or spinal cord injury. Electrical signals, acquired through either invasive or noninvasive neural interfaces, are decoded to subsequently control external devices.
#White blood cell Mediated Therapy for Neurons in Patients with Parkinson Disease Scientists at the University of North carolina at Chapel hill have begun researching the delivery of neurotropic factors to the brain as a potential therapeutic for Parkinson disease.
However, one potential therapy is the development of smarter immune cells that deliver neurotropic factors to neurons damaged by the disease.
In the study, GDNF alleviated neuroinflammation and reversed neurodegeneration in Parkinson disease model mice. One suggested mechanism of activity is that these cells,
This new macrophage mediated protein delivery system could potentially provide a therapy for patients who are afflicted by this debilitating disease e
#Mobileodt Brings Cervical cancer Diagnostics to Developing Countries Early detection significantly improves the survival rates for cervical cancer patients.
Cervical cancer used to be one of the leading causes of cancer deaths in the US,
but mortality rates have declined significantly in the last 40 years due in part to better compliance with regular cervical cancer screening.
and has leveraged this into a new cervical cancer screening product. Their cervical cancer screening system allows any smartphone to be turned into a colposcope,
making this part of the screening process readily available for most clinics. The hardware is equipped with a light source
and magnifying lens that gives a phone camera lens excellent visualization of any abnormalities in the cervical tissue.
But when their population booms, they can quickly become a plague, consuming coral reefs--their favorite food--with a frenzied fervor.
who had been paralyzed for five years after a spinal cord injury, was able to walk about 12 feet (3. 66 meters).
"Even after years of paralysis, the brain can still generate robust brain waves that can be harnessed to enable basic walking,
"We showed that you can restore intuitive, brain-controlled walking after a complete spinal cord injury."
The researchers say the new study provides proof of concept that a person with complete paralysis of both legs can use a brain-controlled system to stimulate leg muscles
or improve walking in individuals with paraplegia due to spinal cord injury, "the researchers said. Before the man could use the system to walk,
but applying these chemicals to the surface of wounds has its limits. To best stem blood loss, those chemicals need to be able to find their way deep into a wound.
There may now be a solution, however, and it comes in the unlikely form of fizz, reports Wired.
propelling them deep into a wound as they pop. The new concoction is composed of powdered marble, tranexamic acid
Water from the blood is the catalysis that sets it fizzing. f you can get the particles in the general area of the wound,
all the way to the damaged internal blood vessels feeding the wound. By clotting so deep into the lesion, the clot was shown to be more stable.
Right now the fizzing agent is a bit messy. While chemicals do get deeper into the wound,
they pop off in every other direction too. Eventually researchers hope to make the delivery process more efficient,
For example, people with arthritis may be able to get pain relieving drugs during walks in doses that are proportional to how many steps are taken.
and a member of MIT Koch Institute for Integrative Cancer Research, is the paper senior author.
The finding demonstrates that the stress of crystal deformation can impart a newfound degree of control over magnetic and electrical behavior in spintronic devices and sensors.
however, apply stress in all directions equally. he biggest challenge we faced was accurately controlling uniaxial stress at temperatures as low as 3 kelvin,
The team constructed a unique cell that clamps a multiferroic barium cobalt germanium oxide (Ba2coge2o7) crystal between a pair of zirconium oxide pistons (Fig. 1). They then investigated how the sample electric polarization changed under uniaxial stress.
In contrast, by deforming the Ba2coge2o7 crystal with varying levels of uniaxial stress, the researchers could tune the polarization output in unprecedented ways, from fully on to fully off,
because they show we can control the spin-driven ferroelectricity in this compound by applying uniaxial stress at the low megapascal level,
particularly for crystals with high levels of symmetry. any multiferroic materials have the potential to show stress-induced effects,
#Nanotechnology developed to help treat heart attack and stroke Australian researchers funded by the National Heart Foundation are a step closer to a safer
and more effective way to treat heart attack and stroke via nanotechnology. The research jointly lead by Professor Christoph Hagemeyer, Head of the Vascular Biotechnology Laboratory at Baker IDI Heart and Diabetes Institute and Professor Frank Caruso,
an ARC Australian Laureate Fellow in the Department of Chemical and Biomolecular engineering at the University of Melbourne, was published today in the leading journal Advanced Materials.
