The sensor, reported in a proof-of-concept study in the ACS journal Analytical Chemistry, has the potential to eliminate finger-pricking for many people with diabetes.
Joseph Wang and colleagues in San diego note that diabetes affects hundreds of millions of people worldwide.
The researchers conclude that the device could potentially be used for diabetes management and for other conditions such as kidney disease e
When 11 year old Naomi Lalandec walked into Dr. Robert Koenekoop's clinic at the Montreal Children's Hospital of the Mcgill University Health Centre (MUHC) with blindness and dwarfism due to
#More clues to how drug reverses obesity diabetes fatty liver disease In addition to illuminating how the drug amlexanox reverses obesity diabetes
and fatty liver disease the findings suggest a new pathway for future treatments. The research was published Jan 12 in Nature Communications.
and improve diabetes in obese mice. The current study revealed that amlexanox exerts its effects through a specialized type of fat cell by increasing the level of a second messenger molecule called camp.
In the livers of diabetic mice interleukin-6 reduces production of glucose so that overall blood sugar is lowered.
The finding is the latest piece of a complex obesity-inflammation-diabetes puzzle that Saltiel lab investigators have been working to solve
In 2013 the researchers discovered that amlexanox an off-patent drug currently prescribed for the treatment of asthma and other uses reversed obesity diabetes and fatty liver in mice.
The U-M study explains how increased camp in fat cells promotes the secretion of the hormone interleukin-6 which signals the liver to stop producing glucose--thus improving overall blood sugar levels in obese diabetic mice e
#New cells may help treat diabetes In the new study published Jan 28 in the journal PLOS ONE the UI team led by Nicholas Zavazava MD Phd UI professor of internal medicine reprogrammed human skin cells
When these cells were transplanted into diabetic mice the cells secreted insulin and reduced the blood sugar levels of the mice to normal or near-normal levels.
Although the cells were not as effective as pancreatic cells in controlling blood sugar levels Zavazava says that the results are an encouraging first step toward the goal of generating effective insulin-producing cells that can be used to potentially cure type 1 diabetes.
This raises the possibility that we could treat patients with diabetes with their own cells says Zavazava who also is a member of the Fraternal Order of Eagles Diabetes Research center at the UI.
which will accelerate treatment of diabetes. In type 1 diabetes a person's immune system attacks
and destroys the pancreatic beta cells that produce insulin. Although it is possible to treat type 1 diabetes with pancreas transplants from deceased donors the demand for transplants far exceeds the availability of donated organs.
Zavazava's team is among several groups aiming to create an alternative source of insulin-producing pancreatic cells that can be transplanted into patients with type 1 diabetes.
However the UI study is the first to use human ips cells to create the insulin-producing cells.
and gradually corrected the blood sugar levels in the diabetic mice over a period of several months.
#Diabetes debate: Triglycerides form in liver despite insulin resistance In type 2 diabetics insulin fails to suppress blood sugar production by the liver
while paradoxically allowing the production of hepatic triglycerides. This combination results in multiple health risks including high blood sugar and fatty liver disease.
but instead reduces fatty liver disease in patients with type 2 diabetes. These results provide new insights into the pathogenesis of nonalcoholic liver disease
Shulman and his team plan to apply similar methodology to translate their findings to insulin-resistant patients with type 2 diabetes hyperlipidemia and fatty liver disease e
a research team led by investigators at Beth Israel Deaconess Medical center (BIDMC) has uncovered previously unknown steps in the development of insulin resistance, a hallmark of type 2 diabetes.
therapies for type 2 diabetes.""We wanted to understand what was initially happening to cause the body to become unresponsive
"explains senior author Evan Rosen, MD, Phd, of the Division of Endocrinology, Diabetes and Metabolism at BIDMC and Professor of Medicine at Harvard Medical school."
or too many nutrients from the mother can lead to a person becoming obese or diabetic in adulthood,
Most importantly, these data tell us that we have an awful lot still to learn about the basic mechanisms by which diabetes is triggered
For example current drugs designed for use in diabetics might be beneficial to other people who need to boost this aspect of immunity.
#'Healthy'fat tissue could be key to reversing type 2 diabetes Researchers from Melbourne's Walter
and Eliza Hall Institute with colleagues from the RIKEN Institute Japan found they could'reverse'type 2 diabetes in laboratory models by dampening the inflammatory response in fat tissue.
