#The time? About a quarter past a kilogram Physicists have created an atomic clock that relies on a fundamental link between time and mass.
#Synthetic vaccine could prevent future outbreaks of foot-and-mouth disease Virologists have devised a way to create an entirely synthetic vaccine for foot-and-mouth disease.
The vaccine could prevent future outbreaks of the disease, and potentially lead to new treatments for polio and other human diseases.
and spurred a decision to protect against future outbreaks with vaccination rather than mass slaughter.
however a vaccine made from inactivated virus caused another UK outbreak. The authors say that there is absolutely no chance that their new vaccine could revert into an infectious virus
because it contains no viral genes. Also being entirely synthetic, it cannot be contaminated with live virus during manufacturing.
It will be 6-8 years before the vaccine is available to farmers, they estimate. But if the method used to create the vaccine proves successful when scaled to commercial production,
it could also be used to create vaccines for human diseases that are caused by viruses of the same family, such as hand, foot and mouth disease,
which is ubiquitous in Southeast asia, and polio, which still blights the lives of millions of people in the developing world."
But if we could use this to move away from inactivated polio viruses in the vaccines,
Earlier attempts to produce a synthetic vaccine for foot and mouth disease were thwarted often by peculiarities of viral geometry.
The team got around the problem by engineering the vaccine to have disulphide bonds cross-linking the protein triangles together.
and Charleston that the new vaccine is unable to cause an infection or outbreak. Marvin Grubman, an animal-disease researcher at the US Department of agriculture in Orient Point, New york, says that the new vaccine"is a good piece of work,
but certainly not very novel, pointing to a foot-and-mouth vaccine his team devised that uses adenovirus to deliver empty viral shells.
That vaccine, he says, has been approved for use in the United states for cases of emergency. The authors however point out that their vaccine does not require the injection of live viruses
and that it would be suitable for preventive vaccination as well as in cases of severe outbreaks o
#Scientists map protein that creates antibiotic resistance Japanese researchers have determined the detailed molecular structure of a protein that rids cells of toxins,
but can also reduce the effectiveness of some antibiotics and cancer drugs by kicking them out of the cells they are targeting.
as opposed to a medical device, and therefore hasn undergone any testing, except those required by the Underwriter Laboratory to ensure its electrical safety.
think about public health it impacts all of those areas. We think of this technology as a tremendous way to sort of improve the system. he company ags,
who also has a Masters of Public health degree from Harvard university, a big component of this company is to empower consumers to understand what they are putting into their bodies,
where health care workers rapidly screened 96 patients for HIV and active and latent forms of syphilis. Compared with gold standard laboratory tests,
But the Korean patient appears to have infected at least 22 family members, health care workers, and fellow patients at a hospital where he was treated from 15 may to 17 may.
but for developing vaccines and studying links between viruses and chronic disease. his is really a technical tour de force,
That observation could inform future vaccine development, he says. Whether the test really catches everything is up for debate,
says immunologist Richard Koup, deputy director of the Vaccine Research center at the National Institute of Allergy and Infectious diseases (NIAID) in Bethesda, Maryland,
who are demonstrating delivery of vaccines in Africa. Delta Drone in France is using the platform for open-air mining operations,
which can be obtained with a finger prick making the procedure minimally invasive and much easier for health care workers than drawing blood intravenously.
But all that time spent in hospitals soon opened their eyes to a major health care issue:
and working with a Dutch health care insurance company to bring the Medeye to 15 hospitals across the country as well as Belgium the United kingdom and Germany.
As an entire system that requires no change in a hospital s workflow or logistics it s more usable and more accessible in health care facilities.
At the same time he started taking heed of MIT s burgeoning startup ecosystem prompting him to contact his longtime medical device colleague.
It can take up to a year to determine the function of a single gene which has slowed efforts to develop new more targeted drugs and vaccines.
whether it s drugs or vaccines says Niles the senior author of a paper describing the technique in the Aug 10 online edition of Nature Methods.
which could generate new drug and vaccine targets. I think the impact could be quite huge Niles says.
the first vaccine against cervical cancer; and many other breakthroughs. Instead of retiring Scolnick took on a new challenge:
Scolnick served as a member of Hyman s National Advisory Mental health Council from 1998 to 2002
This is where we re Going with an expected rise of wireless charging one promising future application Soljacic sees is in medical devices especially implanted ventricular assist devices (or heart pumps) that support blood flow.
for example, if a refrigerated vaccine has ever been exposed to temperatures too high or low. The paper lead authors are MIT postdoc Jiseok Lee and graduate student Paul Bisso.