Professor Frank Caruso from the Melbourne School of engineering said the targeted drug with its novel delivery method can potentially offer a safer alternative with fewer side effects for people suffering a heart attack
or stroke. p to 55,000 Australians experience a heart attack or suffer a stroke every year. bout half of the people who need a clot-busting drug can use the current treatments
because the risk of serious bleeding is too high, he said i
#Aluminium could give a big boost to capacity and power of lithium-ion batteries One big problem faced by electrodes in rechargeable batteries,
This expansion and contraction of aluminum particles generates great mechanical stress, which can cause electrical contacts to disconnect.
and whether there any degradation of those structures in diseases. any diseases are caused either by an invading pathogen or degradation of a cell internal structure.
and cancer drugs Longing to find a cure for cancer, HIV and other yet incurable diseases,
and vaccines against many dangerous diseases including HIV, hepatitis and cancer. The research, led by Yury Stebunov,
a scientist at the MIPT, was published in the ACS Applied materials & Interfaces. The paper is titled"Highly sensitive and selective sensor chips with graphene oxide linking layer".
and low-cost fabrication compared to sensor chips that are already commercially available. ur invention will help in drug development against viral and cancer diseases.
sensitive and low-cost diagnosis of many diseases, including HIVNEW research may revolutionize the slow, cumbersome and expensive process of detecting the antibodies that can help with the diagnosis of infectious and autoimmune diseases such as rheumatoid arthritis and HIV.
An international team of researchers have designed and synthetized a nanometer scale DNA"machine "whose customized modifications enable it to recognize a specific target antibody.
this makes our platform adaptable for many different diseases"."""Our modular platform provides significant advantages over existing methods for the detection of antibodies,"added Prof.
, 2015curcumin Nanodrug Breaks Cancers'Resistance to Treatment May 10th, 2015discoveries First theoretical proof: Measurement of a single nuclear spin in biological samples May 11th, 2015graphene holds key to unlocking creation of wearable electronic devices May 11th, 2015new Method to Produce Dual Zinc oxide Nanorings May 11th
, 2015curcumin Nanodrug Breaks Cancers'Resistance to Treatment May 10th, 2015announcements First theoretical proof: Measurement of a single nuclear spin in biological samples May 11th, 2015graphene holds key to unlocking creation of wearable electronic devices May 11th, 2015new Method to Produce Dual Zinc oxide Nanorings May 11th
, 2015curcumin Nanodrug Breaks Cancers'Resistance to Treatment May 10th, 2015interviews/Book reviews/Essays/Reports/Podcasts/Journals/White papers First theoretical proof:
, 2015curcumin Nanodrug Breaks Cancers'Resistance to Treatment May 10th, 2015artificial Intelligence Making robots more human April 29th, 2015lifeboat Foundation launches Interactive Friendly AI April 6th,
#Gold-diamond nanodevice for hyperlocalised cancer therapy: Gold nanorods can be used as remote controlled nanoheaters delivering the right amount of thermal treatment to cancer cells,
which can potentially be applied to thermal cancer therapy. Pei-Chang Tsai from the Institute of Atomic and Molecular Sciences, at the Academia Sinica, Taipei,
#Artificial blood vessels become resistant to thrombosis Abstract: Scientists from ITMO University developed artificial blood vessels that are not susceptible to blood clot formation.
Surgery, associated with cardiovascular diseases, such as ischemia, often require the implantation of vascular grafts-artificial blood vessels,
#Advance in photodynamic therapy offers new approach to ovarian cancer The findings were published just in the journal Nanomedicine:
and after further research may offer a novel mechanism to address this aggressive and often fatal cancer that kills 14,000 women in the United states each year.
Ovarian cancer has a high mortality rate because it often has metastasized into the abdominal cavity before it's discovered.
