Synopsis: Nutrition:


www.nanotech-now.com 2015 01054.txt.txt

and fatty acids such as phosphonic acids are noted well known Joseph Perry, a professor in the School of Chemistry and Biochemistry at the Georgia Institute of technology."


www.nanowerk.com 2015 04415.txt.txt

and only one therapy has been approved by the Food and Drug Administration. While most of these vaccines are created with dendritic cells,


www.nanowerk.com 2015 04496.txt.txt

ate breakfast, and went back to work at 11, Brandtsegg says. Between the two displays, they worked on improving the way the robot organizes its memories.


www.nanowerk.com 2015 04597.txt.txt

to enable clean printing with metals, gels, pastas or extremely thick fluids s


www.nanowerk.com 2015 04600.txt.txt

#Engineers'synthetic immune organ produces antibodies Cornell engineers have created a functional, synthetic immune organ that produces antibodies

It is made from gelatin-based biomaterials reinforced with nanoparticles and seeded with cells, and it mimics the anatomical microenvironment of lymphoid tissue.


www.nanowerk.com 2015 04709.txt.txt

"The scientists devised a new arrangement of solar cell ingredients, with bundles of polymer donors (green rods) and neatly organized fullerene acceptors (purple, tan.

The plastic materials, called organic photovoltaics, are organized typically like a plate of cooked pasta a disorganized mass of long, skinny polymer spaghetti with random fullerene meatballs.

The UCLA technology arranges the elements more neatly like small bundles of uncooked spaghetti with precisely placed meatballs.

Some fullerene meatballs are designed to sit inside the spaghetti bundles, but others are forced to stay on the outside.


www.nanowerk.com 2015 04717.txt.txt

she had no idea how to remove salt from groundwater to make it more palatable, nor had she ever been to India,

with a possible focus on filtering biological contaminants from groundwater to make it safe to drink. There are already a number of filters on the market that can do this,

Although the available filters made water safe to drink, they did nothing to mitigate its saltiness so the villagers drinking water tasted bad and eroded pots and pans,


www.nanowerk.com 2015 04732.txt.txt

and dipping it into a solution containing metal salts. These molecules then glom onto the self-assembled polymer,


www.nanowerk.com 2015 04749.txt.txt

a natural substance that is an ingredient of many cosmetics. The second was 2-nitroimidazole or NI,

they decided to incorporate these balls of sugar-sensing, insulin-releasing material into an array of tiny needles.

Gu created these icroneedlesusing the same hyaluronic acid that was a chief ingredient of the nanoparticles,

or the diet but the fact that you have to do them all several times a day every day for the rest of your life,


www.nanowerk.com 2015 04757.txt.txt

"builds on recent research by the same team that previously identified a fat-and-sugar molecule called GSL as the chief culprit behind a range of biological glitches that affect the body's ability to properly use, transport

That earlier study showed that animals feasting on high-fat foods remained free of heart disease if pretreated with a man-made compound, D-PDMP,

but animals that got the encapsulated form of the drug had aortas nearly indistinguishable from the aortas of healthy mice fed a regular diet, according to researchers.

when the body gets too much of it from food, when it makes too much of it on its own,

Because the nanoparticles carrying D-PDMP are made of a common laxative ingredient and a naturally occurring sebacic acid,


www.nanowerk.com 2015 04766.txt.txt

the research centre CSP and four wine cooperatives are testing a decision support system (DSS) based on wireless sensor networks,

whether a plant needs more or less watering, pesticides or plant foods. These sensors give us several indexes,

The legume is a presidium of Slow Food, the global organisation that supports the principles of organic agriculture

Despite the strict parameters that define a Slow Food presidium, precision agriculture is a welcome tool:

affirms Ursula Hudson, member of the Executive Committee of Slow Food International l


www.nanowerk.com 2015 04769.txt.txt

#New device tracks chemical signals within cells Biomedical engineers at the University of Toronto have invented a new device that more quickly


www.nanowerk.com 2015 04815.txt.txt

It wasnt just a pie-in-the-sky idea anymore were really treating patients Cima says.


www.nanowerk.com 2015 04830.txt.txt

which cells use to digest nutrients acquired from their microenvironment. He and his colleagues conducted the study using models called 3d mammary tumor spheroids (i e.,


www.nanowerk.com 2015 04888.txt.txt

"In their structure, the crystals resemble sandwiches with a thickness of three atoms (around 4 angstroms:


www.nanowerk.com 2015 04944.txt.txt

Its a little like cooking, explains Dr. Zhang. You throw in a bunch of ingredients, but you need to know how they go together.

