This histone replacement, known as turnover, enables our genetic machinery to adapt to our environment by prompting gene expression,
although some cell types, such as skin cells, constantly self-destruct and are replaced in an ongoing turnover that keeps tissues viable, others,
The research team found that histone turnover regulates how genes in the brain are turned on and off in response to various stimuli,
To study histone composition in mouse nerve cells and related turnover, researchers fed young, post-weaning rodents a special diet containing heavy labeled lysines,
The prevalence of the labeled H3. 3 demonstrated the fact that the older histones had been replaced with newer ones, indicating histone turnover.
In humans, researchers used a technique called 14c/12c bomb pulse dating to measure turnover.
As with the rodent observations, the researchers found that H3. 3 turnover occurs in the human brain throughout life.
confirming the role of histone turnover in neuronal plasticity. The findings thus establish histone turnover as a critical,
and new, regulator of cell-type specific transcription in the brain. istone turnover, shown through our work with H3. 3,
is essential for the behavior of brain cells, said Dr. Maze. urthering our understanding of how the brain works,
David Slotnick Icahn School of medicine at Mount Sinaiimage Credit: Image is credited to Zephyris and is licensed CC BY-SA 3. 0original Research:
Abstract for ritical Role of Histone Turnover in Neuronal Transcription and Plasticityby Ian Maze, Wendy Wenderski, Kyung-Min Noh, Rosemary C. Bagot, Nikos Tzavaras
10.1016/j. neuron. 2015.06.014 Abstractcritical Role of Histone Turnover in Neuronal Transcription and Plasticityhighlights 3. 3 displays a unique saturating profile of nucleosome occupancy in postnatal brain
and behavioral plasticity istone turnover is critical for cell type-specific gene expressionsummary Turnover and exchange of nucleosomal histones and their variants,
Our findings establish histone turnover as a critical and previously undocumented regulator of cell type-specific transcription and plasticity in mammalian brain. ritical Role of Histone Turnover in Neuronal Transcription and Plasticityby
trying to pay the mortgage we all have with Mexico. ource: Investigación y Desarrolloimage Credit:
Image is credited to Investigación y Desarroll e
#Novel Disease Gene Linked to Neurodegenerative Disorders Identified Researchers at the University of Miami (UM) have discovered
Ms Loi supervisor Tara Murphy said her work was impressive. t is to Cleo great credit that she
or waste money buying new batteries, when we now have a technology that saves money, saves energy,
and can cut the number of batteries that end up in landfills by more than half. Currently the only device of its kind, Batteriser will be available for AA, AAA, C and D-cell batteries,
This week, investment company DMY Capital Limited announced its conditional agreement to acquire 100 per cent of Australian robotic building technology company, Fastbrick Robotics,
quicker and cheaper than ever before. excited to see the company gain further funding support
and industry partners from seven European union countries, with EU funding. Sara Colantonio and colleagues from the National Research Council of Italy,
A lack of international funding for the vaccination campaigns is also a problem, says Rosenbaum.
Supporters of those laws say they protect taxpayers. Obama's plans would include technical know-how and financial assistance to those towns,
the president"is risking the success we have witnessed by advocating for the reclassification of broadband as a Title II public utility unprecedented government interference that would stifle private investment,
Knutson told Siegel that cellphone providers aren't worried about the competition saying there always will be a market for people who will pay money to have connectivity wherever they go
#Meet Mafiaboy The'Bratty Kid'Who Took Down The Internet This week, the country's second-largest health insurance company,
and JPMORGAN CHASE have all been attacked in the last nine months alone. In January, President Obama said the cybercrime laws that are supposed to protect consumers from such attacks
Is our money really safe?'"'"For years after the attack, Calce declined to speak to the media,
He says his goal had nothing to do with money and that ultimately, he thinks, his attack has a positive impact.
and it's all about monetization.""For the national security apparatus, the attack was a wake-up call.
#Hackers Strike Health insurer Anthem The country's second-biggest health insurer says cyberattackers infiltrated one of its IT systems
and obtained personal information about current and former customers as well as employees covered by the insurer."
"No credit card information was compromised, nor is there evidence at this time that medical information such as claims, test results,
songs were easier than ever to find and available for little or no money. Every year, the new version of Apple's ipod, first introduced in 2001 with a now-adorable 5gb of storage space, held thousands upon thousands more songs.