"Surgery and chemotherapy are the traditional approaches to ovarian cancer, but it's very difficult to identify all of the places where a tumor has spread,
and in some cases almost impossible to remove all of them, "said Oleh Taratula, an assistant professor in the Oregon State university/Oregon Health & Science University college of Pharmacy."
some tumors in laboratory animals began to regrow after two weeks. But with the addition of the combinatorial genetic therapy to weaken the cancer cell defenses,
there was no evidence of cancer recurrence. During the procedures, mice receiving the gene therapy also continued to grow
is associated with invasion, metastasis, resistance to cancer therapies, and overall cancer cell survival. That excess of DJ1 is silenced by the genetic therapy composed of sirna.
"Our study established a prospective therapeutic approach against ovarian cancer, "the researchers wrote in their conclusion."
"The tumors exposed to a single dose of a combinatorial therapy were eradicated completely from the mice
and study diseases Abstract: Using physical chemistry methods to look at biology at the nanoscale, a Lawrence Berkeley National Laboratory (Berkeley Lab) researcher has invented a new technology to image single molecules with unprecedented spectral and spatial resolution,
and study diseases Ke Xu, a faculty scientist in Berkeley Lab's Life sciences Division, has dubbed his innovation SR-STORM,
and whether there's any degradation of those structures in diseases.""Many diseases are caused either by an invading pathogen or degradation of a cell's internal structure.
Alzheimer's, for example, may be related to degradation of the cytoskeleton inside neurons.""The cytoskeleton system is comprised of a host of interacting subcellular structures and proteins,
"While this proof of principle study demonstrates specific delivery of therapeutic agents to treat cardiovascular disease and bacterial infections,
it also has broad implications for targeted therapy for other diseases such as cancer and neurological disorders,"said Chien.
and certain pathogens such as MRSA bacteria, allowing the nanoparticles to deliver and release their drug payloads specifically to these sites in the body.
platelet-mimicking nanoparticles can also greatly minimize bacterial infections that have entered the bloodstream and spread to various organs in the body.
"We hope to develop platelet-mimicking nanoparticles into new treatments for systemic bacterial infections and cardiovascular disease."
#Portable Nanosensors Help Early Diagnosis of Breast cancer Tumors The nanosensor will be able to help the early diagnosis of breast cancer tumors even at very tiny dimensions after the completion of tests
The aim of the research was to facilitate the diagnosis of cancer tumors, including breast cancer, without the need for advanced clinical devices.
and simulated in this research for the early and easy diagnosis of breast tumors. The nanosensor consists of plasmonic nanoparticles that are placed at regular distance from each other.
the sensor is very sensitive to changes in electromagnetic fields that are dispersed with different tissues (normal and tumor.
The throughputs of waves are different through natural and tumor tissues. Therefore, the interaction of tissues with electromagnetic waves created by a similar electrical field ends in different results.
It means a non-consistency happens in the profile received from the interaction of emitted light and various healthy and cancer tissues.
The meaningful signal is a tool for the detection of tumor tissue e
#Pushing the limits of lensless imaging: At the Frontiers in Optics conference researchers will describe a custom-built ultrafast laser that could help image everything from semiconductor chips to cells in real time Using ultrafast beams of extreme ultraviolet light streaming at a 100,000 times a second, researchers
and fatigue has been a deadly disease for metals, "the researchers wrote.""We weaken the constraint of the substrate by making the interface between the Au (gold) nanomesh and PDMS slippery,
leading to inexpensive devices that could detect dozens of disease markers in less than 5 minutes Chemists used DNA molecules to developed rapid,
may aid efforts to build point-of-care devices for quick medical diagnosis of various diseases ranging from cancer, allergies, autoimmune diseases, sexually transmitted diseases (STDS),
when atoms are brought too close together-to detect a wide array of protein markers that are linked to various diseases.
explains that this novel signaling mechanism produces sufficient change in current to be measured using inexpensive electronics similar to those in the home glucose test meter used by diabetics to check their blood sugar.
allowing us to build inexpensive devices that could detect dozens of disease markers in less than five minutes in the doctor's office
including pathogen detection in food or water and therapeutic drug monitoring at home, a feature which could drastically improve the efficient of various class of drugs and treatments a
and help design new drug therapies against pathogens by targeting enzymes that interact with DNA."
