which are preparing for the next phase of the internet, where billions of small cheap sensors are online providing data about their operations.
"We decided to systematically test why it was that truncating guides too much caused Cas9 to no longer cut the intended genomic site,
We envision future uses for the technology that can help decipher the tangled web of interactions underlying for example cancer drug resistance and stem cell differentiation,
Kleiner and their colleagues zeroed in on the sites in chromosomes where DNA repair happens. Specifically
This process, called phosphorylation, occurs at sites of broken DNA as a way to mediate interactions between key proteins.
This interaction helps bring 53bp1 to the site of DNA damage, where it mediates the repair of double-stranded breaks in DNA by encouraging the repair machinery to glue the two ends back together."
since to phase II trials at multiple test sites. Results have not yet been released. The published findings come from AD patients who participated in safety trials from March 2001 to October 2012 at UC San diego Medical center.
and then attacks a previously unknown binding site on STAT3, disrupting its disease-promoting effects.
and modifies an inhibitor-binding site on the protein coiled coil literally protein coils coiled around each other
to the modified site. his is the confluence of two ideas wee been working on around
The human proteome (the entire set of expressed proteins) is estimated to be phosphorylated at more than 100,000 unique sites,
The reagents are fluorescent detection analytes that competitively bind to a key cofactor binding site of enzymes that catalyze methylation of histones, DNA, and RNA.
Cayman is poised to expand on the technology with a patent pending second-generation SAM mimic-based probe designed to competitively bind to SAM-binding sites of a different set of methyltransferases.
including new cancers at other sites or in the opposite breast.""These patients who had low risk scores by Oncotype did extraordinarily well at five years,
not only attack the main tumor site, but are more likely to find and attach themselves to tumor cells circulating in the bloodstream essentially attacking new tumors before they start,
which the platelet membrane could help us target relevant sites in the body. i
#An Accessible Approach to Making a Mini-brain If you need a working miniature brain say for drug testing, to test neural tissue transplants,
you could use these to measure dissolved oxygen or ph from a lot of different sites all over a pond or a lake,
leading viruses to binding sites that allow infections to spread at the molecular level. They serve as a key of sorts that gives viruses entry into the host to begin spreading.
which cells are transplanted into the injury site, "says research supervisor Dr James St john, from Griffith's Eskitis Institute for Drug Discovery.
and better integrate into the injury site. In turn, this will help the spinal cord to regenerate more effectively."
Music streaming is finally bigger than downloads We've just hit a massive milestone in the evolution of the music industry:
a record label is reporting higher revenues from music streaming than paid downloads. Warner Music group has announced that its streaming revenues have passed those from digital downloads.
CEO Stephen Cooper said"the rate of this growth has made it abundantly clear that in years to come,
"Paid downloads have long been the primary way listeners consume music, with downloads overtaking physical sales in the US (by volume) back in 2012.
But downloads have gone into decline as faster internet connections have allowed the rise of streaming services, often offering users free access to libraries of millions of tracks,
But as digital downloads decline it risks losing its industry-leading position to challengers like Spotify, Tidal, and others.
or more than three for every person on the planet, will be connected to the internet by the end of 2020.
outlined to Business Insider four major ways that advancements in internet technology could threaten national security.
At Infiltrate, a professional penetration tester for a major company in Silicon valley told Business Insider that the easiest way to infiltrate a client's system is to bait an employee into clicking on an infected link in a seemingly innocuous email.
"Modern aircraft are connected increasingly to the internet. This interconnectedness can potentially provide unauthorized remote access to aircraft avionics systems,
Fans remain largely confused as to why Tidal even exists it offers streaming music at twice the price of Google, Apple, and Spotify.
If you used a mobile phone to browse the internet back in 2003, then you probably did
It let older mobile phones download data using their cellular service. It was a precursor to the much faster networks that we use today.
Aspirothe Aspiro website in 2001. Aspiro grew quickly thanks to partnerships with European phone manufacturers such as Ericsson and Nokia.
Flickr/sigurdgaaspiro partnered with a Norwegian music store to launch its streaming site. Aspiro focused on WAP for years,
"a company he had set up with the sole purpose of buying a music-streaming site.