The question of money of royalties is a crucial one to the survival of the recording industry.
but it will also open this technology to a multibillion-dollar heat exchanger market. The project, set to commence in mid-2015,
and accounting for differences in pupil size and corneal shape was another important consideration. With those hurdles now tackled,
As a result, eliminating periodic electronic regeneration will drastically change the economy of the network infrastructure, ultimately leading to cheaper and more efficient transmission of information.
and Investment companies involved in the personnel screening market have expressed already interest in the Q-Eye device.
and raise funding to develop the first commercial prototypes. Professor Parker told opitcs. org, erry Whall and myself are excited about this new company.
We are still looking for further investors into Q-Eye so potential investors are invited to contact us. e differentiate ourselves from other terahertz systems suppliers
will hopefully bring financial gain for the university. c
#Meet the LHC Latest Discovery, the Long-Sought Pentaquark The Large hadron collider, the world most powerful particle accelerator, has given physicists yet another gifthysical proof of the existence of the pentaquark,
However, priced between 10,000 and 30,000 Euros, Egger's invention for now would not be affordable for all l
#Multilayer QD Solar cells Promising for Natcore RED BANK, N. J.,Feb 23, 2015 A new breed of quantum dots (QDS) could enable multilayer solar cells that capture more of the sun energy.
Korean funding came from the National Research Foundation, Center for Advanced Soft Electronics through the Global Frontier Research Program, Priority Research center Program, Center for Topological Matters at the Pohang
and MRI SCANNERS designed to be wheeled over a patient on the operating table cost several millions of dollars each
By comparison, the team anticipates that an OCT-based system would cost hundreds of thousands of dollars.
Society tends to treat electronics as disposable commodities. But unlike a glass bottle that gets recycled or food that hits a compost heap,
Wicab told Popular Science that it will cost $10, 000 per unit, the same as its price when first reported back in 2009.
if the price of producing the substance falls far enough to make it economically viable. Right now, the research group at Bristol says that"self-healing nail polish will have to wait
The startup reached its funding goal of £750, 000 (around $1. 2 million) in 60 hours from 535 investors on Crowdcube.
The crowdfunding platform bypasses traditional investing routes and allows individuals get a stake in highly desirable companies.
and Deutsche bank in delivering important projects to earthquake-ravished Haiti in 2011. Grillo i
#ATM Technology Gets Applied to Kenyan Water Access It comes to no surprise that water is a scarce, precious and too-often polluted resource for people living in many developing nations,
In Kenya Mathare slum, for example, residents must purchase frequently dirty water from vendors who charge exorbitant prices for access.
which they will swipe at a water dispenser just like a Westerner getting cash from an ATM MACHINE.
#Mastercard is experimenting with facial scans and fingerprints to authorize online purchases Soon, you may be able to complete your online shopping by snapping a selfie.
Mastercard plans on launching a pilot program this fall that uses biometrics to approve purchases instead of password verification.
According to CNN Money, Mastercard security expert Ajay Bhalla thinks the selfie generation will ind it cool.
Mastercard has partnered with smartphone makers and is finalizing plans with a major bank to launch the experimental trial,
which will be limited to 500 users. If all goes well, however, the credit card company plans on launching the technology for the public.
Here how it will work: youl download the Mastercard app, and when youe ready to pay for a purchase,
youl select an authorization method. You can go for a fingerprint scan with a touch, or you can opt for the selfie-authorization:
Mastercard won maintain the data of your fingerprint or the facial scan. The fingerprint scan will be saved as a code on your phone,
and the facial scan will convert your face into a numerical code that sent to Mastercard.
Mastercard also plans on trying out voice recognition to approve purchases: check out by talking to your phone.
Current Mastercard customers use a ecurecode, or a traditional password for online purchases. The Securecode was used in three billion transactions last year.
Mastercard facial scan on CNN Mone d
#Developing Nations Turn to Salt water Lamp for Power People in too may parts of the world lack access to reliable power grids,
But what stood out from the sea of gadgets was the Arrow NX F-04g that uses iris recognition to make payments when you shop.
and start sending payments. Nevertheless, one should not underestimate this smartphone as a mere tool for mobile shopping.
Based on these specs, it will give the mobile front runners a run for their money. Additionally back in 2010, NTT Docomo introduced a prototype that uses the eye sensor system to help users navigate their phones with eye movement.