Material scientists know chloride is important, but we didnt know how it stays on the surface of nanogold and nanosilver.


www.nanowerk.com 2015 04946.txt.txt

We may include less of the antimicrobial ingredient without losing effectiveness while at the same time using an inexpensive technique that has a lower environmental burden.


www.nanowerk.com 2015 04985.txt.txt

or lipids, instead of sugars, or glucose, using synthetic biology and metabolic engineering tools to redirect the path of carbon in the cell.

Beliaev's team was able to direct the bacteria to make less sugar and more lauric acid,


www.nanowerk.com 2015 05019.txt.txt

#Sticky-flare nanotechnology exposes RNA misregulation in living cells (Nanowerk News) RNA is a fundamental ingredient in all known forms of life


www.nanowerk.com 2015 05025.txt.txt

particularly storage containers used for food and beverages, but it's still a huge industry.


www.nanowerk.com 2015 05029.txt.txt

and approved by the Food and Drug Administration as a food additive, and polylactic acid, a biodegradable plastic used in compostable cups and glassware.

In that case, both the plastic and the oil-based sauce are hydrophobic and interact together.

to replace the widespread use of organic solvents for everything from decaffeinating coffee to making paint thinners.


www.nanowerk.com 2015 05060.txt.txt

physiological salt concentrations that are more suitable for biological applications of DNA NANOSTRUCTURES, explains Dr Hgberg.


www.nanowerk.com 2015 05069.txt.txt

The solution was to flat-pack the components by building the 3d shape layer-by-layer, much like a miniature exercise in cake decoration.

Wrong proportions of either ingredient result in a lumpy mess, or a 3d shape that isn strong enough to retain the needed flexibility as well as the charge storage ability.


www.nanowerk.com 2015 05114.txt.txt

The physicists in Ralph Ernstorfers group now want to experiment further with precisely these sandwiches of different materials.

and how the energy can flow away in sandwich structures, says Ralph Ernstorfer. In this way, he and his colleagues want to bring GST into a position where it can act as a light switch for optical data processing as well e


www.nanowerk.com 2015 05126.txt.txt

That meant investigating the myriad permutations of the four ingredients, holding three constant while varying the measurement of the remaining one,


www.naturalnews.com 2015 00510.txt.txt

Tesla's pie-in-the-sky ideas admittedly led to some pretty amazing breakthroughs in energy technology.


www.naturalnews.com 2015 00579.txt.txt

Natural News is currently organizing an emergency food aid effort to donate preparedness foods to the families affected.

We also know that with 109 million Americans now on government food assistance a loss of the government's ability to keep funneling free money to one-third of the nation will result in mass social chaos

Stay tuned to Natural News for details of our food aid assistance effort for Central Texas,


www.naturalnews.com 2015 00622.txt.txt

A recent study found that many hospitals across the country are now ditching free infant formula handouts in an attempt to encourage new mothers to exclusively breastfeed their babies rather than pump them up with soy protein, corn syrup solids,

. and her colleagues evaluated data from the Maternity Practices in Infant Nutrition and Care survey,


www.naturalnews.com 2015 00684.txt.txt

what is basically just nutrients from food? Additionally, how can they validate years of cutting into patients via invasive surgery

The main cause of this deficiency is poor diet. Vitamin c should ideally come from a diet rich in fresh fruits and vegetables.

However this diet isn't typical for most. Another main cause of Vitamin c deficiency is an imbalance of copper.

Higher levels of copper can cause issues maintaining a healthy level of Vitamin c. Low levels of Vitamin c can increase your risk for various cancers and arthritis.


www.nature.com 2015 000057.txt

Acrylate, a type of salt also known as waterlock, is the substance that gives nappies their sponginess.

the tissue is treated with a chemical cocktail that makes it transparent, and then with the fluorescent molecules that anchor specific proteins to the acrylate,


www.neurosciencenews.com_neuroscience-topics 2015 00246.txt.txt

drink a beverage, and even play ock, paper, scissors, using a robotic arm. Neural prosthetic devices implanted in the brain movement center,

drinking a beverage; making a handshaking gesture; and performing various tasks with the robotic arm.