These fine details may also help scientists understand how mutations in proteins can lead to disease
and charge to some part of another molecule--such as the binding site of a human protein involved in some physiological process that goes awry in a given disease.
and cancer cells to help us unravel disease mechanisms, and for characterizing cells from diseased tissue of patients.""
#Scientists pave way for diamonds to trace early cancers Physicists from the University of Sydney have devised a way to use diamonds to identify cancerous tumours before they become life threatening.
synthetic version of the precious gem can light up early-stage cancers in nontoxic, noninvasive Magnetic resonance imaging (MRI) scans.
Targeting cancers with tailored chemicals is not new but scientists struggle to detect where these chemicals go since,
if a treatment has been taken up by a cancer. Led by Professor David Reilly from the School of Physics
researchers from the University investigated how nanoscale diamonds could help identify cancers in their earliest stages."
"By attaching hyperpolarised diamonds to molecules targeting cancers the technique can allow tracking of the molecules'movement in the body,
and target cancers long before they become life-threatening, "says Professor Reilly. The next stage of the team's work involves working with medical researchers to test the new technology on animals.
and cure bones damaged due to tumors, cysts or fractures. The use of bone replacement in various forms has increased in recent years.
New Option to Diagnose Leukemia Iranian researchers from Tarbiat Modarres University designed a biosensor that enables the early diagnosis of leukemia in the test sample by using naked eyes.
The aim of the research was to design an effective system to diagnose blood cancer (leukemia) by using gold nanobars.
and their application has been evaluated in the diagnosis of the disease. The presence of some proteins in biological liquids of humans (blood
saliva and urine) with determined concentration can be the sign of dangerous diseases. Therefore, it is effective to monitor
and prevent diseases. Lysozyme protein has been selected as the target biomolecule in this research. The excess secretion of this protein can be a sign of malfunction in kidney performance
and it may result in leukemia. Diagnosis tests are very time-consuming, expensive and difficult in some cases.
In his research, Burke has been exploring the potential of small molecules to treat disease. Plants
Limiting it to a single point allows us to control the parameters, like contact stress and geometry,
This"stress activated"process meant that, the harder the tip squeezed and sheared the ZDDP-containing oil between the tip and sample,
you get a high stress due to the concentration of force. When you push on a less stiff surface,
so the stress is lower. The thicker the film, the more it acts as a cushion to reduce the stress that is needed to cause the chemical reactions needed to keep growing.
It's self-limiting, or in other words, it has a way of cutting off its own growth".
Without being able to control the stress and geometry of a single point of contact
Being able to pinpoint the level of stress at which they begin to break down and form tribofilms allows researchers to compare various properties in a more rigorous fashion."
and Sergei Gryaznov of Aurasense Therapeutics is the first to show spherical nucleic acids (SNAS) can be used as potent drugs to effectively train the immune system to fight disease,
SNAS could be used to target anything from influenza to different forms of cancer. They also can be used to suppress the immune response
a tactic important in treating autoimmune disorders, such as rheumatoid arthritis and psoriasis, where the body's immune system mistakenly attacks healthy tissues."
"Once developed fully, SNAS will lay the foundation for developing an entire new pipeline of drugs to treat a range of diseases, from psoriasis, lupus and rheumatoid arthritis to lymphoma, bladder cancer and prostate cancer."
targeting lymphoma and a form of autoimmune hepatitis.""The spherical nucleic acids always win from potency and speed standpoints,
In a study of mice, the researchers tested SNAS against lymphoma. For the animals treated with SNAS,
the researchers found a significant decrease in tumor growth and a doubling of lifespan. The potency was up to an 80-fold increase over linear nucleic acids of the same sequence.
and destroy lymphoma cells. Next, focusing on nonalcoholic steatohepatitis (NASH), the researchers found eightfold increases in potency when animals were treated with SNAS and a 30 percent greater reduction in the animals'fibrosis score.
