The scientists believe that the inhibition of this enzyme could accelerate tissue recovery from injury, disease,
and patients with colitis may benefit from this approach, "stated co-author James Willson, M d, . associate dean of oncology programs at UT Southwestern Medical center and co-author on the current study."
and may also be a treatment for colitis."The findings from this study were published recently in Science through an article entitled"Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration."
"explained co-author Dr. Joseph Ready, Ph d.,professor of biochemistry and member of the Simmons Cancer Center at UT Southwestern Medical center.
SW033291 or related compounds may merit clinical investigation as a strategy to accelerate recovery after bone marrow transplantation and other tissue injuries. e
The new technique holds the promise of a potent new tool to offset the growing challenge of antibiotic resistance by bacterial pathogens, according to the team.
this new technique is quite promising for future treatment of bacterial pathogens, as it enables de novo detection and characterization of epigenetic heterogeneity in a bacterial population.
and is associated with gastric cancer, the team discovered that epigenetic heterogeneity can quickly emerge as a single cell divides,
or knee osteoarthritis or the severe injuries caused by major trauma, for example in road traffic accidents or war injuries."
or knee osteoarthritis or the severe injuries caused by major trauma, for example in road traffic accidents or war injuries."
#Scientists Smell Success for Treatment of Spinal cord Injuries Three years after they treated patients with spinal cord injury in a randomized clinical trial with transplanted cells from the patients'olfactory mucosa to build a bridge
and daily life activities, wrote the investigators in an article (utologous Olfactory Lamina Propria Transplantation for Chronic Spinal cord Injury:
randomized 12 patients with complete spinal cord injury (SCI) to receive OLP transplants and followed them for three years after transplantation,
Eight of the 12 patients were without bladder sensation at the preoperative evaluation. ptimal outcomes may be related to age, severity and level of injury
#Scientists Devise Promising Strategy to Tackle MERS A Purdue University-led team of scientists studying the Middle east Respiratory Syndrome (MERS) reports that it found molecules that shut down the activity of an essential enzyme
. Purdue's Walther Professor of Cancer Structural biology and professor of biological sciences and chemistry who leads the research team."
what our work with SARS and other related coronaviruses predicted. So, we investigated what was happening
which the virus cannot create more viruses to further an infection. Once inside the cell, the virus creates a long strand of a large viral protein that must be cut at specific points to release individual proteins that serve various functions in building new virus particles.
and its dimer will break apart much more easily than the SARS protease or those of other coronaviruses.
who also is deputy director of the Purdue University Center for Cancer Research e
#New Drug Prevents Cancer cells from Staging Last Stand Unlike many last stands in human history,
the last stands arranged by individual cancer cells often resist being overwhelmed, with dire consequences for cancer patients.
Such a coordinated attack could effectively overrun cancer before it could muster one last defense,
"The finding opens the door to a new way to attack cancer, "said Reuben Shaw, a senior author of the paper, professor in the Molecular and Cell biology Laboratory at the Salk Institute and a Howard hughes medical institute Early Career Scientist."
"This allowed us to find a drug that targeted ULK1 not just in a test tube but also in tumor cells.
Our work provides the basis for a novel drug that will treat resistant cancer by cutting off a main tumor cell survival process. i
#New Target Blocks Malaria Invasion and Transmission With close to 50%of the world population living in endemic areas and it being one of the leading causes of death in children under the age of 5,
malaria is a scourge that humans have endured since before they could walk fully upright. Moreover, the rate of resistance to current drug therapies is growing exponentially
The scientists found that a malaria protein called calcineurin is essential for parasite invasion into red blood cells."
particularly in light of the huge disease burden of malaria,"explained senior author Manoj Duraisingh, Ph d.,professor of Immunology and Infectious diseases at the T. H. Chan School of Public health."
"As drug resistance is a major problem for malaria control and eradication, it is critical that that we continue to develop new antimalarials that act against previously unexploited targets in the parasite to keep priming the drug pipeline."
implicating the protein as a potential target for blocking malaria transmission. Since there is much genetic conservation among parasites in the Apicomplexa phylum,
as it prevented cellular attachment in this parasite species as wellpening up the potential that calcineurin could target other parasitic diseases in addition to malaria."
#Depersonalized Medicine Shows Promising Results Against Cancer Researchers at St louis University (SLU) say they have,
Unlike recent advances in personalized medicine that focus on specific genetic mutations associated with different types of cancer,
this research targets a broad principle that applies to almost every kind of cancer: its energy source.
and in human tumor cells in the lab, showed that a specific drug can stop cancer cells without causing damage to healthy cells or leading to other severe side effects.