They hope that by combining to educate citizens, legislators and stakeholders on best practice, battery recycling will increase throughout Canada.'
and lives-and most of which cost just a few hundred dollars. While other developments in countries like Austria and Argentina have pushed the boundaries of prosthetic offerings,
The Anthromod itself cost only about 600 dollars to make, Lachappelle said. His work is documented in the videos he made at home
"This clinical trial has been advanced with funding from the National Space Biomedical Research Institute (NSBRI.""During space flight, microgravity, dehydration,
This work was supported with funding from the National Science Foundation grant EF-1124651, National institutes of health grant GM078484, USAMRMC grant W81xwh-10-2-0058,
"So unless you plan on covering your driveway with thousands of dollars'worth of magnets,
The company has attracted seed investment in the UK and further funding from the Horizon 2020 program 2
because it is a common cause of genetic deafness, accounting for 4 to 8 percent of cases,
"It's basically how we're moving away from an oil-based economy towards something that has a renewable, sustainable future to it."
Credit: Lieber Research Group, Harvard Universitythe group of scientists Lieber has brought together are trying to solve a longstanding neuroscience mystery:
and costs tens of millions of dollars but it only enables the treatment of thousands of patients per year.
Jeb bush, a Catholic, brushed off the Pope comments, saying don go to mass for economic policy or for things in politics.
and use a control panel on the light to swipe their charge card and register their use.
Last year, Germany was named the world most energy-efficient country by the Washington-based American Council for an Energy-efficient Economy (ACEEE
"Credit: The Caltech Groupcheap, self-cleaning, and easy to install, the Caltech toilet not only recycles the organic waste that runs through it;
he's not sure how close we are to achieving this goal, due to the expense of such systems."
"For this to happen, insurance companies will have to help finance these technologies, "said Millán. Let's hope this happens soon,
"A failed IVF attempt takes an emotional toll on a woman who is anticipating a pregnancy as well as a financial toll on families, with a single IVF treatment costing thousands and thousands of dollars per cycle,"one of the team,
price appropriate solution that in the near future should start to see commercial usage.""O'brien has described previously self-powering wearables as"the Holy grail"for the tech industry
"It means that consumers can look forward to more competitive pricing in the solar energy sector, and according to Dr Jones, the discovery is shot a-in-the-arm for the whole organic materials sector."
#Rate of investment in medical research has declined in U s. increased globally From 2004 to 2012,
the rate of investment in medical research in the U s. declined, while there has been an increase in research investment globally, particularly in Asia, according to a study in the January 13 issue of JAMA.
For the last century medical research including public health advances has been the primary source of and an essential contributor to improvement in the health and longevity of individuals and populations in developed countries.
and has generated more than half the world's funding for many decades. Few previous analyses have compared medical research in the United states with other developed countries according to background information in the article.
Reduced science investment The largest increase in biomedical and health services research funding in the U s. occurred between 1994 and 2004
when funding grew at 6 percent per year. However from 2004 to 2012 the rate of investment growth declined to 0. 8 percent annually
and (in real terms) decreased in 3 of the last 5 years reaching $117 billion (4. 5 percent) of total health care expenditures.
From 1994 to 2004 the medical device biotechnology and pharmaceutical industries had annual growth rates greater than 6 percent per year with biotechnology demonstrating the largest increases.
The share of U s. medical research funding from industry accounted for 46 percent in 1994
Cancer and HIV/AIDS were funded well above the predicted levels based on U s. disability alone with cancer accounting for 16 percent of total NIH funding and 25 percent of all
in comparison with total medical research funding. Private insurers ranked last (0. 04 percent of revenue) and health systems 19th (0. 1 percent of revenue) among 22 industries in their investment in innovation.
An increment of $8 billion to $15 billion yearly would occur if service firms were to reach median research and development funding.
Globalization U s. government research funding declined from 57 percent (2004) to 50 percent (2012) of the global total as did that of U s. companies (50 percent to 41 percent) with the total U s
Asia particularly China tripled investment from $2. 6 billion (2004) to $9. 7 billion (2012.
if the clinical value of its past science investment and opportunities to improve care are to be realized fully.
though public funding can play a greater role. Both will require nontraditional approaches if they are to be politically and economically realistic.
