#Nanotechnology identifies brain tumor types through MRI'virtual biopsy'in animal studies: If results are confirmed in humans,
tumor cells could someday be diagnosed by MRI imaging and treated with tumor-specific IV injections;
new NIH grant will fund future study Abstract: Biomedical researchers at Cedars-Sinai have invented a tiny drug-delivery system that can identify cancer cell types in the brain through"virtual biopsies
and fight tumor cells in the brain without resorting to surgery.""Our nanodrug can be engineered to carry a variety of drugs,
proteins and genetic materials to attack tumors on several fronts from within the brain,"said Julia Ljubimova, MD, Phd,
Ljubimova, director of the Nanomedicine Research center in the Department of Neurosurgery and director of the Nanomedicine Program at the Samuel Oschin Comprehensive Cancer Institute, has received a $2. 5 million grant from the National institutes of health to continue the research.
or stop cancers by blocking them in multiple ways within the brain. The drug is about 20 to 30 nanometers in size-a fraction of a human hair,
such as seeking out cancer cells and binding to them, permeating the walls of blood vessels and tumor cells,
or dismantling molecular mechanisms that promote tumor growth, "said Eggehard Holler, Phd, professor of neurosurgery and director of nanodrug synthesis at Cedars-Sinai.
diagnosing brain tumors by identifying cells that have spread to the brain from other organs, and then fighting the cancer with precise, individualized tumor treatment.
Researchers can determine tumor type by attaching a tracer visible on an MRI. If the tracer accumulates in the tumor,
it will be visible on MRI. With the cancer's molecular makeup identified through this virtual biopsy,
researches can load the"delivery system"with cancer-targeting components that specifically attack the molecular structure.
To show that the virtual biopsies could distinguish one cancer cell type from another, the researchers devised what is believed to be a unique method,
implanting different kinds of breast and lung cancers into laboratory mice to represent metastatic disease-with one type of cancer implanted on each side of the brain.
Lung and breast cancers are those that most often spread to the brain. The researchers used the nano delivery system to identify
and attack the cancers. In each instance, animals that received treatment lived significantly longer than those in control groups."
"Several drugs are quite effective in treating different types of breast cancers, lung cancer, lymphoma and other cancers at their original sites,
but they are ineffective against cancers that spread to the brain because they are not able to cross the blood-brain barrier that protects the brain from toxins in the blood,
Brain tumor Center and the Ruth and Lawrence Harvey Chair in Neuroscience.""The nanodrug is engineered to cross this barrier with its payload intact,
and the Samuel Oschin Comprehensive Cancer Institute contributed to the study with colleagues from the University of Southern California and Arrogene Inc,
The new NIH National Cancer Institute grant R01ca188743, will fund ongoing study.#####For more information, please click herecontacts:
May 27th, 2015fine-tuned molecular orientation is key to more efficient solar cells May 26th, 2015cancer Iranian Scientists Use Magnetic field to Transfer Anticancer Drug to Tumor Tissue May 24th,
The photonics advancement could improve early cancer detection, nanoelectronics manufacturing and scientists'ability to observe single molecules May 23rd,
The photonics advancement could improve early cancer detection, nanoelectronics manufacturing and scientists'ability to observe single molecules May 23rd, 2015aspen Aerogels to Present at the Cowen and Company Technology,
Scientists Use Magnetic field to Transfer Anticancer Drug to Tumor Tissue May 24th, 2015discoveries Who needs water to assemble DNA?
The photonics advancement could improve early cancer detection, nanoelectronics manufacturing and scientists'ability to observe single molecules May 23rd,201 0
"The team tested the therapeutic potential of the nanoparticles by loading them with an anti-melanoma drug
In further experiments, the researchers found they could alter the infusion of the particles into melanoma cells by adjusting the polymer coatings.
