a condition that sees inflammation spread throughout the body that can lead to organ failure and death.
scientists may have found a method to starve tumors to death. Cancer cells must find nutrients to grow.
Sepsis is the single most frequent cause of death in hospitalised patients, causing 8 million deaths each year.
Supportive care is given, underlying infections treated, but there is no effective treatment. Researchers sprinkled a plastic nanoparticle with sialic acid ligands that modulated macrophage immune cells.
The condition can lead to death within five to 10 years. The disease is rare:
and could be targeted specifically to prevent cell death during ameba infection, "she said.""This approach also could be informative for colon cancer chemotherapy,
and could be targeted specifically to prevent cell death during ameba infection, "she said.""This approach also could be informative for colon cancer chemotherapy,
Despite advances in diagnostic approaches and treatment, malaria remains one of the leading sources of disease and death in developing nations.
Cervical cancer used to be one of the leading causes of cancer deaths in the US,
"In other words, the difference between this technology being classified as a death ray as opposed to a solar array is merely a matter of how the reflectors are angled.
which is among the leading causes of death for wounded soldiers. Bandages infused with chemicals designed to assist blood clotting helps,
The research is published today in the American Association for the Advancement of Science's new online journal Science Advances,
The European Association of Geochemistry is highlighting this work as especially interesting. According to study leader Dr James Byrne (Tübingen:"
who is also secretary of the European Association of Geochemistry, said:""This may have some interesting geochemical applications.
and then trigger a specific response, such as cell death. This system can be customized to detect any DNA sequence in a mammalian cell
Cells that did not receive the new gene could be induced to undergo cell death, creating a pure population of the desired cells.
exposure to a particular allergen can cause adverse reactions such as itching, breathing problems or even death.
Oxytocin is a hormone that influences social behaviour and has shown promise for the treatment of mental illness.
Regulates social behaviour Oxytocin has historically been known to play a crucial role in child rearing as it facilitates pregnancy, birth,
More recent research has revealed the importance of oxytocin for social behaviour. Oxytocin is a neuropeptide and was discovered in 1953.
Medicine through the nose Because of oxytocin role in social behaviour, researchers have explored the possibility of administering the hormone for the treatment of mental illness.
in fact, have the opposite effect on social behaviour. The scientists also discovered that individuals with larger nasal cavities had a stronger response to a low dose of oxytocin.
but showed extensive association with microglia obile cells that surround and protect neurons. Another example of Scales practical application came from examining the 3d positions of active microglial cells and amyloid beta plaques.
a detailed 3d reconstruction and analysis using Scales clearing showed that association with active microglial cells occurs early in plaque development,
#Researchers Identify Protein That Opens the Door to Cell Death Findings could aid development of novel therapeutics for conditions ranging from heart failure and stroke to cancer and neurodegeneration.
A protein embedded in the surface of mitochondria the energy-producing batteries of living cells opens the door to cell death,
where extensive mitochondrial dysfunction and cell death hinder tissue recovery. The study, led by Muniswamy Madesh, Phd, Associate professor in the Department of Biochemistry, the Cardiovascular Research center,
a protein complex in the mitochondrial membrane that mediates necrotic cell death (death caused by cell injury).
or increased levels of reactive oxygen species (ROS) the two primary factors that cause mitochondrial dysfunction and cell death via pore opening Dr. Madesh team devised an RNA interference
and cell death could be averted. With colleagues at TUSM, Dr. Madesh plans to explore the effects of SPG7 inhibitors in animals and, potentially, human patients t
#Novel Role of Mitochondria in Immune Function Scientists at The Scripps Research Institute (TSRI) have discovered a new role for an enzyme involved in cell death.
It is among the top 10 causes of death in America
#New Drug Delivery Technique Bypasses Blood-brain barrier Breakthrough could help countless patients with neurological conditions that are currently hard to treat.
a person risks coma and death from plunging glucose levels. A glucose sensor and insulin pump, both attached to the abdomen, are used by some people with type 1 diabetes to manage their condition,
The death toll of the earthquake that shook Nepal over the weekend just topped 5, 000.
Many of the resulting diseases, such as Creutzfeldt-jakob disease (CJD), have long incubation periods but eventually lead to death.