This observation has significant implications for treating liver cancer and cirrhosis patients.""The beauty of the approach is that a very small amount of drug does a tremendous amount of work,
"Mirkin said.""The SNAS trigger the immune response and, without more drug, additional cells are trained to behave the same way as the initial cells.
This gives you a catalytic effect that grows into a systemic search for cells that look for example, like lymphoma cells."
For example, the hydrogel can be designed to remain at the injury site for specific durations by controlling the interactions between the nanosilicates and gelatin,
In addition to its ability to be injected at the site of an injury, the material achieves three-to-four times higher stiffness once inside the body,
vascularized scaffolds that employ the material and could be inserted surgically at the site of more serious injuries where injection is not an option.
would allow the injury site to receive blood flow as part of the enhanced healing process initiated by the nanoparticles.
scientists from the Helmholtz Zentrum Mnchen (HMGU) and the Ludwig-Maximilians-Universitt (LMU) in Munich have developed nanocarriers that site-selectively release medicines/drugs at the tumor site in human and mouse lungs.
In the journal, ACS Nano("Protease-Mediated Release of Chemotherapeutics from Mesoporous Silica Nanoparticles to ex Vivo Human and Mouse Lung Tumors"),the scientists reported that this approach led to a significant increase
in the effectiveness of current cancer medicines in lung tumour tissue. Tumor tissue in the lung.
Image: Sabine van Rijt, CPC/ilbd, Helmholtz Zentrum Mnchen) Nanoparticles are extremely small particles that can be modified for a variety of uses in the medical field.
For example, nanoparticles can be engineered to be able to transport medicines specifically to the disease site while not interfering with healthy body parts.
In elastocaloric materials a change in mechanical stress can create a change in temperature. In the Journal of Applied Physics("Elastocaloric effect of Ni-Ti wire for application in a cooling device"),a team of researchers from Technical University of Denmark report that the elastocaloric effect opens the door to alternative forms
or by applying an external stress. This is responsible for the temperature-induced"shape memory effect "and stress-induced"superelasticity."
"After the stress is removed, the crystal structure reverts back to its austenitic phase, which causes the material to cool down
He worries more about gremlins that plague today's reverse osmosis membranes--growths on membrane surfaces that clog them (called"biofouling)
#Rapid and efficient DNA chip technology for testing 14 major types of food borne pathogens Conventional methods for testing foodborne pathogens is based on the cultivation of pathogens,
So there is demand for alternative methods to test for foodborne pathogens that are simpler, quick and applicable to a wide range of potential applications.
borne pathogens. The so called DNA chip card employs electrochemical DNA chips and overcomes the complicated procedures associated with genetic testing of conventional methods.
and in a collaboration with Kawasaki City Institute for Public health, used to simultaneously detect 14 different types of foodborne pathogens in less than 90 minutes.
The detection sensitivity depends on the target pathogen and has a range of 1e+01? 05 cfu/ml.
Notably, such tests would usually take 4-5 days using conventional methods based on pathogen cultivation.
Examples of pathogens associated with food poisoning that were tested with the DNA chip card d
#Chemists make new silicon-based nanomaterials In a paper published in the journal Nano Letters("A Silicon-Based Two-dimensional Chalcogenide:
wounds compared to no treatment at all. Details of the therapy, which was tested successfully in mice,
a novel microtubule-based regulator of wound healing"."e envision that our nanoparticle therapy could be used to speed the healing of all sorts of wounds,
including everyday cuts and burns, surgical incisions, and chronic skin ulcers, which are a particular problem in the elderly
and people with diabetes, said study co-leader David J. Sharp, Ph d.,professor of physiology & biophysics at Einstein.
Dr. Sharp and his colleagues had discovered earlier that an enzyme called fidgetin-like 2 (FL2) puts the brakes on skin cells as they migrate towards wounds to heal them.
