"The scientist said the Hur-RNA binding site is like a long, narrow groove, not a well-defined pocket seen in other druggable proteins targeted by many current cancer therapies."
"The Hur protein grabs the'rope'r the RNAT a site called'ARE'on the rope.
and involved the collaboration of chemists, cancer biologists, computer modeling experts, biochemists and biophysicists at KUOTABLY the labs of Xu, Jeffrey Aubé in the Department of Medicinal Chemistry and Jon Tunge in the Department of chemistry.
#Insights into potential substitutes for costly platinum in fuel cell catalysts Replacing inefficient and polluting combustion engines with fuel cells is not currently feasible
because the cells require platinum-based catalysts. The PNNL study shows how to create particles with a similar reactivity to platinum that replace some of the platinum with Earth-abundant metals.
It may be used to create alloy nanomaterials for solar cells, heterogeneous catalysts for a variety of chemical reactions, and energy storage devices."
as well as other tools in DOE's EMSL, a national scientific user facility. While this work focuses on single nanoparticles, the final result is extended an array with implications that stretch from the atomic scale to the mesoscale."
"The researchers are now exploring different metal combinations with various platinum ratios to get the desired characteristics for fuel cell catalysts.
#Probabilistic programming does in 50 lines of code what used to take thousands Most recent advances in artificial intelligenceuch as mobile apps that convert speech to textre the result of machine learning, in
which computers are turned loose on huge data sets to look for patterns. To make machine-learning applications easier to build,
computer scientists have begun developing so-called probabilistic programming languages, which let researchers mix and match machine-learning techniques that have worked well in other contexts.
In 2013, the U s. Defense Advanced Research Projects Agency, an incubator of cutting-edge technology launched a four-year program to fund probabilistic-programming research.
At the Computer Vision and Pattern Recognition conference in June, MIT researchers will demonstrate that on some standard computer-vision tasks,
short programsess than 50 lines longritten in a probabilistic programming language are competitive with conventional systems with thousands of lines of code."
"This is the first time that we're introducing probabilistic programming in the vision area, "says Tejas Kulkarni, an MIT graduate student in brain and cognitive sciences and first author on the new paper."
"The whole hope is to write very flexible models, both generative and discriminative models, as short probabilistic code,
"By the standards of conventional computer programs, those"models"can seem absurdly vague. One of the tasks that the researchers investigate,
It requires a little work to translate that description into the syntax of the probabilistic programming language,
and Pushmeet Kohli of Microsoft Research Cambridge. For their experiments, they created a probabilistic programming language they call Picture,
which is an extension of Julia, another language developed at MIT. What's old is new The new work,
Even though their computers were painfully slow by today's standards, the artificial intelligence pioneers saw that graphics programs would soon be able to synthesize realistic images by calculating the way in
which light reflected off of virtual objects. This is essentially, how Pixar makes movies. Some researchers,
Calculating the color value of the pixels in a single frame of"Toy story"is a huge computation,
what probabilistic programming languages are designed to do. Kulkarni and his colleagues considered four different problems in computer vision,
each of which involves inferring the three-dimensional shape of an object from 2-D information. On some tasks, their simple programs actually outperformed prior systems.
Learning to learn In a probabilistic programming language the heavy lifting is done by the inference algorithmhe algorithm that continuously readjusts probabilities on the basis of new pieces of training data.
In that respect, Kulkarni and his colleagues had the advantage of decades of machine-learning research. Built into Picture are several different inference algorithms that have fared well on computer-vision tasks.
Time permitting, it can try all of them out on any given problem, to see which works best.
so that its inference algorithms can themselves benefit from machine learning, modifying themselves as they go to emphasize strategies that seem to lead to good results."
but probabilistic programming may alleviate rewriting code across different problems, "he says.""The code can be generic
""Picture provides a general framework that aims to solve nearly all tasks in computer vision,
"says Jianxiong Xiao, an assistant professor of computer science at Princeton university, who was involved not in the work."
"It goes beyond image classificationhe most popular task in computer visionnd tries to answer one of the most fundamental questions in computer vision:
the progress in micro fabrication technology has revolutionized the world in such fields as computing, signal processing,
For the past several years, Masoud Agah, an associate professor In virginia Tech's Bradley Department of Electrical and Computer engineering
reduced analysis times using temperature and flow programming, as well as fast detection response times suitable for high-speed gas chromatography."
and are enabling new technologies like flexible displays in mobile phone, wearable electronics, and the Internet of things (Iots).
