Pathology, forensics, and beyond Yang explains that when we look at light from an object, we are only able to sense variations in intensity.
The very large field of view that the new system can image could be particularly useful for digital pathology applications,
The researchers say that the new method could have wide applications not only in digital pathology but also in everything from hematology to wafer inspection to forensic photography.
The knowledge of how mutations drive evolution can inform our understanding of how tumors resist chemotherapeutics
or disease-causing microbes. Previous evidence suggests that yeast may experience beneficial mutations that inactivate genes they no longer need.
The new insight may be helpful in finding ways to minimize the potential toxicity of graphene says Agnes Kane chair of the pathology and laboratory medicine department at Brown and one of the study s authors.
Under the microscope Annette von dem Bussche assistant professor of pathology and laboratory medicine was able to verify the model experimentally.
#We ve also started exchanging ideas and information with scientists facing related challenges such as herbicide resistance in weeds and resistance to drugs in bacteria HIV and cancer.#
#Nasty parasites turn up in dead otters CARDIFF U. UK) A variety of disease-causing parasites are turning up in the bodies of dead otters in the UK.
The infection is prevalent across many areas of the UK, with significantly more cases arising in the eastern region.
In humans the parasite can lead to miscarriage and retinal abnormalities. Parasitic flatwormsivided into two species Pseudamphistomum truncatum and Metorchis albidusere found in 18.3 percent of otters.
both are associated with pathological damage to the otter gall bladder. Dissections of affected otters revealed gall bladders to be inflamed or thickened.
this may have implications for vector-borne diseases, which can infect humans and their companion animals. he project research on the parasites that infect otters has revealed previously unknown aspects of their distribution
But smartphones are also capable of transforming into competitive diagnostic tools as a team of biomedical engineers out of Columbia University is showing with their new attachment that can detect both HIV and syphilis in a single 15-minute test.
It means that similar tests screening for other diseases may be just around the corner.##Our work shows that a full laboratory-quality immunoassay can be run on a smartphone accessory#one researcher said#in the school news release.#
the sooner they start taking antiretroviral meds the less likely they are to pass the disease to their babies.
and tests for more than one disease. This kind of development is about to be the new norm as diagnostic tools begin to be compatible with our portable devices as well as capable of spitting out results screening for multiple infectious diseases in just minutes.
The key is being competitive with the most accurate tests; especially when it comes to highly-stigmatized STDS false positive
dozens and possibly hundreds of diseases can result, causing a wide range of problems that include extreme fatigue, dementia, stunted growth, deafness, blindness, multi-organ failure, and even death.
It a newly-discovered category of diseases, most of which have only been characterized in the past decade, and a growing number of geneticists is now exploring the role of misbehaving mitochondria in basic aging.)
The US United Mitochondrial Disease Foundation and 10 other similar groups from around the world described the condition in an open letter to Parliament as nimaginably cruel. t strips our children of the skills they have learned,
inflicts pain that cannot be managed, and tires their organs one by one until their little bodies cannot go on any more,
(or who have died from) mitochondrial diseases. Dr. Gillian Lockwood, a reproductive ethicist, told the BBC that this week vote amounts to a mall changein the legislation. he biggest problem is that this has been described as 3-parent IVF
musicality. t a revolutionary way of preventing these diseases, and wee ready after extensive animal testing.
because theye had children with mitochondrial diseases) can have babies with healthy mitochondria instead, even if that part of the egg must be donated.
if the procedure is effective and safe in humans. t a revolutionary way of preventing these diseases,
when designing nuclear reactors is finding materials that can withstand the massive temperatures, radiation, physical stress and corrosive conditions of these extreme environments.
map cerebral activity to help identify tumors in preparation for surgery, or even create better brain-computer interfaces.
"By making an inexpensive system you could have one in every hospital to test for traumatic brain injuries
and sustain common intestinal microbes on the surface of the device cultured intestinal cells allows the device to simulate some of the physiological features important to understanding many diseases.
"Because the models most often available to us today do not recapitulate human disease, we can't fully understand the mechanisms behind many intestinal disorders,
"Having better, more accurate in vitro disease models, such as the gut-on-a-chip, can therefore significantly accelerate our ability to develop effective new drugs that will help people who suffer from these disorders."
and a spleen-on-a-chip to treat sepsis. The team gut-on-a-chip is detailed in the journal Lab on a Chip.
reduces stress, and makes the milking station less of a bottleneck because there isn't a whole herd trying to get in at the same time.
and pen of the Astronaut 4 are equipped also with sensors to detects signs of mastitis.