Entertainment news site Showbiz 411 heard about the secret meeting and published a list of names that were in attendance.
when musicians began turning their social media profiles light blue in anticipation of the relaunch of Aspiro's streaming service.
and Jay z's streaming site would be called Tidal. The March 30 press conference was meant to be the opportunity for Tidal to reboot its public image and present itself as a major player in the world of music streaming. ew York
The relaunched streaming site would be based around exclusive music and video content, as well as special live events for subscribers.
the site encompasses high quality sound, video, exclusive editorial but there are more features on the way. In time, TIDAL will be not just a streaming service but a platform with enhanced experiences.
"Journalists and amused fans took to Twitter to mock Jay z's ignorance of the fact that people pay taxes
and his music is now available to stream on the site. The backlash against Tidal began in earnest after the New york press conference.
and Swedish news site Breakit claimed that 25 employees in Aspiro's Norway office had also been forced to leave."
Jay z took to Twitter on April 26 to air his views on Tidal.""Stream of consciousness coming in 5, 4, 3, 2,
Another view that Jay z made clear in his Twitter"stream of consciousness"was that he felt that other music-streaming services were out to get him.
"Tidal employees suggested via email at the time that Jay z was referring to rivals like Apple and Spotify.
I take my respectpharrell even told me go with the safest betjimmy Iovine on for the safety netgoogle dig around a crazy checki feel like Youtube is the biggest culpritthem n---pay you a 10th of what you supposed to getyou know I came in this game independent right?
they ain say s---Jay z suggested that Google offered him money to partner with its own streaming service,
but hinted that he was upset with music appearing on Youtube (and the diminished revenue he receives from it).
The Tidal Twitter account publicly shut down the rumour. Right now there are two big reasons why someone would sign up to Tidal:
and it just raised $40 million Massdrop is a new kind of Internet retailer. Actually, it's technically not a retailer at all.
The site doesn't have any kind of item on hand to sell you. Instead, it acts as a middleman between manufacturers, enthusiasts, and would-be customers."
the site now has over one million monthly users. To keep up with that demand, Massdrop's employees have ballooned from 14 just over a year ago to 70 today.
El-Hage says that the company's unique relationship with vendors sets it apart from other failed flash sale websites.
Multiple sources confirm that Google Wallet saw a jump in payment volume following the launch of Apple Pay.
and why the fledgling mobile payments feature is sure to be a success. Provides a quarterly update on the mobile payments industry including analysis of Softcard, Google Wallet, Currentc, Paypal, and Looppay.
a popular social coding site for programmers, is fighting a days-long cyberattack that reportedly originates in China.
The U s. coding site Github said on Sunday it was deflecting most of the traffic from the cyberattack that had caused intermittent outages.
The attackers paralyzed the site at times by using distributed denial of service, or DDOS, attacks, a technique commonly used to disrupt websites and computer networks,
according to the Wall street journal. They pushed massive amounts of traffic to Github by redirecting overseas users of the popular Chinese search engine Baidu Inc,
according to the Wall street journal. The newspaper said they targeted two Github pages that link to copies of websites banned in China-a Mandarin-language site from the New york times Co and Greatfire. org,
which helps Chinese users circumvent government censorship. A Beijing-based Baidu spokesman said a thorough investigation had determined it was neither a security problem on Baidu's side nor a hacking attack."
"We have notified other security organizations and are working to get to the bottom of this, "the spokesman said.
On its blog, Github said the attack began early on Thursday and involved"every vector we've seen in previous attacks as well as some sophisticated new techniques that use the web browsers of unsuspecting, uninvolved people to flood github. com with high levels of traffic.
Github said it believed the intent of the attack was to convince the company to remove a specific class of content.
#Facebook says drones could help extend internet access around the world A fleet of solar-powered drones could help provide high-speed internet to people around the world who currently live without it,
Facebook says of a project in development. The company's chief technology officer Mike Schroepfer unveiled the plans during a keynote speech on Thursday at the F8 conference in San francisco. The drones,
000 metres, the drones are designed to beam down internet connectivity to regions of the world where wireless internet access is unavailable,
."Facebook CEO Mark Zuckerberg said in a post on Thursday, paired with a photo of an early prototype drone soaring over Palo alto,
a U k.-based company that Facebook acquired in 2014. Despite Facebook's obvious enthusiasm for the project, it's still in the early stages of development.