"This is a versatile platform to carry a multitude of drugs-for melanoma, for other kinds of cancers and for other diseases,
but it is our hope that this could one day be used to deliver drugs directly to spinal cord injuries, ulcerations, deep bone injuries or tumors,
Cancer Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015news and information Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015sweeping lasers snap together nanoscale geometric grids:
News and information Scientists highlight the importance of nanoscale hybrid materials for noninvasive cancer diagnosis June 24th,
and the Environment June 24th, 2015discoveries Scientists highlight the importance of nanoscale hybrid materials for noninvasive cancer diagnosis June 24th,
2015announcements Scientists highlight the importance of nanoscale hybrid materials for noninvasive cancer diagnosis June 24th, 2015physicists fine-tune control of agile exotic materials:
and the Environment June 24th, 2015interviews/Book reviews/Essays/Reports/Podcasts/Journals/White papers Scientists highlight the importance of nanoscale hybrid materials for noninvasive cancer diagnosis June 24th,
News and information June 29th, 2015efforts to Use Smart Nanocarriers to Cure Leukemia Yield Promising Results June 29th, 2015making new materials with micro-explosions:
A novel microscope for nanosystems June 25th, 2015iranian Researchers Synthesize Nanostructures with Controlled Shape, Structure June 25th, 2015discoveries June 29th, 2015efforts to Use Smart Nanocarriers to Cure Leukemia Yield
New technique combines electron microscopy and synchrotron X-rays to track chemical reactions under real operating conditions June 29th, 2015announcements June 29th, 2015efforts to Use Smart Nanocarriers to Cure Leukemia Yield Promising
chemotherapy packed nanoparticles may target cancer stem cells June 30th, 2015graphene flexes its electronic muscles: Rice-led researchers calculate electrical properties of carbon cones, other shapes June 30th,
and innovation programm 1 e. Its main objective is to reach a level of international excellence in nanomedicine characterisation for medical indications like cancer, diabetes, inflammatory diseases or infections,
EU-NCL is partnered with the sole international reference facility, the Nanotechnology Characterization Lab of the National Cancer Institute in the U s. US-NCL) 3,
This venture holds great promise for using nanotechnologies to overcome cancer and other major diseases around the world.
#New Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment Iranian researchers designed a biosensor with application in assessment of effectiveness of drugs on the stability of the four-strand structure of DNA to prevent the growth
The four-strand structure of DNA plays an important role in the process of creation of cancerous cells and in the prohibition of a type of active enzyme in cancers.
#Sensor technology can improve accuracy of prostate cancer diagnosis, research shows Abstract: New research has shown how a smart sensor chip,
and efficiency of prostate cancer diagnosis. Researchers at the University of Birmingham believe that the novel technology will help improve the process of early stage diagnosis. Glycoprotein molecules,
Because of their essential role in our immune response, they are useful clinical biomarkers for detecting prostate cancer and other diseases.
In doing so, they developed a more accurate and efficient way of diagnosing prostate cancer than the current tests
the sugar part of the prostate cancer glycoprotein is reacted with a custom-designed molecule that contains a boron group at one end (the boron linkage forms a reversible bond to the sugar).
and the only key that will fit is the specific prostate cancer glycoprotein that we're looking for.
"Dr John Fossey added,"It's estimated that one in eight men will suffer from prostate cancer at some point in their life,
which could overcome current shortcomings of low drug efficacy and multi-drug resistance in the treatment of cancer as well as viral and bacterial infections.
the study identified a new mechanism of targeting multi-subunit complexes that are critical to the function of viruses, bacteria or cancer,
Guo holds a joint appointment at the UK Markey Cancer Center and in the UK College of Pharmacy."
"##Guo focuses much of his work on the use of ribonucleic acid (RNA) nanoparticles and a viral nanomotor to fight cancer, viral infections and genetic diseases.