"Targeting cancer metabolism has become a hot area over the past few years, though the idea is not new,"according to Dr. Burris.
In fact, this is how doctors use positron emission tomography to scan images to spot tumors. PET scans highlight the glucose that cancer cells have accumulated.
In a paper (road Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis published in Cancer cell
Dr. Burris reports that the Warburg effect is the metabolic foundation of oncogenic growth, tumor progression,
and metastasis as well as tumor resistance to treatment.""Cancer cells look for metabolic pathways to find the parts to grow and divide.
"If the Warburg effect and lipogenesis are key metabolic pathways that drive cancer progression, growth, survival, immune evasion, resistance to treatment,
and disease recurrence, then, Dr. Burris hypothesized, targeting glycolysis and lipogenesis could offer a way to stop a broad range of cancers.
He and his colleagues created a class of compounds that affect a receptor that regulates fat synthesis. The new compound, SR9243,
and in human tumor cells grown in animal models. Because the Warburg pathway is a feature of almost every kind of cancer,
researchers are testing it on a number of different cancer models.""It works in a wide range of cancers both in culture and in human tumors developing in animal models,"explained Dr. Burris."
"Some are more sensitive to it than others. In several of these pathways, cells had been reprogramed by cancer to support cancer cell growth.
This returns the metabolism to that of more normal cells.""In human tumors grown in animal models,
it reportedly worked well on lung, prostate, and colorectal cancers and, to a lesser degree, in ovarian and pancreatic cancers."
"It also seems to work on glioblastoma, an extremely difficult to treat form of brain cancer,
though it isn't able to cross the brain-blood barrier very effectively. The challenge for researchers in this scenario will be to find a way to allow the drug to cross this barrier, the body's natural protection for the brain,
which can make it difficult for drug treatments to reach their target. When SR9243 is used in combination with existing chemotherapy drugs,
it increases their effectiveness, in a mechanism apart from SR9243's own cancer fighting ability, added Dr. Burris B
like recognizing an invading pathogen and mounting a response. If so, one might program those cells to collaboratively diagnose the flu or malaria:
just add saliva to a packet of yeast and see if it changes color. For now,
a versatile hormone that controls everything from where a plant's roots develop to how effectively they fight off pathogens.
San diego School of medicine and Moores Cancer Center led an international team that discovered that cancer stem cell properties are determined by epigenetic changes.
which was carried out on human tumor samples and mouse models, is published in the Proceedings of the National Academy of Sciences.
The team reports that Lysine-Specific Demethylase 1 (LSD1) turns off genes required to maintain cancer stem cell properties in glioblastoma, a highly aggressive form of brain cancer.
rather than specific DNA sequences, determines tumorigenicity in glioblastoma cancer stem cells.""One of the most striking findings in our study is that there are dynamic and reversible transitions between tumorigenic
whether or not glioblastoma cells can proliferate indefinitely as cancer stem cells is their relative abundance of LSD1,
turning off a number of genes required for maintaining cancer stem cell properties, including MYC, SOX2, OLIG2 and POU3F2."
In fact, this spare can help the genome steer clear of cancer. Various kinds of damage can happen to DNA,
which is a hallmark of cancer. One common way that our genetic material can be harmed is from a phenomenon called oxidative stress.
When our bodies process certain chemicals or even by simply breathing, one of the products is a form of oxygen that can acutely damage DNA bases,
predominantly the G. In order to stay cancer-free, our bodies must repair this DNA. This is where the special vulnerability noted earlier comes in.
They scanned the sequences of known human oncogenes associated with cancer, and found that many contain the four G-stretches necessary for quadruplex formation
When they exposed these quadruplex-forming sequences to oxidative stress in vitro, a series of different tests indicated that the extra G allowed the damages to fold out from the quadruplex structure,
Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress:
which the G4 sequences act as sensors of oxidative stress e
#New Cell Structure Finding Might Lead to Novel Cancer Therapies University of Warwick scientists in the U k. say they have discovered a cell structure
which could help researchers understand why some cancers develop. For the first time a structure called'the mesh'has been identified
which helps to hold together cells. They believe their study (he mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle,
which is found to change in certain cancers, such as those of the breast and bladder, according to Stephen Royle, Ph d.,team leader and associate professor and senior Cancer Research UK Fellow at the division of biomedical cell biology at Warwick Medical school."