#Shape changing display could spell the end for the 2d graph Imagine your computer screen could change shape.
Imagine if that screen could spring to life at the touch of a fingertip, translating numbers and trends into shapes
Researchers have developed a 3d prototype display which brings data to life in just this way sounding the death knell for the two dimensional bar chart.
Human computer interaction specialists at Lancaster University have built a device which translates data into a three dimensional display.
The interactive grid of 100 moving columns enables people to understand and interpret data at a glance.
People can also physically interact with data points by touching selecting and swiping through them to hide,
filter and compare sets of data easily. The 3d display is radically different to interacting with data on a flat screen.
A month's sales figures for example spring to life and take on a'shape'in front of you,
numbers become'things, 'trends become gradients which you can reach out and touch. Lancaster hosts a world-leading Human computer interaction research lab, developing the kind of shape changing displays
which could one day make it into our homes, offices and perhaps even our mobile phones. The group, led by Dr Jason Alexander
will present some of their work to one of the world's leading human computer interaction conferences CHI 2015 in April.
Dr Alexander believes this type of technology, which enables people to quickly identify patterns and absorb large amounts of information,
But for these shape-changing displays to be effective, researchers and developers first need to understand how people interact with them.
This tactile platform allows us to use those inherent skills to examine datasets normally confined to flat 2d displays."
"Our challenge was to produce a design that allows users to quickly comprehend large datasets
and in public areas to quickly and meaningfully convey data-driven information. He said:""What would it be like
if every pixel on your screen could move? Imagine the possibilities. Our lab works to develop new devices that merge the physical and digital worlds
or underperforming panels is very lowust 0. 1%per year according to new data of 50,000 systems analyzed by the Energy department's National Renewable energy Laboratory (NREL).
whether the panels are to be mounted directly on a roof or on open racks. Quality management of the manufacturing process.
Rigorous quality management will help assure that panels manufactured on one day of the month will be the same quality as those manufactured on any other day of the month.
Data on 50,000 systems reveal they stand up to hurricanes, hail Kurtz and NREL's Dirk Jordan have analyzed data from 50,000 solar energy systems installed between 2009 and 2013 and discovered that just 0. 1%of all PV systems reported being affected by damaged or underperforming modules per year,
and less than 1%each year had hardware problems. Inverter failures and fuse failures were reported more commonly than panel failure.
Despite hurricanes hail, shading, vandalism, and hookup delays, approximately 85%of all systems each year produced 90%or more of the electricity predicted,
and the typical system produces more electricity than predicted. Year to year comparisons suggest that the degradation ratehe gradual loss of energy productions in the historical range of 0. 5%%per year.
but there is very little data on how many of them are living with Cryptosporidium infections. This stems from the difficulties of diagnosing an infection in the field-poor sensitivity and a short window of spore secretion both limit the viability of acid-fast staining,
The microfluidic chip was designed by Autocad software and manufactured from a widely used silicon-based organic polymer known as PDMS.
in order to deal with these roadblocks and transmit accurate genetic data. Lesions in DNA can occur as often as 100,000 times per cell per day.
#Tablet for 2 waiting at an Olive Garden near you soon Olive Garden, owned by Florida's Darden Restaurants Inc,
. started using Ziosk tablets in some of its restaurants last year. The chain said Tuesday that locations using the devices have experienced faster dining times and increased tip percentages for wait staff.
and we're excited to give our guests the ability to customize their visit by leveraging the technology of Ziosk's tabletop tablets,"Dave George,
Tablets have made appearances in airports, where travelers can have delivered food to where they sit, but are limited still in the traditional restaurant scene.
Ziosk tablets are in use at Chili's restaurants and are in the process of launching nationwide at Red Robin.
In 2012 it was paused for an extensive upgrade. The new upgraded and supercharged LHC restarts at almost twice the energy
so it will deliver much more data.""I think that in the LHC Run 2 we will sieve through more data than in all particle physics experiments in the world together for the past 50 years,
"Stroynowski said.""Nature would be really strange if we do not find something new.""SMU is active on the LHC's ATLAS detector experimentwithin the big LHC tunnel,
That's a lot of collision data, says SMU physicist Robert Kehoe, a member of the ATLAS particle detector experiment with Stroynowski and other SMU physicists.
