was linked to a 41 percent increase in the detection of invasive cancers as well as a 15 percent drop in the recall rate,
if they miss a cancer because they weren using tomosynthesis, they could end up being sued by someone who said,
Such 2-D mammograms can create superimposed shadows that look like cancer, and they sometimes fail to detect cancer lesions behind normal tissue.
In tomosynthesis approved by the FDA in 2011, a series of x-ray images are taken in an arc across the breast,
and location of any abnormalities and judge whether the tumors are invasive. ight now the prohibitive issue is the costatients can afford to pay for this expensive technology,
and some suffered leukemia-like diseases as a side effect (see he Glimmering Promise of Gene therapy.
in fact, a lot of what we know about cancer genetics comes from research on our fungal friends.
#Machine that unboils eggs now being used to improve cancer treatment A machine that can be used to uncook eggs is now being used to dramatically improve the effectiveness of a cancer treatment.
Using the invention on carboplatin a common cancer treatment drug, used against ovarian and lung cancers has boosted the potency by almost five times.
"Raston told ABC News. A machine that can be used to uncook eggs is now being used to dramatically improve the effectiveness of a cancer treatment.
Using the invention on carboplatin a common cancer treatment drug, used against ovarian and lung cancers has boosted the potency by almost five times.
#In a first, cold sore virus used to fight cancer cells Scientists have the first proof that a"brand new"way of combating cancer,
Specialists at the NHS Royal Marsden Hospital and the Institute of Cancer Research (ICR) confirmed that melanoma skin cancer patients treated with a modified herpes virus (the virus that causes cold sores) had improved survival-a world first.
randomised trial of a so-called oncolytic virus to show success. Cancer scientists predict it will be the first of many in the coming years-adding a new weapon to our arsenal of cancer treatments.
Other forms of immunotherapy-the stimulation of the body's own immune system to fight cancer-using antibodies rather viruses,
Viral immunotherapies are also being investigated for use against advanced head and neck cancers, bladder cancers and liver cancers.
Kevin Harrington, UK trial leader and professor of biological cancer therapies at the ICR and an honorary consultant at the Royal Marsden, said he hoped the treatment could be available for routine use within a year in many countries
"We hope this is the first of a wave of indications for these sorts of cancer fighting agents that we will see coming through in the next decade or so."
and kill human cells that can make them such promising cancer treatments.""The study, which is published in the Journal of Clinical Oncology, included 436 patients, all of
is that they work by stimulating an immune response against cancer, "he said.""The field has moved very quickly clinically.
"Dr Hayley Frend, science information manager at Cancer Research UK, said the potential for viruses in future cancer treatments was"exciting"."
Melanoma is the fifth most common cancer in the UK, and is becoming more widespread
if the cancer-indicated by the appearance of a new mole on the skin-is caught early.
and 2, 000 people still die from melanoma in the UK every year. Scientists have the first proof that a"brand new"way of combating cancer,
using genetically modified viruses to attack tumour cells, can benefit patients, paving the way for a"wave"of new%potential treatments over the next decade.
Specialists at the NHS Royal Marsden Hospital and the Institute of Cancer Research (ICR) confirmed that melanoma skin cancer patients treated with a modified herpes virus (the virus that causes cold sores) had improved survival-a world first.
randomised trial of a so-called oncolytic virus to show success. Cancer scientists predict it will be the first of many in the coming years-adding a new weapon to our arsenal of cancer treatments.
Other forms of immunotherapy-the stimulation of the body's own immune system to fight cancer-using antibodies rather viruses,
Viral immunotherapies are also being investigated for use against advanced head and neck cancers, bladder cancers and liver cancers.
Kevin Harrington, UK trial leader and professor of biological cancer therapies at the ICR and an honorary consultant at the Royal Marsden, said he hoped the treatment could be available for routine use within a year in many countries
"We hope this is the first of a wave of indications for these sorts of cancer fighting agents that we will see coming through in the next decade or so."
and kill human cells that can make them such promising cancer treatments.""The study, which is published in the Journal of Clinical Oncology, included 436 patients, all of
is that they work by stimulating an immune response against cancer, "he said.""The field has moved very quickly clinically.
"Dr Hayley Frend, science information manager at Cancer Research UK, said the potential for viruses in future cancer treatments was"exciting"."