I want to be able to drink my own beero be able to take a drink at my own pace,

when I want to take a sip out of my beer and to not have to ask somebody to give it to me.


www.neurosciencenews.com_neuroscience-topics 2015 00268.txt.txt

multilayered retinal tissue in a dish. A RIKEN team has succeeded in developing a culture method that allows human embryonic stem cells to be efficiently

and help contribute to retinal tissue growth in the culture dish. This degree of cellular organization is the closest scientists have yet come to building self-growing retinal tissue from stem cells. ur results are consistent with the current view that the retinal pigment epithelium


www.neurosciencenews.com_neuroscience-topics 2015 00303.txt.txt

Alex Parker team is already actively testing drugs that have been approved previously by the US Food and Drug Administration for treatment of such disorders as rheumatoid arthritis


www.neurosciencenews.com_neuroscience-topics 2015 00345.txt.txt

professor of cellular microbiology. he sensing component of the artificial neuron senses a change in chemical signals in one dish,

This electrical signal is translated next into the release of the neurotransmitter acetylcholine in a second dish,


www.neurosciencenews.com_neuroscience-topics 2015 00409.txt.txt

They transform food into fuel that allow cells to carry out energy-demanding functions. itochondria play a large role in human health,


www.news.com.au_technology 2015 00204.txt.txt

and has already been sent to the US Food and Drug Administration and the European Medical Agency for approval and researchers hope it will be available for consumers as early as next year.


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#Brain implant allows paralysed man to sip a beer at his own pace A brain implant that can decode what someone wants to do has allowed a man paralysed from the neck down to control a robotic arm with unprecedented fluidity

and enjoy a beer at his own pace. Erik Sorto was left unable to move any of his limbs after an accident severed his spinal cord 12 years ago.

When reaching for a drink, for example, they would have to think about moving their arm forward, then left,

scissors and to switch on a blender to make a smoothie. Most importantly to him, he was able to smoothly pick up a beer

and take a swig.""The one thing he said he wanted to be able to do at the start of the experiment was to drink a beer with his friends

and control how fast he drank it, rather than having to rely on others, says Andersen."

after drinking his beer.""I would hope some day that people with these conditions will have a robotic arm


www.newscientist.com 2015 01295.txt.txt

plumbing the collagen artery into an artificial circulatory system to provide nutrients, oxygen and electrical stimulation to the limb.


www.newscientist.com 2015 01533.txt.txt

Shining red light on skin or cells in a dish gives an instant energy boost that could help heal wounds,


www.npr.org 2015 0000181.txt

the way the intestine stretches as it moves food along, "Fouke-Abel explains. Cells plucked from a human intestine will be put into a tiny chamber around that membrane,


www.npr.org_research-news 2015 000040.txt

U s. agencies including the Food and Drug Administration have also been looking into the process.


www.npr.org_research-news 2015 000056.txt

"It will die as soon as you remove that essential nutrient, "Church says. The scientists say this radical re-engineering actually makes these synthetic life forms safer,

Other uses might include engineering oil-eating bacteria to use on a spill. They could be killed off

Countless acres of genetically engineered crops would need to be fed this manmade ingredient, from a crop duster or by some other means.


www.npr.org_sections_research-news 2015 00267.txt.txt

#Ebola Vaccine Hailed As'Game Changer'In Fight Against The Virus Doctors Without Borders is calling it a"champagne moment."

preliminary results of this vaccine trial from Guinea,"says Dr. Jesse Goodman, an infectious disease specialist at Georgetown University, who once led vaccine development at the U s. Food and Drug Administration.


www.npr.org_sections_technology 2015 00421.txt.txt

Levine said the Food and Drug Administration initially wanted to take a"watch and wait"approach


www.optics.org 2015 00212.txt.txt

The terahertz technology may also prove useful in discovering concealed goods in the retail industry or for non-destructive monitoring, for example quality control in drugs or food.


www.photonics.com 2015 01753.txt.txt

A microbial contamination on a contact agar plate with a 405-nm light source in the background.


www.photonics.com 2015 01807.txt.txt

"said Leeds professor Gin Jose, who developed the technology.""This will allow people to self-regulate


www.popsci.com 2015 01145.txt.txt

#This Sheet Of Rubber Generates Power As It Stretches It may look like a Fruit Roll up from a kid's lunch box,


www.popsci.com 2015 01151.txt.txt

as well as their food source, calcium lactate. The powdery substances are mixed then into wet concrete before it gets poured into place.