More than 850000 Australians are estimated to have type 2 diabetes which is the most common type of diabetes
and its prevalence is rising. The disease is linked strongly with'lifestyle'factors such as being overweight
Long-term complications of type 2 diabetes include kidney eye and heart disease and there is no cure.
People with type 2 diabetes have reduced sensitivity to insulin a hormone that normally triggers uptake of glucose by cells
When Treg numbers are reduced inflammatory diseases such as diabetes and rheumatoid arthritis can occur he said. Recent studies have shown that fat tissue has its own unique type of Tregs
and high blood glucose levels a classic hallmark of type 2 diabetes. The research team discovered a key hormone called IL-33 (interleukin-33) was able to selectively boost Treg populations in fat tissue effectively halting the development of type 2 diabetes
or even reversing the disease in preclinical models. Treating fat tissues with IL-33 restored normal Treg cell levels
Treatments that mimic IL-33 could have the potential to reduce obesity-related inflammation and type 2 diabetes.
#Probiotic helps treat diabetes in rats could lead to human remedy In the study published Jan 27 in the journal Diabetes the researchers engineered a strain of lactobacillus a human probiotic common in the gut to secrete a Glucagen-like peptide
(GPL-1). They then administered it orally to diabetic rats for 90 days and found the rats receiving the engineered probiotic had up to 30 percent lower high blood glucose a hallmark of diabetes.
The study was a proof of principle and future work will test higher doses to see
The researchers found that upper intestinal epithelial cells in diabetic rats were converted into cells that acted very much like pancreatic beta cells
Also though it replaces the insulin capacity in diabetic rats the researchers found no change in blood glucose levels
Human patients would likely take a pill each morning to help control their diabetes March said d
Ultimately it will help researchers achieve breakthroughs in a wide variety of areas in the life sciences such as neuroscience diabetes and cancer.
For the future, the researchers also envisage the use of Glucolight in other fields, such as diabetes s
and health conditions like diabetes and heart disease. Identifying the changes that occur at a cellular level due to these psychosocial factors allows us to understand the causes of these poor health conditions
The bacteria thus programmed detect the abnormal presence of glucose in the urine of diabetic patients.
and detected the abnormal presence of glucose in the urine of diabetic patients.""We have deposited the genetic components used in this work in the public domain to allow their unrestricted reuse by other public
including diabetes, heart disease, and cancer. According to Carrie Partch a professor of chemistry and biochemistry at UC Santa cruz and corresponding author of the paper, the connection between clock disruption and cancer is still unclear."
it could also be applied to other autoimmune diseases such as Type 1 diabetes s
#Drug-induced tissue regeneration demonstrated by scientists A study led by Ellen Heber-Katz, Phd, of the Lankenau Institute for Medical Research (LIMR), part of Main line Health (MLH),
"Catherine Godson, Phd, co-senior author and director of the UCD Diabetes Complications Research Centre in UCD School of medicine and UCD Conway Institute, said the study's findings demonstrate the value
an important process that when abnormal can promote diabetes, cancer, and rare genetic diseases. The researchers determined that an enzyme called Protein kinase c (PKC) can regulate
'This process is defective in a variety of diseases including diabetes and cancer.''Scientists have known how glucose is transported across cells,
and treatment of diseases, including G1d, diabetes, and cancer,'said Wang, whose lab focus includes non-melanoma skin cancer, in
The discovery could eventually benefit millions of patients with chronic pain from trauma, diabetes, shingles, multiple sclerosis or other conditions that cause nerve damage."
"Working with Professor Fawaz Haj of the UC Davis nutrition department, Bettaieb found that key molecular signatures associated with diabetes
and diabetic pain were linked to ER stress. Neuropathic pain is a common consequence of both Type 1
and Type 2 diabetes, affecting up to 70 percent of patients. Inceoglu, working in Hammock's laboratory,
especially for diabetics and the elderly Researchers from the University of Sheffield's Department of Biomedical science discovered the ultrasound transmits a vibration through the skin
when treating diabetics and the elderly. There are 11 million over-65s three million diabetics, and 10 million smokers in the UK--all of whom are likely to suffer problems with healing wounds.
A quarter of diabetics suffer from skin ulcers, particularly foot ulcers, due to the loss of sensation and circulation in the legs.
