#Uncovering Genetic Factors in Leukemia Northwestern Medicine scientists have discovered how a gene linked to leukemia functions,
. and Lora S. Lurie Professor in Medicine-Hematology/Oncology and Biochemistry and Molecular genetics, and a member of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.
Now, in a paper published in the Journal of Experimental Medicine, they expanded on that research by studying the gene in depth.
In addition to the direct medical implications, the new study also shifts a fundamental principle of biochemistry known as allostery.
care medicine at Johns hopkins university School of medicine and Paul Knight, M d.,Ph d.,a professor of anesthesiology at the University of Buffalo School of medicine and Biomedical sciences, along with others
Researchers at Rice university, working with colleagues at Baylor College of Medicine and the University of Texas MD Anderson Cancer Center, have made a small molecule that could deliver a one-two punch to proteins that resist chemotherapy
from a medicinal perspective, is that this compound also works in a mouse model, he said. ll the other compounds worked in cells,
An estimated 10 to 30 percent of global medicines sold in developing countries like Afghanistan
Medical professionals would then be able to check these small notches with a scanner before they give the medication to a patient.
Golland and her colleagues will describe their new system at the International Conference on Medical Image Computing and Computer Assisted Intervention in October.
biotechnology and medical treatments. The study appears September 21 in Nature Materials. he very simple design rules that we have discovered provide a powerful engineering tool for many biomedical
James Collins, the Termeer Professor of Medical Engineering and Science in MIT Department of Biological engineering and Institute of Medical Engineering and Science (IMES).
and director of the Eli and Edyth Broad Center of Regeneration Medicine and Stem Cell Research at UCSF. ooking at these early stages in development is the best opportunity to understand our brain evolution.
Results were published online Monday by the New england Journal of Medicine and discussed at the European Cancer Congress in Vienna.
, based on a new study from Northwestern Medicine and the University of Chicago. Children with the disease lose significant muscle strength early in life.
Mcnally is director of the Center for Genetic Medicine at Northwestern University Feinberg School of medicine and the former director of the Institute of Cardiovascular Research at UCHICAGO,
She also is a physician at Northwestern Medicine. The new therapy has been licensed to the Kurt+Peter Foundation,
Mcnally said. his partnership is a perfect example of how precision medicine can help address very rare diseases.
and medical doctor Martin D. Burke, built the machine to assemble complex small molecules at the click of a mouse,
They are very important in medicine most medications available now are small molecules as well as in biology as probes to uncover the inner workings of cells and tissues.
The automated synthesis technology has been licensed to REVOLUTION Medicines Inc.,a company that Burke co-founded that focuses on creating new medicines based on small molecules found in nature.
The company initially is focusing on antifungal medications, an area where Burke s research has made already strides.
"South africa remains at the forefront of medical progress, "says Prof Jimmy Volmink, Dean of SU's Faculty of medicine and Health Sciences (FMHS)."
"This procedure is another excellent example of how medical research, technical know-how and patient-centred care can be combined in the quest to relieve human suffering.
"Van der Merwe was assisted by Prof Frank Graewe, head of the Division of Plastic Reconstructive Surgery at SU FMHS, Prof Rafique Moosa, head of the FMHS Department of Medicine, transplant
"We are proud of the medical team, who also form part of our own staff compliment at Tygerberg Hospital.
s Alectinib Shrank Tumors in Nearly Half of Patients With Specific Lung cancer Mutation Genentech Investigational Medicine Alectinib Shrank Tumors in Nearly Half of People With Specific Type of Lung cancer--Alectinib showed response rates of up to
and the NP28761 study will be presented by Dr. Leena Gandhi, assistant professor of medicine, Dana-Farber Cancer Institute, Boston (Abstract#8019, Monday, June 1, 8: 00-11:30 A m. CDT).
and review of medicines intended to treat serious diseases and to help ensure patients have access to them through FDA approval as soon as possible.
About Alectinib Alectinib (RG7853/AF-802/RO5424802/CH5424802) is an investigational oral medicine created at Chugai Kamakura Research Laboratories
medicines and tests that can help people with this deadly disease. Our goal is to provide an effective treatment option for every person diagnosed with lung cancer.
We currently have approved two medicines to treat certain kinds of lung cancer and more than 10 medicines being developed to target the most common genetic drivers of lung cancer
or to boost the immune system to combat the disease. About Genentech Founded more than 35 years ago
develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions.