however, is most likely in health care, with the potential for clinical diagnostics or rapid detection of contamination in hospital rooms with the aim of decreasing the 1. 7 million cases of hospital-associated infections recorded in the United states each year.
and for our understanding of how infections take hold in medical devices. The findings the result of microscopic analysis of bacteria inside microfluidic devices were made by MIT postdoc Roberto Rusconi former MIT postdoc Jeffrey Guasto (now an assistant professor of mechanical engineering at Tufts
#Hitchhiking vaccines boost immunity Many vaccines, including those for influenza, polio, and measles, consist of a killed or disabled version of a virus. However, for certain diseases,
this type of vaccine is ineffective, or just too risky. An alternative, safer approach is made a vaccine of small fragments of proteins produced by a disease-causing virus or bacterium.
This has worked for some diseases, but in many cases these vaccines don provoke a strong enough response.
Now a team of engineers at MIT has developed a new way to deliver such vaccines directly to the lymph nodes
where huge populations of immune cells reside: These vaccines hitch a ride to the lymph nodes by latching on to the protein albumin, found in the bloodstream.
In tests with mice, such vaccines produced very strong immune responses, the researchers report in the Feb 16 online edition of Nature. he lymph nodes are where all the action happens in a primary immune response.
T cells and B cells reside there, and that where you need to get the vaccine to get an immune response.
The more material you can get there, the better, says Darrell Irvine, a professor of biological engineering and of materials science and engineering,
This approach could be especially useful for delivering HIV vaccines and for stimulating the body immune system to attack tumors,
Free ride Vaccines made of protein or sugar fragments, also known as subunit vaccines, have been successful against a few diseases, such as hepatitis and diphtheria.
To develop subunit vaccines for other diseases, scientists have tried targeting them to lymph nodes using nanoparticles to deliver them,
or tagging them with antibodies specific to immune cells in the lymph nodes. However these strategies have had limited only success,
because it is difficult to get all of the vaccine to the lymph nodes without some escaping to the rest of the body,
immune cells in the lymph nodes efficiently capture the albumin. e realized that might be an approach that you could try to copy in a vaccine design a vaccine molecule that binds to albumin
so the researchers added a fatty tail called a lipid to their vaccine peptides. They created a few different vaccines
targeting HIV, melanoma, and cervical cancer, and tested them in mice. Each one generated a large population of memory T cells specific to the viral
one in three T cells in the blood was a vaccine-specific T cell, which is something you usually only see with vaccines delivered by viruses. The albumin-targeted vaccines provoked immune responses five to 10 times stronger than those generated by the peptide antigens alone.
The melanoma vaccine slowed cancer growth and the cervical cancer vaccine shrank tumors. t certainly is an interesting approach,
and the results are very convincing, says Pal Johansen, a professor of dermatology at University Hospital Zurich who was not part of the research team. oth the effect on the stimulated immune responses
and the consequential suppression of tumor growth are results that would suggest further development and clinical testing.
Controlled inflammation The researchers also tested this delivery strategy with an adjuvant a molecule that enhances the immune responses of vaccines.
The researchers are planning to test this method to deliver HIV vaccines in nonhuman primates,
and they are also working on further developing cancer vaccines, including one for lung cancer. The research was funded by the Koch Institute Support Grant from the National Cancer Institute, the National institutes of health, the U s. Department of defense,
#Cochlear implants with no exterior hardware Cochlear implants medical devices that electrically stimulate the auditory nerve have granted at least limited hearing to hundreds of thousands of people worldwide who otherwise would be totally deaf.
The researchersdesign exploits the mechanism of a different type of medical device known as a middle-ear implant.
that sheds empirical light on the inner workings of health care in the U s. The study takes advantage of Oregon recent use of a lottery to assign access to Medicaid, the government-backed health-care plan for low-income
along with Katherine Baicker, a professor at the Harvard School of Public health. The study, which is being published today in the journal Science,
However, Medicaid also lowers the out-of-pocket costs of other types of health care, such as primary-care doctors.
#Creating a permanent bacteria barrier Any medical device implanted in the body attracts bacteria, proteins, and other microbes to its surface, causing infections and thrombosis (blood clotting) that lead to hundreds of thousands of deaths annually.
and CEO David Lucchino MBA 6 is developing a novel biomaterial for implanted medical devices that permanently barricades these troublesome microbes from the device surface.
when applied to a medical device, sprouts a thicket of polymers that attract water, creating an impenetrable barrier for microbes.