"and start eating the food. As a result, the bacteria excrete a hard limestone filler

these bacteria can stay dormant for 200 years without food, potentially extending the life of a concrete structure for decades past its expiration date.


www.popsci.com 2015 01212.txt.txt

But unlike a glass bottle that gets recycled or food that hits a compost heap,


www.popsci.com 2015 01435.txt.txt

the Food and Drug Administration (FDA) announced that medical device company Wicab is allowed to market a new device that will help the blind ee.


www.popsci.com 2015 01476.txt.txt

By filling a metallic waffle-like nanostructure with liquid crystal, and sandwiching it between layers of plastic,

The amount of voltage applied to the liquid crystal sitting in the waffle wells alters its molecular orientation,


www.popsci.com 2015 01814.txt.txt

#Terminator-Like Vision Could Help Robots Do Our Dishes If the above gif looks familiar it probably because it looks eerily similar to this:

while they navigate our complex world. deally we want robots to be cleaning our dishes at some point in the future.


www.popsci.com 2015 01835.txt.txt

The sunscreen you buy at your local pharmacy contains ingredients to block two different types of light from the sunv-A,

Though the Food and Drug Administration (FDA) has been slow to approve new sunscreens in the past, Chemical and Engineering News notes,


www.psfk.com 2015 00176.txt.txt

Pavegen CEO and Founder Laurence Kemball-Cook shares, ut we need several hundred thousand footsteps to allow the vehicle to drive 20 minutes within London busiest streets. avegen electricity

and is headed currently by Laurence Kemball-Cook, a 29-year old industrial engineer and graduate of Loughborough University.


www.psfk.com 2015 00334.txt.txt

The SALT (Sustainable Alternative Lighting) lamp offers a healthier solution with a saltwater-powered battery.


www.science20.com 2015 00441.txt.txt

#Robot Tongue Identifies The Correct Beer Every Time machines mimicking a human's sense of taste are going on a beer-tasting binge.

pouring beer onto wagging, mechanical tongues.""It's just a bunch of wires and buttons and computers,"said María Luz Rodríguez-Méndez, a professor of inorganic chemistry at University of Valladolid in Spain."

"However it looks, Méndez and colleagues developed an electronic tongue that accurately distinguished between four styles of lager beer 100 percent of the time.

A variety of screen-printed sensors"taste"electrochemical compounds in the beer to predict the brews'color index and alcoholic strength 76 percent and 86 percent of the time.

One potential application of electronic tongues is to help the industry produce their signature drinks more efficiently,

This means that one expert must always test the beer before it leaves the factory.""But your experts don't work at 3 a m

Electronic sensors could share a supporting role by continuing to check the beer while the brewmasters are sleeping."

sensors nestled in the taste buds react to molecules in the food and send the appropriate signals to the brain:

this taste is explained from coffee Méndez. You compare sensory response patterns for every mouthful of food,

"then you decide it's a banana because you've tasted it before.""The study's electronic tongue emulates a simpler version of this process.

antioxidants produced by the grains and ingredients that ferment into beer, such as barley and hops.

Phenols give beer its bitter taste, determine its golden color and conduct electricity. The electronic tongue distinguishes between lagers by detecting the different concentrations of polyphenols.

A beer is classified as a lager based on the type of yeast and a low fermentation temperature.

Méndez and her colleagues tested the electronic tongue on 25 types of commercial beer across four lager styles.

The researchers chose the styles based on their distinct alcohol strength and the European Beer Convention color value.

The four styles were alcohol-free beer, which has low polyphenol levels; Pilsners which have a light yellow to golden color;

the computer can then compare new beer samples against the established, learned signal patterns. They tested each of the 25 beer samples seven times.

Many existing tongues using an array of sensors only get one data point for each sensor,

The researchers immerse the electrodes in beer and track the electrochemical signals as they turn up the voltage,

the electronic tongue was able to place the commercial beer sample into the correct lager category with 100 percent accuracy.

It also predicted the beer's color with 76 percent accuracy and its alcohol content with 84 percent accuracy."


www.science20.com 2015 00842.txt.txt

Plants remain a proven and efficient production system delivering Kg amounts per hectare of active pharmaceutical ingredients (API) at relatively low cost.


www.science20.com 2015 00938.txt.txt

One way is to have a sandwich comprising a surface that is conducting juxtaposed with a bulk that is insulating.


www.sciencealert.com 2015 00381.txt.txt

#Audi has made a synthetic, high-grade fuel from plant sugars Just last month, German car manufacturer Audi invented a carbon-neutral diesel fuel,

the fuel is produced by converting corn-derived glucose-a renewable source of biomass sugar-into isobutane gas.