The results of the study were published in the Journal of Medicinal Chemistry. Surgery, associated with cardiovascular diseases, such as ischemia,
they actively release medicine into the blood. The lifetime of such grafts is determined often by the amount of drug stored within the graft,
The technique could improve access to medicines in impoverished nations. For thousands of years, people have used yeast to ferment wine,
Now Stanford researchers have engineered genetically yeast to make painkilling medicines, a breakthrough that heralds a faster and potentially less expensive way to produce many different types of plant-based medicines.
Writing Aug 13 in Science, the engineers describe how they reprogrammed the genetic machinery of baker yeast
It can take more than a year to produce a batch of medicine, starting from the farms in Australia,
and refined into medicines. hen we started work a decade ago, many experts thought it would be impossible to engineer yeast to replace the entire farm-to-factory process,
plant-based medicines. his is only the beginning, Smolke said. he techniques we developed and demonstrate for opioid pain relievers can be adapted to produce many plant-derived compounds to fight cancers, infectious diseases and chronic conditions such as high blood pressure and arthritis.
From plant to test tubes Many medicines are derived from plants which our ancestors chewed or brewed into teas,
to reprogram the cells into custom chemical assembly lines to produce medicinal compounds. An important predecessor to the Stanford work has been the use of genetically engineered yeast to produce the antimalarial drug artemisinin.
the team had to fill in a missing link in the basic science of plant-based medicines.
Many plants, including opium poppies, produce (S)- reticuline, a molecule that is a precursor to active ingredients with medicinal properties.
Smolke said. e need options to help ensure that the bio-based production of medicinal compounds is developed in the most responsible way.
where opioid medicines are already widely available, the focus is on potential misuse. But the World health organization estimates that 5. 5 billion people have little
and the techniques we developed show that it is possible to make important medicines from scratch using only yeast,
and fairly provide medicines to all who need. Stanford has patents on the technology, and Smolke and researchers on her team have formed a company.
According to the American Academy of Sleep Medicine, transient insomnia symptoms occur in 30 to 35 percent of the population.
The researchers are presenting the paper at the International Conference on Medical Image Computing and Computer Assisted Intervention this week.
."Although rehabilitation medicine has resulted in reductions in mortality, the current outcome for patients is permanent paralysis, with an overall cost to the community of $2 billion a year."
The tomatoes themselves could potentially become the source of increased nutritional or medicinal benefit. Professor Cathie Martin said:"
Our work will be of interest to different research areas including fundamental research on plants, plant/microbe engineering, medicinal plant natural products,
"Medicinal plants with high value are often difficult to grow and manage, and need very long cultivation times to produce the desired compounds.
Our research provides a fantastic platform to quickly produce these valuable medicinal compounds in tomatoes.
which are the major groups of medicinal compounds from plants
#3-D Pancreatic cancer Organoid May Help Predict Clinical Responses, Nature Medicine Publishes 3-D pancreatic cancer organoid may help predict clinical responses,
personalize treatments. Clonally derived organoids could be used to ID patient-specific sensitivities to novel therapeutics.
The findings are reported currently in the Advance Online issue of the journal Nature Medicine.""These 3d organoids are, essentially,
The medical advisory board for the Celiac disease Foundation, a nonprofit based in Woodland Hills, California, could not reach a consensus on the viability of Miller's research.
while antibiotics used in medicine by humans have developed resistance in just 70 years. The team has registered copsin for patent approval l
so that it takes away that need for your medical knowledge, "he said. The 24/7 device monitors a user's blood pressure, heart rate, blood oxygen levels
Professor John Aplin, a specialist in reproductive medicine at Manchester University who also took part in the study,
And the results may be useful in creating better memory storage systems for computers or medical sensors.
when he was struggling to sleep during his exams at a medical university. He said:'
THE BENEFITS OF THC There's already evidence to suggest certain compounds in marijuana might be helpful for certain medical conditions.
There's already evidence to suggest certain compounds in marijuana might be helpful for certain medical conditions.
is precisely the type of knowledge medicine needs if we are to improve IVF methods.
Major general Steve Jones, commander of the Army Medical Department Centre and chief of the US ARMY Medical Corps
Speaking at a medical conference sponsored by the Association of the US ARMY near the Pentagon in Arlington County, Virginia,
Professor Rodney Phillips, a former Oxford don and now dean of medicine at the University of New south wales, played an instrumental role.
they created an easy way to tweak the genetic information in a cell nucleus. This has implications for medicine and agriculture.
to this year meeting of the American Society of Tropical Medicine and Hygiene, in Philadelphia, has changed that.
