficient natural factories, researchers say.'
'he told Reuters. That could lead to agricultural production of drugs such as noscapine, a cough-suppressant that may also fight cancer,
as well as improved plant strains with higher yields of morphine. The University of York team worked on the project with scientists from Glaxosmithkline.
The drugmaker has long been a major supplier of opiates but agreed in March to sell its Australian-based business to India's Sun pharmaceutical Industries.
For centuries opiates have been the go-to drugs for pain relief and they remain the most potent treatments for severe pain,
generating global prescription sales of around $12 billion annually. Morphine and codeine are used directly as painkillers while a third compound,
thebaine, is a starting-point for semisynthetic opiates, including oxycodone and hydrocodone. The molecular structure of these drugs is so complex that chemists have never been able to produce them from off-the-shelf components.
But understanding the genetics means it is now possible to engineer a microbe like yeast to do the job.
The gene plays a vital role in the back-to-back steps in the plants'morphine-producing pathway by converting a compound known as (S)- reticuline into a variation called (R)- reticuline u
Separately, a similar Novartis gene therapy trial is under way to help restore hearing in people who have become deaf through damage or disease.
Work at Novartis is advanced more, with the first patient treated last October in an early-stage clinical trial that will recruit 45 subjects in the United states,
Novartis research head Mark Fishman describes it as a'spare parts'approach to fixing ageing-related frailty.
disease or exposure to certain drugs, including some antibiotics. But it will not help the one to three babies per 1
The new hearts will allow new drugs to be tested, and give researchers a new insight into how the heart develops.
and a drug-screening tool to make pregnancies safer.''We believe it is the first example illustrating the process of a developing human heart chamber in vitro,
who is co-senior author of the study with Dr. Bruce Conklin, a senior investigator at the Gladstone Institute of Cardiovascular disease and a professor of medical genetics and cellular and molecular pharmacology at UC San francisco.'
'This technology could help us quickly screen for drugs likely to generate cardiac birth defects, and guide decisions about
which drugs are dangerous during pregnancy.''Published in the journal Nature Communications, the researchers used biochemical and biophysical cues to prompt stem cells to differentiate
To test the potential of the system as a drug-screening tool, the researchers exposed the differentiating cells to thalidomide,
a drug known to cause severe birth defects. They found that at normal therapeutic doses, the drug led to abnormal development of microchambers, including decreased size,
problems with muscle contraction and lower beat rates compared with heart tissue that had not been exposed to thalidomide.'
'Each year, as many as 280,000 pregnant women are exposed to drugs with evidence of potential fetal risk.
and the potential for generating cardiac defects is of utmost concern in determining drug safety during pregnancy.'
and other UC Berkeley researchers publicly debuted a system of beating human heart cells on a chip that could be used to screen for drug toxicity.
and other planets all while burning calories and toning muscles. he first design model was developed on the basis of VR in 2012,
The Scio handheld spectrometer instantly analyzes foods and pharmaceuticals at a molecular level; a quick scan provides nutritional info,
or authenticates medications. Cold butter meets its match with the Butterup knife. Your bread will thank you c
and philosophies that form the basis of the Amelia platform, convinced that his research into cloning human thought processes would stretch no longer than a couple of years.
#This MIT Grad Is Changing Medicine With a Needle-Covered Pill While medical injections are unpleasant and inconvenient, theye also necessary for people with illnesses like diabetes.
Carl Schoellhammer, 28, has created a pill that would render syringes unnecessary. A graduate student at MIT, he recently won $15, 000 at the Lemelson-MIT National Collegiate Student Prize in the health-care category. hen I received the phone call telling me I won,
His prizewinning innovation is the Microneedle Pill (mpill an ingestible capsule covered in microneedles--that is,
The pill allows drugs that are injected typically to be delivered directly into the gastrointestinal tract. he GI TRACT is a dense network of blood capillaries,
Schoellhammer explains. he outer layer is a bit of a barrier so the needles are a nice way to introduce a drug into the tissue
the drug gets into your system faster than it would if administered via injection. Although an image of the pill that was used in testing might remind people of a cactus or a porcupine,
the plan is for the pill to be coated smaller and when it hits the market.