News and information SUNY Poly CNSE to Present Cutting-edge Semiconductor Technology Developments at SEMICON West 2015 Conference July 10th, 2015super graphene can help treat cancer July 10th,
2015super graphene can help treat cancer July 10th, 2015graphene-based film can be used for efficient cooling of electronics July 10th,
2015new Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment July 4th, 2015discoveries Super graphene can help treat cancer July 10th,
2015graphene-based film can be used for efficient cooling of electronics July 10th, 2015scientists Apply Magnetic nanoparticles to Eliminate Cancerous Cells July 10th,
Replacing silver coating on catheters with graphene increases treatment effect July 9th, 2015materials/Metamaterials Super graphene can help treat cancer July 10th,
2015super graphene can help treat cancer July 10th, 2015graphene-based film can be used for efficient cooling of electronics July 10th,
2015interviews/Book reviews/Essays/Reports/Podcasts/Journals/White papers Super graphene can help treat cancer July 10th, 2015graphene-based film can be used for efficient cooling of electronics July 10th,
#Nanospheres shield chemo drugs, safely release high doses in response to tumor secretions Scientists have designed nanoparticles that release drugs in the presence of a class of proteins that enable cancers to metastasize.
so that the very enzymes that make cancers dangerous could instead guide their destruction.""We can start with a small molecule
and build that into a nanoscale carrier that can seek out a tumor and deliver a payload of drug,
The system takes advantage of a class enzymes called matrix metalloproteinases that many cancers make in abundance.
The shell fragments form a ragged mesh that holds the drug molecules near the tumor.
builds on his group's earlier sucess using a similar strategy to mark tumors for both diagnosis and precise surgical removal.
That means the drug was inactivated as it flowed through the circulatory system until it reached the tumor.
The protection allowed the researchers to safely give a dose 16 times higher than they could with the formulation now used in cancer clinics,
in a test in mice with grafted in fibrosarcoma tumors. In additional preliminary tests, Callmann and colleagues were able to halt the growth of the tumors for a least two weeks,
using a single lower dose of the drug. In mice treated with the nanoparticles coated with peptides that are impervious to MMPS or given saline,
the tumors grew to lethal sizes within that time. Gianneschi says they will broaden their approach to create delivery systems for other diagnostic and therapeutic molecules."
We'll test this in other models-with other classes of drug and in mice with a cancer that mimics metastatic breast cancer, for example."
"##Additional authors include Matthew Thompson in Gianneschi's chemistry research group and Christopher Barback, David Hall and Robert Mattrey in UC San diego's Moores Cancer Center.
Callmann holds a fellowship through the Cancer Researchers in Nanotechnology Program at UC San diego. The National Institute of Biomedical Imaging
This can allow scientists to see fine features of objects such as tumors, or minute flaws within airplane wings in industrial testing, that may otherwise be unobservable due to an instrument's diffractive limit.
and training the body's own immune system to better fight cancer and infection. Now, results of a study led by Johns Hopkins investigators suggests that a device composed of a magnetic column paired with custom-made magnetic nanoparticles may hold a key to bringing immunotherapy into widespread and successful clinical use.
and rapidly multiplying immune system white blood cells known as T cells because of their potential as an effective weapon against cancer,
that we could use them as the basis of a therapy for cancer patients. We've taken a big step toward solving that problem,
This process activates the T cells to ward off a virus, bacteria or tumor, as well as to make more T cells.
priming the T cells both to battle the target cancer and divide to form more activated cells.
humans with magnetic aapcs bearing antigens from tumors. They then ran the plasma through a magnetic column.
The tumor-fighting T cells bound to aapcs and stuck to the sides of the column,
which relies on other white blood cells called tumor-infiltrating lymphocytes. Those cells are trained already"to fight cancer,
and researchers have shown some success isolating some of the cells from tumors, inducing them to divide,
and then transferring them back into patients. But, Schneck says, not all patients are eligible for this therapy,
because not all have tumor-infiltrating lymphocytes. By contrast, all people have naive T cells, so patients with cancer could potentially benefit from the new approach
whether or not they have tumor-infiltrating lymphocytes.""The aapcs and magnetic column together provide the foundation for simplifying
and streamlining the process of generating tumor-specific T cells for use in immunotherapy, "says Juan carlos Varela, M d.,Ph d,
. a former member of Schneck's laboratory who is now an assistant professor at the Medical University of South carolina.
which they say could help combat the problem of tumors mutating to evade the body's defenses."