The discoverers of ivermectin predecessor, avermectin, were among the winners of this year Nobel prize for medicine.
Bloodless surgery and long-range molecule détection Two-micron spectral domain has potential applications in medicine, environmental sciences and industry.
The tomatoes themselves could potentially become the source of increased nutritional or medicinal benefit. Professor Cathie Martin said:"
Our work will be of interest to different research areas including fundamental research on plants, plant/microbe engineering, medicinal plant natural products,
"Medicinal plants with high value are often difficult to grow and manage, and need very long cultivation times to produce the desired compounds.
Our research provides a fantastic platform to quickly produce these valuable medicinal compounds in tomatoes.
which are the major groups of medicinal compounds from plants
#Wood instead of petroleum: Producing chemical substances solely from renewable resources Petroleum might well be replaced by wood soon
and a professor of clinical biomedical science in FAU's Charles E. Schmidt College of Medicine and a professor in FAU's Christine E. Lynn College of Nursing."
research leader at MIMS, Molecular Infection Medicine Sweden at Umeå University. Our innate immune system is activated
These discoveries will form the basis for precision medicine of CLL and other tumor types
'In recent years, Héctor Peinado, Head of the Microenvironment and Metastasis Group at the Spanish National Cancer Research Centre (CNIO), David Lyden from Weill Cornell Medical College,
. of the U-M division of Otolaryngology-Head and Neck Surgery. 3-D printing has had many medical applications.
Green and Hollister are leading efforts to design customized medical implants for those and other patients s
Efstathios Karathanasis, a biomedical engineer at Case School of engineering, has developed chainlike nanoparticles that can carry drugs across the blood-brain barrier that keeps standard medicines from reaching their target--a highly aggressive brain cancer called
The nanochains will tote bombs of chemotherapy medicine and glioblastoma stem cell inhibitors identified by Jeremy Rich,
Ketan Ghaghada, assistant professor of radiology at Baylor College of Medicine, will guide and oversee the steps taken to translate the research toward clinical trials.
The multi-institutional group includes researchers from Baylor College of Medicine Rice university, Stanford university and the Broad Institute.
and avenues for commercialization, including non-fouling medical tools and devices, such as implants and scalpels, nozzles for 3d printing and, potentially, larger-scale applications for buildings and marine vessels.
Medical steel devices are one of the material's most promising applications, said Philseok Kim,
and cofounder and vice president of technology AT SEAS spin-off SLIPS Technologies Inc."Because we show that this material successfully repels bacteria and blood, small medical implants,
."Although rehabilitation medicine has resulted in reductions in mortality, the current outcome for patients is permanent paralysis, with an overall cost to the community of $2 billion a year."
highly sensitive magnetometers intended for life science and medical applications
#Scientists gain insight into origin of tungsten-ditelluride's magnetoresistance Scientists recently discovered that tungsten ditelluride (WTE2) is electronically three-dimensional with a low anisotropy.
"explained corresponding author James Hamilton, Phd, professor of physiology and biophysics and research professor of medicine at BUSM."
The new findings, described in today's issue of the journal Science Translational Medicine, show that this molecule,
However, fields such as medicine or controlled catalysis call for more precise distribution in order to achieve the greatest possible efficiency of the active agent.
"We have discovered that it is the plant equivalent of the nude mouse used in medical research.""
Eye and Ear is a Harvard Medical school teaching hospital and trains future medical leaders in ophthalmology and otolaryngology, through residency as well as clinical and research fellowships.
"We should expect to see 3-D bioprinting continue to grow as an important tool for a large number of medical applications."
Otherwise, hey, better medical technology thanks to 3d printing is good for everyone o
#This new high-power diamond laser can cut steel Although lasers based on diamond have been around around for several years,
the device could have applications in voice-command electronics, medical sensing devices that use waves, like ultrasound,
practice medicine and improve the quality of life for patients. These other services create a better experience for both patient and provider.
including medical appointments. These workers will bring the senior citizen an ipad, and sit with them
The app will remind patients to take their medicines (the fictional anecdote used by IBM executives to explain that used a woman who kept forgetting her blood pressure medicine
the patient high blood pressure would mean that getting her to take her medicine more often would improve her life.
or the last couple miles in helping improve medical adherence and patient outcomes. Especially as more doctor visits and care end up shifted to telehealth,
But a big opportunity for rapid progress has emerged as online medical education becomes increasingly common.
