Tropes

www.medgadget.com 2015 00451.txt.txt

#Rice Microendoscope Hopes to Make Esophageal Biopsies Thing of Past (VIDEO) At Rice university engineers have been working on making certain biopsies unnecessary by imaging suspected tissues without excising them. The microendoscope device provides a high resolution image of tissues down to the level of individual cells, offering a view of the cellular morphology that can show signs of the presence of cancer. In a study conducted in the U s . and China of patients suspected of having malignant squamous cell tumors, the device was used alongside a regular endoscope. Results of biopsies ordered after a traditional endoscopic imaging were compared with the results from the microendoscope. These showed that the technology is capable of sparing patients unnecessary biopsies and can be used alongside traditional Lugol chromoendoscopy for diagnosing esophageal squamous cell neoplasia. Some details from the study in journal Gastroenterology: In this prospective trial, 147 consecutive high-risk patients were enrolled from two US and two Chinese tertiary centers. Three expert and four novice endoscopists performed white light endoscopy followed by LCE and HRME. All optical images were compared to gold standard of histopathology. Using a per biopsy analysis, sensitivity of LCE vs. LCE+HRME was 96%vs. 91%(p=0. 0832), specificity 48%vs. 88%(p<0. 001), PPV 22%vs 45%(p <0. 0001), NPV 98%vs. 98%(p=0. 3551), and overall accuracy 57%vs. 90%(p<0. 001). Using a per patient analysis, sensitivity of LCE vs. LCE+HRME was 100%vs. 95%(p=0. 16), specificity 29%vs. 79%(p<0. 001), PPV 32%vs. 60%,100%vs. 98, %and accuracy 47%vs. 83%(p<0. 001). With use of HRME, 136 biopsies (60%;%95%CI: 53-66%)could have been spared, and 55 patients (48%;%95%CI: 38-57%)spared any biopsy y

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