Melanoma is the fifth most common cancer in the UK, and is becoming more widespread
if the cancer-indicated by the appearance of a new mole on the skin-is caught early.
and 2, 000 people still die from melanoma in the UK every year r
#Cells that aid hearing, balance created in lab LONDON: Scientists have developed successfully a way to coax embryonic stem cells to become the inner-ear hair cells
#Tata doctors find way to cut oral cancer risk Tata Memorial Hospital, the cancer hub in Parel, announced a breakthrough on Tuesday that could
not only reduce the risk of death for oral cancer patients by 36 %but also prevent recurrence of the disease by 55%.
%The innovation is an'extra cut'-a dissection in medical parlance-along the neck to detect
if the patient's cancer had spread from his/her oral cavity to the neck. The cut would be a prophylaxis-a preventive medicine-against aggressive cancer forms
and prevent the need for chemotherapy or radiation. The findings were announced by Tata Memorial Centre's Dr Anil D'Cruz at an ongoing meeting of American Society of Clinical Oncology at Chicago on May 31.
because India carries the highest burden of oral cancer in the world, with around 1 lakh new patients detected every year.
It is the most common cancer among Indian men and third most common among Indian women.
whether the cancer has progressed beyond to the neck region. This is especially in the early stages of oral cancer.''
''At present, patients may choose to not undergo neck dissection and wait until some cancerous bulge-basically,
whether or not early stage oral cancer patients should undergo a neck dissection. On one hand, the dissection is a delicate operation
they may be at the risk of not diagnosing the cancer's complete spread early enough.
#Tata docs find way to cut oral cancer risk Tata Memorial Hospital, the cancer hub in Parel, announced a breakthrough on Tuesday that could
not only reduce the risk of death for oral cancer patients by 36 %but also prevent recurrence of the disease by 55%.
%The innovation is an'extra cut'-a dissection in medical parlance-along the neck to detect
if the patient's cancer had spread from his/her oral cavity to the neck. The cut would be a prophylaxis-a preventive medicine-against aggressive cancer forms
and prevent the need for chemotherapy or radiation. The findings were announced by Tata Memorial Centre's Dr Anil D'Cruz at an ongoing meeting of American Society of Clinical Oncology at Chicago on May 31.
because India carries the highest burden of oral cancer in the world, with around 1 lakh new patients detected every year.
It is the most common cancer among Indian men and third most common among Indian women.
whether the cancer has progressed beyond to the neck region. This is especially in the early stages of oral cancer.''
''At present, patients may choose to not undergo neck dissection and wait until some cancerous bulge-basically,
whether or not early stage oral cancer patients should undergo a neck dissection. On one hand, the dissection is a delicate operation
they may be at the risk of not diagnosing the cancer's complete spread early enough.
#New sensor to detect cancer, HIV, hepatitis Researchers have developed a highly sensitive nanomechanical sensor that can detect cancerous tumours as well as viral disease markers for HIV,
#New sensor to detect cancer, HIV Researchers have developed a highly sensitive nanomechanical sensor that can detect cancerous tumours as well as viral disease markers for HIV,
The breakthrough, described in the journal Human Reproduction, gives hope to thousands of young cancer victims who face treatments such as chemotherapy which can damage the ovaries
The breakthrough, described in the journal Human Reproduction, gives hope to thousands of young cancer victims who face treatments such as chemotherapy which can damage the ovaries
a breakthrough that could potentially save the careers of top athletes besides cure untreatable injuries caused from accidents and surgeries due to cancer."
those who have had surgery for cancer, or sufferers of amyotrophic lateral sclerosis (ALS).""This technology could cure (recently retired Chinese hurdler) Liu Xiang's injury,
"This invention will allow us to detect anything we might be interested in, bacterial contamination or perhaps a protein molecule that is a cancer marker.
#New sensor chip to detect prostate cancer early Researchers have developed a smart sensor chip that can detect prostate cancer more accurately
will help improve the process of early stage prostate cancer diagnosis, researchers said. Glycoprotein molecules play an essential role in our immune response, because of
which they are useful clinical biomarkers for detecting prostate cancer and other diseases. The team of chemical engineers and chemists at the University of Birmingham, created a sensor chip with synthetic receptors along a 2d surface to identify specific
#Sugar trail may lead to early cancer detection NEW DELHI: In a breakthrough that could lead to a new protocol for cancer detection and treatment,
scientists have identified a glucose delivery mechanism which helps cancer cells to survive and grow. The discovery can help in early detection of not only pancreatic and prostrate cancer but many others like cancer of the breast and colon.