While the team initially tested the new method only on cancer antigens, Schneck says it could also potentially work for therapies against chronic infectious diseases, such as HIV.
the National Institute of General Medical sciences (grant number GM 07309), the National Cancer Institute (grant numbers CA 43460, CA 62924, CA 09243 and CA108835), the Troper Wojcicki
Foundation, the Virginia and D. K. Ludwig Fund for Cancer Research, the Sol Goldman Center for Pancreatic cancer Research,
safely release high doses in response to tumor secretions July 14th, 2015chemotherapeutic coatings enhance tumor-frying nanoparticles:
Duke university researchers add a drug delivery mechanism to a nanoparticle therapy already proven to target,
heat and destroy tumors July 13th, 2015super graphene can help treat cancer July 10th, 2015govt. -Legislation/Regulation/Funding/Policy Researchers Build a Transistor from a Molecule and A few Atoms July 14th, 2015world first:
Significant development in the understanding of macroscopic quantum behavior: Researchers from Polytechnique Montral and Imperial College London demonstrate the wavelike quantum behavior of a polariton condensate on a macroscopic scale and at room temperature July 14th, 2015nanospheres shield chemo drugs,
safely release high doses in response to tumor secretions July 14th, 2015better memory with faster lasers July 14th,
safely release high doses in response to tumor secretions July 14th, 2015chemotherapeutic coatings enhance tumor-frying nanoparticles:
Duke university researchers add a drug delivery mechanism to a nanoparticle therapy already proven to target,
heat and destroy tumors July 13th, 2015magnetic hyperthermia, an auxiliary tool in cancer treatments July 8th, 2015discoveries For faster,
safely release high doses in response to tumor secretions July 14th, 2015globalfoundries Completes Acquisition of IBM Microelectronics Business:
New device offers clues (Nanowerk News) Why do some cancer cells break away from a tumor and travel to distant parts of the body?
Cancer becomes deadly when it spreads, or metastasizes. Not all cells have the same ability to travel through the body,
The differences in individual cancer cells are a key aspect of how cancer evolves becomes resistant to current therapies or recurs."
"A primary tumor is not what kills patients. Metastases are what kill patients. Understanding which cells are likely to metastasize can help us direct more targeted therapies to patients,
"says co-senior study author Sofia D. Merajver, M d.,Ph d.,scientific director of the breast oncology program at the University of Michigan Comprehensive Cancer Center.
The researchers believe this type of device might some day help doctors understand an individual patient's cancer.
Which cells in this patient's tumor are really causing havoc? Is there a large population of aggressive cells?
"In this work, extensive studies were performed on cell lines representing various types of cancer. The new device was designed to trace how cells move, sorting individual cells by their movement.
and appearance under the microscope of metastatic cells and expressed significantly higher levels of markers associated with metastatic cancer."
"Understanding specific differences that lead some cancer cells to leave the primary tumor and seed metastases is of great benefit to develop
hold great promise for treating cancer and other diseases. However, several inefficiencies have limited their translation to the clinic,
says Gregory Szeto, a postdoc at MITS Koch Institute for Integrative Cancer Research and the papers lead author.
"The ability to detect even smaller amounts of chemical and biological molecules could be helpful with biosensors that are used to detect cancer, Malaria, HIV and other illnesses."
stroke and cancer. o work out the factors we should be worried about, and how we can intervene,
The sensor will enable doctors to identify tumor markers, whose presence in the body signals the emergence and growth of cancerous tumors.
The sensitivity of the new device is characterized best by one key feature: according to its developers, the sensor can track changes of just a few kilodaltons in the mass of a cantilever in real time.
stretchy electronic sensors are also capable of detecting harmful levels of UV radiation known to trigger melanoma.