Evaluating that much data isn't humanly possible so a computerized ATLAS hardware"trigger system"grabs the data,
makes a fast evaluation, decides if it might hold something of interest to physicists, than quickly discards
"That gets rid of 99.999 percent of the data, "Kehoe said.""This trigger hardware system makes measurements
but they are very crude, fast and primitive.""To further pare down the data, a custom-designed software program culls even more data from each nanosecond grab,
reducing 40 million events down to 200. Two groups from SMU, one led by Kehoe, helped develop software to monitor the performance of the trigger systems'thousands of computer processors."
"The software program has to be accurate in deciding which 200 to keep. We must be very careful that it's the right 200 the 200 that might tell us more about the Higgs boson, for example.
If it's not the right 200, then we can't achieve our scientific goals."
"The ATLAS computers are part of CERN's computing center, which stores more than 30 petabytes of data from the LHC experiments every year, the equivalent of 1. 2 million Blu-ray discs.
Flood of data from ATLAS transmitted via tiny electronics designed at SMU to withstand harsh conditionsan SMU physics team also collaborates on the design,
construction and delivery of the ATLAS"readout"system an electronic system within the ATLAS trigger system that sends collision data from ATLAS to its data processing farm.
Data from the ATLAS particle detector's Liquid Argon Calorimeter is transmitted via 1 524 small fiber-optic transmitters.
A powerful and reliable workhorse, the link is one of thousands of critical components on the LHC that contributed to discovery and precision measurement of the Higgs boson.
The custom-made high-speed data transmitters were designed to withstand extremely harsh conditions low temperature and high radiation.""It's not always a smooth ride operating electronics in such a harsh environment,
"Failure of any transmitter results in the loss of a chunk of valuable data. We're working to improve the design for future detectors because by 2017 and 2018,
the existing optical data-link design won't be able to carry all the data.""Each electrical-to-optical and optical-to-electrical signal converter transmits 1. 6 gigabytes of data per second.
Lighter and smaller than their widely used commercial counterpart, the tiny, wickedly fast transmitters have been transmitting from the Liquid Argon Calorimeter for about 10 years.
Upgraded optical data link is now in the works to accommodate beefed-up data flow A more powerful data link much smaller and faster than the current one'is in research and development now.
it has the capacity to deliver 5. 2 gigabytes of data per second. The new link's design has been even more challenging than the first
but handles more data, while at the same time maintaining the existing power supply and heat exchanger now in the ATLAS detector.
The link will have the highest data density in the world of any data link based on the transmitter optical subassembly TOSA, a standard industrial package,
Fine-tuning the new, upgraded machine will take several weeksthe world's most powerful machine for smashing protons together will require some"tuning"before physicists from around the world are ready to take data,
so physicists on shifts in the control room can take high-quality data under stable operating conditions.
Sekula said. 10 times as many Higgs particles means a flood of data to sift for gems LHC Run 2 will collide particles at a staggering 13 teraelectronvolts (Tev),
"On paper, Run 2 will give us four times more data than we took on Run 1,
"But each of those multiples of data are actually worth more. Because not only are we going to take more collisions,
"SMU's Maneframe supercomputer plays a key role in helping physicists from the Large hadron collider experiments.
One of the fastest academic supercomputers in the nation, it allows physicists at SMU and around the world to sift through the flood of data,
quickly analyze massive amounts of information, and deliver results to the collaborating scientists. During Run 1, the LHC delivered about 8, 500 Higgs particles a week to the scientists,
but some will be more important than others There are a handful of major new discoveries that could emerge from Run 2 data,
and Professor Lennart Lindfors, of Astrazeneca, Sweden, have mapped out'in diagram format the actual movements made by chemical molecules on their breeding journey using computer simulations.
T. C. Chang Professor of Computer science at Columbia Engineering, has invented a prototype video camera that is the first to be fully self-poweredt can produce an image each second, indefinitely, of a well-lit indoor scene.
They designed a pixel that can not only measure incident light but also convert the incident light into electric power.
who directs the Computer Vision Laboratory at Columbia Engineering. He notes that in the last year alone,
Digital imaging is expected to enable many emerging fields including wearable devices, sensor networks, smart environments, personalized medicine,
At the heart of any digital camera is an image sensor, a chip with millions of pixels.
The key enabling device in a pixel is the photodiode, which produces an electric current when exposed to light.
This mechanism enables each pixel to measure the intensity of light falling on it. The same photodiode is used also in solar panels to convert incident light to electric power.
The photodiode in a camera pixel is used in the photoconductive mode while in a solar cell it is used in the photovoltaic model.
