"If the fluorescence molecules glow, this indicates that the mouse is developing chronic epileptic seizures, "says the molecular biologist Prof.
the researchers tested for the first time to pre-treat undifferentiated mouse embryonic stem cells with mitomycin C a drug already prescribed to treat cancer.
the researchers reproduced the hyperexcitability of epileptic neurons in mouse brains in vitro. They then injected GABA,
a multi-institutional team used a new discovery approach to identify drugs that could activate mouse
--and saw the medication prompt a similar response as seen in the mouse cells. Both medications worked well,
"We have pioneered technologies that enable us to generate both mouse and human OPCS in our laboratory,"said Fadi Najm, MBA, the first author of the study and Research Scientist in the Department of Genetics & Genome Sciences at the Case Western Reserve School of medicine."
and isolating tooth stem cells by working on the pulp from the mouse molar. The researchers were
"By studying mouse models, we first showed this gene is essential for the survival of neurons
and mouse fibroblast cells (cells involved in wound healing) on flat graphene sheets and on wrinkled ones.
"Moreover, most functional screens are carried out in mouse ESCS. The only functional screen on human ESCS was published in 2010 from our laboratory at the GIS.
making it more clinically relevant than studies using mouse ESCS.""Co-lead author Research Fellow Dr Liang Hongqing at GIS'Stem Cell and Regenerative Biology added,
and evaluated the penetration capability by using mouse brains in vitro/in vivo. In addition, as an actual needle application, we demonstrated fluorescenctce particle depth injection into the brain in vivo,
and expensive mouse avatars that are created by injecting human tumor cells into mice.""This is really the first time that it's been demonstrated that you can use a rapid methodology like this to spatially define cancer cells and macrophages,
What sets the team's model apart from mouse avatars and hard plastic plates is that it can replicate much more accurately the sizes and shapes of the microenvironment within the patient's problem area.
showing that samples of brain tissue from two human MSA patients were able to transmit the disease to a mouse model for Parkinson's disease,
and that infected mouse brain tissue could itself spread the disease to other mice. The discovery that alpha-synuclein prions can transmit MSA raises a public health concern about treatments
in contrast to the 120 days it takes for the disease to spread to mouse models."
"You have to let the mouse models develop for such a long time that research on cures is really slow to progress.
By combining Scales with Abscale--a variation for immunolabeling--and Chemscale--a variation for fluorescent chemical compounds--they generated multicolor high-resolution 3d images of amyloid beta plaques in older mice from a genetic mouse
The oviductosomes from a female mouse were labeled pre with a fluorescent dye and incubated together with the sperm.
The researchers used mouse embryonic fibroblast cells to determine biocompatibility; that, along with the fact that the stretchability of gold nanomesh on a slippery substrate resembles the bioenvironment of tissue
a two-drug combination discovered by UF Health researchers that inhibits tumors and kills cancer cells in mouse models.
Researchers then tested its effectiveness on human pancreatic cells that had been implanted in mouse models. Daily doses of the compound reduced tumor volume by about 50 percent after 25 days, they found.
In testing on two mouse cell lines, the drug combination reduced the viability of cancer cells by about 50 percent
Against the backdrop of healthy mouse tissue, rogue metastatic cells from the human tumor stick out like flares.
The researchers developed a new method using flow cytometry that let them capture individual human metastatic cancer cells traveling through the mouse's blood
Whereas 44 percent of control mice (11 of 25) developed secondary tumors within four weeks, researchers could only find metastatic cells in one drug-treated mouse (4 percent.
With the click of a mouse, the inquirer sends a question and the respondent answers"yes"or"no"by focusing on one of two flashing LED LIGHTS attached to the monitor,
Preclinical studies using mouse models of bladder cancer have demonstrated the efficacy of the mycobacterium M. brumae in the treatment of this disease.
Interestingly, a subsequent challenge with a lethal strain of mouse malaria parasite in these vaccinated animals showed considerable protection against malaria.
and Ear/Harvard Medical school and Boston University have shown successfully neuroprotection in a Parkinson's mouse model using new techniques to deliver drugs across the naturally impenetrable blood-brain barrier.
In mouse models of human glioblastoma, one molecule they found shrank the average tumor size by half.
The most effective of these candidate drug molecules, called SKOG102, shrank human glioblastoma tumors grown in mouse models by an average of 50 percent."