The needed changes include better coordination across funders and research institutions development of new funding sources improved grant evaluation processes changes in education and training rationalization of capital
investments and improved operational efficiencies. By taking the necessary political and institutional steps to ensure commitment of adequate resources over time adopting a comprehensive research strategy
Also lending third-party support for Dr. Samadani's research is M. Sean Grady MD the Charles Harrison Frazier Professor and Chairman of the Department of Neurosurgery at the Perelman School of medicine at the University
and trade and rising food prices are triggering the food crisis. Experts participating in the Global Rice Market
and Trade Summit organized by the International Rice Research Institute (IRRI) in Bangkok Thailand in October 2014 remarked that there was a noticeable rise in the local rice prices in the affected countries
and its price and accessibility directly influence social stability. Annual per capita consumption of rice (about 100 kg) is amongst the highest in Sub-saharan africa.
and Sierra leone at their request to revive their rice sectors under the umbrella of the World bank-funded West Africa Agricultural productivity Program (WAAPP).
and Bong districts in Liberia supported by the World bank. In August 2014 for reasons of safety Africarice Management decided to pull out its regional and international researchers from Liberia and Sierra leone.
and planning strategies to make improved rice seed available to farmers with strong support from donors such as the Government of Japan the African Development bank FAO the International Fund for Agricultural development the United states Agency for International Development
(USAID) and the World bank among others as well as the Economic Community of West african States (ECOWAS). These activities are part of the overall effort to support the Ebola-hit countries on the road to economic recovery and growth.
Meanwhile remembering the quiet heroism of scientists in these countries Africarice economist Ali Toure who was working in Sierra leone remarked We are praying for the safety of our brave colleagues who are continuing their work under very difficult and even dangerous situations.
The World bank estimates the regional economic toll could reach US$32 billion by the end of 2015 5
Protection at an affordable price In 2004, MVP partnered with SIIL to develop an affordable, tailor-made vaccine for use against meningitis A in Sub-saharan africa.
"Developing the Menafrivac vaccine fit exactly Serum's ingrained philosophy of bringing down prices of vaccines
and deployed across multiple countries at a price that was sustainable.""""The benefits of childhood immunization last a lifetime and the Menafrivac vaccine is one of the greatest success stories that shows
Liu, 1 Dongqing Xiao, Guoyan Zhou, Jungwoo Lee, Ha Uk Chung, Huanyu Cheng, Wen Ren, Anthony Banks, Xiuling Li, Ungyu
adding extra danger for patients and expense for the NHS. Now the team at Manchester have come up with a new algorithm
and Lewis'lab played a key role in ana lyzing and testing the com pound for resis tance from pathogens.
Lewis then tested the com pound for resis tance devel op ment and did not find mutant MSRA or Mycobac terium tuber cu losis resis tant to teixobactin,
which could be used for banking transactions and personal emails. We believe it will soon be possible to distribute quantum information between any two points on the globe said lead author Manjin Zhong from the Research School of Physics and Engineering (RSPE) at The Australian National University (ANU.
"From 216 applications, this project was one of six selected for funding by The british Enhancing Learning
The problem is compounded by modern chips'reliance on caches--high-speed memory banks where cores store local copies of frequently used data.
Biomolecular interaction analysis a cornerstone of biomedical research is accomplished traditionally using equipment that can cost hundreds of thousands of dollars said Wyss Associate Faculty member Wesley P. Wong Ph d. senior author
and cartilage grafts from organ donors compared to the current preservation method used by tissue banks.
and elimination measures where this is possible with reasonable effort and expenditure,"states the environmental lawyer Prof.
as it is hard to combat species that have just become established or only to do so at great expense.
Do you remember the Six Million Dollar Man? asks Dr. Grande. The Bionic man is not the future it's the present.
and fits in with the ethos of helping build long-term local economies rather than simply donating finished goods. Just weeks into the project
which will form part of the Made in Brunel Exhibition on London's South Bank in Summer 2015 Cara is already coming across unexpected challenges.
and its Innovation Corp. Partial funding also came from Office of Naval Research and Air force Office Scientific research.
and he credits Google as the impetus for being unstuck in the project. UK students are also driving the progress.
and their causes could result in 10 million extra deaths a year by 2050 at a cost of $100 trillion to the global economy.
despite the various complexities and hurdles the policy faced,"said the study's lead author, Daniel Polsky, Phd, executive director of the Leonard Davis Institute of Health Economics at the University of Pennsylvania."
