this could help the rational design of more specific therapies to inhibit the division of cancer cells,
said, hile stem cell therapy is an exciting new development for the treatment for osteoarthritis,
It will help in the search to develop more targeted therapies for arthritis patients. o-Lead author Dr. James Fox said,
takes us a step closer to our aim of developing an injectable, safe, stem cell therapy for people with osteoarthritis. pcoming in Stem Cell Reports
That general approach is in clinical trials as a therapy for other cancers, viral infections and other illnesses.
"Current therapies for profound hearing loss like that caused by the recessive form of TMC1 are hearing aids,
"This is a great example of how the basic science can lead to clinical therapies, "says Holt."
Ultimately, this could help the rational design of more specific therapies to inhibit the division of cancer cells,
"So in addition to the destructive power of the T-VEC cells themselves, the therapy summons the immune system right to where it's needed-the tumour."
it has far fewer side effects than traditional therapies, and early trials show that they may also be far more effective-with studies so far proving immunotherapy is successful against aggressive forms of melanoma and glioblastoma.
Manufacturing these therapies by viral vectors requires industrial-sized manufacturing plants and costs tens of millions of dollars but it only enables the treatment of thousands of patients per year.
yet have remained the backbone of therapy over the last decade, "said senior researcher Scott Lowe from the Weill Cornell Medical College in New york
so you can do multidrug therapy with the same particles.""H/T: Techrada d
#This new insulin patch could soon replace injections for diabetics A new'smart patch'lined with painless microneedles full of insulin has been developed by researchers in the US in an effort to do away with the uncomfortable injections that have become a part of life for the millions
"The potential to offer a life-changing therapy to patients without requiring surgery would be a major advance;
so that the physician and the patient can select a therapy that is best for them.""The results have been published open-access in the Journal of Neurotrauma u
and may guide frequency of post-transplant surveillance and adjuvant therapy y
#Rate of investment in medical research has declined in U s. increased globally From 2004 to 2012,
suggests therapies, and allows some patients to join clinical trials. While more than 200 genes for retinal degenerations have been identified,
#Mechanism leading to drug resistance metastasis in melanoma patients discovered Moffitt Cancer Center researchers have discovered a mechanism that leads to resistance to targeted therapy in melanoma patients
Targeted biological therapy can reduce toxicity and improve outcomes for many cancer patients, when compared to the adverse effects of standard chemotherapeutic drugs.
However, patients often develop resistance to these targeted therapies, resulting in more aggressive cells that can spread to other sites or cause regrowth of primary tumors.
However over time many patients become resistant to B-Raf and B-Raf/MEK inhibitor therapy.
and MEK inhibitors are given to patients intermittently may reduce the aggressiveness of the diseasemeaning patients could stay on therapy for more time,
This suggests that drugs that target Epha2 may prevent the development of new disease in patients who receive B-Raf and B-Raf/MEK inhibitor therapy.
The findings also explain the longstanding paradox of why insulin therapy does not exacerbate but instead reduces fatty liver disease in patients with type 2 diabetes.
Newer genome editing tool shows promise in engineering human stem cells In a recent online report on the work in Molecular Therapy the Johns Hopkins team says the findings could streamline
when we can use ipscs for human therapy aren't that far away says Zhaohui Ye Ph d. an instructor of medicine at the Johns hopkins university School of medicine.
therapies for type 2 diabetes.""We wanted to understand what was initially happening to cause the body to become unresponsive
which we can approach drug therapy for this disorder
#Byproducts from bacteria awaken dormant T-cells HIV viruses Dental and medical researchers from Case Western Reserve University found another reason to treat periodontal disease as soon as possible.
HIV antiviral therapy prevents active HIV cells from replicating and doesn't affect the quiet viruses in sleeping T-cells.
#Blood test for prostate cancer investigated Mitchell believes the technique will be transformative in providing improved cancer diagnostics that can both predict treatment outcomes and monitor patient responses to therapy.
not only before a patient begins therapy but also following patient responses to therapy said Mitchell the paper's corresponding author and professor of Pathology Microbiology and Immunology.