%Their findings are reported in an invited presentation at the 22nd Association of Computing Machinery (ACM) Conference on Computer and Communications security, Denver."
the group who had normalized testosterone levels after TRT had significantly fewer deaths and cardiovascular events than those who did not.
and 15,000 deaths per year in the United states, costing the country more than $4 billion in health-care expenses,
with symptoms ranging from severe diarrhea to intestinal lesions to death. Bogyo's team has developed ways of conducting high-throughput screens of small molecules to speedily test their ability to inhibit
%and its value for identifying causal rare variants of complex human disease phenotypes in genetic association studies.
which is the second most common cancer and accounts for over one-quarter of all cancer-related deaths.
and not enjoyable, said Norman Edelman of the American Lung Association, who was not involved with the research, in comment to Dennis Thompson at Healthday
some 750 million people across the globe don't have access to clean drinking water, a problem that's responsible for around 840,000 deaths every year-more than the entire population of San francisco o
However, it causes more deaths than any other cancer of the female reproductive system, and so new techniques to battle it would have a significant impact n
The study, presented this week at the American Public health Association annual meeting in Chicago, may help actual scientists such as doctors
"After lung cancer, prostate cancer is the second-leading killer cancer among men, with more than 240,000 new diagnoses and 28,000 deaths every year.
is a key mediator of oxidative damage and cell death in biological systems. The way cell death occurs
when using LTP treatment is different from other therapies. The active agents in the LTP break up DNA
resulting in cell death. This is different to some current therapies which cause apoptosis, where cells are prompted to die through natural mechanisms that can result in treatment resistance.
and ultimately necrotic cell death. Using clinically relevant, close to-patient samples, we have presented the first experimental evidence promoting the potential of LTP as a future focal cancer therapy treatment for patients with early stage prostate cancer.
"The team was amazed to find a consistent association, throughout cells: the location of PTEN proteins closely coincided with the presence of tiny highways called microtubules that crisscross throughout every cell.
a condition that is the second most common cause of death among premature infants in the United states. The researchers emphasized that the finding does not suggest that breast milk from mothers without an active copy of the gene is less nourishing or healthy.
resulting in roughly 27,500 deaths s
#Hyper-stretchable elastic-composite energy harvester Scientists have developed a hyper-stretchable elastic-composite energy harvesting device called a nanogenerator.
#Shape-shifting molecule tricks viruses into mutating themselves to death A newly developed spectroscopy method is helping to clarify the poorly understood molecular process by
"The researchers used summary statistics from genome-wide association studies of more than 200,000 individuals, looking for overlap in single nucleotide polymorphisms (SNPS) associated with clinically diagnosed AD and CRP and the three components of total cholesterol:
They found up to a 50-fold enrichment of AD SNPS for different levels of association with CRP, LDL, HDL and TG, which then lead to identification of 55 loci--specific locations on a gene,
and nivolumab against ipilimumab alone in previously untreated patients, were presented today at the 2015 Annual Meeting of the American Association for Cancer Research
Notably, three of the deaths in the combination group were determined to have been combined related to the therapy."
being presented as part of a poster presentation at the Annual Meeting of the American Association for Cancer Research (AACR) being held in Philadelphia,
Then, combining that tissue-specific functional signal with the relevant disease's DNA-based genome-wide association studies (GWAS),
the researchers were able to identify statistical associations between genes and diseases that would otherwise be undetectable.
which they called a'network-guided association study, 'or Netwas, thus integrates quantitative genetics with functional genomics to increase the power of GWAS
and pathways, permitting discovery of novel associations. SCDA director Leslie Greengard says, "Olga and her collaborators have demonstrated that extraordinary results can be achieved by merging deep biological insight with state-of-the-art computational methods,
#New material for creating artificial blood vessels Arteriosclerotic vascular disorders are one of the most common causes of death in industrialized countries.
A new report published in the Journal of the American Association for Pediatric Ophthalmology and Strabismus (AAPOS) describes the effectiveness of a new computer-based vision-screening test, the Jaeb Visual acuity Screener (JVAS),
One-shot learning was apparent in cases where participants made an association between an image and an outcome after a single pairing.
and stimulate cell death if the damage cannot be repaired. Moffitt researchers found that SIRT1 is modified by a process called ubiquitination, in
leading to either DNA repair or cell death. The researchers performed studies to determine how ubiquitin modification changes SIRT1 function.