Announcing the findings, scientists from the University of California, Los angeles (UCLA) also suggested the use of certain antidiabetic drugs to reduce the growth of tumours.
Experts and doctors say the findings can give a new protocol worldwide for cancer detection and treatment.
along with positron emission-tomography tomography (PET) that can enable early detection of these cancers cells. Experts say this is the first promising evidence that PET imaging techniques
and treat pancreatic and prostate cancers. The findings also provide strong evidence that certain type-2 diabetic drugs,
and reduce tumour growth and increase survival among pancreatic and prostate cancer patients. Pancreatic cancer, estimated as the fourth leading cause of cancer-related deaths in the US behind only lung,
colon and breast cancers, is also increasing significantly in India. In most cases, the tumour is detected at a very late stage,
Prostate cancer, though generally more treatable, is also witnessing a rapid increase in incidence in India as well as globally.
While globally it is the second leading cause of cancer-related deaths in men in India, the incidence of prostate cancer among men has increased by over 220%between 1900 and 2013.
Researchers at UCLA will next begin a clinical study to further investigate the importance of sodium-dependent glucose transporters in glucose delivery.
#Chinese doctor removes kidney tumor with the aid of a 3d printed replica May 23, 2015 By Simonwhile wee seen how developments to additive manufacturing technologies have helped both bring down the cost of getting something 3d printing as well as delivering results faster,
More recently, doctors at the Xiangya Hospital of Urology at Central South University in China were able to leverage 3d printing technology in an effort to help successfully remove a tumor from a 60-year-old woman kidney.
Thanks to the use of a 3d printed model in advance of the surgical procedure, the doctors were not only able to remove the tumor-but also save the kidney itself;
Because the left renal tumor was located directly next to the renal hilum-an area of the kidney that features many vital arteries
Dr. Qi Lin took a series of CT SCANS of the patient kidney, tumor and surrounding area
and were successfully able to remove the tumor while keeping the kidney intact with patient.
and allowed us to pinpoint the tumor, the arteries and the surrounding kidney tissue before surgery,
#MEDPRIN 3d prints world first biological meningioma Redura for use in brain surgery While 3d bioprinting innovations sound lifesaving and revolutionary, most are still years away from impacting ordinary
Called MEDPRIN, they have developed the world first 3d printed biological meningioma called Redura a replica of tissue covering the brain
When patching everything up, they'paste'an artificial Meningioma layer on the area in question and sew everything together.
and have a tendency to disrupt a patient life-as most artificial meningioma layers contain metal parts
Over a course of up to three months, a completely new Meningioma beings to grow, while the artificial structure naturally degrades.
The Californa Nanosystems Institute and the Johnsson Comprehensive Cancer Center also contributed, with support from the National Science Foundation and the Howard Hughes Medical Institute.
#Plasmons Influence Carbon-Based Nanoparticles for Sensitizing Cancerous Tumors In a study published in EPJ D,
It was released in June 2011 and donated to the BC Cancer Agency at Vancouver General Hospital.
stretchy electronic sensors are also capable of detecting harmful levels of UV radiation known to trigger melanoma.
The sensor will enable doctors to identify tumor markers, whose presence in the body signals the emergence and growth of cancerous tumors.
The sensitivity of the new device is characterized best by one key feature: according to its developers, the sensor can track changes of just a few kilodaltons in the mass of a cantilever in real time.
a professor of chemistry at Tufts and senior author on the paper, worked with iodine-125 radioactive isotope that is routinely used in cancer therapies.
Gold-Plated Cancer Fighters? Then Alex Pronschinske, Ph d.,first author on the paper and a postdoctoral researcher in Sykeslab, suggested that they measure the electrons emitted by the sample without prodding from X-rays in the photoelectron spectrometer.
because they break cancer cellsdna into pieces. Because these electrons can travel only 1 to 2 nanometers human hair is about 60,000 nanometers widehey do not affect healthy tissue and organs nearby.
then affix the nanoparticles to antibodies targeting malignant tumors and put them in a liquid that cancer patients could take via a single injection.
Theoretically, the nanoparticles would attach to the tumor and emit low energy electrons, destroying the tumor DNA.
The gold-based nanoparticles would be flushed out of the body, Sykes says, unlike free iodine-125,
which can accumulate in the thyroid gland and cause cancer. If proven, this approach could be a potential improvement over current radiation therapy protocols, in
which doctors treat some cancers by putting radioisotopes, including iodine-125, into tiny titanium capsules and implanting them in tumors.