Medical education in emerging markets typically suffers from two problems. First, medical universities and residency programs rarely have qualified enough instructors,
and sometimes lack access to modern curricula and equipment. Second, weak or nonexistent continuing medical education (CME) programs prevent health workers from later keeping their skills sharp.
Medical education typically begins with university coursework, and many medical schools now use e-learning tools like webcasts
In radiology, for instance, a growing number of hospitals around the world now use software by Lifetrack Medical Systems,
Irrespective of specialty, medical education must be a lifelong pursuit for all healthcare professionals, and in developed countries, regulators and professional associations typically require health workers to periodically participate in ongoing programs to keep their skills sharp.
FHI360 is another NGO using innovative online platforms to provide continuing medical education in emerging markets.
Unlike in the Premera breach, medical data and banking information were believed not to have been exposed in the Anthem breach.
or pharmacies seeking prescriptions. he law says we have a corresponding responsibility to make sure that medications are used for legitimate medical purposes,
The material potentially could extend the life of medical implants, fiber-optic cables, and other hard-to-repair objects,
He is aiming to improve the acoustic imaging method for potential use in biological research or medicine
and Women Hospital in Boston and is now an assistant professor of medicine in the nephrology division at the University of Washington. nswering this question was important for understanding the potential of mini-kidneys for clinical kidney regeneration and drug discovery.
and potentially cheaper way to make other types of plant-based medicine. Hydrocodone and its chemical relatives such as morphine and oxycodone are opioids,
It can take more than a year to produce a batch of medicine, starting from the farms in Australia, Europe,
and refined into medicines. hen we started work a decade ago, many experts thought it would be impossible to engineer yeast to replace the entire farm-to-factory process,
400 gallons of bioengineered yeast to produce a single dose of pain reliefhe experiment proves that bioengineered yeast can make complex plant-based medicines. his is only the beginning,
infectious diseases and chronic conditions such as high blood pressure and arthritis. any medicines are derived from plants, which our ancestors chewed
to reprogram the cells into custom chemical assembly lines to produce medicinal compounds. An important predecessor to the new work has been the use of genetically engineered yeast to produce the antimalarial drug artemisinin.
the Stanford team had to fill in a missing link in the basic science of plant-based medicines.
Many plants, including opium poppies, produce (S)- reticuline, a molecule that is a precursor to active ingredients with medicinal properties.
Smolke says. e need options to help ensure that the bio-based production of medicinal compounds is developed in the most responsible way. molke says that in the United states,
where opioid medicines are already widely available, the focus is on potential misuse. But the World health organization estimates that 5. 5 billion people have little
and the techniques we developed show that it is possible to make important medicines from scratch using only yeast,
and fairly provide medicines to all who need. tanford has patents on the technology and Smolke and researchers on her team have formed a company o
senior author James Collins, Ph d.,professor of medical engineering and science in MIT's Department of Biological engineering and Institute of Medical Engineering and Science (IMES)."
This new design could aid efforts in building point-of-care devices for quick medical evaluations.
which would enhance the effectiveness of medical interventions. The findings from this study were published recently in the Journal of the American Chemical Society through an article entitled highly selective electrochemical DNA-based sensor that employs steric hindrance effects to detect proteins directly in whole blood.
"said co-senior investigator Poul Sorensen, M d.,Ph d.,UBC professor of pathology and laboratory medicine.
"There is some irony that a disease as destructive as malaria might be exploited to treat another dreaded disease,"stated lead author Ali Salanti, Ph d.,professor of immunology and microbiology in the Centre for Medical Parasitology, at the University
and send it off to a medical professional for analysis, wherever in the world they may be.
With the speed improvements in mind, the method is now approaching a state viable for widespread medical use.
The new imaging system could have huge implications in medicine because it drastically reduces the time required to analyze
Watson can handle extremely large amounts of data as an aid to decision making in medicine, customer service, finance,
Getting the medicine to the clot takes some guesswork and there's no guarantee it will arrive in the right dosage,
The results of this research were presented recently at the 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society in Milan
and record subsequent images which a medical professional can then download and add to the complete diagnostic data Set in testing thus far,
the researchers believe that the feasibility of the propulsion model will move their creation toward the next set of experiments and onward to eventual deployment in working medical applications.