In 2012, Semprus sold to a medical device-manufacturing giant for an amount that could reach $80 million.
and recently earned clearance from the Food and Drug Administration as a medical device deemed safe and effective for commercial distribution in the United states. It also recently received designation as a product meeting European union standards of health, safety,
a chemical engineering Phd student, was charged with developing medical devices that could permanently be inserted in the body without triggering an immune response in other words,
creating medical devices that ooked more human, Loose says. Loose developed a means of applying naturally occurring antibiotics,
and human sweat on medical devices. These peptides would puncture bacteria that came near, and microbes would have trouble developing resistance to them.
So they ent to schoolon the medical device market, canvassing hospitals to meet patients and to talk with nurses and doctors about unmet clinical needs. e learned quickly that the most successful entrepreneurs are good listeners,
Loose says, they were ahead of the curve in addressing the nmet needof the medical devices market. e realized an unmet need that was going to grow over the next few years
Blood transfusions can sometimes prevent such attacks, but there are currently no good ways to predict when a vaso-occlusive crisis,
annually in unnecessary health care costs from additional hospital visits and other issues. Failure to follow prescriptions, the study also found, causes around 125,000 deaths annually and up to 10 percent of all hospitalizations.
and an expert in nanoengineering for health care and medical applications. hen you think about field deployment,
Because our research demonstrates a clear cardiovascular health risk associated with this trend steps need to be taken to help ensure that potential health
For example conventional manufacturing techniques are not practical for medical devices that need to be fit to a patient's particular shape
Researchers at the University of Basel and The swiss Tropical and Public health Institute have developed now so-called nanomimics of host cell membranes that trick the parasites.
This could lead to novel treatment and vaccination strategies in the fight against malaria and other infectious diseases.
For many infectious diseases no vaccine currently exists. In addition resistance against currently used drugs is spreading rapidly.
and vaccines strategies in the future says Adrian Najer first-author of the study. Since many other pathogens use the same host cell receptor for invasion the nanomimics might also be used against other infectious diseases.
According to TAU doctoral student and research team member Dr. Lilach Bareket there are already medical devices that attempt to treat visual impairment by sending sensory signals to the brain.
#Breakthrough in flexible electronics enabled by inorganic-based laser lift off Flexible electronics have been touted as the next generation in electronics in various areas ranging from consumer electronics to bio-integrated medical devices.
#Paper electronics could make health care more accessible Flexible electronic sensors based on paper an inexpensive material have the potential to some day cut the price of a wide range of medical tools from helpful robots
#'Stealth'nanoparticles could improve cancer vaccines Cancer vaccines have emerged recently as a promising approach for killing tumor cells before they spread.
Now scientists have developed a new way to deliver vaccines that successfully stifled tumor growth when tested in laboratory mice.
And the key they report in the journal ACS Nano is in the vaccine's unique stealthy nanoparticles.
Hiroshi Shiku Naozumi Harada and colleagues explain that most cancer vaccine candidates are designed to flag down immune cells called macrophages and dendritic cells that signal killer T cells to attack tumors.
But how could one get a vaccine to these special immune cells without first being gobbled up by the macrophages
When molecules for signaling killer T cells were put inside the nanoparticles they hindered tumor growth far better than existing vaccines.
Hitchhiking vaccines boost immunity More information: Nanogel-Based Immunologically Stealth Vaccine Targets Macrophages in the Medulla of Lymph node
and Induces Potent Antitumor Immunity ACS Nano 2014 8 (9) pp 9209#9218. DOI: 10.1021/nn502975r Because existing therapeutic cancer vaccines provide only a limited clinical benefit a different vaccination strategy is necessary to improve vaccine efficacy.
We developed a nanoparticulate cancer vaccine by encapsulating a synthetic long peptide antigen within an immunologically inert nanoparticulate hydrogel (nanogel) of cholesteryl pullulan (CHP.
After subcutaneous injection to mice the nanogel-based vaccine was transported efficiently to the draining lymph node and was engulfed preferentially by medullary macrophages
but was sensed not by other macrophages and dendritic cells (so-called immunologically stealth mode). Although the function of medullary macrophages in T cell immunity has been unexplored so far these macrophages effectively cross-primed the vaccine-specific CD8+T cells in the presence of a Toll-like receptor (TLR) agonist as an adjuvant.
The nanogel-based vaccine significantly inhibited in vivo tumor growth in the prophylactic and therapeutic settings compared to another vaccine formulation using a conventional delivery system incomplete Freund's adjuvant.