If cells are exposed to a drug called etoposide, SIRT1 ubiquitination blocks cell death. However, if cells are exposed to oxidative stress,
SIRT1 ubiquitination promotes cell death. These results are important because they increase scientists'understanding of how proteins and cells function,
#New test predicts sudden cardiac death in hemodialysis patients ICNC is organised by the Nuclear Cardiology
and Cardiac CT section of the European Association of Cardiovascular Imaging (EACVI), a registered branch of the European Society of Cardiology (ESC), the American Society of Nuclear Cardiology (ASNC),
and the European Association of Nuclear medicine (EANM). ICNC 12 is held 3 to 5 may 2015 in Madrid, Spain.
"Hemodialysis patients are increased at risk of sudden cardiac death because they often have latent ischaemic heart disease
to predict the risk of sudden cardiac death in hemodialysis patients. All 3 methods were performed at rest.
20 sudden cardiac deaths occurred. Patients who suffered sudden cardiac death were more likely to have abnormal BMIPP scintigraphy,
abnormal Q wave and a greater C reactive-protein protein level compared to patients who did not experience sudden cardiac death.
There were no differences between the 2 groups in other clinical, laboratory or hemodialysis parameters. Taken on their own, patients with a BMIPP score greater than 16 had an 11-fold increased risk of sudden cardiac death,
while an abnormal Q wave conferred an 18-fold increased risk, and A c-reactive protein level greater than 2. 38 mg/dl predicted a 7-fold increased risk.
Patients with 2 or 3 of the predictors had a sudden cardiac death risk that was 145 times greater than patients with normal levels on all 3 measures.
"The most powerful way to predict sudden cardiac death was to combine the measures. Hemodialysis patients who had 2
In hemodialysis patients, abnormal uptake of BMIPP has an independent and incremental value in the prediction of sudden cardiac death in combination with C reactive-protein protein and Q wave.
"For the first time there is a way to predict sudden cardiac death in hemodialysis patients. In a clinical setting, BMIPP scintigraphy can be used in hemodialysis patients who are identified as high risk by abnormal Q wave and increased C reactive-protein protein.
which could be an effective therapeutic target for preventing sudden cardiac death.""He concluded:""Further diagnostic tests should be considered in high risk patients with abnormal BMIPP scintigraphy.
and help physicians select a prophylactic therapeutic strategy against sudden cardiac death in hemodialysis patients."
#New test predicts sudden cardiac death in hemodialysis patients ICNC is organised by the Nuclear Cardiology
and Cardiac CT section of the European Association of Cardiovascular Imaging (EACVI), a registered branch of the European Society of Cardiology (ESC), the American Society of Nuclear Cardiology (ASNC),
and the European Association of Nuclear medicine (EANM). ICNC 12 is held 3 to 5 may 2015 in Madrid, Spain.
"Hemodialysis patients are increased at risk of sudden cardiac death because they often have latent ischaemic heart disease
to predict the risk of sudden cardiac death in hemodialysis patients. All 3 methods were performed at rest.
20 sudden cardiac deaths occurred. Patients who suffered sudden cardiac death were more likely to have abnormal BMIPP scintigraphy,
abnormal Q wave and a greater C reactive-protein protein level compared to patients who did not experience sudden cardiac death.
There were no differences between the 2 groups in other clinical, laboratory or hemodialysis parameters. Taken on their own, patients with a BMIPP score greater than 16 had an 11-fold increased risk of sudden cardiac death,
while an abnormal Q wave conferred an 18-fold increased risk, and A c-reactive protein level greater than 2. 38 mg/dl predicted a 7-fold increased risk.
Patients with 2 or 3 of the predictors had a sudden cardiac death risk that was 145 times greater than patients with normal levels on all 3 measures.
"The most powerful way to predict sudden cardiac death was to combine the measures. Hemodialysis patients who had 2
In hemodialysis patients, abnormal uptake of BMIPP has an independent and incremental value in the prediction of sudden cardiac death in combination with C reactive-protein protein and Q wave.
