https://www. youtube. com/watch? v=rpputm u pm. In addition to imaging the structures at high-resolution, the team microscopy technique gathered precise measurements of the cell electrochemical performance. his technique allows us to follow subtle nano-sized structural
The study also used resources at Center for Nanophase Materials sciences, a DOE Office of Science User Facility at ORNL.
and now sells Nanosave N1-Organic from their website and it is available directly from Amazon.
It has proven to be one of the best selling oil products in the Nanosave N1 lineup. http://www. amazon com/nanosave Video Link:
. a Core Faculty member at the Wyss Institute for Biologically Inspired Engineering at Harvard university and the Amy Smith Berylson Professor of Materials science at Harvard School of engineering and Applied sciences (SEAS), has developed an entirely new,
as well as specific sites where Nano-85 and the P domain formed bonds. According to Hansman,"this is,
"Interestingly, the investigators found that the site where Nano-85 bound to the P domain was hidden actually under the viral particle's surface."
"From the virus's point of view, this could be a strategy to keep potentially vulnerable sites protected from attack,
#Canatu Announce Multitouch, Button-Free Automotive Panels with Carbon nanobud Films Canatu, a leading manufacturer of transparent conductive films, has in partnership with Schuster Group
and Display Solution AG, showcased a pioneering 3d encapsulated touch sensor for the automotive industry. The partnership is delivering the first ever,
3d shaped true multitouch panel for automotives, being the first to bring much anticipated touch applications to dashboards and paneling.
The demonstrator provides an example of multifunctional display with 5 finger touch realized in IML technology.
New possibilities for design Specifically designed for automobile center consoles and dashboards, household machines, wearable devices, industrial user interfaces, commercial applications and consumer devices,
#Touch-Sensitive Flexible Silicone Stickers Worn on the Skin Can Help Control Mobile devices Someone wearing a smartwatch can look at a calendar
A method currently being developed by a team of computer scientists from Saarbrücken in collaboration with researchers from Carnegie mellon University in the USA may provide a solution to this problem.
and executes commands and thus controls mobile devices. Depending on the type of skin sticker used, applying pressure to the sticker could, for example,
'The stickers allow us to enlarge the input space accessible to the user as they can be attached practically anywhere on the body,
Users can also design their iskin patches on a computer beforehand to suit their individual tastes.'
Users can therefore decide where they want to position the sensor patch and how long they want to wear it.'
For example, a keyboard sticker could be used to type and send messages. Currently the sensor stickers are connected via cable to a computer system.
According to Steimle, inbuilt microchips may in future allow the skin-worn sensor patches to communicate wirelessly with other mobile devices.
The publication about'iskin'won the'Best Paper Award'at the SIGCHI conference, which ranks among the most important conferences within the research area of human computer interaction.
The researchers will present their project at the SIGCHI conference in April in Seoul Korea, and beforehand at the computer expo Cebit,
which takes place from the 16th until the 20th of March in Hannover (hall 9, booth E13) E
forming a water-soluble nanoparticle with the drug hidden in its core. These nanoparticles are highly soluble in blood
The former have a shell that is bonded directly to the core, but yolk-shell particles feature a void between the two equivalent to where the white of an egg would be.
the aluminum core continuously shrinks to become a 30-nm-across olk, which shows that small ions can get through the shell.
Computer-assisted technology developed especially for this purpose combines the advantages of both methods and suppresses unwanted noise.
while a first pulse excites the sample under study, a second pulse monitors the change in the sample.
the teams led by the two Dresden physicists have managed to combine all the advantages of both methods in their nanoscope. e have developed software with a special demodulation technology with whichn addition to the outstanding resolution of near-field
The team is led by principal investigator Ali Passian of ORNL Quantum Information system group. The novel hybrid photonic mode-synthesizing atomic force microscope,
Passian This unique microscope will enable users to analyze samples ranging from engineered nanostructures and nanoparticles to naturally occurring plant cells, biological polymers and tissues.
which exceptional topological data could be procured, thereby promoting basic research in sustainable biofuels. This made the ORNL scientists to visualize several other applications.
Until now, a major limitation for FXS has been a lack of mathematical methods to efficiently interpret the data.
and physical bioscientist Peter Zwart have introduced new mathematical theory and an algorithm, which they call ulti-tiered iterative phasing (M-TIP),
to solve the reconstruction problem from FXS data. Their code can quickly determine general structure in only a few minutes on a desktop computer.
