Or even a query in natural language like, hat are papers saying about middle-aged women with diabetes and this particular drug?'
codenamed Big Mechanism, to read all the scientific papers on certain types of cancer and use that knowledge to identify potential treatments.
and is designed to treat seizures in people suffering from epilepsy. It's a new version of a seizure medication that's been on the market for years."
And they've already implanted the device into the chest of a 54-year-old cancer patient.
The man lost his sternum and pieces of four ribs when doctors removed a large tumor.
Cancer tissue, for example, is less dense than healthy tissue. The method therefore opens up the prospect of detecting tumors that are less than 1mm in diameter in an early stage of growth before they spread through the body
and exert their lethal effect. For this purpose however, researchers must shorten the wavelength of the X-rays even further
in order to be able to diagnose diseases earlier, to find new active ingredients faster and more reliably,
The developers say the system can be used to identify biomarkers that are early indicators of a disease
an existing anticonvulsant used to treat epilepsy that has been available as a generic in the U s. since 2008.
#New uper-Tomatocan Fight Cancer, Heart disease, Diabetes and Alzheimer Scientists said that they have invented a uper-tomatowhich can fight cancer, heart disease, diabetes and Alzheimer.
The makers of this unique tomato said it has high quantities of disease-fighting antioxidant plant chemicals.
whereas genistein could help in prevention of some cancers, including breast cancer. The study published in the journal Nature Communications said that the super-tomatoes contain a protein called Atmyb12,
For example, the material could be engineered to detect specific pollutants, toxins or pathogens, with the results instantly visible through color emission.
The findings could help identify ways to repair damaged neural connections in patients with spinal cord injuries or neurodegenerative diseases like amyotrophic lateral sclerosis (ALS), also known as Lou gehrig's disease.
That's a key finding for research on how to treat spinal cord injuries and ALS,
"This really is a completely new platform for closing wounds or holes anywhere in the body,"said Harvard professor Dr. Conor Walsh."
But researchers recently found that a thousand-year-old Anglo-saxon treatment for eye infections works as an antibiotic against one of today most notorious bacteria, Methicillin-resistant Staphylococcus aureus (MRSA.
The researchers tested the concoction on cultures of MRSA bacteria in synthetic wounds as well as in rats.
they've developed software that can gauge the speed at which a typist is tapping the keyboard to help diagnose Parkinson disease.
(which slows all motor skills) and diseases that affect the central nervous system, including Parkinson. For the first version of this study, the researchers were looking at typing patterns that indicated
#Glowing Tumor Paint Shows Surgeons Where To Cut Brain surgery is complicated notoriously. Before surgeons go in to remove a tumor,
they study the size and location of the tumor. But once theye in, they have to rely on their fingers
and eyes to distinguish tumor cells from healthy brain cells. Now researchers have developed a"paint"that can be injected into a patient's veins to make tumor cells glow.
After a number of successful studies in mice and dogs, the paint is now being tested in humans in California.
The paint is made from two chemicals. The first is chlorotoxin a protein derived from scorpion venom,
which targets the chloride receptors on the surface of tumor cells. The protein carries a second,
Researchers injected the tumor paint into the patients'veins and it was successfully able to cross the blood-brain barrier,
The first few test subjects had tumors that were deep in the brain so the surgeons had to remove a piece of the tissue before shining a light on it.
The paint may also be used for other types of tumors in the future. Ideally, doctors wouldn be using surgery at all to eliminate tumors--it still a rudetechnique,
as one researcher said. But while surgery is still a standard treatment, tumor paint could help surgeons be much more precise m
#A 3d printed, Battery-Powered Rocket engine Nothing demonstrates engineering prowess and technical knowhow quite like rocket science.
or fracture in the earth's crust. There are many different types of faults. A thrust fault, like the one that caused the earthquake Saturday,
because people need malaria meds. You feel like you've spent time in these places after spending hours digitizing aerial imagery.
They attempted to delete a gene for a blood disorder called beta thalassemia from the DNA of 86 nonviable embryos.
which causes Tay-sachs disease--a disease in which children develop normally for six months and then become progressively deaf, blind, unable to swallow, and paralytic,
before dying at four-will benefit future generations. We lose nothing by editing this gene out of the human lineage.