In their proof-of-concept study, they sent light from the LED through an optical fiber to stimulate neurons in mouse brain slices.
or suppress infection in mouse and nonhuman primate models of HIV. But these animal models are very rough approximations of human infections,
and significantly increased survival in a mouse model of pancreatic neuroendocrine tumor. Bergers noted that the discovery potentially gives physicians a way to determine how effective anti-VEGF therapy might be in individual patients
the researchers reproduced the hyperexcitability of epileptic neurons in mouse brains in vitro. They then injected GABA,
The team used mouse models of asthma and human airway tissue from asthmatic and non-asthmatic people to reach their findings.
The finding, in both mouse and human cells, suggests that manipulating a natural process could someday be an alternative way to not just reduce the severity of the flu,
In a series of experiments in mouse and human lung cells, Yount and colleagues showed that inhibiting NEDD4 from doing this job led to an accumulation of IFITM3 in the cells
While most of the work described in the study was done in mouse models, the researchers also found similar cells in human livers.
Karin team examined three different mouse models of liver cancer. They found no signs of hybrid hepatocytes in any of the tumors,
The authors show that human irisin is similar to the mouse hormone and that it circulates in the range previously reported.
and expensive mouse avatars that are created by injecting human tumor cells into mice. his is really the first time that it been demonstrated that you can use a rapid methodology like this to spatially define cancer cells and macrophages,
What sets the team model apart from mouse avatars and hard plastic plates is that it can replicate much more accurately the sizes and shapes of the microenvironment within the patient problem area.
from a genetic mouse model of Alzheimer disease. Then scientists put new technology to its practical application.
by teaching it to differentiate between species (a yeast cell is different from a mouse).
#Scientists test new gene therapy for vision loss from a mitochondrial disease NIH-funded study shows success in targeting MITOCHONDRIAL DNA in mice Researchers funded by the National institutes of health have developed a novel mouse model for the vision disorder
Their success in creating a mouse model of LHON and using it to test an investigational gene therapy is described today in the Proceedings of the National Academy of Sciences.
This modified virus has been the key to creating a mouse that replicates LHON and to an investigational gene therapy for LHON that is currently in clinical trials.
To create a mouse model for LHON, the researchers loaded the virus with a defective copy of the ND4 gene carrying the same mutation that causes about 70 percent of LHON cases.
Then they injected the virus into fertilized mouse egg cells, and grew the cells to maturity.
the researchers had their mouse model. The presence of the virally encoded ND4 mutation in the eye was confirmed by essentially doing an eye exam to look for the red fluorescent marker.
Prior to development of the new mouse model Dr. Guy lab had shown that they could produce temporary signs of LHON in mice.
The mouse research is helping inform an ongoing NEI-supported clinical trial, which is led by Dr. Guy
Now University of Pennsylvania researchers have shown at the molecular level how experiencing stress changes a male mouse sperm in such a way that it affects his offspring response to stress.
me that seemingly mild stress to a male mouse would trigger this massive change in microrna response
To find out, the team microinjected the nine mirs into mouse zygotes, which were implanted then into normal female mice who carried them as surrogates.
this indicates that the mouse is developing chronic epileptic seizures, says the molecular biologist Prof. Dr. Susanne Schoch from the department of Neuropathology at the University of Bonn.
mouse models were used in this research. Team of scientists took mouse hematopoetic progenitor cellsells that give rise to white blood cells.
especially the mouse model, will be used by academics to isolate healthy cells modified by tumors, and by the pharmaceutical industry in the quest for novel anticancer drugs that block tumor-organ communication,
Sure enough, when the researchers spiked mouse serum with a dose of nicotine equivalent to one cigarette, then added Nica2 to the mix, the enzyme cut nicotine half-life from more than two hours to less than 15 minutes.
they may inject them into the mouse bloodstream. The bubbles should travel into the tiny blood vessels of the brain.
according to the in vitro mouse study published last week (October 15) in Science. reviously, with plastic material,
Bao and her colleagues demonstrated that the sensors could relay pressure signals to the mammalian nervous system by linking them to a blue LED light that in turn stimulated slices of mouse brain that had been engineered to respond to those wavelengths.
and that can indeed improve resistance to pneumonia in our mouse model l
#Researchers turn to 3-D technology to examine the formation of cliffband landscapes A blend of photos
Scientists at the National institutes of health (NIH) report that newly formed brain cells in the mouse olfactory system--the area that processes smells--play a critical role in maintaining proper connections.