The social media giant told the New york times it hopes to have a fleet of 1 000 drones,
but it will probably be years before it becomes a reality. And that's to say nothing of the red tape Facebook would have to manoeuvre to get a fleet of remotely controlled aircraft in the skies around the world.
The Aquila project is part of Facebook's Internet. org initiative, which it says aims to extend internet access to people around the world who live outside of mobile networks."
"Aircraft like these will help connect the whole world, because they can affordably serve the 10 per cent of the world's population that live in remote communities without existing internet infrastructure,
"wrote Zuckerberg g
#India's top court upholds free speech online or via cellphone India's top court affirmed people's right to free speech in cyberspace Tuesday by striking down a provision that had called for imprisoning people who send"offensive"messages by computer or cellphone.
Police arrested a man last year for saying on Facebook that Prime minister Narendra Modi, then still a candidate, would start a holocaust in India
And last week, police in the northern state of Uttar Pradesh arrested a teenage student for posting comments on Facebook he attributed to a top state minister.
although his son had filed a police complaint in 2012 against a businessman for allegedly disparaging him in Twitter messages."
"Cyber analysts said the ruling marked a positive step in ensuring that the Internet would be governed by the same norms and laws as newspapers, TV commentary and other forms of communication as India's Internet users increase from today's 100 million online."
however, that there was still more work to be done in guaranteeing the Internet was governed fairly, including a provision that allows the government to block websites without announcing
or explaining its decision to do so. The Supreme court on Tuesday upheld that part of the law."
#The internet is almost out of IP ADDRESSES It turns out even the internet operates within finite dimensions.
The web is about to exhaust its supply of Internet Protocol (IP ADDRESSES. Now, technology companies are scrambling to get onto a new system to route internet traffic to the right place.
IP ADDRESSES are like the internet's phone numbers. Under the web's current system, there are billions of them. 3 billion to be exact.
But as more of us do more and more online, those addresses are being gobbled up. And soon, very soon, that supply will run out."
"The second half of 2015, maybe if we're lucky we could stretch it to early 2016,
"Over time, you'll realize you wont be able to reach half the internet. You won't be able to watch the video you want to watch.
At issue is one of the weirdest quirks of the internet's history. In 1981, as the internet was being built,
volunteers created a system to direct traffic and make sure people landed on the page they were looking for.
They called it IPV4 (though they didn't build versions 1 2 or 3). They made 4. 3 billion IP ADDRESSES to handle all that traffic.
But in 1981, the internet was a mere shadow of what it is today. Now, everything on the internet has an IP ADDRESS:
laptops, mobile phones, tablets, cameras, even coffee makers and thermostats. By 2020, there will be an estimated 50 billion devices online.
The Wall street journal claims that's enough to assign an IP ADDRESS to every atom On earth. But not everyone is rushing to adapt to the new technology.
The Canadian Internet Registration Authority (CIRA) says the transition to IPV6 has been slow at least in part because the changes are all happening behind the scenes"Nobody really knows about it.
But really IPV4 as a resource in any meaningful way is exhausted. And you can see that in that there is a secondary market that has sprung up,
the price per IP ADDRESS will only grow. In 2011, Microsoft bought up more than 660,000 IP ADDRESSES from Nortel for $7. 5 million US ($11. 36 each.
#India orders clampdown on internet porn websites India has ordered Internet service providers to block access to more than 850 adult websites in
users may still view the sites through virtual private networks and proxy servers. He said the move would protect children.
dated last Friday, orders Internet service providers to block access to the 857 sites on grounds of morality and decency.
The Supreme court said earlier in July that ordering a ban on adult websites was not its job
Not sex,"popular Indian author Chetan Bhagat said on Twitter.""Porn ban is anti-freedom, impractical, not enforceable.
In the past, India has tried to control social media sites like Facebook and Twitter and ask them to take down offensive material.