"For the first time there is a way to predict sudden cardiac death in hemodialysis patients. In a clinical setting, BMIPP scintigraphy can be used in hemodialysis patients who are identified as high risk by abnormal Q wave and increased C reactive-protein protein.
which could be an effective therapeutic target for preventing sudden cardiac death.""He concluded:""Further diagnostic tests should be considered in high risk patients with abnormal BMIPP scintigraphy.
and help physicians select a prophylactic therapeutic strategy against sudden cardiac death in hemodialysis patients
and have immediate practical application in associations of farmers and agrifood companies m
#Sensor detects spoilage of food VTT has developed a sensor that detects ethanol in the headspace of a food package.
In validation of the approach, the researchers identified previously reported associations between specific mutations and resistance to particular drugs.
The organoids also revealed a novel gene-drug association, indicating that the subset of cancer patients with RNF43 mutations would strongly benefit from a drug that inhibits a protein called porcupine."
which has frequently been observed in autistic children, its association with gastrointestinal diseases --which often accompany autistic disorders
#Device may detect urinary tract infections faster Sepsis is a major killer and accounts for about half of the hospital deaths in the US by some estimates.
and preventing HIV more difficult, leading to sicker patients and more deaths. In turn, once someone is infected with HIV,
Aortic stenosis can lead to heart failure and death. About 100,000 people in the United states have aortic stenosis a
a disease that the World health organization estimates was responsible for 584,000 deaths in 2013, along with an estimated 198 million new cases in that span of time.
which infects 50 million people and causes 40,000-110,000 deaths via severe diarrhea worldwide.""Chelsea is a fearless experimenter.
A follow-up experiment showed that new intestinal cells treated with E. histolytica showed potassium efflux--the flow of potassium from inside a cell out through the cell wall--directly before cell death."
"The parasite was causing potassium efflux right before cell death and cells that happened to be unable to transport potassium didn't die."
"This is a major finding with translational implications for this infection that causes so many deaths worldwide, but also proof that this cancer-science approach can be used to explore genetic mechanisms of resistance in the field of infectious disease,
which is the world's leading cause of infant death and the origin of potentially severe,
937 deaths in the U s. Although current infection rates are declining, the majority of these deaths, about 8,
but showed extensive association with microglia--mobile cells that surround and protect neurons. Another example of Scales's practical application came from examining the 3d positions of active microglial cells and amyloid beta plaques.
a detailed 3d reconstruction and analysis using Scales clearing showed that association with active microglial cells occurs early in plaque development,
and prevents cellular death. The authors first discovered that an enzyme related to HSD10, Csga, produces energy during sporulation in the bacterium Myxococcus xanthus.
or cell death. HSD10 activity is inhibited strongly when bound to the amyloid beta peptide so prevalent in Alzheimer's disease."
"But with rampant oxidative stress leading to uncontrolled cellular death, you end up with diseases such as Alzheimer's and Parkinson's.
As of now, transplanted cell death remains a major challenge. To improve the therapeutic ability of transplanted stem cells,
In all of these chronic conditions, muscle wasting predicts earlier death.""Cancer patients often present with muscle wasting even prior to their initial cancer diagnosis,
#Novel role of mitochondria identified in immune function Scientists at The Scripps Research Institute (TSRI) have discovered a new role for an enzyme involved in cell death.
and then trigger a specific response, such as cell death. This system can be customized to detect any DNA sequence in a mammalian cell
Cells that did not receive the new gene could be induced to undergo cell death creating a pure population of the desired cells.
The Canadian Diabetes Association reports that more than 20 Canadians are diagnosed newly with the disease every hour of every day.
It is also the seventh leading cause of death in Canada, with associated health-care costs estimated at nearly $9 billion a year.
an aging population and heightened awareness of the disease stemming from the 2011 death of Apple Inc. cofounder Steve jobs. Zajac-Kaye's group discovered that a single protein is behind the process that allows pancreatic neuroendocrine tumors to thrive.
and induced the death of pancreatic cancer cells. Researchers then tested its effectiveness on human pancreatic cells that had been implanted in mouse models.