In the first set of mouse experiments Dr. Belluscio's team first disrupted the organization of olfactory bulb circuits by temporarily plugging a nostril in the animals to block olfactory sensory information from entering the brain.
Surprisingly the loss of STAT3 in NK cells of the mouse led not to a decrease but to an increase in killing activity against melanoma cells and leukemia cells.
and Bruce Maryanoff, formerly at Johnson & johnson and currently a visiting scholar at TSRI, the researchers tested this synthetic peptide in a mouse model prone to atherosclerosis.
The researchers showed in mouse models that chronic skin inflammation caused by continuous skin contact with allergens contributes to tumor development.
To investigate whether inflammation from the implant contributed to the tumor the researchers studied mouse models of contact allergy.
Working in mouse embryonic stem cells (ESCS) the Young lab examined the scaffolding landscape found within topologically associated domains.
Using brain scans from the ENIGMA Consortium and genetic information from The Mouse Brain Library he was able to identify a novel gene,
MGST3 that regulates the size of the hippocampus in both mouse and human, which is linked to a group of neurodegenerative diseases.
and the corresponding genes and then matching those with genes in mice from the BXD system held in the Mouse Brain Library database we could identify this specific gene that influences neurological diseases."
The Mouse Brain Library, established by Professor Robert Williams based at the University of Tennessee Health Science Center,
and colleagues have shown that a lentivirus encoding let-7 injected into mouse neurons promotes the autophagic turnover of toxic misfolded proteins associated with neurodegenerative disease. e also demonstrate that treatment with anti-let-7 can block autophagy
-and-mouse game between ad blocking contributors and Secret Media. Montagnon, Julien Romanetto and the rest of the team have been flying under the radar for the past few months not to raise awareness.
we have continued to interface with them via monitor, keyboard, and mouse. More recently, tools for making things in the physical world have changed a lot
#How An Intelligent Thimble Could Replace the Mouse In 3d Virtual reality Worlds The way in
which humans interact with computers has been dominated by the mouse since it was invented in the 1960s by Doug Engelbert.
A mouse uses a flat two-dimensional surface as a proxy for a computer screen. Any movements of the mouse over the surface are translated then into movements on the screen.
These days a mouse also has a number of buttons and often scroll wheel that allow interaction with on-screen objects.
The mouse is a hugely useful device but it is also a two-dimensional one. But what of the three-dimensional world and the longstanding but growing promise of virtual reality.
What kind of device will take the place of the mouse when we begin to interact in three-dimensions?
Today we get to see one idea developed at the University of Wyoming in Laramie by Anh Nguyen and Amy Banic.
It s been possible to buy a computer mouse for some time that senses its position in three dimensions.
In addition the 3dtouch has an optical flow sensor that measures the movement of the device against a two-dimensional surface exactly like that inside an ordinary mouse.
technologies that add physical sensations a common feature in products like computer mouses that vibrate and game joysticks that shake,
or a facial feature that you really can get just using a regular mouse. As a practical matter, it will also offer museum restoration artists
its GPS coordinates and even the position of your computer mouse. The data is now on a public Web page and available for analysis and aggregation;
The team applied this simpler approach to mouse embryonic stem cells in a dish, which have the potential to become any cell type.
"The vaccine appears to work well in our mouse model to'prime'the antibody response,
One will be a finger-touch device similar to a computer mouse. The other will be a wearable version for continuous monitoring,
One will be a finger-touch device similar to a computer mouse. The other will be a wearable version for continuous monitoring,
the scientists explain how they used Sticky-flares to quantify ß-actin mrna in Hela cells (the oldest and most commonly used human cell line) as well as to follow the real-time transport of ß-actin mrna in mouse embryonic
In the first demonstration of how the technology works, published July 30 in the journal Cell, the researchers look inside the brain of an adult mouse at a scale previously unachievable, generating images at a nanoscale resolution.
"The researchers have begun the process of mining their imaging data by looking first at an area of the brain that receives sensory information from mouse whiskers,
The research team found that the new patch could reduce blood glucose levels in a mouse model of type 1 diabetes for as long as nine hours.