It had blocked briefly several Twitter accounts in 2012 citing security and law and order fears.
It also blocked access to a homegrown soft-porn website in 2009. Kaul said more websites may be added to the list of those to be blocke e
#Airbus patents plane that could fly from New york to London in 1 hour A rocket-plane that could fly from Vancouver to Tokyo in three hours instead of 10 has been patented by Airbus. The U s. patent for an"ultra-rapid air vehicle
and related method for aerial locomotion"was awarded to Airbus, also known as the European aeronautic defence and space company, in July. Airbus said the plane would be targeted mainly at business travel
along with a Youtube video. The feat was accomplished using a system allowing the brain to bypass the injured spinal cord
Smart thermostat maker Nest uses its internet-connected thermostat to respond to demand response requests on peak demand days.
Building and maintaining offshore wind technology is compared expensive with onshore wind projects because of challenges such as transporting equipment and workers to the sites
Google patents a way for autonomous vehicles to understand hand signals A Google patent has revealed that the firm self-driving cars will be able to detect
Google announced its self-driving cars would be capable of doing this last year, but the latest patent reveals new details about how it would work.
Google algorithms can then decide whether a cyclist is present, and then identify parts of his or her body.
HOW DOES GOOGLE'S AUTONOMOUS CAR WORK? Google's prototype two-seater'bubble'cars have buttons to begin and end the drive,
but no other controls. An onboard computer uses data from sensors, including radar, a laser and cameras,
Under the vision unveiled by Google, passengers might set their destination by typing it into a map
and the ability to self-drive will depend on specifically designed Google road maps tested on the company's current fleet of vehicles.
and will be able to use Google's extended maps service, using GPS technology to locate the vehicle's exact position on an electronic map.
leaving open different possibilities for exactly how Google self-driving cars could work. Google says it begun discussions with most of the world's top automakers in a bid to get self-driving cars on the road by 2020.
In March, a separate patent revealed that Google's self driving car could have airbags both inside and out.
It shows an external airbag system in action that inflates if the car hits a pedestrian or other object.
The head of self-driving cars for Google expects real people to be using them on public roads in two to five years.
and Google would collect data on how they interact with other vehicles and pedestrians. Google is working on sensors to detect road signs and other vehicles,
and software that analyzes all the data. The small, bulbous cars without steering wheels or pedals are being tested at a Google facility in California.
Urmson wouldn't give a date for putting driverless cars on roads en masse saying that the system has to be safe enough to work properly.
He told reporters at the Automotive News World Congress in Detroit that Google doesn't know yet how it will make money on the cars.
Google may face state regulatory hurdles depending on where it chooses to test the cars in public.
Under legislation that Google persuaded California lawmakers to pass in 2012, self-driving cars must have a steering wheel and pedals.
As well as asking for money, the demand also features an email address containing one of the show's most famous lines,
'Computer users who see the message are directed then to a website that shows them how to buy Bitcoins to pay the hackers.
A Youtube video is opened in the background featuring a song used in a fictional radio station in the game Grand Theft Auto V.'We believe that the crypto ransomware uses social engineering techniques as a means of infecting victims'
writes Symantec on its blog.''The malware arrives through a malicious zip archive, which uses the name of a major courier firm in its file name.'
Trojan) which when executed, downloads the crypto ransomware onto the victim's computer.''The threat also downloads and opens a legitimate. pdf file to trick users into thinking that the initial zip archive was not a malicious file.'
'There is currently no estimate to how many people have been affected by this particular virus . But the FBI says ransomware such as this is a growing problem.
Ransomware infiltrates a computer after a user clicks on a link or attachment in an email.
when a user visits a website, including well-known ones with good security systems, according to technology consultant Greg Miller of CMIT Solutions of Goshen, New york. Once inside the computer,
#Audi, Mercedes and BMW hit back at Google and Appple: Firms buy Nokia's map business in bid to beat tech firms with self driving cars and navigation German carmakers BMW,
known as HERE, clubbing together to keep the assets away from Internet rivals such as Uber of Silicon valley and China's Baidu and Tencent.
their parts suppliers and software rivals like Uber, Google or Apple.''With the joint acquisition of HERE, we want to secure the independence of this central service for all vehicle manufacturers,
which many in the automotive, Internet and logistics industries see as key to their own strategies.'