Nayar, working with research engineer Daniel Sims BS'14 and consultant Mikhail Fridberg of ADSP Consulting, used off-the-shelf components to fabricate an image sensor with 30x40 pixels.
each pixel's photodiode is operated always in the photovoltaic mode. The pixel design is very simple,
and uses just two transistors. During each image capture cycle, the pixels are used first to record
and read out the image and then to harvest energy and charge the sensor's power supplyhe image sensor continuously toggles between image capture and power harvesting modes.
such as a phone or a watch. Nayar notes that the image sensor could use a rechargeable battery and charge it via its harvesting capability:"
What the EU says Google is doing wrong The European union slapped Google Inc. with antitrust charges Wednesday,
saying it is abusing its dominance in Web search to promote its own products Here are the major allegations:
The EU says Google is unfairly favoring its own comparison-shopping service in general search results.
a coffee mug would find Google Shopping results for mugs displayed at the top of the search page,
The EU says part of the reason for competing sites'low rankings is applied that Google different parameters to comparison-shopping services,
The EU pointed out that a previous Google shopping site called Froogle did not use a favorable system
The current Google Shopping product which allegedly uses the favorable system, is experiencing higher growth.
Also under investigation is Google's smartphone operating system, Android. The EU is looking in whether the company is giving smartphone makers unfair incentives for preinstalling Google's applications,
such as the Chrome Web browser and Youtube. The EU is also continuing a formal investigation into concerns that Google copies rivals Web content and places undue restrictions on advertisers a
#Using composite material samples, NRL scientists predict aspects of F/A-18 performance The U s. Naval Research Laboratory (NRL) has built a robot to pull, bend,
and twist samples of the composite materials used to build F/A-18s and other aircraft.
and wing panel composite skin abnormalities, engineers have had to do extensive analysis to develop repairs.""So the need for certifying a new material comes in,
A custom-developed machine vision system, with four cameras, captures digital images of what's happening in real-time.
the scientists use custom-developed full field measurement algorithms Michopoulos'group has patented now to"take those digital images
"So we do have a very rich database, "says Michopoulos. Computations from robot data predict how materials behave in aircraft A snapped composite specimen is one thing;
a theory of how that material will behave when formed into a jet wing is another.
they were still getting the same results as CRC-ACS because of all the data they'd captured with NRL66. 3."For me,
"NRL collected 12 terabytes of data during the testing period.""Just to tell you how much richness there is in these data,
"he says, out of the 72 loading paths we applied, an MIT student"based one dissertation out of one of these paths."
"Michopoulos wants to offer design engineers a simulation environment based on actual data.""Instead of asking the question,
A robot that has a process to optimize its own performance based on how well it collects data for material characterization."
we can have the machine decide where it wants to go to get the best possible data for characterizing the material in real time."
'Instead of asking me an engineering and mathematics question, he is asking me this question. So then I knew I had to stay. e
Professor Shu Kobayashi's group at the Graduate school of Science has developed highly active immobilized catalysts (heterogeneous catalysts)
and demonstrated simple and highly efficient synthesis of (R)- and (S)- rolipram by an eight-step continuous flow reaction using multiple column reactors containing the immobilized catalysts.
Professor Kobayashi's application of flow chemistry techniques to the production of fine chemicals using heterogeneous catalysts has resulted in simple method to synthesize (R)
and without purification of products from catalysts. Professor Kobayashi says"This new technology can be applied to not only other gamma aminobutyric-acids acids and medicines but also various chemicals such as flavors, agricultural chemicals,
"The core transcription machinery of RNA polymerase copies the information found in DNA genes onto MESSENGER RNA molecules that then govern the production of proteins.
She and her team then devised special binary codes to encode individual RNAS, and labeling and imaging schemes to decode these RNA codes.
and act as easily accessed landing sites for fluorescently labeled"readout probes"that are applied to the cells in subsequent rounds.
Those fluorescent spots are translated to the first bit of the binary code: any RNAS that fluoresce at this step are assigned a 1,
Although 16 rounds of imaging could yield more than 60,000 unique binary codes, the team used only a special subset of these codes to encode their RNAS.
her team borrowed an error-correction strategy from the field of digital communications. Instead of assigning all possible codes as identifiers of specific RNAS, they use only codes that differ from all others by more than one bit."
"By applying information theory to the problem, Singer says, Zhuang has gotten around limits to how many fluorescent labels can be discriminated as discrete colors."