"The hotline administrator can'push'customized content (such as in cases of drought, pest and disease) to callers based on crop,
#Freedom Driver allows man with artificial heart to await transplant at home Heart failure patients awaiting organ transplants normally find themselves anchored to the hospital bed by a washing machine-sized device that keeps blood pumping through their veins.
This organ shortage means that sufferers of advanced heart failure are implanted with devices to aid in survival.
We are prepared not to deal with an outbreak of pathogens such as E coli and salmonella in tainted foods.
But a team of scientists are urging caution with a study conducted at the Technion-Israel Institute of technology suggesting that exposure to silicon-based nanoparticles may play a role in the development of cardiovascular disease.
The team was seeking to explore the effects that the nanoparticles have on the development of atherosclerosis a condition that leads to the hardening of the arteries and cardiovascular events such as heart attack and stroke.
or lipids leading to the development of lesions and hastening the onset of atherosclerosis. This exposure may be especially chronic for those employed in research laboratories
and overuse of existing antibiotics has led to the increasing emergence of multidrug-resistant pathogens, with the World Health Organisation warning of an impending"post-antibiotic era"where common infections will once again pose the risk of death,
as was the case before the discovery of the first antibiotics in the early 20th century.
As a result, we've seen various research efforts that take a non-antibiotic approach to bacterial infection
The researchers hope the gelatin nanoparticles administered through the nasal cavity can help deliver other drugs to more effectively treat a variety of brain injuries and neurological diseases.#
and bone cancer pain suggesting a promising new approach to pain relief. The scientific efforts led by Salvemini,
whose main use case is letting surgeons physically eelanomalies such as tumors in CT SCANS, could also revolutionize everything from advertising to architecture.
#Fast-growing Network Beyond Superchargers One of the most commonly cited arguments against electric cars is range anxiety.
But Tesla plan to solve range anxiety goes beyond its Supercharger network. There is another, less-followed network of a different type of charger Tesla has been quietly rolling out at a rapid clip.
#South korea Training Children as Dementia Supporters in One of the Worlds Fastest Aging Countries They were stooped,
Alzheimer disease and other dementias. As one of the world fastest-aging countries, with nearly 9 percent of its population over 65 already afflicted, South korea has opened a ar on Dementia, spending money and shining floodlights on a disease that is,
here as in many places, riddled with shame and fear. South korea is training thousands of people,
Besides the aging simulation exercise, they viewed a Powerpoint presentation defining dementia and were trained, in the hall Dementia Experience Center, to perform hand massage in nursing homes. hat did
I do with my phone? It in the refrigerator, said one instructor, explaining memory loss. ave you seen someone like that?
Hundreds of neighborhood dementia diagnostic centers have been created. Nursing homes have tripled nearly since 2008. Other dementia programs
providing day care and home care, have increased fivefold since 2008, to nearly 20,000. Care is subsidized heavily. And a government dementia database allows families to register relatives
and receive iron-on identification numbers. Citizens encountering wanderers with dementia report their numbers to officials, who contact families.
To finance this, South korea created a long-term-care insurance system, paid for with 6. 6 percent increases in people national health insurance premiums.
In 2009, about $1 billion of government and public insurance money was spent on dementia patients.
dementia is straining the country, socially and economically. t least one family member has to give up workto provide caregiving,
families may also lose dementia sufferersincomes. Most families no longer have generations living together to help with caregiving,
Dementia Epidemic South korea is at the forefront of a worldwide eruption of dementia from about 30 million estimated cases now to an estimated 100 million in 2050.
South korea also worries that dementia, previously stigmatized as host-seeingor ne second childhoodcould ilute respect for elders,
So the authorities promote the notion that filial piety implies doing everything possible for elders with dementia,
disease of knowledge and the brain which makes adults become babies. But South korea low birth rate will make family caregiving tougher. feel
saying that it destigmatizes dementia and that patients who egress to earlier daysmay ind it easier to relate to young children.
and saying, addy, don drink so much because it not good for dementia. At a Dementia March outside the World cup Soccer Stadium, children carried signs promoting Dr. Yang Mapo district center:
ake the Brain Smile! and ow is Your Memory? Free diagnosis center in Mapo. The Mapo Center for Dementia perches at a busy crossroads of old and new, near a university and a shop selling naturopathic goat extracts.