This approach is an important step in unlocking the door to new advances in biophysics and has the promise of ushering in new tools to help solve some of the most challenging problems in the life sciences. hese are exciting times,
Deciphering FXS with M-TIPPART of the challenge of generating a model from fluctuation scattering data stems from the fact that,
inverting FXS data requires the recovery of the three-dimensional intensity information as well. The team new-TIPALGORITHM alternatingly projects a model to agree with the FXS data along with any prior known constraints about the solution, such as density upper and lower bounds, size,
and/or symmetry, and can simultaneously determine the intensities, complex phases, and molecular structure. n order to develop a robust and efficient FXS reconstruction algorithm,
we had to solve a number of non-trivial mathematical problems, says Donatelli of Berkeley Lab Computing Sciences Division. eriving the relation between structure
and FXS data involves a substantial amount of harmonic analysis and linear algebra and we also needed to develop several new computational tools,
such as a fast and reliable polar Fourier transform. iven that FXS is still a relatively new technique,
To compensate for the lack of such data Donatelli, Sethian and Zwart tested their method on simulated FXS data on various test shapes,
including a model of a pentameric ligand-gated ion channel (plgic). Their-TIPALGORITHM was able to quickly produced accurate, high-resolution reconstructions of these shapes from their corresponding FXS data.
CAMERA: Innovation through Cross-Disciplinary Sciencethis work is part of a new project being undertaken by CAMERA (The Center for Advanced Mathematics for Energy Research Applications.
CAMERA is a joint effort between DOE Office of Advanced Scientific Computing Research and Office of Basic energy Sciences.
CAMERA brings together mathematicians, experimental scientists, computer scientists, and software engineers to develop and deliver new mathematical tools
and software to data and imaging challenges at the DOE facilities, including work at synchrotron light sources and nanoscience research centers.
OE light sources offer a rich environment for tackling wonderful math problems whose solutions can make a major impact on fast moving sciencesays Sethian. ombining Zwart insight into the problem with Donatelli
and iterative phasing algorithms set the stage for a new way to think about reconstruction from FXS data. he Future of FXSBEAMTIME at the LCLS was awarded recently to the authors as part of a large multi-institutional collaboration to collect FXS data
if necessary, tune their reconstruction techniques on experimental data. ltimately, the goal is to provide the scientific community with a powerful new tool to determine the structure and dynamics of nano-sized particles in a routine,
but this is an important breakthrough. he researchers emphasize that FXS data may also be collected using an ultrabright synchrotron light source from particles cryogenically frozen in place.
The work was supported by DOE Office of Science (Office of Advanced Scientific Computing Research and Office of Basic energy Sciences) and by the National institute of health e
SSRL and LCLS are DOE Office of Science User Facilities. The researchers combined and analyzed hundreds of X-ray images from about 150 protein crystals to reveal the atomic-scale details of the joined structure.
#EPGL Challenges Google in Smart Contact lens Revolution EP Global Communications, Inc. announces a challenge to Google to confirm it is speed up to with EPGL in the smart contact lens revolution.
A year ago, Google announced with great fanfare that it had developed a smart contact lens for monitoring glucose levels.
Google also announced that they possess technology for an"Autofocus"contact lens. Various executives from Google were quoted as saying that smart contact lenses could help millions of people in the future
and other technology writers and industry executives have predicted a multi-billion dollar market is coming.
EPGL fully agrees with Google on this point. EPGL has several patents pending now in the smart contact lens arena
Today, EPGL is issuing a challenge to Google to update the world on their smart contact lens progress
EPGL is challenging Google to make an announcement by August 31, 2015 that it has solved for the critical Silicone Hydrogel mass market production challenges as EPGL has."
"Google is an incredible company with incredibly talented engineers and executives. We have nothing but respect for them,
however, you can just collect the amount of data you need and the number of proteins you want to pass through the pore
#MRI SCANNERS can Non-Invasively Steer Cells with Nanoparticles to Tumour Sites Magnetic resonance imaging (MRI SCANNERS have been used since the 1980s to take detailed images inside the body-helping doctors to make a medical diagnosis
which have been injected with tiny super-paramagnetic iron oxide nanoparticles (SPIOS), to both primary and secondary tumour sites within the body.
The study, published today (date) in Nature Communications shows that cancer mouse models injected with immune cells carrying SPIOS and armed with the cancer killing oncolytic virus (OV)
#Universitat Jaume I Patents Graphene-Based Catalysts for Energy conversion and Storage Researchers at the Universitat Jaume I have developed materials based on graphene that can catalyse reactions for the conversion and storage of energy.