"As a cell biologist you dream of finding a new structure in cells but it's so unlikely.
which has been linked to a range of tumors in different body organs. The mitotic spindle is responsible for sharing the chromosomes
TACC3, is overproduced in certain cancers. When this situation was mimicked in the lab, the mesh and microtubules were altered
According to Emma Smith, Ph d.,from Cancer Research UK, his early research provides the first glimpse of a structure that helps share out a cell's chromosomes correctly
and it might be a crucial insight into why this process becomes faulty in cancer
so as to reduce the stress on the couple. About 13%of couples of reproductive age experience fertility problems.
#Dissolvable Microneedles May Herald New Age of Vaccine Delivery Scientists from Osaka University report that flu vaccines delivered using microneedles that dissolve in the skin can protect people against infection even better than the standard needle-delivered vaccine.
The authors of the study (linical study and stability assessment of a novel transcutaneous influenza vaccination using a dissolving microneedle patch,
The continued threat of pandemics such as H1n1 swine flu and emerging infectious diseases such as Ebola makes vaccine development and mass vaccination a priority for global healthcare.
and brings the risk of needle-related diseases and injuries. The new microneedle patch is made of dissolvable material,
The researchers compared the new system to traditional needle delivery by vaccinating two groups of people against three strains of influenza:
#Cell cycle protein Reverses Metabolic Reprogramming of Cancer cells Understanding how cancers cells reprogram cellular metabolic pathways is critical toward the development of novel therapeutic compounds.
Cutting off a cancer cell ood supplyis a veritable lynchpin for the efficient removal of tumors and now researchers at the University of Texas MD Anderson Cancer Center believe they may have found a protein that serves that very function.
and also serve to protect cells from the transformation into tumors.""We know that all cancers grow by learning how to reprogram their metabolism,
"said senior author Mong-Hong Lee, Ph d, . professor of molecular and cellular oncology at MD Anderson Cancer Center. ut exactly how this occurs has not been understood fully.
Our study showed that 14-3-3s opposes and reverses tumor-promoting metabolic programs.""The findings from this study were published recently in Nature Communications through an article entitled ell cycle regulator 14-3-3s opposes
and reverses cancer metabolic reprogramming. 14-3-3s is part of a family of conserved regulatory molecules that are expressed in all eukaryotic cells.
Moreover, the 14-3-3 proteins have been observed to be involved actively in regulating an array of signaling molecules such as kinases, phosphatases,
and transmembrane receptors. 14-3-3s has been shown previously to regulate cancer genes, such as p53 and suppress tumor growth,
but in this instance the investigators were able to observe the protein acting on metabolic pathways
Dr. Lee and his team showed that 14-3-3s opposed tumor-promoting metabolic programs by increasing the degradation of the transcription factor c-Myc.
Additionally, 14-3-3s demonstrated a suppressive effect on cancer glycolysis, mitochondrial biogenesis, as well as a range of other major metabolic processes of tumors."
"14-3-3s expression levels can help predict overall and recurrence-free survival rates, tumor glucose uptake,
and metabolic gene expression in breast cancer patients,"explained Dr. Lee.""These results highlight that 14-3-3s is an important regulator of tumor metabolism,
and loss of 14-3-3s expression is critical for cancer metabolic reprogramming.""The MD Anderson team is excited about the findings from this new study
and feels that it adds extended insight into the connective pathways between the cell cycle and cancer cell metabolism."
"We anticipate that pharmacologically elevating 14-3-3s's function in tumors could be a promising direction for targeted anticancer metabolism therapy development in the future,"concluded Dr. Lee r
which are linked closely to early embryonic development and to diseases such as cancer. In plants as in animals and humans, intricate molecular networks regulate important biological functions, such as development and stress responses.
The system can be likened to a massive switchboardhen the wrong switches are flipped, genes can be inappropriately turned on or off,
leading to the onset of diseases. Now, VARI scientists report that they have unraveled how a plant protein known as TOPLESS interacts with other molecules responsible for turning genes off.
and how they interact with other molecules in health and disease states.""Although the new study provides further insight into human molecular pathways,
and an earlier Science paper, both of which describe how plants respond to drought and temperature stress.
Market Drivers An important driver of the cell culture market is the production of seasonal influenza vaccines,
Seasonal influenza vaccines have traditionally been produced using egg-based technology. However, this labor-intensive approach to vaccine development is currently being replaced by cell-culture systems.
Prefluce, the first cell culture-based vaccine, received European approval in March 2011 and was available for the 2011012 influenza season in the 13 participating European union countries.
which is the first U s.-licensed (trivalent inactivated) influenza vaccine manufactured using cell culture technology.