The engineered organ has implications for everything from rapid production of immune therapies to new frontiers in cancer or infectious disease research.
blood cancer can result. n the long run, we anticipate that the ability to drive immune reaction ex vivo at controllable rates grants us the ability to reproduce immunological events with tunable parameters for better mechanistic understanding of B cell development and generation of B cell tumors,
as well as screening and translation of new classes of drugs, Singh said g
#3d potential through laser annihilation (Nanowerk News) Whether in the pages of H g wells, the serial adventures of Flash gordon,
and could identify new targets for cancer medications. Throughout the human body, certain signalling chemicals--known as hormones--tell various cells
leading to cancer. To look into the responses of different cells, the U of T team harnessed the emerging power of digital microfluidics,
or proteins that could be targeted by drugs, eventually leading to new medicines to fight cancer r
It also helps improve our understanding of the development of some diseases that involve a defective transportation to the nuclear pores-such as intestinal ovarian and thyroid cancer r
for example, diabetes, cancer, multiple sclerosis, and osteoporosis. Michael Cima (left) and Robert Langer Now Microchips Biotech will begin co-developing microchips with Teva Pharmaceutical, the worlds largest producer of generic drugs,
who is affiliated with the Purdue Center for Cancer Research. And thats one of the reasons we were looking at this particular type of cancer cell with this particular form of Syk in it.
One goal of the research is to correlate physical properties of cells with tumor suppression and the action of the kinase on the cell.
#Chitosan coated, chemotherapy packed nanoparticles may target cancer stem cells (Nanowerk News) Nanoparticles packed with a clinically used chemotherapy drug
and kill cancer stem-like cells, according to a recent study led by researchers at The Ohio State university Comprehensive Cancer Center-Arthur G. James Cancer Hospital
and Richard J. Solove Research Institute (OSUCCC-James). Cancer stem-like cells have characteristics of stem cells
and are present in very low numbers in tumors. They are highly resistant to chemotherapy
and radiation and are believed to play an important role in tumor recurrence. This laboratory and animal study showed that nanoparticles coated with the oligosaccharide called chitosan
and encapsulating the chemotherapy drug doxorubicin can target and kill cancer stem-like cells six times more effectively than free doxorubicin.
The study is reported in the journal ACS Nano("Chitosan-Decorated Doxorubicin-Encapsulated Nanoparticle Targets and Eliminates Tumor Reinitiating Cancer Stem-like Cells").
""Our findings indicate that this nanoparticle delivery system increases the cytotoxicity of doxorubicin with no evidence of systemic toxic side effects in our animal model,
and be used to treat many types of cancer.""This study showed that chitosan binds with a receptor on cancer stem-like cells called CD44,
enabling the nanoparticles to target the malignant stem-like cells in a tumor. The nanoparticles were engineered to shrink,
break open, and release the anticancer drug under the acidic conditions of the tumor microenvironment and in tumor-cell endosomes and lysosomes,
which cells use to digest nutrients acquired from their microenvironment. He and his colleagues conducted the study using models called 3d mammary tumor spheroids (i e.,
, mammospheres) and an animal model of human breast cancer. The study also found that although the drug-carrying nanoparticles could bind to the variant CD44 receptors on cancerous mammosphere cells,
which could overcome current shortcomings of low drug efficacy and multi-drug resistance in the treatment of cancer as well as viral and bacterial infections.
"the study identified a new mechanism of targeting multi-subunit complexes that are critical to the function of viruses, bacteria or cancer,
Guo holds a joint appointment at the UK Markey Cancer Center and in the UK College of Pharmacy."
Guo focuses much of his work on the use of ribonucleic acid (RNA) nanoparticles and a viral nanomotor to fight cancer
it can be a source for triggering cancer, for example, said Hickson. It is well known that microscopic cable-like structures,
In fact, all cancers are unchecked characterised by cell division, and the underpinning processes are potential targets for therapeutic interventions that prevent cancer onset and spread.