Thus, the patented materials can be used both in the development of catalysts as well as storage batteries or other energy types p
postdoctoral fellow Dong Li and their colleagues have added the two new technologies-both variations on SIM-to the set of tools available for super-resolution imaging.
"In traditional SIM, the sample under the lens is observed while it is illuminated by a pattern of light (more like a bar code than the light from a lamp).
Computer software then extracts the information in the moiré images and translates it into a three-dimensional, high-resolution reconstruction.
He says SIM has received not as much attention as other super-resolution methods largely because those other methods offer more dramatic gains in spatial resolution.
But he notes that SIM has offered always two advantages over alternative super-resolution methods including photoactivated localization microscopy (PALM),
SIM, however, is different.""I fell in love with SIM because of its speed and the fact that it took so much less light than the other methods,
"Betzig says. Betzig began working with SIM shortly after the death in 2011 of one of its pioneers, Mats Gustafsson,
who was a group leader at Janelia. Betzig was convinced already that SIM had the potential to generate significant insights into the inner workings of cells,
and he suspected that improving the technique's spatial resolution would go a long way toward increasing its use by biologists.
Gustafsson and graduate student Hesper Rego had achieved higher-resolution SIM with a variation called saturated depletion nonlinear SIM
Saturated depletion enhances the resolution of SIM images by taking advantage of fluorescent protein labels that can be switched on and off with light.
or more to generate data for the final image. The principle is very similar to the way super-resolution in achieved in STED or a related method called RESOLFT,
"Instead, the new method, called patterned photoactivation nonlinear SIM, begins by switching on just a subset of fluorescent labels in a sample with a pattern of light."
The combined effect of those patterns leads to final images with 62-nanometer resolution--better than standard SIM and a threefold improvement over the limits imposed by the wavelength of light."
I have to take the data in a tenth of a second, or else it will smear out,
Patterned photoactivation nonlinear SIM captures the 25 images that go into a final reconstruction in about one-third of a second.
The team used patterned photoactivation nonlinear SIM to produce videos showing structural proteins break down and reassemble themselves as cells move
Betzig's team also reports in the Science paper that they can boost the spatial resolution of SIM to 84 nanometers by imaging with a commercially available microscope objective with an ultra-high numerical aperture.
by combining the high numerical-aperture approach with patterned photoactivatable nonlinear SIM, Betzig and his colleagues could follow two proteins at a time with higher resolution than the high numerical aperture approach offered on its own.
Betzig's team is continuing to develop their SIM technologies, and say further improvements are likely.
For now, scientists who want to experiment with the new SIM methods can arrange to do so through Janelia's Advanced Imaging Center,
it should be fairly straightforward to make the SIM technologies accessible and affordable to other labs."Most of the magic is in the software, not the hardware,
said Margaret Murnane, professor of Physics and Electrical and Computer engineering at the University of Colorado,
assistant professor of electrical and computer engineering at UC Davis and the paperssenior author. hat happens is the debris in biological samples,
and Ling Wang in the Department of Electrical and Computer engineering at UC Davis were the other authors of the papers.
assistant professor of electrical and computer engineering at UC Davis and the paperssenior author. hat happens is the debris in biological samples,
and Ling Wang in the Department of Electrical and Computer engineering at UC Davis were the other authors of the papers.
One purpose of this experiment was to show we could integrate bacterial catalysts with semiconductor technology.
especially the catalysts that convert water and carbon dioxide into sugars at room temperatures.""This is not about mimicking nature directly
These lasers will be combined with an ultrafast signal acquisition algorithm to increase the sensitivity and minimize errors in perception due to motion that may be induced by patient hand movements.
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#Structured Illumination Microscopy and SPA Help Study SPB Duplication in Living Yeast Cells Cellular mitosis depends in part on small organelles that extend spindles to pull apart chromosome pairs.
Now, a team of researchers from the Stowers Institute for Medical Research and the University of Colorado Boulder has devised a novel optical technique--a combination of structured illumination microscopy (SIM
"The use of SIM to study SPB structure completely changes the types of questions we can ask and answer,
and it is likely that SIM will work in living cells, "says Sue Jaspersen, Ph d,
The research team turned to SIM as an optical alternative. SIM uses a laser-generated field of horizontal lines to project an interference pattern onto a sample.
According to Jay Unruh, Ph d.,a Stowers research advisor and co-author, analyzing these patterns enables researchers to effectively double their resolution."