According to those findings, all individuals who received the vaccine were protected against Ebola virus infection within 6 to 10 days of vaccination. he results of this interim analysis indicate that rvsv-ZEBOV might be highly efficacious and safe in preventing Ebola virus disease
when delivered during an Ebola virus disease outbreak via a ring vaccination strategy, the study team concluded.
that enough. n the immediate vaccination group, there were no cases of Ebola virus disease with symptom onset at least 10 days after randomization,
whereas in the delayed vaccination group there were 16 cases of Ebola virus disease from seven clusters,
and Médecins sans Frontières. he extraordinary efforts of the team in Guinea and other experts have yielded interim results that suggest a potential role for our rvsv-ZEBOV vaccine in the fight against Ebola disease, Roger
and Sanitation and the U s. Centers for Disease Control and Prevention (CDC); The Partnership for Research on Ebola Vaccines in Liberia (PREVAIL) Phase II study being conducted by a Liberia-NIH partnership in Liberia.
and replacing it with a single Ebola virus gene that alone cannot cause the disease. In November 2014
and the Public health Agency of Canada in helping conduct the studies have been NIH and its National Institute of Allergy and Infectious diseases,
and the U s army Medical Research Institute of Infectious diseases. Major funding for these studies has come from sources that include the U s. Department of defense Defense Threat Reduction Agency and Joint Vaccine Acquisition Program, the U s. Department of health and Human Service Biomedical Advanced Research Development Authority,
but primarily due to clinical trial expenses related to its pipeline of product candidates, including its Hyperacute immunotherapy cancer programs and its IDO pathway inhibitor (indoximod) programs
when EL panels made from plastic are bent too sharply, fractures and a severely diminished output usually result.
advancing efforts to create blood for surgery and treat leukaemia and other cancers. His latest work continues in this same vein,
but activate the body's own immune system to stave off harmful tumors. The clinical trial was conducted across 64 research centers around the world
and led by The Institute of Cancer Research in London. It saw 436 patients suffering from inoperable skin cancers treated with a modified form of herpes virus called Talimogene Laherparepvec T-VEC.
whose genetic errors give rise to weaker defences against infections. The result is engineered a genetically virus with the ability to grow in cancer cells and blow them up from the inside.
What's more, T-VEC is designed also to produce a molecule known as GM-CSF that moves the body's immune system to destroy tumors
when used in the less advanced stages of the cancer, suggesting that T-VEC could prove a valuable early treatment option for skin cancers that are unable to be removed by a surgeon.
Patients with stage III and early stage IV melanoma a condition that was shown to carry an average survival of 21.5 months
The scientists say that T-VEC is the first of such viral therapies to be proven beneficial in treating melanoma in a phase III clinical trial.
Some also see potential for the portable paper power tech to create diagnostic tools for disease control in the developing world.
A pulse generator inserted under the skin below the collarbone provides electrical signals that create a lesion,
sticking to the tissue at the site of injury and creating a barrier over a wound."
and had no toxic effects on living cells in the lab. The team also discovered that mixing the gel with silica nanoparticles gave it the ability to more effectively prevent bleeding,
something that could allow better protection of a wound and stop bleeding with a single treatment.
with smartphones repurposed as blood-scanning microscopes, HIV testers and sleep apnea detectors. The latest advance in this area comes in the form of a fiber optic sensor for smartphones that monitors bodily fluids,
a tool that could be used for biomolecular tests such as pregnancy or diabetes monitoring. Surface plasmon resonance (SPR) is a process where a stream of light is directed onto a metallic film, with most,
#Ultrasound cuts healing time of chronic wounds by 30 percent Further to the mental anguish, a lot of time in a hospital bed can bring about some agonizing physical discomfort.
This is most commonly brought about by skin ulcers and bedsores, which threaten to evolve into dangerous and potentially deadly infections if left untreated.
But a British research team has happened upon a technique that promises to cut the healing time of these
and other chronic wounds by around a third, using simple low-intensity ultrasounds. Wound healing presents a serious problem for two demographics in particular
the elderly and those with diabetes. When a young and healthy person incurs an injury to the skin,
connective tissue cells called fibroblasts migrate to the site of the wound and kickoff the healing process.
But skin defects that are typical of above groups prevent the migration of fibroblasts and make healing problematic, sometimes leading to amputation.