The study collected serum from more than 200 patients with prostate cancer and more than 200 controls.
Since cell-free DNA has a relatively short half-life in the circulation sequencing of cell-free DNA soon after therapy may be used to detect minimal residual disease in solid tumors Mitchell said.
Mitchell further predicted that liquid biopsies will quantify immediate tumor responses to therapy y
#New technology focuses diffuse light inside living tissue In the Jan 5 issue of Nature Communications Wang the Gene K. Beare Professor of Biomedical engineering at Washington University in St louis reveals for the first time a new
This improvement in speed is an important step toward noninvasive optical imaging in deep tissue and photodynamic therapy.
or plan for the next one or rule out therapies that are unlikely to remain effective for long said Duke graduate student Pablo Gainza-Cirauqui who co-authored the paper.
However if there is no approved treatment for an ailment the FDA has a compassionate therapy exception that allows the patient to agree to try an experimental approach.
which is working to get the therapy into production for human use. Human patients would likely take a pill each morning to help control their diabetes March said d
The researchers suggested cells'internal expression of jagged may also increase the production and maintenance of therapy-resistant cancer stem cells.
The discovery could lead to targeted therapies and interventions for Alzheimer's disease, autism and other neurological conditions.
#New cancer-fighting strategy would harden cells to prevent metastasis Existing cancer therapies are geared toward massacring tumor cells
This is a novel approach to cancer therapy that we believe could fight the disease with less potential for side effects
and possibly developing new forms of therapy says Associate professor Kristensen. The researchers isolated their antibodies from a library consisting of billions of different antibodies
could point the way to new therapies that suppress the inflammatory allergic response, offering potential relief to millions of Americans with the chronic lung condition and potentially other allergic diseases.
which might give an impact on tyrosine kinase-targeted leukemia therapy, was found to be expressed in a leukemia cell line.
and may help to develop new leukemia therapies. Recent transcriptomic studies have revealed the existence of numerous RNAS that are relatively long
Leukemia characterized by a mutated copy number of CCDC26 might be treated by KIT-targeted therapy"quoted Dr. Hirano o
"Understanding how PASD1 is regulating the circadian clock could open the door to developing new therapies.
"Current therapies only treat the symptoms and slow the progression of the disease, "Professor Thomas said."
"We are committed to the quest to discover therapies that make healthy tissue regeneration a possibility in humans
FKBP10 represents a potential new target molecule for the individualized therapy of IPF, "said Claudia Staab-Weijnitz."
Together with his team of researchers, he is studying the pathogenic mechanisms with the aim to develop causal therapies--and thus one day to actually cure IPF.
At the moment a lot of therapies are focused on the site of infection or injury itself but this data suggests that it's the signals that are being sent out from the gut that are impacting the whole immune system.
"While stem cell therapy is an exciting new development for the treatment for osteoarthritis, up to now it has been something of a lottery
It will help in the search to develop more targeted therapies for arthritis patients.""Co-Lead author Dr James Fox said"Working with colleagues across the Arthritis Research UK Tissue Engineering Centre will help to bring our discovery closer to patient treatment."
takes us a step closer to our aim of developing an injectable, safe, stem cell therapy for people with osteoarthritis
doctors gave her hormone replacement therapy to induce the onset of menstruation. Ten years later the patient received counselling after expressing a desire to become pregnant.
Belgium), stopped the hormone replacement therapy, thawed some, but not all of the frozen ovarian tissue and grafted four fragments on to the remaining left ovary,
when hormone replacement therapy is an efficient, standard, and noninvasive alternative for inducing puberty? Should the procedure only be proposed for patients with a high risk of ovarian failure or for those at low risk as well?
improve manufacturing and help develop therapies for disease. The need for this optics technology will grow with the construction of the next-generation of light sources
as well as for the identification of new targets for drug therapy.''The identification of more than one stem cell pool in the colon has proven challenging,'stresse Asfaha.'