'There is a risk that the other automakers will be pushed further into the arms of Google, 'said Richard Windsor an independent financial analyst who tracks major tech players.
'It comes just weeks after Google has admitted it's self driving cars are being hit'surprisingly often'by other drivers
'said Google's Chris Urmson. The three Google employees on board complained of minor whiplash, were checked out at a hospital
and cleared to go back to work following the July 1 collision, Google said. The driver of the other car also complained of neck and back pain.
The simulation shows Google's car being rear ended at 17mph at a junction in Mountain view after stopping at a red traffic lightin a blog post
he says the problem has been common.''Our self-driving cars are being hit surprisingly often by other drivers who are distracted and not paying attention to the road.'
'New data released by Google reveals other drivers have hit the firm's cars 14 times since the start of our project in 2009,
It comes as the latest version of Google's self-driving car-a pod-like two-seater that needs no gas pedal
Google says. The technology giant's mission is to have driverless cars available to consumers in the next five years.'
'Google said.''They're ultimately designed to work without a steering wheel or pedals, but during this phase of our project we'll have safety drivers aboard with a removable steering wheel, accelerator pedal,
And the pod can only drive in areas that have been mapped thoroughly by Google. At first it will likely even have a steering wheel
But Google is lobbying for more flexible regulations. Google will initially build and test 25 pods,
mostly in neighborhoods surrounding its Mountain view headquarters. It will eventually build between 50 and 100,
and will broaden testing to sites that are hillier and rainier. The ultimate goal, says Google cofounder Sergey Brin,
is controlled computer cars that can eliminate human error, which is a factor in an estimated 90 percent of the 1. 2 million road deaths that occur worldwide each year.
Google shocked the auto industry in 2010 with its announcement that it was working on a driverless car.
Brin insists Google doesn't aspire to be a car company, but wants its technology to be adopted by automakers.'
Chris Urmson, who directs Google's self-driving car project, says the slow-moving, friendly looking prototype-his young son thinks it looks like a koala because of the nose-like black laser on the front-is a good bridge between the company's current test fleet of 20 specially outfitted Lexus SUVS
Earlier this week, in response to questions from The Associated press, Google acknowledged 11 minor accidents in the six years it has been testing autonomous cars.
and notes that Google's vehicles have completed more than 1. 7 million miles of testing. He says all but one of the accidents were caused by drivers in other cars;
in the only incident caused by a Google car, a staffer was driving in manual mode.
Urmson says Google needs to do a better job of educating people about self-driving technology and updating them on Google's progress.
and the site will feature a monthly report that will include details of any accidents involving Google cars.
The site will also have a section where people can send feedback when they interact with the cars.
The prototype cars-assembled in suburban Detroit by Roush Industries-have the same array of radars, lasers and cameras as Google's fleet of Lexus SUVS,
the head of software for the self-driving car project, says Google's software has gotten much better over the last year at classifying objects, like trees and mailboxes,
For example, Google's cars will slow down if they sense that a car in the next lane is speeding up to cut in front of them.
And in one recent test, a Google car paused when a cyclist ran a red light.
one of Google's Lexus SUVS seemed momentarily confused when a mail truck partially blocked its path.
Later, during a demonstration drive in Google's parking lot, the prototype-without a wheel or pedal-braked
like the time a Google SUV stopped and waited while a woman in a wheelchair chased a duck with a broom.
Google isn't alone in developing self-driving cars. Mercedes-benz Infiniti and other brands already have advanced driver assistance systems, like lane keeping and adaptive cruise control,
Unlike Google, automakers think self-driving cars will arrive feature-by-feature instead of all at once, giving people plenty of time to adapt to autonomous driving.
says Google's'moon shot'strategy is difficult and riskier than just adding features to existing cars.
Google could make self-driving urban pods for universities or urban centers, for example, or sell its technology to automakers.
Overtext Web Module V3.0 Alpha
Copyright Semantic-Knowledge, 1994-2011