Lead author of the study Dr Mark Bass, from the University's Centre for Membrane Interactions and Dynamics (CMIAD), said:"
essential in the treatment of chronic diabetic kidney disease. The drug, given in this trial at one of four doses based on disease severity,
Patients most at risk are those with chronic kidney disease combined with diabetes and hypertension or heart failure.
patients with hyperkalemia, hypertension, type 2 diabetes and chronic kidney disease. All patients were taking RAAS inhibitors to treat their CKD prior to and during study treatment.
The combination of chronic kidney disease, type 2 diabetes, high blood pressure, hyperkalemia and, in about one-third of cases, heart failure, can be deadly.
#Noninvasive device could end daily finger pricking for people with diabetes A new laser sensor that monitors blood glucose levels without penetrating the skin could transform the lives of millions of people living with diabetes.
Currently, many people with diabetes need to measure their blood glucose levels by pricking their fingers,
this technology opens up the potential for people with diabetes to receive continuous readings, meaning they are alerted instantly
or readings directly to doctors, allowing them to profile how a person is managing their diabetes over time."
"Diabetes is a growing problem, with the need for noninvasive glucose monitoring becoming ever more critical.
This unique technology could help empower millions of people to better manage their diabetes and minimise interventions with healthcare providers.
The ultimate development of two distinct products--a finger-touch and a wearable--could give people with different types of diabetes the option of a device that best suits their lifestyle."
Professor Grant, Professor of Medicine at the University of Leeds and Consultant diabetes specialist, said:"
"Noninvasive monitoring will be particularly valuable in young people with Type 1 diabetes. Within this group, those who are attempting very tight control such as young women going through pregnancy
and effective drugs with fewer side effects to treat conditions including high blood pressure, diabetes, depression and even some types of cancer.
The sensor reported in a proof-of-concept study in the ACS journal Analytical Chemistry has the potential to eliminate finger-pricking for many people with diabetes.
Joseph Wang and colleagues in San diego note that diabetes affects hundreds of millions of people worldwide.
The researchers conclude that the device could potentially be used for diabetes management and for other conditions such as kidney disease e
Can the neuropathy that diabetic patients experience be mimicked in a dish? It also paves the way for the discovery of new pain drugs that don just numb the perception of pain.
in that one might be able to look at a patient with Type 2 Diabetes and predict whether they will experience neuropathy by running tests in the lab using their own neural cells derived from their blood sample. his bench to bedside research is very exciting
and creates an increased risk for cancer and diabetes. When a healthy person is infected by a virus,
#Smart insulin patch could replace painful injections for diabetes This is the mart insulin patch, developed by researchers in the joint UNC/NC State Biomedical engineering Department.
A joint effort between diabetes doctors and biomedical engineers could revolutionize how people with diabetes keep their blood sugar levels in checkpainful insulin injections could become a thing of the past for the millions of Americans who suffer from diabetes, thanks to a new invention
painless patch could lower blood glucose in a mouse model of type 1 diabetes for up to nine hours.
but the approach shows great promise. e have designed a patch for diabetes that works fast,
and the UNC Diabetes Care Center. he whole system can be personalized to account for a diabetic weight and sensitivity to insulin,
Patients with type 1 and advanced type 2 diabetes try to keep their blood sugar levels under control with regular finger pricks and repeated insulin shots, a process that is painful and imprecise.
John Buse, MD, Phd, co-senior author of the PNAS paper and the director of the UNC Diabetes Care Center, said,
or even more disastrous consequences such as diabetic comas and death. esearchers have tried to remove the potential for human error by creating losed-loop systemsthat directly connect the devices that track blood sugar
they had to figure out a way to administer them to patients with diabetes. Rather than rely on the large needles
The researchers tested the ability of this approach to control blood sugar levels in a mouse model of type 1 diabetes.
when administered too frequently. he hard part of diabetes care is not the insulin shots, or the blood sugar checks,
the director of the North carolina Translational and Clinical Sciences (NC Tracs) Institute and past president of the American Diabetes Association. f we can get these patches to work in people,
Clinicians worry that transplanting stem cells to heal diabetes or Parkinson disease raises the risk of endless cell divisions and cancer.
including history of diabetes, elevated cholesterol levels, documented high blood pressure or family history of coronary heart disease.
Because these immune-system cells play important roles in a wide range of diseases, from diabetes to AIDS to cancer, the achievement provides a versatile new tool for research on T cell function,
A particular problem in older people, open wounds such as ulcers, complications from diabetes and skin conditions like dermatitis and psoriasis are painful, often difficult to treat,
It is involved also in developing a contact lens for measuring glucose levels in tears for diabetics
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