It has exercise machines out front and a van with pictures of smiling elderly people. Even people without symptoms come,
ou do not have dementia and can visit two years later. Cha Kyong-ho family was wary of getting him tested. ementia was a subject to hide,
Dr. Yang said. his is the very beginning stages of Alzheimer disease. He suggested that Mr. Cha get a government-subsidized brain M. R i. to confirm the diagnosis,
Students as Helpers Schools offer community service credit, encouraging work with dementia patients, whom students call grandmas and grandpas.
17, was shaken to realize that dementia could explain why her grandfather recently grabbed a taxi
The dementia caregiving program had made him onder why I wasn able to do that with my own grandma,
Citing an epidemic of childhood obesity, regulators are taking aim at a range of tactics used to market foods high in sugar,
The guidelines were created at the request of Congress and written by the commission, the Food and Drug Administration, the Agriculture department and the Centers for Disease Control.
The need for better traceability became clear after a national outbreak of salmonella illness in spring 2008 that sickened more than 1, 300 people across the country.
Initially, investigators at the FDA and the Centers for Disease Control and Prevention identified tomatoes as the culprit
#3d printed eye cells could one day cure blindness Researchers have printed actually viable retina cells using an inkjet printer.
Living, 3d printed retina cells could someday aid in curing many#kinds of blindness.####At the University of Cambridge, researchers have pulled off something of a 3d printing coup.
possibly even including damaged nerve cells and spinal chord injuries. Via Dvice Share Thissubscribedel. icio. usfacebookredditstumbleupontechnorat t
Americans xenophobia. We want to hear from people who sound just like us. In the course of reporting this story,
What kind of anxiety might you start to feel each time you opened your mouth? No wonder people like hitting the button that says,##Hello, I m Richard!##
What was seen previously as the domain of paranoid nitpickers has exploded into the public consciousness, shaking international ties and making many people reevaluate how they live their lives online.##
The discovery has implications for understanding age-related diseases including cancers, neurodegenerative disorders and diabetes.##One way all mammalian cells produce energy is via aerobic respiration, in
which can lead to conditions such as Alzheimer s disease and diabetes. To investigate why this decline occurs,
These mice also had higher levels of a protein produced by the nucleus called hypoxia inducible factor (HIF-1a.
At the end of the week, markers of muscular atrophy and inflammation had dropped and the mice had developed even a different muscle type more common in younger mice.
##We found that modulating this pathway can improve mitochondrial function and age-associated pathologies in old mice,
##You ll be able to pick up problems like dyslexia instantly, ##Meyerson said.####If a child has extraordinary abilities,
##Doctors will use your DNA to keep you well Global cancer rates are expected to jump by 75 percent by 2030.
IBM wants computers to help doctors understand how a tumor affects a patient down to their DNA.
They could then figure out what medications will best work against the cancer, and fulfill it with a personalized cancer treatment plan.
The hope is that genomic insights will reduce the time it takes to find a treatment down from weeks to minutes.##
to help those with disabilities better navigate urban streets. Of course, as in the upcoming video game Watch Dogs from Ubisoft, a bad guy could hack into the city and use its monitoring systems in nefarious ways.
Most supplements do not prevent chronic disease or death, their use is justified not, and they should be avoided##The evidence also has implications for research.
our connected devices will be able to monitor our state##inactivity could indicate sickness or depression.
The amazing discovery is expected to open new doors to the diagnosis and treatment of diseases, according to a new study.##
and give clues for the treatments of diseases.####The fact that the genetic code can simultaneously write two kinds of information means that many DNA changes that appear to alter protein sequences may actually cause disease by disrupting gene control programs
or even both mechanisms simultaneously,##said Stamatoyannopoulos. Speaking about the discovery, Stamatoyannopoulos said that the##new findings highlight that DNA is an incredibly powerful information storage device,
##People with autism, who can have a hard time reading facial expressions, may be among the beneficiaries, Dr. Burleson said.
The electrode could even be used to simulate sugary treats for people with diabetes. In fact this same research team is also working on a digital lollipop:
Wearable device mania has swept the whole world. An Australian research institute predicted that one fifth of Australians would have one wearable device each in the future year, with shipment reaching 36 million units.
which can cause infections. Witricity is working with heart pump maker Thoratec to create a wireless solution.