The team tested the patch on a mouse model of type 1 diabetes and compared it to injecting insulin as standard.
"With a few clicks of your mouse, you get a complete list of the DNA strands that you need to mix in a test tube,
a postdoctoral fellow in Kipnis'lab. The vessels were detected after Louveau developed a method to mount a mouse's meninges-the membranes covering the brain-on a single slide
"The researchers also looked at the process in a mouse model and found that Grb2 depletion results in the development of multiple tumours in the vicinity of a primary tumour,
By studying mouse and frog embryos as well as human stem cells they confirmed that the PRDM12 gene is switched normally on during the development of pain-sensing nerve cells.
So far the team has had success with the delivery system in mouse models. A clinical study at the University of Oxford is currently investigating using an existing drug in combination with ultrasound but without the bubble technology,
Louveau discovered the vessels after analyzing the meninges of a mouse. According to reports, the vessels were hidden very well
painless patch could lower blood glucose in a mouse model of type 1 diabetes for up to nine hours.
The researchers tested the ability of this approach to control blood sugar levels in a mouse model of type 1 diabetes.
In mouse brains, as in human brains, adult neural stem cells reside on the walls of cavities called ventricles,
Alvarez-Buylla and his team traced the development of mouse adult neural stem cells back to their embryonic progenitors.
when the mouse embryo is between 13 and 15 days old, uite early in embryonic brain development, said Alvarez-Buylla,
the scientists found that the mouse adult neural stem cells they studied are derived from embryonic neural stem cells that produce neurons in entirely different parts of the brain. his means that, somehow,
mouse brains have long been accepted as excellent basic research models for the human brain, he said.
In mouse models, delivering sirna into cancer cells inhibited the expression of Twist, which in turn reduced epithelial-mesenchymal transition
Dr. Hauser and his team used a mouse model of Pseudomonas aeruginosa (PA) pneumonia to examine how the bacterium uses its secretion system to inject a toxin, called Exos, into cells.
extracted from the bone marrow of healthy mouse donors and grafted into the bloodstream, can migrate into the brains of sick mice,
move your mouse or touch your phone screen. Behaviosec tracks these movements and maps them against past interactions to see
showed promising results in a mouse model of type 1 diabetes. Researchers hope to see similar success in subsequent clinical trials in humans. he whole system can be personalized to account for a diabetic weight
and pushing their mouse to one side as eye-control becomes the latest way to play games.
and more natural input than with traditional mouse, keyboard, or controller as these were invented originally for 2d games and applications.
even the force or rhythm of key strokes or the temperature of the hand controlling the mouse. f Amelia is to become the most faithful service agent,
which caused the mouse to move in a circle. In other mice, shining a light directly onto brain cells expressing a light-sensitive protein prompted the release of dopamine,
the scientists explain how they used Sticky-flares to quantify ßctin mrna in Hela cells (the oldest and most commonly used human cell line) as well as to follow the real-time transport of ßctin mrna in mouse embryonic fibroblasts.
Complicated process The researchers focused on five different types of cells in a particular area of the mouse cortex
faster and less expensive than using a mouse model, for instance, "he explained.""The big finding is that we have a single receptor that does two different jobs,"noted Dr. Xue."
wrote the investigators. n A549 lung cancer cellased mouse xenograft studies, 6-thio-dg caused a decrease in the tumor growth rate superior to that observed with 6-thioguanine treatment.
They confirmed this using a combination of studies in mouse and frog models, and in human induced pluripotent stem cells.
the drug-treated mice showed a six-day-faster reconstitution of hematopoiesis after bone marrow transplantation. tudying mouse models,
which prompted the mouse to begin moving in circles. In another experiment, the scientists shone light directly onto specific brain cells.
After a period of clinical trials and commercial development by spinoff company Glucosense Diagnostics, it is hoped that two versions of the device will be commercially available a computer mouse-sized tabletop unit,
At a basic level, motion controllers are premised on the idea that a user hands replace traditional input devices like touch screens or mouse and keyboards.
Although similar, mouse brains don exactly follow the same developmental trajectory as human brains, so we don know how well the findings translate.
after all, how can one know for sure that a mouse is depressed autistic or hallucinating? Then there one more perk.
and used an infrared laser to scan each mouse. The researchers found that the nanoparticles caused bright spots where cancer cells
researchers at the University of Bonn in Germany made a skeletal muscle of a mouse contract in response to light.