We also revealed that lymph node macrophages were highly responsive to TLR stimulation which may underlie the potency of the macrophage-oriented nanogel-based vaccine.
These results indicate that targeting medullary macrophages using the immunologically stealth nanoparticulate delivery system is an effective vaccine strategy e
#Nanoparticles accumulate quickly in wetland sediment (Phys. org) A Duke university team has found that nanoparticles called single-walled carbon nanotubes accumulate quickly in the bottom sediments of an experimental wetland setting an action they say could indirectly damage the aquatic food chain.
which could lead to an associated reduction in health risks. Supercapacitors are Bluevine Graphene Industries'second application under development for its Folium graphene.
An atomically thin two-dimensional ultrasensitive semiconductor material for biosensing developed by researchers at UC Santa barbara promises to push the boundaries of biosensing technology in many fields from health care to environmental protection to forensic industries.
#Researcher's nanoparticle key to new malaria vaccine A self-assembling nanoparticle designed by a UCONN professor is the key component of a potent new malaria vaccine that is showing promise in early tests.
For years, scientists trying to develop a malaria vaccine have been stymied by the malaria parasite's ability to transform itself
The key to the vaccine's success lies in the nanoparticle's perfect icosahedral symmetry (think of the pattern on a soccer ball)
In tests with mice, the vaccine was 90-100 percent effective in eradicating the Plasmodium falciparum parasite
the world's most advanced malaria vaccine candidate currently undergoing phase 3 clinical trials, which is the last stage of testing before licensing."
"Both vaccines are similar, it's just that the density of the RTS, S protein displays is much lower than ours,
"The homogeneity of our vaccine is much higher, which produces a stronger immune system response. That is why we are confident that ours will be an improvement."
"With RTS, S, only about 14 percent of the vaccine's protein is from the malaria parasite.
The search for a malaria vaccine is one of the most important research projects in global public health.
It took the researchers more than 10 years to finalize the precise assembly of the nanoparticle as the critical carrier of the vaccine
"Testing the vaccine's efficacy was difficult because the parasite that causes malaria in humans only grows in humans,
and put in its DNA a piece of DNA from the human malaria parasite that we wanted our vaccine to attack.
That allowed us to conduct inexpensive mouse studies to test the vaccine before going to expensive human trials."
A request for an additional $7 million in funding from the U s army to conduct the next phase of vaccine development, including manufacturing
"We are on schedule to manufacture the vaccine for human use early next year, "says Lanar."
or more before the vaccine is available for licensure and public use, Lanar says. Martin Edlund, CEO of Malaria No more, a New york-based nonprofit focused on fighting deaths from malaria,
says,"This research presents a promising new approach to developing a malaria vaccine. Innovative work such as what's being done at the University of Connecticut puts us closer than we've ever been to ending one of the world's oldest
holds the patent on the self-assembling nanoparticle used in the malaria vaccine. Burkhard is also exploring other potential uses for the nanoparticle,
including a vaccine that will fight animal flu and one that will help people with nicotine addiction.
Professor Mazhar Khan from UCONN's Department of Pathobiology is collaborating with Burkhard on the animal flu vaccine e
from prosthetic skin to electronic paper, for implantable medical devices, and for flexible displays and touch screens. They can be used in rubberlike electronic devices that,
In addition to solving the longstanding problem of productivity for monoclonal antibodies the nanoparticle approach can be applied to many other therapeutic proteins and also to viral vaccines.
and telecommunications medical devices and security he says. If these could be made flexible they could be integrated in clothes rolled up
Personalised medicine is one of the new developments that is deemed to revolutionise health care. A key component is the detection of biomarkers, proteins in blood or saliva, for example,
vaccinations, cancer imaging and other medical treatments. Currently, the predominant practice is using viruses for delivery to cells.
and medical devices and even fast food and using it to create next generation battery materials, "said Zachary Favors,
They envision the fiber supercapacitor could be woven into clothing to power medical devices for people at home or communications devices for soldiers in the field.
and U s. federal agencies want to fast-track human trials of a promising vaccine. If all goes well,
the vaccine may be available sometime in 2015, Anthony Fauci, director of the National Institute of Allergy and Infectious diseases, told USA Today.
It notably supports citizen empowerment through self management of health and disease health promotion and disease prevention.
Most astronauts complete medical training which equips them with the skills to perform procedures such as first aid and basic surgery.
#Sharp futuristic Health care Support Chair a proactive health care solution Sharp has developed a health care support chair that combines a range of sensors for checking the user health.