Instead of emitting large amounts of low energy electrons as the gold-bound iodine does, the titanium capsules inhibit radiation,
Sykes says, making such therapies less effective than they could be. He has applied for a patent on the new technique.
for example, diabetes, cancer, multiple sclerosis, and osteoporosis. Now Microchips Biotech will begin co-developing microchips with Teva Pharmaceutical, the world largest producer of generic drugs,
and plays a critical role in cancer by allowing cancer cells to divide rapidly. Researchers used a technique called electron cryo-microscopy,
Scientists from The Institute of Cancer Research, London, and the Medical Research Council (MRC) Laboratory of Molecular biology in Cambridge were able to visualise the proteasome complex down to a resolution of around 3. 5 Angstroms,
and was funded by Cancer Research UK and the MRC. The research could help other scientists to use CRYO EM in structure-based drug design studies-in which researchers build the best possible drugs starting from a molecule which already binds to the active site of a target protein.
Blocking the proteasome prevents this regulated recycling of amino acids and triggers controlled cell death, particularly in fast-dividing cells typical of cancer.
Senior study author Dr Edward Morris, Team Leader in Structural Electron microscopy at The Institute of Cancer Research, London, said:"
"Dr Emma Smith, senior science communications officer at Cancer Research UK, said:""Revealing the molecule's detailed shape could be the first step towards designing more precise drugs to block it.
This molecule plays an important role in some cancers and drugs that block it are already available to patients
#Smart Sensor Chip with Nanocavities for Early Prostate Cancer Diagnosis Researchers at the University of Birmingham believe that the novel technology will help improve the process of early stage diagnosis. Glycoprotein molecules,
Because of their essential role in our immune response, they are useful clinical biomarkers for detecting prostate cancer and other diseases.
In doing so, they developed a more accurate and efficient way of diagnosing prostate cancer than the current tests
the sugar part of the prostate cancer glycoprotein is reacted with a custom-designed molecule that contains a boron group at one end (the boron linkage forms a reversible bond to the sugar).
and the only key that will fit is the specific prostate cancer glycoprotein that we're looking for.
"Dr John Fossey added,"It's estimated that one in eight men will suffer from prostate cancer at some point in their life,
#Discovery of Mesh Cell Structure Could Help Understand Development of Cancer For the first time a structure called he meshhas been identified
which is found to change in certain cancers, such as those of the breast and bladder.
The finding was made by a team led by Dr Stephen Royle, associate professor and senior Cancer Research UK Fellow at the division of biomedical cell biology at Warwick Medical school.
and support from Cancer Research UK and North West Cancer Research. Dr Royle said: e had been looking in 2d
TACC3, is overproduced in certain cancers. When this situation was mimicked in the lab, the mesh and microtubules were altered
Dr Emma Smith, senior science communications officer at Cancer Research UK, said: roblems in cell division are common in cancer cells frequently end up with the wrong number of chromosomes.
and it might be a crucial insight into why this process becomes faulty in cancer
and whether drugs could be developed to stop it from happening. orth West Cancer Research (NWCR) has funded the research as part of a collaborative project between the University of Warwick and the University of Liverpool,
which could potentially better inform future cancer therapies. s a charity we fund only the highest standard of research,
Major human diseases such as cancer inflammation, neurodegeneration and bacterial/viral infection are primarily diseases of cells.
This is essential for pharmaceutical research particularly cancer research--to observe how cells and tissues respond to specific chemicals and experimental drugs.
which find application in cancer treatment, pollution reduction, renewable energy collection. Scientists from Harvard, Boston, and Princeton universities have played also a role in the development of this innovative technique, called D Structure Identification of Nanoparticles by Graphene Liquid Cell EM (SINGLE),
which was the first genetic-based approach that is able to detect live circulating tumor cells out of the complex matrix that is human blood.
for Integrative Cancer Research. Eliana Martins Lima, of the Federal University of Goiás, is the other co-author.
--whose deregulation is associated with diseases ranging from diabetes to cancer to epilepsy--have gradually been brought to light.
No one doubts that this is an important pathway with implications for aging cancer and diabetes and we had figured out the core machinery of the pathway says Sabatini.
because hyperactivation of the pathway can lead to aberrant growth seen in cancer or metabolic abnormalities associated with diabetes.