It found the technique reduced healing times by 30 percent in aged and diabetic mice,
The team also observed that the technique could be replicated successfully in human venous leg ulcer patients,
indicating that it could be applicable to other chronic human wounds. And because it is modelled on
#Smart capsule keeps hold of payload until reaching its target We have drugs to treat nasty conditions like irritable bowel syndrome and Crohn's disease,
a bacterial infection that causes the body to lose microorganisms essential in fighting off infection. One method used to treat C. difficile involves transplanting feces from another person into the large intestine to provide it with the missing microorganisms.
It may one day be used to reverse acquired blindness, alter pain thresholds and even hit the rest button on our biological clocks.
The scientists say the technology could be used to one day treat pain, epilepsy, depression and other neurological disorders.
#Laser device may soon non-invasively monitor diabetics'glucose levels In order to monitor their blood glucose levels, diabetics typically have to perform painful and inconvenient finger-prick blood tests in some cases, several times a day.
Using an implantable glucose-monitoring sensor is one alternative, although it must be installed surgically and subsequently removed for replacement.
this technology opens up the potential for people with diabetes to receive continuous readings, meaning they are alerted instantly
or readings directly to doctors, allowing them to profile how a person is managing their diabetes over time."
#Pill on a string pulls early signs of cancer As with every form of the deadly disease,
early detection of oesophageal cancer is critical to recovery. The current approach of detecting the cancer through biopsy can be a little hit and miss,
so the University of Cambridge's Professor Rebecca Fitzgerald and her team have developed what they claim to be a more accurate tool for early-diagnosis. Billed as"a pill on a string,
According to Fitzgerald, the five-year survival rate for oesophageal cancer is only 13 percent, a fact
which has led researchers to hunt for signs of a condition that precedes the disease, known as Barrett's oesophagus.
Between one and five of every 100 people with Barrett's oesophagus go on to develop oesophageal cancer.
Using biopsies to detect the pre-cancer condition is problematic for a couple of reasons. It requires trained scientists to pore over the samples looking for abnormalities,
which introduces a degree of subjectivity and possible human error. And although a stretch of oesophagus affected by Barrett's could measure as much as 10 cm (4 in),
The team's latest research into Barrett's oesophagus and oesophageal cancer was published in the journal Nature Genetics.
#Mussel-inspired surgical glue shuts down bleeding wounds in 60 seconds The ability of mussels to stubbornly bind themselves to underwater surfaces has intrigued scientists for years.
the scientist say it was able to close bleeding wounds in less than 60 seconds and healed them without inflammation
the implant received market approval from the Food and Drug Administration (FDA) in the US, for the treatment of Retinitis Pigmentosa (RP) a degenerative condition that affects the peripheries of patient vision.
and to have the opportunity to help a great deal more people living with blindness, "says Second sight's Executive officer, Dr. Robert Greenberg."
or face so that tumors can be removed from the pituitary gland and skull base. It can also be done through the nasal cavity with an endoscope (a thin tube with a camera attached),
In addition to bio-sensing gloves that could react selectively to different pathological agents, Omenetto says the ability to print antibiotics in topographical patterns would enable"smart"bandages in
which therapeutics are incorporated custom into the bandage to match a specific injury. Additionally, although the researcher's tests only involved the use of one ink cartridge,
#Noninvasive spinal cord stimulation gets paralyzed legs moving voluntarily again Five men with complete motor paralysis have regained the ability to move their legs voluntarily
and it is known to induce walking motions in mice with spinal cord injuries. All five men had been paralyzed for more than two years prior to receiving the treatment,
Edgerton now hopes to test the noninvasive stimulation on people with partial paralysis. He also notes that,
#World First Blood test To Diagnose Irritable bowel syndrome World First Blood test To Diagnose Irritable bowel syndrome Newshealthby Good News Network-May 21,
whether a person actually has developed irritable bowel syndrome a common disorder that includes bouts of relentless diarrhoea,
which plagues about ten percent of the world population and nearly 40 million Americans. adsbygoogle=window. adsbygoogle.
or another that the disease was psychological, all in their head, said Dr Pimentel. he fact that we can now confirm the disease through their blood,
not their head, is going to end a lot of the emotional suffering I have seen these patients endure.
or READ more at Daily mail) Pass on the Good Newsbelow) TAGSBREAKTHROUGHHEALTHINNOVATIONMEDICALSCIENCEWELLNESS Cuban Cancer Vaccine Could Soon be Available in U s. May 20,
Overtext Web Module V3.0 Alpha
Copyright Semantic-Knowledge, 1994-2011