 â##The technology will empower health care facilities to more effectively use their limited resources to deliver greater value in the increasingly resource-constrained U s. health care environment. â#SEDASYS will cost about $150 per procedure on a fee-peruse plan from J&j
Nursing care robots are designed to fulfill functions which help patients live independently and reduce the burden on caretakers.
and mobility technologies developed by irobot with state-of-the-art telemedicine and electronic health record integration developed by Intouch Health.
#Kubi telemedicine device gets HIPAA clearance for streaming medical data Revolve Robotics and Swymed have collaborated to create a HIPAA compliant telepresence device called Kubi that can stream medical data.
While there are other telemedicine apps out there that provide consultations, like Teledoc or Doctor on Demand,
business and economic growth does need not to happen at the cost of the environment and public health and safety.
Beyond inspiring curiosity, Prakash hopes Foldscopes can help health care workers quickly, cheaply and safely diagnose blood-borne illnesses in the field."
was conducted by a team from the Vaccine Research center at the U s. National Institute of Allergy and Infectious diseases (NIAID) in Bethesda, Maryland.
director of NIAID Vaccine Research center and head of the group reporting the Nature Communications study.
says draining a reservoir ultimately may require combining bispecific antibodies with other latency reversing approaches and immune system stimulators like anti-HIV vaccines.
a professor of immunology and infectious diseases at Harvard School of Public health who was involved not in the research. trikingly,
cell-instructive implants, engineered tissue and organ replacements, hybrid medical devices and therapeutic cell and molecule delivery.
She recently received a grant from the Pediatric Medical device Consortium at the Children's Hospital of Philadelphia to research this possibility.
Medical devices designed to reside in the stomach have a variety of applications, including prolonged drug delivery, electronic monitoring,
#Unexpected Discovery Offers Insight into Mechanisms of Asthma, Other Diseases A new study from the Harvard T. H. Chan School of Public health reveals an unexpected discovery In people with asthma,
While medical devices that remain in the body may be jostled out of place or fail to cover the hole as the body grows,
sterilize medical devices, and even to make diamonds green and pearls black. A key accelerator parameter is the acceleration gradient,
medical devices and Internet of things devices anything that doesn require massive amounts of electricity. It will be launching on Kickstarter in one month for $99,
150, were associated with inpatient stays in health care facilities, according to the Active Bacterial Core surveillance report by the Centres for Disease Control and Prevention in US.
This inspiring 3d printing venture has been developed by actual public health physician dr. Wong, who realized that 3d printers are making life in the west much easier,
drafts on the individual customization of the medical devices regulations will be introduced for comment, he adds. That will hopefully bode very well for the future d
K2m, a global medical device company focused on developing complex and minimally invasive spine solutions for patients suffering from the most complicated spinal pathologies
In turn, they crossed paths with Aussie medical device company Anatomics. Anatomics CEO Andrew Batty realized that the only process for producing such an implant was through metal 3d printing
and vaccines traditionally given by injection. Cheap, lightweight and portable, the advanced nebulizer delivers precise drug doses to patients with life-threatening
or to painlessly vaccinate infants currently subjected to needles. Professor Leslie Yeo, Director of RMIT University Micronanophysics Research Laboratory, said the Respite technology had the potential to revolutionize how patients were treated with drugs
Recent trials in Melbourne also showed sheep given a DNA flu vaccine via a nebulizer had comparable immune responses to animals injected with the vaccine.
This makes the development of an effective vaccine to protect against infection, as well as antiviral therapy to combat already-existing infections,
Administering a vaccine to protect against infection would overwhelm the patient's immune system. However, if he or she has the option of receiving an antiviral to eliminate the infection,
and aims to expand its activities in the field of regenerative medicine and developing medical devices s
and Neck Surgery in the UAMS College of Medicine UAMS is the state only comprehensive academic health center, with colleges of Medicine, Nursing, Pharmacy, Health professions and Public health;
This is a crucial step in creating a new generation of foldable electronics-think a flat-screen television that can be rolled up for easy portability-and implantable medical devices.
indicating it is a good material for implantable medical devices. Fatigue is a common problem for researchers trying to develop a flexible, transparent conductor,
This single, self-contained medical device will be effective, for example, in quickly detecting liver toxicity which is a common side effect of chemotherapy.
a mix of human-made chemicals thought to pose a risk to public health. A team led by Cockrell School of engineering associate professor Christopher Ellison found that a synthetic coating of polydopamine--derived from the natural compound dopamine--can be used as a highly effective, water-applied flame retardant for polyurethane foam.
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