MOUNTAIN VIEW, CA September 18, 2013 Google today announced Calico, a new company that will focus on health and well-being, in particular the challenge of aging and associated diseases.
a new company that will focus on health and well-being, in particular the challenge of aging and associated diseases.
Art and I are excited about tackling aging and illness. These issues affect us allrom the decreased mobility
to life-threatening diseases that exact a terrible physical and emotional toll on individuals and families.
me about a venture that would take the long term view on aging and illness, I was intrigued deeply.
Might there be a direct link between certain diseases and the aging process? We agreed that with great people, a strong culture and vision and a healthy disregard for the impossible,
The crisis is attributed generally to a mixture of disease, parasites, and pesticides. Other scientists are pursuing a different tack:
Does it suggest a level of paranoia to want to be forgotten on the internet? Are we really revealing that much about ourselves that privacy has become something of an antiquated concept?
#Chemotherapy will be obsolete in 20 years as scientists launch DNA project Scientists launch a new landmark project to map the genetic causes of disease.
Scientists have predicted the end of chemotherapy after launching a landmark project to map 100,000 genomes to find the genes responsible for cancer and rare diseases.
I believe we will be able to transform how devastating diseases are diagnosed and treated in the NHS and across the world,
In rare congenital disease, in cancer and in infections, genomic insights are already transforming diagnosis and treatment.
Prof Farrer also predicted that genome sequencing to find the causes of the disease will become standard within our lifetime.
Over the next four years, about 75,000 patients with cancer and rare diseases, plus their close relatives, will have their whole genetic codes,
Cancer patients will have the DNA of both healthy and tumour cells mapped, making up the 100,
Claims about ablack pathology also#fall short. But police scrutiny often falls most heavily on people of color nonetheless.#
antibiotics to prevent infections, or even living cells to the scaffolds. At the moment, calcium phosphate powder is temporarily bound using an acidic binder chemical typically phosphoric acid
and even pest and disease resistance. There is potential for these multifunctional techno-greenhouses built around LED grow lights to increase the quality of the food we eat
Something that acts almost human but not quite, reads to our brain's pattern recognition systemas illness.
we read this as a sign of disease meaning the close but no cigar robot reads as a costly mate
and she makes the stress melt away at the end of a long day. But Lucy isn t Mr. Petrone s girlfriend.
##If it s a friend or a girlfriend, there s always points in time where there could be stress within that relationship,
Developers had to overcome unusual challenges to help people with visual impairments move their reading fingers along a straight line of printed text that they could not see.
and resources to build some of the bleeding edge mobile computing hardware available today on the cheap.
I'll need solid coverage for my impending heart attack. Via Fast Company Shar r
#Bionic pancreas shows promise in managing diabetes The bionic pancreas In 2000, Ed Damiano s son was diagnosed with type 1 diabetes.#
#Damiano s son was 11 months old. The biomedical engineer, decided to create a device that would help his child
and millions of others better manage their disease. He set a goal of having it ready
Type 1 diabetes occurs when beta islet cells in the pancreas die off. These cells sense levels of blood sugar, aka glucose,
The disease usually occurs early in life and can be managed through careful monitoring of blood insulin levels,
An app for that But controlling the disease is all-consuming, lurking in the back of every waking decision.
Damiano, who works at the University of Boston, says a bionic pancreas his team has developed with colleagues at the Massachusetts General Hospital offers hope of a normal life to people with type 1 diabetes.
A smartphone-linkedpancreas removes the need for people with type 1 diabetes to constantly monitor
were monitored also for five days at a summer camp for kids with diabetes. For both groups, the results with the bionic pancreas were compared with five days of the participants using their usual method of controlling the disease pricking their finger to monitor glucose levels
and using an insulin pump, that requires them to manually calculate the dosage. The device performed beyond our expectations,
what the participants were able to do managing their own diabetes prior to the trial, he says.
the longer you can stave off the long-term health complications of diabetes, says Damiano. Emotional impact The study had a tremendous emotional impact on participants.