"The study, conducted by a team of physician scientists and public policy researchers at the Leonard Davis Institute of Health Economics and the Perelman School of medicine at the University of Pennsylvania,
"However, these findings suggest that higher Medicaid payments are an effective strategy for ensuring Medicaid patient access to primary care providers,
Any change in those genes appears to alter your mental bank account or brain reserve by 2 or 3 percent.
Funding was provided by the Bill & Melinda Gates Foundation and the United states Air force Office of Scientific research h
when it came to accounting for differences within a pair of twins. This environmental dominance was pronounced more in older identical twins (age 60 and up) than in younger twins (under age 20.
the study is directed by Erwin Wagner head of the BBVA Foundation-CNIO Cancer cell Biology Program.
In developing regions where the economy is weak and medical services are limited, global health experts say as many as 200 million women want access to long-term,
and probably increase prices where quality can be guaranteed d
#Noncoding RNA CCDC26 regulates KIT expression An long noncoding RNA (lncrna), which might give an impact on tyrosine kinase-targeted leukemia therapy,
"This work was supported with funding from the National Science Foundation grant EF-1124651, National institutes of health grant GM078484, USAMRMC grant W81xwh-10-2-0058,
Arrayto date, 300,000 euros has been invested in the project, awarded by the Madrid-MIT M+Visión Consortium.
They are now waiting on further funding to be able to continue with the technological development and a pilot study in patients.
Castro believes that, with sufficient funding, they will be able to have a finished product that complies with European regulations by the end of 2018 f
Subsequently, NSF has provided funding for the work at Lehigh and, through Lehigh's International Materials Institute for New Functionalities in Glass, for the international collaborations as well.
and delivered a healthy boy in November 2014, weighing 3140 grams (6. 9 pounds). Dr Demeestere said:"
That funding and additional collaboration with the Maritime Applied Physics Corporation, an engineering company that frequently partners with the U s. military, helped support the advancement of NS honeycomb technology.
antibodies and growth factors while lending itself to many different mechanically robust formats, said Fiorenzo Omenetto, Ph d.,senior author on the paper and associate dean for research and Frank C. Doble Professor
This work was supported by funding from the Office of Naval Research (N14-13-1-0596) and the AFOSR (FA9550-14-1-0015
and provide funding, which is often difficult to source, to help bring new developments like this to market.'
''We will be using the Venture Prize award money to help us develop a robust and scalable manufacturing process,
Datta credits a theoretical understanding of the electron transport in the 2d layered materials to his post-doc
so this has broad implications for cellular turnover in any organ, and even in cancer,"said Dr. Sadek,
but having a single catalyst also reduces two sets of capital investment to one, 'Cui said.'
24m has raised $50 million in financing from venture capital firms and a U s. Department of energy grant. The company is initially focusing on grid-scale installations,
so they require much larger initial capital expenditures. By 2020, Chiang estimates that 24m will be able to produce batteries for less than $100 per kilowatt-hour of capacity.
The Lehigh team presented this process recently to a national showcase of investors and industrial partners at the Techconnect 2015 World Innovation Conference and National Innovation Showcase in Washington
and Innovation (EFRI Grant No. 1332349) and builds on the success of the initial funding,
harnessing nature to create functional inorganic materials will provide a pathway to a future environmentally friendly biomanufacturing based economy.
since previous efforts have found that optimising one function came at the expense of the other.
"This study was made possible by funding from Carl Bennet AB, VINNOVA, Karolinska Institutet, the Swedish Research Council, Swedish Brain Power, Knut and Alice Wallenberg Foundation, the Royal
Battling an HAI can often add tens of thousands of dollars to the cost of treating a single patient.
This could be useful for medical servers, government data communications, financial markets and military communication channels, as well as quantum cloud communications and distributed quantum computing."
and Investment companies involved in the personnel screening market have expressed already interest in the Q-Eye device.
and raise funding to develop the first commercial prototypes. Melody Stokes adds:""We're delighted to have distinguished Warwick alumnus Phil O'Donovan advise the team.
The study has been financed by the"Plan Nacional"of the Ministry of Economy and Competitiveness and by the European union programme Marie Curie Actions,
"A failed IVF attempt takes an emotional toll on a woman who is anticipating a pregnancy as well as a financial toll on families, with a single IVF treatment costing thousands and thousands of dollars per cycle.
the MU Informatics Institute and the Bond Life sciences Center to analyze vast genomic data sets and to formulate the design of RNAMINER.
because it is a common cause of genetic deafness, accounting for 4 to 8 percent of cases,
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