www.sciencealert.com 2015 00385.txt.txt

With previous research showing that cooking in an iron pan increased the iron content of food,

or soup for 10 minutes, remove from the heat, and add a generous dash of lemon juice to foster iron absorption.

because fish is our everyday food.""The fish are now being used by about 2, 500 Cambodian families and another 9,

"They have a really poor diet-a big plate of white rice and maybe a small cut of fish,

"That's their two meals a day. And it's just not meeting their nutritional requirements."


www.sciencealert.com 2015 00464.txt.txt

With a huge binary brain to draw on and no need for either food or sleep,


www.sciencealert.com 2015 00472.txt.txt

Schouenborg is also working on his own gelatin-based'needle'for delivering electrodes into the brain a


www.sciencealert.com 2015 00526.txt.txt

recognise food calories from a photo and even cook by watching Youtube videos.""With appropriate uses of the deep learning technologies, we could be a further step closer to the true human intelligence,


www.sciencealert.com 2015 00559.txt.txt

or the diet, but the fact that you have to do them all several times a day every day for the rest of your life",


www.sciencealert.com 2015 00577.txt.txt

The Argus II received limited Food and Drug Administration (FDA) approval in 2013, but this clinical trial set out to show that the device could be used more broadly by testing it over three years.


www.sciencealert.com 2015 00591.txt.txt

"The sensing component of the artificial neuron senses a change in chemical signals in one dish,

"This electrical signal is translated next into the release of the neurotransmitter acetylcholine in a second dish,


www.sciencealert.com 2015 00600.txt.txt

and mustard leaf. A pesticide free farming process-the results of 18 months of research and preparation-has been designed to produce crops with the least amount of energy expenditure possible.

the project backers claim theyl be able to deliver produce rom farm to fork in under four hours and all without the usual environmental impact of truck-based food transportation across England motorways.

it heartening to see food innovation like Growing Underground take off. Or should that be take root


www.sciencealert.com 2015 00675.txt.txt

The research focussed on the main psychoactive ingredient in cannabis, known as THC (tetrahydrocannabinol), which is not only responsible for the high associated with the drug-plus hallucinations, delusions, memory loss,


www.sciencealert.com 2015 00698.txt.txt

you're no doubt familiar with the nightly ritual of plugging it in to charge overnight so it doesn run out of juice halfway through the day.


www.sciencedaily.com 2015 00001027.txt

#Alzheimer's plaques reduced by targeting sugar attachment to the BACE1 enzyme A major factor contributing to Alzheimer's disease is the formation of pathogenic A?

and Naoyuki Taniguchi at RIKEN in collaboration with Tamao Endo and Shigeo Murayama at the Tokyo Metropolitan Institute of Gerontology showed that much of the BACE1 found in the brains of Alzheimer's disease patients is modified by the attachment of a particular sugar with the help of the enzyme

because BACE1 without the sugar is destroyed and cannot interact with APP. Using a difficult procedure called subcellular fractionation they determined that sugared BACE1 is located near APP within cells.

However if the sugar is attached not to it it is found further from APP and closer to lysosomes--subcellular structures that degrade unneeded molecules.

This research highlights the importance of glycosylation--the modification of proteins by sugars. Far from being rare it is the most common way in

although a sugar change is considered often just a marker for disease or a specific cell type our team has demonstrated clearly the functional role of a glycan during AD development.


www.sciencedaily.com 2015 00001082.txt

The sections are stacked then with solid electrolytes in between for a multilayer sandwich with multiple microsupercapacitors.


www.sciencedaily.com 2015 00001196.txt

and manipulation movements required for cooking by watching online cooking videos. The key breakthrough is that the robots can think for themselves determining the best combination of observed motions that will allow them to efficiently accomplish a given task.

But cooking is complex in terms of manipulation the steps involved and the tools you use. If you want to cut a cucumber for example you need to grab the knife move it into place make the cut


www.sciencedaily.com 2015 0000136.txt

Although there was a glimmer of hope for an end in sight to the Ebola epidemic these countries were reported to be on the brink of a major food crisis. The United nations Food and agriculture organization (FAO)

and the World Food Programme (WFP) revealed in December that the Ebola outbreak had left nearly half a million people in the three countries severely food insecure:

unless urgent measures are taken to significantly enhance access to food and safeguard crop and livestock production in these countries