But before we get there, we must continue to expand our knowledge about the basic processes
such as mental disability, autism and cancer. A new technology--called"Sticky-flares"--developed by nanomedicine experts at Northwestern University offers the first real-time method to track
which was the first genetic-based approach that is able to detect live circulating tumor cells out of the complex matrix that is human blood.
a substance that can derail the body's hormone balance and potentially cause cancer or birth defects.
for Integrative Cancer Research. Eliana Martins Lima, of the Federal University of Goiás, is the other co-author.
#A'nanomachine'for surgery with no incision (Nanowerk News) A surgical operation has long been considered one of the first options in cancer treatment;
or magnevist) broadly used as an MRI contrast agent to the affected area("Hybrid Calcium phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron capture Tumor Therapy").
and is delivered to cancer tissues. The research team has clarified that selective accumulation of the developed nanomachine in a cancer tumor enables contrast imaging of a solid cancer.
Moreover, when the Team applied the nanomachine to cancer neutron capture therapy, they confirmed a remarkable curative effect.
This nanomachine therapy enables an imaging-guided thermal neutron irradiation treatment; thus it can be expected to lead to a reliable cancer treatment with no missed cancer cells.
The realization of surgery with no incision (chemical surgery) by nanomachine allows us to anticipate outpatient treatment with no need of hospitalization n
Now, researchers at MITS Koch Institute for Integrative Cancer Research and Massachusetts General Hospital (MGH) have created a polymer gel that overcomes this safety concern
inflammation and cancer, is reported on today in the research journal Nature Methods("A microfluidic device for epigenomic profiling using 100 cells").
the team plans to use this technology to study other epigenomic changes involved in inflammation and cancer in the near future e
#Vitamin c shown to annihilate cancer Vitamin c is a well-known antioxidant and is used commonly to fight off a cold.
Inexpensive possible cancer treatment may never reach patients Conducted in vitro, lab tests were performed by injecting high doses of Vitamin c into human ovarian cells.
This major finding could potentially save millions of lives and at only a fraction of the price of modern cancer treatments.
"Patients are looking for safe and low-cost choices in their management of cancer. Intravenous Vitamin c has that potential based on our basic science research and early clinical data."
Low levels of Vitamin c can increase your risk for various cancers and arthritis. Other health issues caused by low levels of Vitamin c include:
More news on Greece deficit Learn these simple tips for preventing cancer naturallymonsanto: The world's poster child for corporate manipulation and deceitextreme bias at Wikipedia on homeopathic medicineguatemalan STD medical experiments were just one crime in a long history of medical-government collusion to use humans
and sometimes lead to cancer it turns out that these breaks are part of the physiological function of the cell,
Professor Azim Surani from the Wellcome Trust/Cancer Research UK Gurdon Institute at the University of Cambridge, explains:
#Imaging Technique Provides Color Coded Map Showing Cancerous Brain areas New imaging technique could make brain tumor removal safer and more effective,
When removing a tumor, for example, neurosurgeons walk a tightrope as they try to take out as much of the cancer as possible
while keeping crucial brain tissue intact and visually distinguishing the two is often impossible. Now Johns Hopkins researchers report they have developed an imaging technology that could provide surgeons with a color-coded map of a patient brain showing
and are not cancer. A summary of the research appears June 17 in Science Translational Medicine. s a neurosurgeon,
I in agony when I taking out a tumor. If I take out too little the cancer could come back;
too much, and the patient can be disabled permanently, says Alfredo Quinones-Hinojosa, M d.,a professor of neurosurgery,
thought OCT might provide a solution to the problem of separating brain cancers from other tissue during surgery.
Kut first built on the idea that cancers tend to be relatively dense, which affects how they scatter
Once they had found the characteristic OCT ignatureof brain cancer, the team devised a computer algorithm to process OCT data and,
nearly instantaneously, generate a color-coded map with cancer in red and healthy tissue in green. e envision that the OCT would be aimed at the area being operated on,
and the surgeon could look at a screen to get a continuously updated picture of where the cancer is
and in surgeries to remove brain tumors from mice. The researchers hope to begin clinical trials in patients this summer.
The system can potentially be adapted to detect cancers in other parts of the body, Kut says.
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