"For all of its advantages, SIM still involves sifting through a great deal of noise. To deal with this problem,
often with even greater precision than via SIM alone,"says Jaspersen.""We estimate the precision to be in the 10-30 nm resolution range."
"The SPA-SIM technique made up part of a two-color structured illumination microscopy approach that used endogenously expressed fluorescent protein derivatives.
According to Unruh, this study represents the first combined use of SPA with SIM, and one of the first dual-color super-resolution SPA papers.
According to Jaspersen, the SPA-SIM technique is applicable to a wide variety of subjects beyond SPB structure."
In a study to be published on the elife website on September 15 2015, a team of researchers from the Stowers Institute for Medical Research and the University of Colorado Boulder combined two optical systems in a new way to get around the natural limits of optical microscopes.
One, called structured illumination microscopy (SIM), makes laser-based interference patterns that change based on what they interact with,
#Platelet-Mimicking Nanoparticles Could Effectively Deliver Drugs to Targeted Sites Nanoparticles disguised as human platelets could greatly enhance the healing power of drug treatments for cardiovascular disease and systemic bacterial infections.
San diego, are capable of delivering drugs to targeted sites in the body--particularly injured blood vessels,
and release their drug payloads specifically to these sites in the body. Enclosed within the platelet membranes are made nanoparticle cores of a biodegradable polymer that can be metabolized safely by the body.
The nanoparticles can be packed with many small drug molecules that diffuse out of the polymer core and through the platelet membrane onto their targets.
To make the platelet-membrane-coated nanoparticles, engineers first separated platelets from whole blood samples using a centrifuge.
the platelet membranes were broken up into much smaller pieces and fused to the surface of nanoparticle cores.
Researchers observed that the docetaxel-containing nanoparticles selectively collected onto the damaged sites of arteries
This quality makes ferroelectric materials useful for an array of electronic applications, such as computer memory chips.
One of the most critical biological and medical tools available today, it lies at the core of genome analysis. Reading the exact make-up of genes,
This is a crucial step in creating a new generation of foldable electronics-think a flat-screen television that can be rolled up for easy portability-and implantable medical devices.
The researchers used mouse embryonic fibroblast cells to determine biocompatibility; that, along with the fact that the stretchability of gold nanomesh on a slippery substrate resembles the bioenvironment of tissue
and re-scan it repeating the process until the desired spatial resolution is achieved before combining the data from each scan using a computer algorithm.
This makes them ideal candidates for the development of novel user interfaces for touchless devices, says Professor Bettina Lotsch of the Department of chemistry at LMU and the Max Planck Institute for Solid State Research in Stuttgart.
In comparison with other vapor sensors based on nanosheets, the new photonic architecture displays markedly increased response times, higher sensitivity and long-term stability. his unique combination of properties enables it to track
"Nowadays, software and techniques to design and simulate DNA NANOSTRUCTURES are extremely powerful and user friendly, and thus, researchers can easily construct their own DNA-objects for various uses.
The big boom in the field of structural DNA NANOTECHNOLOGY happened in 2006, when Paul Rothemund introduced a technique dubbed'DNA origami'.
What they ended up with was a Rubik's Cube of three dimensional data, which in the end had a unique solution that explained the structure of the TOM 40 protein complex
Lithium-ion batteries have been used commonly in laptop and tablet computers, electric vehicles and renewable energy systems for more than two decades.
#Nanostructure Changes Colour When Finger Comes Near Touchscreens suffer from mechanical wear over time and are a transmission path for bacteria
What they really want is to use it in touchless displays. ecause these sensors react in a very local manner to any increase in moisture,
it is quite conceivable that this sort of material with moisture-dependent properties could also be used for touchless displays
and monitors, said Ganter. Touchless screens of this kind would require nothing more than a finger to get near the display to change their electrical or optical properties and with them the input signal at a specific point on the display.
Taking phosphatoantimonate nanosheets as their basis the Stuttgart scientists then developed a photonic nanostructure which reacts to the moisture by changing colour. f this was built into a monitor,
the users would then receive visible feedback to their finger motionexplained Katalin Szendrei, also a doctoral student in Bettina Lotsch group.