'These findings are exciting as we have identified an important new target for cancer therapy. It is also proof that more than one stem cell can give rise to
telling us that our cancer therapy needs to target more than one stem cell pool.''Until now, the only stem cell population linked to colon cancer was radiation sensitive,
and we must find new forms of therapy to target the disease, 'says Asfaha a
Researchers develop a faster way to treat the heart after a heart attack Stem cell have been the main focus of healing therapy research
For healing after a heart attack, the ideal time to administer these therapies is when reopening the clogged blood vessel
A new study in the American Journal of Physiology--Heart and Circulatory Physiology reports a more practical approach called microsphere therapy that can be kept on hand
The therapy, however, did not improve heart function. It also did not decrease the size of the area damaged by the heart attack or the composition of the scar.
the study shows that microsphere therapy can potentially be an"off-the-shelf and immediate alternative to stem cell therapy"for treating heart attacks and potentially other diseases s
'In people who already have colorectal cancer, therapies that boost the expression of AIM2, such as interferons, might reduce tumor progression.
Seeding measurements can also aid in determining the optimal dosage of a new therapy. Additionally, gauging the seeding property of misfolded proteins may prove to be useful in the development of new treatments for other neurodegenerative diseases, such as Alzheimer's, ALS and Parkinson's.
and are actively pursuing the creation of novel therapies. Earlier this year, study contributor Leslie Thompson of UCI's Sue & Bill Gross Stem Cell Research center and UCI MIND received a $5 million grant from the California Institute for Regenerative medicine to continue her CIRM
In this project, Thompson and her colleagues plan to create a therapy employing human embryonic stem cells that can be evaluated in clinical trials s
and provide the basis for developing new and more effective therapies s
#Iron: A biological element? Arrayclark Johnson, a professor of geoscience at the University of Wisconsin-Madison,
and may provide clues to the development of therapies for infectious diseases, cancers and immune diseases.,"
Wilson said the researchers believe their findings mean that drugs used to inhibit Akt could be used as a personalized therapy for people who don have AIM2. ur research paves the way for future clinical trials that screen for AIM2 expression in colon cancer
and possibly other cancers to identify patients who may potentially benefit from personalized anti-Akt therapy,
Moreover, her studies are the first to indicate that therapies targeted at controlling the properties of smooth muscle cells within lesions may be highly effective in treating a disease that is the leading cause of death worldwide.
#Activated T cell therapy for advanced melanoma developed Published in the July/August issue of Journal of Immunotherapy,
"This study is unique in that the source of T cells for therapy is derived from the lymph node,
The new Phase I clinical trial is being supported by University Hospitals as well as a significant philanthropic effort including the Immunogene Therapy Fund, Paula and Ronald Raymond Fund and the Kathryn and Paula Miller Family Fund."
Our goal is to eventually combine these T cells with other immune therapies which will result in cures.
These types of clinical trials place the UH Seidman Cancer Center at the forefront of immune therapy of cancer."
"Additionally, the research team has been researching the possibility of using lymph nodes from patients with pancreatic cancer to develop T cell therapy.
"Current therapies for profound hearing loss like that caused by the recessive form of TMC1 are hearing aids,
"This is a great example of how the basic science can lead to clinical therapies, "says Holt."
which could potentially better inform future cancer therapies.""As a charity we fund only the highest standard of research,
Advances in the understanding of the molecular processes that cause these tumors has resulted in therapies aimed at delivering specific genes into tumors--genes that make proteins to kill
"In the future, the investigators envision that doctors would administer this therapy during the surgery commonly used to treat glioma in humans.