FAO and WFP stated that the Ebola epidemic has caused a significant shock to the food

and trade and rising food prices are triggering the food crisis. Experts participating in the Global Rice Market


www.sciencedaily.com 2015 00001392.txt

For clinical relevance it remained necessary to more fully investigate intact components of function such as the ability to form a healthy barrier while still absorbing nutrition or specific mechanisms of electrolyte exchange.


www.sciencedaily.com 2015 00001409.txt

which involves a com bi na tion of ther a pies with neg a tive side effects.


www.sciencedaily.com 2015 00001590.txt

In addition to improving nutrition, Cedars-Sinai is also using new specially designed mattresses to help improve sleep patterns


www.sciencedaily.com 2015 00001644.txt

However Yale researchers tested a theory that triglycerides formed in the liver were more dependent on the delivery of fatty acids to the liver than on insulin action.

I. Shulman the George R. Cowgill professor of medicine and cellular & molecular physiology--developed a novel method to measure the rate of triglyceride production from fatty acids in three types of animals:

normal rats insulin-resistant rats fed a high-fat diet and rats with genetically modified insulin receptors.


www.sciencedaily.com 2015 00001705.txt

or too many nutrients from the mother can lead to a person becoming obese or diabetic in adulthood,


www.sciencedaily.com 2015 00001710.txt

"Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFB and multiple histone modifications,"


www.sciencedaily.com 2015 0000185.txt

"said study co-author James Cook, director of MU's Comparative Orthopaedic Laboratory and the Missouri Orthopaedic Institute's Division of Research."

"Cook.""Like a normal joint, the implanted tissue can renew itself, resulting in decreased physical limitations to the patient


www.sciencedaily.com 2015 0000199.txt

Neuroprotectin D-1 discovered in the Bazan lab is derived from docosahexaenoic acid (DHA) an essential omega 3 fatty acid found in fish oil.


www.sciencedaily.com 2015 0000295.txt

Researchers at the Feinstein Institute know how to make cartilage from a mixture of cells called chondrocytes nutrients to feed them and collagen

Medical research can take years to move from bench to bedside as can US Food and Drug Administration (FDA) approval.


www.sciencedaily.com 2015 0000311.txt

The amount of time to reduce glucose levels following a meal is the same as in a normal rat


www.sciencedaily.com 2015 0000329.txt

sponsored by the US Food and Drug Administration (FDA), that used a new stent graft that can repair the aortic aneurysm without the need to open the chest."


www.sciencedaily.com 2015 000039.txt

They discovered a novel link between food intake during the early stages of infection and the outcome of the disease, identifying two molecular pathways that could serve as new targets for treatment."

"We have known for a long time that nutrition can affect the course of infectious disease, but we were surprised at how rapidly a mild reduction in food intake could improve outcome in a mouse malaria model,

"said senior author James Mitchell, associate professor of genetics and complex diseases.""However, the real importance of this work is the identification of unexpected molecular pathways underlying cerebral malaria that we can now target with existing drugs."

or nutritionally by reducing food intake during the first two days of infection, protected against cerebral malaria.


www.sciencedaily.com 2015 0000430.txt

or salt-and-pepper patterns seen in some organisms when cells tell their neighbors to be not


www.sciencedaily.com 2015 0000745.txt

#Connection between childhood adversity psychiatric disorders seen at cellular level Mitochondria convert molecules from food into energy that can be used by cells


www.sciencedaily.com 2015 0000788.txt

A cancer tumour deprived of oxygen and nutrients becomes dormant and is made thereby harmless. If it receives a supply from the bloodstream


www.sciencedaily.com 2015 0000848.txt

Published in Proceedings of the National Academy of Science the paper details how lack of the Ngly1 protein results in the incomplete removal of the sugar portion of glycoproteins--a process called deglycosylation.

which can be changed through the addition or subtraction of sugar chains. When proteins are made not correctly they are sent to be broken down in the cytosol.

NGLY1 is a cytosolic enzyme that removes the sugar chains from specific types of glycoproteins

and ENGASE is another cytosolic enzyme in animal cells that degrades the free sugars left behind.

and how much of the undegraded portion still had attached sugar chains. As expected they found sugar chains were removed not from the model protein in the double knockout cells

First removal of sugar chains by ENGASE appeared to have created a form of the protein that in the absence of Ngly1 could not be degraded properly.

when the model protein was sugared de by ENGASE one sugar molecule remained attached to the protein.

as long as the incomplete removal of sugars by ENGASE was prevented. People with the NGLY1 mutation have many severe symptoms from delayed development


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