#3d printed guide aids in complex nerve regeneration Complex nerve injuries are a challenging problem for the medical fraternity,
In addition to inhibiting bacterial damage to teeth implants, the researchers believe the material may also be suitable for orthopaedic and non-medical applications
including medicine, to be able to have glues that would work in an aqueous environment,
The process may be suited aptly for this field of medicine because nerves do not regenerate much after injury
This makes the announcement in Nature Medicine that salsalate inhibits and reverses the acetylation of tau particularly significant.
As a backup, medical tape can ensure the device stays put. undamentally, what we were trying to do was remove the relative motion between the body and detector system,
But once that happens, such devices could help revolutionize medicine by providing an unprecedented amount of data for understanding health conditions such as diabetes, the hardening of arteries,
and other high-dose medicines that rapidly disintegrate with a small amount of liquid, and says it has exclusive rights to pharmaceutical applications of the technology.
and senior author of a new study in Science Translational Medicine. ou need to get macrophages under control quickly in sepsis.
what it takes to cope with stress in much the same way that a sports star medical information might be handed over
or by specialists in specific medical fields. Rodelis Therapeutics acquired the rights to TB drug cycloserine in August,
denying seniors access to many medicines, said Thrope. nd, artificially low prices could deprive drug companies of future funds to invest in the risky, expensive research that leads to better treatments and cures.
Earlier research by Raichle, the Alan A. and Edith L. Wolff Distinguished Professor of Medicine, played a pivotal role in the discovery of brain regions now known as the efault mode network.
The tomatoes themselves could potentially become the source of increased nutritional or medicinal benefit.""Our study provides a general tool for producing valuable phenylpropanoid compounds on an industrial scale in plants,
"said Martin."Our work will be of interest to different research areas including fundamental research on plants, plant/microbe engineering, medicinal plant natural products,
""Medicinal plants with high value are often difficult to grow and manage, and need very long cultivation times to produce the desired compounds.
Our research provides a fantastic platform to quickly produce these valuable medicinal compounds in tomatoes,
which are the major groups of medicinal compounds from plants
#Scientists Produce Tomatoes with Industrial Quantities of Natural Compounds Given the opportunity to drink fifty bottles of wine or eat one tomato,
The tomatoes themselves could potentially become the source of increased nutritional or medicinal benefit.""Our study provides a general tool for producing valuable phenylpropanoid compounds on an industrial scale in plants,
"said Martin."Our work will be of interest to different research areas including fundamental research on plants, plant/microbe engineering, medicinal plant natural products,
""Medicinal plants with high value are often difficult to grow and manage, and need very long cultivation times to produce the desired compounds.
Our research provides a fantastic platform to quickly produce these valuable medicinal compounds in tomatoes,
which are the major groups of medicinal compounds from plants
#Snake Venom-infused Hydrogel Stops Bleeding A nanofiber hydrogel infused with snake venom may be the best material to stop bleeding quickly, according to Rice university scientists.
The substance used for medicine is produced by genetically modified bacteria and then purified, avoiding the risk of other contaminant toxins.
and Women Hospital in Boston and is now an assistant professor of medicine in the nephrology division at the University of Washington. nswering this question was important for understanding the potential of mini-kidneys for clinical kidney regeneration and drug discovery.
Biochemical engineer Christina Smolke and colleagues had been working on the problem of synthesizing opioids and other plant-based medicines in the lab for about a decade.
that it would require thousands of gallons of yeast to make a single dose of medicine."
would need to be addressed for engineered yeast to ever realize home-brew biosynthesis of medicinal opiates at meaningful yields."
published this week by the IEEE Engineering in Medicine and Biology Society, is UCLA research scientist Parag Gad.
a pediatric oncologist at Fred Hutchinson and the senior author of the CIVO report, published today (April 22) in the journal Science Translational Medicine.
also published today in Science Translational Medicine. Unlike CIVO the cylinder is designed to be implanted into the tumor,
said Dr. David Milzman, a professor of emergency medicine at Georgetown University School of medicine.""Even more than food, you need clean water,
Still, several organizations are working to provide survivors with essential items and medical supplies. The Red cross says it has 19,000 relief kits,
And the World health organization has distributed medical supplies that can meet the needs of 40,000 people for three months,
a medical implant designed to change shape over time, that helped them keep breathing, researchers say."
"This is the first time 3d printing has been used to create a medical implant for treating a life-threatening disease,
The scientists detailed their findings online today (April 29) in the journal Science Translational Medicine e
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