Of course, gene editing techniques are nowhere near ready to eradicate human diseases. The modifications are difficult to target
pitching coaches can do little to predict the injury. They look at certain metrics--throwing speed and pitch count--to guess
It our single biggest health problem, affecting the lives of 100 million adults--more than heart disease, cancer,
and diabetes combined. And that figure, from a 2011 Institute of Medicine report, doesn even count kids in pain, veterans with devastating war injuries,
or people in nursing homes. Yet despite the fact that chronic pain is the primary reason Americans receive disability benefits, its one of the least understood afflictions.
according to the Centers for Disease Control and Prevention The new method produced dramatic images showing how glial cells
The researchers next plan to study how their technology could help heal wounds n
#Can You Catch Alzheimer? The gradual loss of memory and thinking skills caused by Alzheimer disease are debilitating.
Scientists aren quite sure what causes the condition, but have hypothesized long that the disease results from a combination of genetic, environmental,
and lifestyle factors. Now a team of British researchers might have discovered a new cause: transmissible clumps of proteins called prions.
but can sometimes cause disease. Unlike bacteria or viruses, prions don have any of their own DNA;
they cause disease when they become misfolded so that they can no longer function properly, and they propagate throughout the brain.
Many of the resulting diseases, such as Creutzfeldt-jakob disease (CJD), have long incubation periods but eventually lead to death.
thought to be a driver of Alzheimer disease. In fact, four patients had uite substantial Alzheimer-like pathology,
says John Collinge, one of the authors of the study said in a press conference. n that age group you don really see this sort of pathology;
it only really seen in elderly individuals unless you have a genetic predisposition to it,
and none of these patients did suspected. he researchers that other prion diseases might increase the production of amyloid beta,
so they checked the records of 116 other patients with different types of prion disease.
#Nose-Like Biosensor Sniffs Out Stinky Drinking water Electronic noses can detect bugs, disease or even explosives.
paralyzed due to a spinal injury, was able to feel a physical sensation thanks to a hand prosthetic attached to his brain,
and Better Memory ST LOUIS By hardwiring into the brains of people with traumatic injuries, scientists have been able to restore the feeling of touch
could help people suffering from traumatic brain injury. The Defense department research wing shared both milestones last week at a conference called ait, What?
which could help people with memory problems including those with traumatic brain injuries, Sanchez said. s the technology of these fully implantable devices improves,
and after Chinese researchers reported they had employed indeed successfully the CRISPR/Cas9 system on nonviable human embryos to remove a part of the gene that causes a genetic blood condition called beta thalassemia.
and even preventing certain diseases, if given the proper basic research. Niakan told The Guardian:
#FDA Approves Use Of Engineered Herpes virus To Treat Cancer Yesterday, the Food and Drug Administration (FDA) announced that it had approved the drug Imlygic to treat late-stage melanoma on the skin and lymph nodes.
The drug, which relies upon a genetically engineered herpes virus to attack and kill the cancerous cells,
And while malignant cancers often slip by the immune system, the viruspresence ignites the immune response. Combined, these reactions mean that virology can successfully treat even some late-stage cancers that are often resistant to other treatment methods.
Before it was approved, Imlygic was tested in more than 400 patients with metastatic melanoma, which kills about 10,000 people per year in the United states,
which had caused lesions in patientsskin or lymph nodes. When the drug was injected into the cancerous sites over the course of six months,
more than 16 percent of patients saw their lesions shrink. So far, virology treatments haven worked as well in cancers in tissues deeper in the bodyhe drug has to be injected directly into the tumor site
or the immune system will launch its attack too early, according to Nature News. But a number of drugs using different viruses
and to treat several types of cancer are already in clinical trials. Now that the first virology cancer treatment has been approved,
researchers hope that many more are to follow e
#This Flexible Electronic Sticks To Your Skin And Can Measure Your Blood Flow The blood coursing through your arteries
and veins bring necessary nutrients to organs throughout the body as well as take waste away. But conditions such as diabetes, kidney disease,
and certain types of inflammation can limit blood flow to various parts of the body
when the sensing of light overlaps within these conesnchroma glasses allow wearers with red-green color blindness to see color again.
the MCA Chicago is making a move that might inspire other museums to increase accessibility for visitors with color blindness h
Compasses and GPS help people without disabilities find their destinations every day, but are of less use to the visually impaired,
The device is designed to detect syphilis, gonorrhoea, chlamydia and trichomoniasis, the most common in the category,
In these type of tests, reagents bond to specific proteins formed by the body under attack from an infection.
when testing for HIV infection and herpes. Other STDS are tested by confirming virus or bacterial presence in swabs or sample tissue from the patient.
Because it tests for antibodies, which is a bodily response, there is timeframe for false negatives.
overall minimizing the possibility of an undetected infection. The startup team is headed by Kazakhstani Damel Mektepbayeva,
a biotechnologist who has helped developed stem cell-based treatments for ischemic diseases. The Hoope idea originated from a NASA camp where Damel team bested 80 other scientists in developing an impactful product.