--which could broaden the use of the therapy for a wide range of solid tumors and systemic cancers s
Ultimately, this could help the rational design of more specific therapies to inhibit the division of cancer cells,
This new trial will be for patients advancing on standard of care therapies, and will be available at multiple centers connected through the Prostate Cancer Clinical Trials Consortium,
so that we can treat them with more aggressive therapy earlier, "says Dr. Knudsen.""Given the role of DNA-PKCS in DNA repair as well as control of tumor metastasis,
More specifically, in a subgroup of 41 patients who had received previously anti-EGFR therapy, it was revealed that they had acquired KRAS mutations during the course of their disease.
lead to a selection of therapy which may not be the most appropriate for these patients.
enabling us to better target therapy to the specificities of patient's tumor; this could have a considerable impact on clinical practice,
and deliver targeted therapies tailored to the particularities of each tumor for an increasing number of patients.
Since few to no causal therapies are in place for most lung diseases, it is important to understand how these healing processes,
and may also be relevant for developing new tumour therapies in the future, "explains Markus Hengstschläger g
despite antiretroviral therapy,"describes Dr. Cohen, who also leads Cancure, a team of leading Canadian researchers working towards an HIV cure."
which--by the way--is a very expensive form of therapy, "says Zhang Yang g
#Simulations lead to design of near-frictionless material While reviewing the simulation results of a promising new lubricant material,
Many therapies are designed therefore to suppress IL-6 or STAT3. But the situation is different in prostate cancer.
According to Kenner, this means that therapies that block the IL-6 pathway may enhance the growth of prostate cancer.
"Women who receive combination antiretroviral therapy (cart) during pregnancy do not pass HIV on to their baby.
"So far, therapies aimed at lowering the production of beta amyloid have shown only a modest ability to slow cognitive decline
Personalized cancer therapies could be developed by targeting breast cancer cells that express copious levels of IL13RA2,
and ultimately drug development and therapy y
#Paper Test Quickly Detects Ebola, Dengue, And Yellow fever Researchers in the US have developed a silver nanoparticle-based paper test to simultaneously detect dengue, yellow fever and Ebola.
These encouraging results from in vitro tests in humans and in vivo tests in mice were published in the Annals of Neurology. e believe we have identified the first therapy that will impact the quality of life of people with multiple sclerosis by significantly reducing the disability and the disease progression
therefore open new research possibilities in terms of preventive therapies for the pathologies associated with normal aging a
or personalized medical therapy for patients suffering with neuropathic pain. ource: Mcmaster Universit i
#Controlling a robotic arm with a patient intentions Giving himself a drink for the first time in 10 years,
such as those of the Andersen Lab at Caltech, to human patients, ultimately turning transformative discoveries into effective therapies, says center director Charles Y. Liu, professor of neurological surgery, neurology,
inoperable malignant melanoma to receive either an injection of the viral therapy, called Talimogene Laherparepvec, or a control immunotherapy.
because their infection defences are compromised by genetic errors. UK trial leader Professor Kevin Harrington, Professor of Biological Cancer Therapies at The Institute of Cancer Research, London,
and there is hope that therapies like this could be even more effective when combined with targeted cancer drugs to achieve long term control
could help scientists design therapies to manipulate the cell repair process and direct immune cells away from sites where they are doing damage,
and allow us to design therapies to direct immune cells away from sites where they are doing damage
For some, the therapy has lengthened their survival by years. hari Wells from Ashland, Kentucky is one of those patients.
#Petri dish tumor test could personalize drug therapy for cancer patients In a highly successful, first-of-its-kind endeavor,
a drug commonly used in multiple myeloma therapy. And after only three days, the researchers could determine
The researchersresults could have interesting and wide-ranging implications for the future of cancer treatment and therapy,
The engineered organ has implications for everything from rapid production of immune therapies to new frontiers in cancer or infectious disease research.
Alvarez-Buylla also noted that the paper has possible implications for the success of human stem cell therapy in the brain
the likelihood of our being able to use stem cell therapy to repair brain injury is very low. ource:
as well as to make it carry several different drugs at the same time to allow for a multidrug therapy with the same particles.
which will eventually lead to innovative drug therapies for cancer and other diseases i
#Access to electricity and artificial light shortened time of our sleep Science knows that nowadays people tend to sleep less than they used to before modern times.