The coating will dissolve in stomach acid, freeing the needles to introduce the medicine. Once the drugs are delivered,
the capsule can pass through the body safely. In the future, though, Schoellhammer hopes he can create the needles out of crystallized sugar.
pharmaceutical giant Novartis announced this week that it testing similar technology through a collaboration with a startup called Rani Therapeutics.
Needle-covered pills aren the only thing up Schoellhammer sleeve. He working on the Ultrasound Probe (uprobe
The latest was undisclosed a previously breach at a U s. pharmaceutical group, which cost the firm hundreds of millions of dollars in sensitive research and development work.
and disclose how they are managing them on a voluntary basis. Almost 50 investors are signed up to the Montréal Pledge launched late last year
and publicly disclosing the carbon footprint of their investment portfolios on an annual basis. The new legal requirement is contained in Article 48 of The french Energy Transition Law
We strive to make water conservation efforts prevalent in our operations on a daily basis. A resource this precious cannot be preserved nor can access be maintained
or agic bulletto describe new drugs he was working on to cure syphilis and cancer. In theory, such drugs would leave healthy tissue intact
while targeting only the diseased. Psychologists later appropriated this term to describe the phenomenally widespread panic that ensued
the country is nonetheless leading the way in developing robots that can assist nurses with the enormous workloads they handle on a daily basis. The latest example is from researchers at Toyohashi University of Technology,
history, and medications are available instantly on the robot display for reference. Terapio can recognize possible allergies and potentially dangerous medication interactions.
And naturally, when not displaying data, the display shows the robot ace, which offers a friendly smile
and in theory work as the basis for a next-generation computer processor. Happily, this purely theoretical study was supplemented by another, practical one,
DNA microcapsules have been studied for their potential to deliver drugs directly to where theye needed most.
chocolate, baked and dairy products and pharmaceutical syrups, while a second generation particle called S2 can be used in beverages.
They would have no reason to think differently from the Food and Drug Administration (FDA),
You look at Watson ability to help pharmaceutical researchers, to help oncologists find targeted diagnoses. In each of these cases, Watson reads
#Device delivers drugs to brain by remote control A new wireless device the width of a human hair can be implanted in the brain
and activated by remote control to deliver drugs. The technology, demonstrated for the first time in mice, may one day be used to treat pain, depression, epilepsy,
the research is a major step forward in pharmacology and builds on earlier work in optogenetics, a technology that makes individual brain cells sensitive to light
researchers made the tiny wireless devices capable of delivering drugs directly into the brain, with the remote push of a button.
it should be possible to manufacture therapeutic drugs that could be activated with light, says co-principal investigator Michael R. Bruchas, associate professor of anesthesiology and neurobiology at Washington University in St louis. ith one of these tiny devices implanted,
we could theoretically deliver a drug to a specific brain region and activate that drug with light as needed.
This approach potentially could deliver therapies that are targeted much more but have fewer side effects. Previous attempts to deliver drugs or other agents
such as enzymes or other compounds, to experimental animals have required the animals to be tethered to pumps
But the new devices were built with four chambers to carry drugs directly into the brain.
By activating brain cells with drugs and with light, the scientists are getting an unprecedented look at the inner workings of the brain.
If we want to influence an animal behavior with light or with a particular drug, we can simply point the remote at the animal
OTHER PARTS OF THE BODY, TOO As part of the study, the researchers showed that by delivering a drug to one side of an animal brain
But the researchers were able to interfere with that light-activated pursuit by remotely controlling the release of a drug that blocks the action of dopamine on its receptors.
the devices contain only four chambers for drugs, but in the future, the researchers hope to incorporate a design much like a printer ink cartridge
so that drugs can continue to be delivered to specific cells in the brain, or elsewhere in the body, for as long as required without the need to replace the entire device.
says Dandekar. ithout drugs, the virus can come back at the same threat level for patients.
The UC Davis team may have succeeded with PEP005, the active ingredient in the FDA-approved anticancer drug PICATO
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