"And the technique might also shed light onto why new treatments-immunotherapies-that are being deployed in the fight against cancers work in some individuals and not in others.
as well as lifestyle diseases such as obesity, cancer and mental disorders. The circadian rhythm is also related to seasonal reproduction,
it can be a source for triggering cancer, for example,"said Hickson. It is well known that microscopic cable-like structures,
In fact, all cancers are unchecked characterised by cell division, and the underpinning processes are potential targets for therapeutic interventions that prevent cancer onset and spread."
"But before we get there, we must continue to expand our knowledge about the basic processes
#Study finds non-genetic cancer mechanism Cancer can be caused solely by protein imbalances within cells,
a study of ovarian cancer has found. The discovery is a major breakthrough because, until now, genetic aberrations have been seen as the main cause of almost all cancer.
The research, published today in the journal Oncogene, demonstrates that protein imbalance is a powerful prognostic tool,
whether you have a predisposition to cancer and, ultimately, use a precision medicine-based approach to develop a therapeutic approach.
"The research, led by scientists at the University of Leeds and The University of Texas MD Anderson Cancer Center, focused on the"Akt pathway,
"a signalling pathway within cells that drives cancer formation and the spread of cancers through the body.
A conventional approach to diagnosing this cancer would be to look for genetic modification of the receptor
In this way, an imbalance in the amount of the two proteins can lead to cell proliferation and cancer formation.
which cancer can occur. We found that in cells where Grb2 is depleted, FGFR2 was vulnerable to Plc?
indicating that protein imbalance can have a role in metastasis, the spread of a cancer through the body.
1 was predictive of the progress of ovarian cancers in patients. Measuring the levels of the proteins in patient tissues followed by database analysis of clinical information from The Cancer Genome Atlas
and other sources revealed that a high level of Grb2 relative to Plc? 1 and FGFR2 was associated with a significantly more favourable prognosis than patients with elevated levels of Plc?
"Previous research findings have emphasised the roots of cancer in genetic mutation. Some studies have pointed to cancers that occur without genetic causes,
such as through epigenetic modifications of proteins, however the present study reveals that signalling though cell wall-based receptors can occur without receptor activation
and therefore that non-genetic causes may be critical to understanding cancer in large numbers of patients.
The researchers are now working with clinicians at the University of Leeds to study the same mechanisms in other forms of cancer.
#Study paves way for genetics-first approach to brain cancer treatment Two US studies have identified specific genetic mutations in gliomas
'This molecular data helps us better classify glioma patients, so we can begin to understand who needs to be treated more aggressively
Gliomas are tumours which develop from the glial cells of the brain and spine, and make up 80 percent of malignant brain tumours.
Patients who develop gliomas are treated usually with a combination of radiotherapy, surgery and chemotherapy; however it is currently difficult to work out how useful these treatments will be.
three mutations were identified in patients with gliomas. Tumours taken from glioma patients were scored as positive or negative for these mutations,
which led to the creation of five categories of mutation combinations. The genetic profiles of the tumours were associated then with patient age, prognosis and the response of the tumour type to different treatments.
This profiling would allow doctors to choose the most appropriate treatment for an individual glioma patient based on their genetic classification.
as survival statistics would be specific to the glioma type, as opposed to the general class of glioma.
Currently histology is used to classify gliomas by their visual characteristics; however this method is not sufficiently effective to predict how the glioma will respond to therapy.
Doctors are also often unable to predict how aggressive a tumour will behave over a long period of time.'
'These markers will potentially allow us to predict the course of gliomas more accurately, treat them more effectively
and identify more clearly what causes them in the first place, 'said Professor Margaret Wrensch from the University of California,
'Both studies can justifiably claim that molecular classification captures the biologic features of glioma variants better than does histopathological evaluation,
The professor told in-Pharmatechnologist. com the method can be used to help small and large molecule medicines hone in on their targets. ith all therapies that are used currently particularly cancer the major problem is very little of the drug makes it to the target site.
Scientists see the technology being used in remote laboratory settings to diagnose cancers and central nervous system disorders such as Alzheimer
Kai Liu. he ability to detect even smaller amounts of chemical and biological molecules could be helpful with biosensors that are used to detect cancer,
and creates an increased risk for cancer and diabetes. When a healthy person is infected by a virus,
and developmental disorders, including some forms of leukemia and inherited heart problems. Until now, Hetzer said,
The work and the researchers involved were supported by grants from the National institutes of health and the National Cancer Institute
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