Collins says. ou can use this to kill off very specific species of bacteria as part of an infection therapy,
in order to get a more effective therapy, he says. This is in contrast to repeated infection with bacteriophages,
the research suggests that it is likely to take them far longer to develop resistance to phagemids than to conventional bacteriophage therapy,
The researchers have created an improved form of phage therapy that may become the antibiotics of the future,
a private British biopharmaceutical company focused on the development of therapies for retinal dystrophies. e are leading the way in the development of an effective gene therapy treatment for choroideremia,
Researchers believe this new approach to eye therapy has promise for treating people early on before too many cells in the retina have been lost.
These results suggest that idiopathic pulmonary fibrosis may be treated by therapies based on the activation of the enzyme telomerase.
This finding opens up new avenues for the development of therapies to treat a disease for
and this is already helping us to test novel therapies that we hope will prove effective
Holt hopes to partner with clinicians at Boston Children Department of Otolaryngology and elsewhere to start clinical trials of TMC1 gene therapy within 5 to 10 years. urrent therapies for profound hearing loss like that caused by the recessive
restoring hearing in the recessive deafness model and partial hearing in the dominant deafness model. his is a great example of how the basic science can lead to clinical therapies,
Shen said. ur expectation is that a PTEN blood test in the near future will help clinicians decide on the right therapies for each cancer patient,
and more than 2 million new infections develop each year. lthough antiretroviral therapies have prolonged the lives of HIV-1 infected patients,
and persist in small populations of long-lasting reservoirs despite antiretroviral therapy, describes Dr. Cohen, who also leads Cancure,
Bone marrow-derived autologous human mesenchymal stem cells (MSCS) are one of the most promising cell sources for cell therapy to treat heart failure.
and enhanced the efficacy of cell therapy. We hypothesized that the transplantation of MSC sheets may be a feasible, safe,
The innovative approach may lead to more effective therapies with fewer side effects, particularly for diseases such as cancer, heart disease and neurodegenerative disorders.
interaction and function of each of these groups of proteins is vital to developing effective therapies.
GPCRS are major targets in the development of new therapies and account for about 40 percent of current drug targets.
patientsadherence to long-term therapies for chronic illnesses is only 50 percent in developed countries, with lower rates of adherence in developing nations.
as well as a path toward CRISPR/Cas9-based therapies for many serious health problems. Using their novel approach,
He hopes that Cas9-based therapies for T cell-related disorders, which include autoimmune diseases as well as immunodeficiencies such as ubble boy disease,
director of the National Institute of Biomedical Imaging and Bioengineering. he potential to offer a life-changing therapy to patients without requiring surgery would be a major advance;
but also by their response to therapies. An international team of scientists from Berlin, Düsseldorf, Hannover, Heidelberg, Kiel,
nevertheless, the results signal significant progress towards the eventual goal of developing a therapy for a wide range of individuals with spinal cord injury. hese encouraging results provide continued evidence that spinal cord injury may no longer mean a lifelong
. director of the National Institute of Biomedical Imaging and Bioengineering at NIH. he potential to offer a life-changing therapy to patients without requiring surgery would be a major advance;
so that the physician and the patient can select a therapy that is best for them. ource:
The therapy involves inserting electrodes into certain regions of the brain and producing electrical pulses meant to regulate abnormal ones.
an observation that could have important implications with the increased attention to immune-system-based cancer therapies. e are only at the beginning of our quest to understand the role and biology of CTC clusters,
it combines the effect of several other therapies but works faster. V, ozone and electrotherapy are already available,
and devise therapies to alleviate them s
#CERN Scientists Welcome Two New Particles To The Atomic Family CERN Large hadron collider in Europe, the giant atom-smashing machine, has discovered two new subatomic particles.
and lymphoma patients with a first generation of experimental T cell therapies developed by its academic partners.
T cell therapies have treated relatively rare blood-borne cancers. If that the extent of the treatment reach,
Overall, however, Brentjens cautions that no one can yet predict which patients might respond favorably to T cell therapy.
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