The team introduced a gene into a mouse that codes for a protein normally produced by light sensing blue-green algae.
but by producing it within the mouse own cells, it has the same effect of contracting muscle cells
The researchers specifically focused on the larynx that they removed from the mouse so that light can be delivered correctly.
Here a video of a mouse larynx being opened and closed in response to light g
#Rice Microendoscope Hopes to Make Esophageal Biopsies Thing of Past (VIDEO) At Rice university engineers have been working on making certain biopsies unnecessary by imaging suspected tissues without excising them.
minimally invasive device for controlling brain cells with drugs and lighta study showed that scientists can wirelessly determine the path a mouse walks with a press of a button.
A summary of the research, conducted in mouse and human cells, appears online July 14 in the journal ACS Nano.
painless patch could lower blood glucose in a mouse model of type 1 diabetes for up to nine hours.
The researchers tested the ability of this approach to control blood sugar levels in a mouse model of type 1 diabetes.
-actin mrna in mouse embryonic fibroblasts. Sticky-flares are built upon another technology from Mirkin's group called Nanoflares,
and progenitor cells isolated from the fetal liver of a mouse in Tan's lab. As Tan explained,"
In the first demonstration of how the technology works, published July 30 in the journal Cell("Saturated Reconstruction of a Volume of Neocortex"),the researchers look inside the brain of an adult mouse at a scale previously unachievable, generating images
"The researchers have begun the process of mining their imaging data by looking first at an area of the brain that receives sensory information from mouse whiskers,
In one experiment with inflated mouse brain tissue, the researchers gauged the distance between two proteins that sit on opposite ends of neural synapses.
At the meeting, he showed an image of a half-millimetre slab of the mouse brain's hippocampus
The vessels were detected after Louveau developed a method to mount a mouse meninges the membranes covering the brain on a single slide
Aix-Marseille and the German Mouse Clinic teamed up to investigate the initiation process of dendritic spines.
To study histone composition in mouse nerve cells and related turnover, researchers fed young, post-weaning rodents a special diet containing heavy labeled lysines,
and the system is ly by mousewith the operator using the computer mouse to control the aircraft
This unique configuration permitted volumetric imaging of cortical dendrites in the awake, behaving mouse brain.
smaller than the width of a human hair, let the scientists determine the path a mouse walks using a remote control to inject drugs
The device is mounted to the head of the mouse and is powered by a small battery, removing the need for it to be wired,
In one such experiment, mice were made to walk in circles after a drug that mimics morphine was injected into the region of the mouse's brain that controls motivation and addiction.
Using mouse models and human airway tissue taken from both asthmatic and non-asthmatic people,
The other type of mouse, called Beethoven, has a specific TMC1 mutation--a change in a single amino acid
but with gene therapy, they jump as high as a normal mouse, "says Holt. The force of their jump was measured by a plate on the floor underneath them;
and reversibly disrupt Apc activity in a mouse with cancerous tumours in its colon. They already knew that the Apc gene was linked closely to an important pathway known as the Wnt signalling pathway,
"The patch has been tested in mouse models and so far, looks very promising. According to the paper published in the Proceedings of the National Academy of Sciences,
The new study determined that mouse TESI is highly similar to the TESI derived from human cells
In the mouse study the insulin-producing cells were placed under the kidney capsule--a thin membrane layer that surrounds the kidney--where they developed into an organ-like structure with its own blood supply.
Working in a mouse model the research team led by Drs. Nicolas Bazan Boyd Professor and Director of the LSU Health New orleans Neuroscience Center of Excellence and Alberto Musto Assistant professor of Research Neurosurgery and Neuroscience found that brief small electrical microbursts
but we were surprised at how rapidly a mild reduction in food intake could improve outcome in a mouse malaria model,
but also in activating adaptive immune and inflammatory responses--is increased upon infection in a mouse model of cerebral malaria,
The researchers found in a mouse model of sepsis that sildenafil more commonly known as Viagra induced the liver to produce greater amounts of a protein called CYCLIC GMP
of mouse Ngly1 gene expression. Published in Proceedings of the National Academy of Science the paper details how lack of the Ngly1 protein results in the incomplete removal of the sugar portion of glycoproteins--a process called deglycosylation.
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