Farmedhere produce is grown indoors in urban facilities, away from the bugs, diseases, pesticides, and weather that impact most produce today.
when she saw the side effects of cancer and how the drugs used to kill cancer cells also killed other parts of the body.
This discovery could provide new clues about genetic diseases and allow researchers to reprogram cells by directly modifying the loops in genomes.
An abnormally high or low white blood count, for instance, might indicate a bone marrow pathology or AIDS.
The rupturing of white blood cells might be the sign of an underlying microbial or viral infection.
Strangely shaped cells often indicate cancer. While this old, simple technique may seem a quaint throwback in the age of high-technology health care tools like genetic sequencing,
"We are excited about pursing this research for the treatment and eradication of HIV infections.""The two therapies were tested together in laboratory experiments using human immune cells
Gelbard, director of UR's Center for Neural development and Disease, developed URMC-099 to treat HIV-associated neurocognitive disorders or HAND,
reduce side effects and help people manage the disease, because they won't have to think about taking medication every day. a
#Snake venom helps hydrogels stop the bleeding A nanofiber hydrogel infused with snake venom may be the best material to stop bleeding quickly, according to Rice Univ. scientists.
and quickly turns into a gel that conforms to the site of a wound, keeping it closed,
It has been used in various therapies as a way to remove excess fibrin proteins from the blood to treat thrombosis and as a topical hemostat.
This is important because surgical bleeding in patients taking heparin can be a serious problem. The use of batroxobin allows us to get around this problem
and injected at the site of a wound, where they reassemble themselves into a gel.
Tests showed the new material stopped a wound from bleeding in as little as six seconds and further prodding of the wound minutes later did not reopen it.
The new work builds upon the Rice lab extensive development of injectable hydrogel scaffolds that help wounds heal
What we did was combine it with the hydrogel wee been working on for a long time. e think SB50 has great potential to stop surgical bleeding, particularly in difficult cases in
Those results raised concerns about the use of CRISPR technology in studying human diseases. As a potential solution
and potentially treating human diseases such as cancer, cardiovascular disease, neurodegenerative conditions and diabetes, which can be driven by mutations in control regions of the genome.
and fix the root causes of many diseases. It could also help researchers understand and change how different people respond to drugs.
how those switches differ between individuals and the implications of these insights for human traits and diseases.
#Brain training app could help people with schizophrenia Scientists at Cambridge university said tests on a small number of patients who played the game over four weeks found they had improvements in memory and learning.
Schizophrenia is a long-term mental health condition that causes a range of psychological symptoms, ranging from changes in behavior through to hallucinations and delusions.
While some psychotic symptoms can be treated reasonably well with medication patients often still have debilitating problems with memory
and cognitive function, meaning they struggle to get back to work or stay in education. There is increasing evidence that computer-assisted training can help people with schizophrenia overcome some of their symptoms, with better outcomes in their daily lives.
This study, published in the journal Philosophical Transactions of the Royal Society B, found that 22 patients who played the memory game made significantly fewer errors
since lack of motivation is a common feature of schizophrenia.""We need a way of treating the cognitive symptoms of schizophrenia, such as problems with episodic memory,
but slow progress is being made toward developing a drug treatment, "said Barbara Sahakian from the department of psychiatry at Cambridge university."
was approved for oral use as a prescription adjunctive therapy in the treatment of epilepsy, the company said on Monday.
British scientists have used also 3d printing to create personalized replica models of cancerous parts of the body to allow doctors to target tumors more precisely y
#Non-Genetic Cancer Mechanism Found Cancer can be caused solely by protein imbalances within cells, a study of ovarian cancer has found.
The discovery is a major breakthrough because genetic aberrations have been seen as the main cause of almost all cancer.
The research in Oncogene demonstrates that protein imbalance is a powerful prognostic tool, indicating whether or not patients are likely to respond to chemotherapy
and whether a tumor is likely to spread to other sites. The findings also open the possibility of new therapies aimed at measuring
led by scientists at the University of Leeds and The University of Texas MD Anderson Cancer Center, focused on the"Akt pathway,"a signaling pathway within cells that drives cancer formation and the spread of cancers
A conventional approach to diagnosing this cancer would be to look for genetic modification of the receptor
In this way, an imbalance in the amount of the two proteins can lead to cell proliferation and cancer formation.
whether you have a predisposition to cancer and, ultimately, use a precision medicine-based approach to develop a therapeutic approach.
which cancer can occur. We found that in cells where Grb2 is depleted, FGFR2 was vulnerable to Plc?
and found that Grb2 depletion results in the development of multiple tumors in the vicinity of a primary tumour,
indicating that protein imbalance can have a role in metastasis, the spread of a cancer through the body.