They got a glimpse of life without diabetes and that is pretty profound, he says. In many cases, the participants were reluctant to give the devices back,
both in the US and in the UK, says Alasdair Rankin, director of research at Diabetes UK,
but there is now real hope that this technology has the potential to transform the lives of people with type 1 diabetes within a generation,
The results of Damiano s study and several other groups working on artificial pancreases were presented today at the meeting of the American Diabetes Association in San francisco. Via New Scientist Share Thissubscribedel. icio. usfacebookredditstumbleupontechnorat t
and memory associated with neurodegenerative diseases and aging. The new research was published June 9 in the Proceedings of the National Academy of Sciences.
Memory loss is a major health problem both in diseases like Alzheimer s, but also just associated with aging, said Yanhong Shi,
Ph d.,lead author of the study and a neurosciences professor at City of Hope. In our study, we manipulated the expression of this receptor by introducing an additional copy of the gene
and those who have a neurological disease or brain injury. The bulk of the brain s development happens before birth,
#Sanaria will use robots to mass produce a promising new malaria vaccine Sporobot would increase the speed of production 20 30 times over.
What if you had developed a vaccine for malaria that, in early trials, was 100%effective.
That s exactly what#Sanaria, a biotechnology founded in 2003 by long-time malaria researcher Stephen Hoffman and based in a suburb of Washington,
#Malaria#infects about 200 million people every year and kills 600,000 of them.##Vaccines have been notoriously ineffective against the disease,
which stems from a parasitical infection. Last year, Sanaria reported that in a Phase I clinical trial
whose participants were consenting U s. veterans, the vaccine administered at the higher of two doses kept all the patients who got it from becoming infected with malaria
when bitten by mosquitos carrying#Plasmodium falciparum, #which causes 98 percent of all malaria deaths.
This year, the company will conduct trials in the U s.,Mali, Tanzania, Equatorial guinea and Germany.
which is important for a disease that disproportionately affects developing countries. What s left is to assemble the various functions into a single desktop robot,
If robotics manage to subdue malaria where other modern medical technologies have failed so far, it will be a powerful sign of how much the technology might accomplish as it matures.
Malinow, who holds the Shiley Endowed Chair in Alzheimer s disease Research in Honor of Dr. Leon Thal,
noted that the beta amyloid peptide that accumulates in the brains of people with Alzheimer s disease weakens synaptic connections in much the same way that low-frequency stimulation erased memories in the rats.
#Researchers discover new treatment for diabetes Researchers discovered a small molecule that inhibits an enzyme that degrades insulin.
and treat diabetes after decades of searching. They have discovered a whole different method for maintaining insulin in the blood:
and helps regulate the body response to sugars process that goes awry in type 2 diabetes.
Genetic studies have shown that people with type 2 diabetes are more likely to have mutations in the gene that encodes a protein called insulin-degrading enzyme, or IDE.
Patients with type 2 diabetes either have an insufficient amount of insulin in their blood
Researchers have speculated for decades that a drug that could inhibit IDE might help some type 2 diabetes patients.
such as an enzyme or other protein known to be involved in a disease. Pharmaceutical companies may use robotics to test many chemical reactions in parallel.
The newly identified IDE inhibitor could be the starting point for developing a powerful new drug for type 2 diabetes.
#The Living Heart Project will use 3d simulation of the human heart to combat heart disease The World health organization recent research has revealed that 17.3 million people died from cardiovascular diseases worldwide in 2008,
A report by the American Heart Association, Forecasting the Future of Cardiovascular disease in the United states, believes the total direct medical costs of cardiovascular disease will reach $818. 1 billion over the next three decades.
and prevent disease. Normally, this is done by physically analyzing the anatomy of a human being, but a groundbreaking idea could change the face of medicine for good. 3d software design companies Dassault systèmes
and combat he biggest challenge in the medical science right nowcardiovascular disease. The project started by partnering with some of the best brain
The project is breaking new ground in the study of heart disease and personalized treatment, since researchers are limited currently at being able to predict a pacemaker effect on a patient before surgery, for example.
This could provide a promising avenue of research for tackling Alzheimer disease. The study lead author, Dena Dubal said:
his could be a major step toward helping millions around the world who are suffering from Alzheimer disease and other dementias.
we may be able to counter dementias. In the human arm of the research, the scientists gave a whole battery of cognitive tests to over 700 people with and without the gene variant.
sex or genetic risk factors for Alzheimer disease. Another of the study authors, Roderick Corriveau, said:
Although preliminary, they suggest that a form of klotho could be used to enhance cognition for people suffering from dementia.
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