#New software analyses the effect of climate change on buildings from the cloud Large Spanish construction companies have begun to use a simulation software package,
and Technology at the Polytechnic University of Catalonia (CIT UPC) have developed the first-ever software to analyse the entire life of a building,
Certain details regarding the technology have been published in the journal Advances in Engineering Software. Even before its commercialization, Spanish construction groups such as Acciona and VIA had used already it in some of their projects.
"Another of the software's most original features is the ability to simulate models to show how global warming may affect construction.
Materials database Furthermore, NECADA has integrated an database which can be used to improve construction and design buildings that are adapted to European legislation.
The algorithms that are implemented currently in the system are some of the heuristic classics uch as hill-climbing, simulated annealing, NSGA-II,
Pau Fonseca indicates that the software consists of a core made up of a motor referred to as SDLPS that enables simulations to be carried out from complete representations of the models using languages such as SDL
"This core can be executed in a computer or be combined in a distributed way in a cluster, speeding up the extraction of results"."
enabling a user who is not familiar with simulation to customise the model and execute it in a distributed way,
Furthermore, the software integrates"key factors such as the price of materials, and their transportation, assembly and disassembly so the construction company can calculate the total cost of the building."
The technology, using a large screen to enhance the sense of reality and interactive avatars, synchronises the different realities so they all coordinate as one.
The project also involves Essex computer science alumnus Victor Zamudio whose Mexican company Fortito produced the intelligent home prototype Buzzbox used in the experiment.
engineering and mathematics (STEM) in almost 300 locations across Mexico. The trial was also key in showing that distance was no longer a barrier to STEM laboratory work.
As an open access tool, researchers and crop breeders can submit their own data to Polymarker
In one new software tool, we have applied expertise in advanced algorithm development, knowledge on genetics and principles of genome architecture."
Germany and Canada have built a miniature particle accelerator that uses terahertz radiation instead of radio waves to create pulses of high-energy electrons.
and some physicists are keen on using the radiation in much the same way that radio waves
which causes them to emit intense flashes of X-ray light. Currently, access to large-scale FELS is limited,
#Lasers burn holes in quantum security systems A new way to hack quantum-cryptography systems has been unveiled by physicists in Canada.
and this latest disruption comes as quantum-cryptography experts have modified already their systems to make them immune to other eavesdropping techniques.
when two people exchange a cryptographic key. This secret key then allows them to exchange information using conventional communications.
receivers and other hardware used to implement it. According to Vadim Makarov of the University of Waterloo and colleagues, many scientists assume that
Faking states In the case of free-space cryptography Makarov and colleagues showed that they could enable a"faked-state attack".
so that it misses the core of three of the four fibres leading to Bob's polarization detectors.
says this idea of actively damaging QKD components was"not previously on the radar screen"of scientists working on quantum-communication technologies.
the development of QKD is"always a cat and mouse game
#China Stocks Extend Slide Amid Warning of Severe Trade Pressure Shanghai/Beijing: Chinese stock markets tumbled for a second straight day on Wednesday as investors crowded the exits,
within a few days of the poor July export data and other official figures showing factory-gate prices continued their three-year slide in July, touching a six-year
, according to data from National securities Depository Limited (NSDL. The sales helped push the Nifty down 6. 6 per cent in August, its worst monthly performance since November 2011.
Data on Tuesday showed India's economy grew 7 per cent in the April-June quarter from a year earlier, much slower than expected,
"said Davish Jain, chairman of the Soybean Processors Association of India.""Our oilseed and edible oil production will not rise
#E-commerce Players Betting Big on Offline Presence Many e-commerce players have started foraying into physical retail space
some e-tailers are setting up shops offline. According to property consultant JLL India, Pepperfry is the latest to go'hybrid'.
"A significant share of our customers still prefer to buy offline and consider online website as a research tool.
The bigger ticket items are bought generally offline.""Therefore, in the race to provide a complete solution,
such phenomenon of online players going offline should stay, "said Vikas Bhasin, CFO, Pine Labs, an integrated payment solutions company."
"A larger portion of the Indian society is dominated middle class. This clientele is very skeptical about what,
For this strong bastion of middle class milieu, offline models like retailer shops have mushroomed all over, "said R P Yadav, CMD, Genius Consultants.
and offline models of e-commerce, "said Dinesh Gulati, Director, Indiamart. According to Tripti Lochan, CEO of VML, a leading digital marketing agency,"pureplay online retail will continue to live as not every e-commerce player has need either the
One of our apps is built specifically to help users visualise our sofas in their home with augment reality."
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