1 was predictive of the progress of ovarian cancers in patients. Measuring the levels of the proteins in patient tissues followed by database analysis of clinical information from The Cancer Genome Atlas
and other sources revealed that a high level of Grb2 relative to Plc? 1 and FGFR2 was associated with a significantly more favorable prognosis than patients with elevated levels of Plc?
It involved researchers from the University of Leeds, The University of Texas MD Anderson Cancer Center and the UT Health Science Center at Houston t
#Normalization Of Testosterone Level After Testosterone Replacement Therapy Patients with low testosterone levels who have gone then on to have testosterone replacement therapy (TRT) could be at lower risk of cardiovascular events such as heart attack or stroke,
In the study, researchers from Kansas city VA Medical centre in Kansas city, USA, examined the effect of TRT on cardiovascular outcomes by comparing incidences of heart attack, stroke,
#Researchers Discover Key Mechanism To Emergence Of Deadly Strep Bacteria The incidence of serious strep infections has risen dramatically in the last three decades,
a virus infected the strep bacteria creating a deadly strain of lesh-eatingbacteria that has evolved to produce serious human infections worldwide. ust like a computer virus might come in
The research focuses on the major human pathogen group A Streptococcus (trep) Among the most important of all human infectious disease agents,
strep is responsible for a wide range of diseases, ranging from simple throat and skin infections to life-threatening invasive conditions such as necrotizing fasciitis (lesh-eating disease and toxic shock syndrome.
Strep is estimated to cause over 700 million infections each year; over 650,000 of these are dangerous invasive forms.
The UCSD-Australian research team sought to identify what special characteristics make the invasive M1t1 strep clone so virulent for humans.
They observed that during the early stages of a simple skin infection, a small subpopulation of the strep bacteria hijack a protein called plasminogen from the human bloodstream.
the human immune system normally would clear a localized infection. But in the case of the M1t1 strep clone, natural selection instead favors the emergence of the invasive mutants.
can generate hypervirulent bacterial variants with an increased risk of producing invasive infections, said lead author Mark Walker, Ph d. a Professor of Biological sciences at the University of Wollongong. n the case of the invasive strep clone,
a bacteriophage provided the bacterium a genetic advantage that turned a relatively benign pathogen into a potential deadly disease agent.
When neutrophils of the immune system are summoned to clear a simple strep infection, they apply a natural selective pressure favoring the genetic mutation. he mutation allows the bacteria
and other severe forms of strep infection, said Walker. The research team used genetically engineered mice expressing human plasminogen
then spread throughout the body to produce a fatal infection. When the researchers eliminated the single bacteriophage gene encoding the neutrophil resistance factor
and could no longer spread to produce severe infection. Ancestral strains of the M1t1 strep, isolated before the acquisition of the bacteriophage,
also failed to undergo the mutation to produce serious disease. The collaborative study was initiated during Prof.
Katrin Dinkla and Gurshan Chhatwal of the Helmholtz Centre for Infection Research in Braunschweig, Germany;
#Spontaneous Rare Mutations Cause Half Of Autism Researchers are saying a new analysis of data on the genetics of autism spectrum disorder disputes a commonly held belief that autism results from the chance combinations
instead, further evidence to suggest that devastating"ultra-rare"mutations of genes that they classify as"vulnerable"play a causal role in roughly half of all autism spectrum disorder cases.
a Cold Spring Harbotr Laboratory assistant professor and on faculty at the New york Genome Center, finds that"autism genes"-i e.,
and give rise to autism, usually don't remain in the gene pool for more than one generation before they are,
This is because those born with severe autism rarely reproduce. The team's data helps the research community prioritize which genes with LGDS are most likely to play a causal role in ASD.
The team pares down a list of about 500 likely causal genes to slightly more than 200 best"candidate"autism genes.
#Drug Disarms Deadly C. Difficile Bacteria Without Destroying Healthy Gut Flora Scientists successfully defeated a dangerous intestinal pathogen, Clostridium difficile,
said the study's senior author, Matthew Bogyo, Phd, professor of pathology and of microbiology and immunology at Stanford university School of medicine.
By not aiming to kill the pathogen with antibiotics, scientists were able to avoid wiping out sizeable numbers of beneficial gut microbes.