To this end, the scientists created a multilayer sandwich material with alternating layers of ultrathin phosphatoantimonate nanosheets and silicon dioxide (Sio2) or titanium dioxide nanoparticles (Tio2.
for instance by moving a finger towards the screen. he reason for this lies in the storage of water molecules between the phosphatoantimonate layers,
A layer protecting against chemical influences has to let moisture through The scientists can imagine their materials being used in much more than just future generations of smartphones, tablets or notebooks. ltimately,
we could see touchless displays also being deployed in many places where people currently have to touch monitors to navigate,
Displays in public placesthat are used by many different people would have distinct hygiene benefits if they were touchless.
if theye going to be used in anything like a display. And that, again, has to meet not one but two different requirements:
so that the signal of the nanoswitch may be read using a mobile phone. This will make our approach really available to anyone!
and enables individual creative expression by allowing users to control a number of music and art-based software programs with their breath. e are delighted to further Governor Andrew M. Cuomo vision for a vibrant high-tech sector in New york state as
it strengthens local companies, such as the maker of the Jamboxx, by providing a valuable high-tech solution that will make the device more reliable for their customers,
a USB-powered breath-controlled device that resembles a harmonica and comes with special software to allow musicians to play digital music or control a computer with varying levels of breath.
The device consists of a tilt sensor for octave selection a pressure sensor to produce sound,
Interestingly, a subsequent challenge with a lethal strain of mouse malaria parasite in these vaccinated animals showed considerable protection against malaria.
Future work for Tkaczyk and his colleagues includes developing an automated algorithm for identifying white blood cells,
The use of low-cost components such as LEDS, reflectors and USB detectors, combined with the all-plastic housing and lenses, will allow future versions of the prototype to be mass-produced h
#Graphene Shows Potential for Energy-efficient Data storage Technologies Graphene can be used to produce energy-efficient, high-density memory chips.
Researchers at Stanford used graphene in three different ways to create data storage technology that has the best features of both volatile and nonvolatile silicon chips.
Phones, laptops and other electronic devices all use memory chips to function. To be desireable they must be fast,
Engineers are presently trying to develop nanomaterial-based memory chips that perform better than their silicon counterparts to be used in low energy data centers and gadgets with a longer battery life.
Data is stored by memory chips in the form of ones and zeroes. Silicon-based memory chips are classified as either volatile and nonvolatile.
Volatile memory can store data only when power is available. Random access memory (RAM) is an example of volatile memory.
Nonvolatile memory is slow but stable and it continues to store the data even when power is not available.
The flash memory used in cell phones is an example of nonvolatile memory. Engineers led by Stanford have demonstrated a way to create memory that combines the stability of flash memory with the speed of RAM.
They used new technologies and materials to create memory that consumed comparatively less energy than silicon.
In the RRAM chips metal oxides are changed between conductive and resistive states by the application of a small joly of electricity. in these RRAM chips.
A zero is created when the electron flow is resisted by the metal oxides, and a one is created
Like flash memory, RRAM has the ability to store data without power, and it is also fast like volatile silicon memory.
This enables fabrication of smaller RRAM cells that have the capacity to store more data than conventional metal-based conductors.
This material has the ability to store data even when power is not available. Pop and Wong state that graphene unique
thermal, electrical and atomically thin properties could help create data storage with better energy efficiency, and transform the manner in
which digital data is stored and accessed in the future e
#Nanofiber Hydrogel Infused with Snake Venom May Quickly Stop Bleeding A nanofiber hydrogel infused with snake venom may be the best material to stop bleeding quickly, according to Rice university scientists.
and quickly turns into a gel that conforms to the site of a wound, keeping it closed,
and injected at the site of a wound, where they reassemble themselves into a gel.
Previously, printing techniques have been applied to integrate electronics into plastic labels only, but with the VTT methods it is now also possible to produce more environmentally friendly paper-based security tags.
electronic circuits and sensors can be integrated directly into different materials by printing, thus producing novel security tags for sealing shipments
In the ROPAS project, VTT showed that roll-to-roll technology for printing electronics is suited also to the manufacturing of paper-based security tags.
#Prosthetic Hands with Macro-Sieve Peripheral Nerve Interface Can Feel Hot and Cold and Sense of touch Daniel Moran, Phd, professor of biomedical engineering in the School of engineering & Applied science and of neurobiology,
While the advanced prosthetic arm allows users to perform six different grips, such as picking up small objects,
it does not provide users with the senses of touch and orientation of a natural hand.
whose expertise is in motor neurophysiology and brain-computer interfaces, and his team have developed an electrode designed to stimulate sensory nerve cells in the ulnar and median nerves in the arms.
users will have more control over the prosthesis. Moran and his team, which includes Harold Burton, Phd, professor of neurobiology;
Once implanted, Moran and the team will train the nonhuman primates to play a joystick-controlled video game in
which the team will give them cues as to where to move the joystick by stimulating specific sectors in the ulnar and median nerves
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