They reasoned that the healing cells could reach their destination faster if their levels of FL2 could be reduced.
and applied the nanoparticles to wounds on mice. The treated wounds healed much faster than untreated wounds.
FL2 belongs to the fidgetin family of enzymes, which play varying roles in cellular development and function.
When those cells were placed on a standard wound assay (for measuring properties like cell migration and proliferation),
Dr. Sharp and project co-leader Joshua Nosanchuk, M d.,professor of medicine at Einstein and attending physician, infectious diseases at Montefiore Medical center, developed a wound-healing therapy that uses
In both cases, the wounds closed more than twice as fast as in untreated controls. ot only did the cells move into the wounds faster,
#High-tech method allows rapid imaging of functions in living brain Researchers studying cancer and other invasive diseases rely on high-resolution imaging to see tumors and other activity deep within the body's tissues.
Using a new high-speed, high-resolution imaging method, Lihong Wang, Phd, and his team at Washington University in St louis were able to see blood flow, blood oxygenation, oxygen metabolism and other functions inside a living mouse brain at faster rates than ever before.
In the future, photoacoustic imaging could serve as an important complement to fmri, leading to critical insights into brain function and disease development."
Given the importance of oxygen metabolism in basic biology and diseases such as diabetes and cancer,
and Netrin-1 Guides Commissural Axons"),could eventually help develop tools to repair nerve cells following injuries to the nervous system (such as the brain and spinal cord).
""This scientific breakthrough could bring us closer to repairing damaged nerve cells following injuries to the central nervous system,"states Dr. Charron."
"A better understanding of the mechanisms involved in axon guidance will offer new possibilities for developing techniques to treat lesions resulting from spinal cord injuries,
and possibly even neurodegenerative diseases.""Injuries to the central nervous system affect thousands of Canadians every year and can lead to lifelong disabilities.
Most often caused by an accident, stroke or disease, these injuries are currently very difficult to repair.
Research is required therefore for the development of new tools to repair damage to the central nervous system m
#Nanoparticles provide novel way to apply drugs to dental plaque Therapeutic agents intended to reduce dental plaque
and prevent tooth decay are removed often by saliva and the act of swallowing before they can take effect.
as well as other biofilm-related diseases s
#A new breakthrough in thermoelectric materials French physicist Jean Charles Athanase Peltier discovered a key concept necessary for thermoelectric (TE) temperature control in 1834.
effectively acting as a 2-D liquid("Interactions and Stress Relaxation in Monolayers of Soft Nanoparticles at Fluid-Fluid Interfaces".
#Scientists use nanotechnology to visualize potential brain cancer treatments in real time (Nanowerk News) Virginia Tech Carilion Research Institute scientists have developed new imaging techniques to watch dangerous brain tumor
and describes how the research team used nanotechnology to watch tumor stem cells respond to therapy. ee never been able to directly observe the actions of potential cancer treatments this way before,
a cancer biologist and an assistant professor of biomedical sciences and pathobiology at the Virginiaaryland College of Veterinary medicine. t was astounding.
Glioblastoma is a brain cancer with a poor prognosis. Even with surgical interventions or traditional treatments
and grow new tumors. lioblastoma tumors are hard to target, Sheng said. heye aggressive and resistant to therapeutics.
what is used in some cancer treatments and watched the process in cell cultures using in situ transmission electron microscopy.
whether we could isolate these types of toxic cells from the other brain tumor cells, while developing new imaging tools at the single-cell level to visualize the course of therapies needed to eradicate these cells,
Researchers say the technology has many potential applications. ne may be able to directly observe an influenza virus, HIV,
or other human pathogens infecting a cell, or even test new cancer treatments at the cellular level, Kelly said.
Sheng pointed to another characteristic that makes cancer cells difficult to treat: broad heterogeneity. In the same cancer population, even neighboring cells can differ drastically,
and each cell can respond to treatments differently. e can look at single-cell delivery of cancer treatments,
and see how the individual cells respond, Sheng said. f we can learn how to kill these cells,
Overtext Web Module V3.0 Alpha
Copyright Semantic-Knowledge, 1994-2011