"Unlike antibiotics--which are both the front-line treatment for C. difficile infection and, paradoxically, possibly its chief cause--the drug didn't kill the bacteria,
Infection often recurs About one in 20 people, and possibly many more, harbor C. difficile in their gut, said study co-author Justin Sonnenburg, Phd, professor of microbiology and immunology,
Usually, the pathogen causes no harm, he said. But in those with immune systems weakened by age,
Plus, the pathogen can dehydrate and condense into shrunken, long-lived spores, making it difficult to get rid of.
Most C. difficile infections originate in settings such as hospitals, clinics and assisted living facilities. Making matters worse,
the infection recurs despite antibiotic treatment. When it does succeed, antibiotics in eliminating it only 25 percent of the time.
About 7 percent of infected people die within 30 days of diagnosis. Treatments for C. difficile infection include fecal transplants,
with symptoms ranging from severe diarrhea to intestinal lesions to death. Bogyo's team has developed ways of conducting high-throughput screens of small molecules to speedily test their ability to inhibit
Helping the good guys"We figured that a molecule that interfered with the pathogen's virulence could prevent inflammation
ebselen also has been tested in clinical trials for chemotherapy-related hearing loss and for stroke. Preclinical testing provided evidence that ebselen is safe and tolerable,
whose lab is adept at using mouse models of C. difficile infection. The researchers incubated Toxin B in a solution either containing
The upshot of this and other experiments conducted by Bogyo's team is that using ebselen to disable a toxin in C. difficile was enough to significantly reduce the clinical symptoms of the infection and block the persistent gut damage in mice e
and arm movement to patients immobilized by spinal cord injuries in the neck, reports a new study.
The researchers assessed outcomes of nerve-transfer surgery in nine quadriplegic patients with spinal cord injuries in the neck.
Ultimately, medical professionals hope to discover a way to restore full movement to the estimated 250,000 people in the United states living with spinal cord injuries.
More than half of such injuries involve the neck. However, until a cure is found, progress in regaining basic independence in routine tasks is important.
"People with spinal cord injuries cannot control those functions because their brains can't talk to the nerves in the lower body,
But in the past five years, the same technique has been used to restore limited movement to patients with spinal cord injuries.
The operation can be performed even years after a spinal cord injury. It usually takes four hours,
the technique targets patients with injuries at the C6 or C7 vertebra, the lowest bones in the neck.
It typically does not help patients who have lost all arm function due to higher injuries in vertebrae C1 through C5.
surgeons reroute healthy nerves sitting above the injury site, usually in the shoulders or elbows, to paralyzed nerves in the hand or arm.
Mackinnon, director of the School of medicine's Center for Nerve Injury and Paralysis, and the Sydney M. Shoenberg Jr. and Robert H. Shoenberg Professor of Surgery."
"But once established, the surgery's benefits provide a way to let individuals with spinal cord injuries improve their daily lives."
"Another patient benefiting from the nerve-transfer technique is a 72-year-old right-handed man who had the surgery two years after he suffered a cervical spinal cord injury.
in turn, reduced his risk of developing urinary tract infections and has bolstered his overall health h
#Rare Variant Discovered Through Deep Whole-genome Sequencing Of 1, 070 Japanese People A research group at Tohoku Medical Megabank Organization (Tommo) has constructed successfully a Japanese population reference panel (1kjpn), from the genome information of 1,
%and its value for identifying causal rare variants of complex human disease phenotypes in genetic association studies.
and study of the genes related to the physical constitution and diseases that are peculiar to the Japanese.
which is the second most common cancer and accounts for over one-quarter of all cancer-related deaths.
"The scientists demonstrated that blocking PEPCK in cancer cells could slow tumor growth in mice. Alternative fuels for cancer cells The group also found evidence of increased PEPCK levels in tissues from lung-cancer patients."
"The fact that PEPCK levels are elevated in some cases of human lung cancer suggests that this enzyme may play a role in the human disease,
"adds Russell Jones, Associate professor of Physiology at Mcgill University's Goodman Cancer Research Centre. The study suggests that nutrient availability in the organism,
and other nutrients, can impact cancer progression.""Our work shows that cancers can use alternative fuel sources to help drive their growth under stressful conditions,"notes Prof.
Jones."This remarkable flexibility is part of what makes cancer so deadly, but offers hope in finding new therapies.""
""Understanding the mechanisms used by cancer cells to adapt to their environment creates new possibilities to treat this deadly disease,
"explains Alexey Sergushichev, bioinformatician and Phd student at the Department of Computer technologies at ITMO University."
and the metabolic alterations in lung cancer cells will lead to innovations in treatment for non-small cell lung cancer, one of the most deadly types of cancer
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