Metastases cause the vast majority of cancer deaths, but their tiny seeds are so difficult to track that few researchers have managed to study them.
despite the fact that it causes virtually all breast cancer deaths. Previous work by Werb's group had found a subset of cells at the edges of breast cancer tumors that seemed primed to metastasize.
undifferentiated state and relatively immune to cell death, which the researchers surmised might help metastatic colonies survive in new and hostile environments.
or death in the cabozantinib arm as compared with the everolimus arm. Regaining tumour control after prior targeted therapy may reduce symptoms related to kidney cancer
Risk Factors for Cardiovascular disease Approximately 610,000 people die from heart disease every year in the United states--that's one of every four deaths.
'Understanding how subtle changes in our genes may trigger brain cell death is one of the most promising avenues for the development of new treatments for Parkinson's.'
and death for a person waiting for a transplant or suffering from advanced heart failure.""An LVAD relieves symptoms,
If any of these associations are disrupted, the transcription factor is inhibited. In this study, Tsigelny and team aimed to disrupt the OLIG2 buddy system as a potential treatment for glioblastoma.
Cancer is a leading cause of death worldwide, accounting for over 8 million deaths per year,
and 70%of the world's cancer deaths occur in Africa, Asia and Central and South america.
The number of new cancer cases is expected to rise by 70%over the next two decades 1. With the help of his Research Associate Ana Isabel Barbosa,
natural cell death no longer functioned properly. According to the researchers, the apoptotic process is to be seen as completely independent of the uptake mechanism.
but can lead to severe adverse reactions. 150 deaths between 2004 and 2008 in the US were thought to be a result of drug manufacturers deliberately cutting heparin with OSCS to save money.
The astronomers created a video explaining the slow death of the universe to illustrate the discovery.
According to the American Heart Association, African americans are at a higher risk than whites to die of heart disease.
The innate neuronal property might be utilized to protect neurons from degeneration or cell death in the future.
we might be able to protect neurons from degeneration or cell death. Recent studies have suggested that changes in a region at the presynaptic membrane
Lam and his fellow researchers followed up this observation by looking at different types of cancers with known pain associations for instance, certain breast and melanoma cell lines.
what we know clinically about pain association, adds Lam. A New Direction for Drug Research The startling discovery of TMPRSS2 role in triggering cancer pain may lead to the creation of targeted cancer pain therapies that effectively shut down the expression of this gene
Police sources spoke of 1000 more deaths in the rural areas of Nepal. 50 more people were killed in northeastern India,
The total death toll for both quakes exceeded 5000. In 1934 Nepal and the neighboring Indian state of Bihar suffered severe damage when an 8. 2 quake struck.
Professor Thomas said. ut a common end result of this compensatory growth is eventual heart failure, a major cause of death in Australia. uring laboratory tests,
CGL4, which usually leads to death in the patient teenage years. Many children presumably also die from this disease during their first week of life,
without any diagnosis other than udden infant death syndrome'says Karl Swärd and Catarina Rippe, researchers at Lund University.
Conference on Artificial intelligence, organized by the Association for the Advancement of Artificial intelligence. A two-year seed grant from the UW-Madison Graduate school currently supports this work.
disability and death in the U s. Smokers who want to quit can turn to various pharmacological aids.
as such big injuries of an incredibly vascular structure inevitably require a clot in order not to bleed to death,
One-third of patients diagnosed with breast cancer eventually develop metastases in distant organs, with an increased risk of death.
As of now, transplanted cell death remains a major challenge. To improve the therapeutic ability of transplanted stem cells,
but hotspots are regions of volcanic activity at Earth surface that show no obvious association with plate boundaries.
but have extensive association with microglia (mobile cells that surround and protect neurons) instead. Scientists found a different application for Scales too.
this 3d analysis showed that association with active microglial cells occurs early in plaque development,
overweight and obese individuals The relative association between blood pressure and diabetes decreased as body mass index (BMI)
Last flu season, H3n2 contributed to some 36,000 deaths in the United states. And in some patients particularly young children
Approximately 610,000 people die from heart disease every year in the United states oughly one of every four deaths
The disease affects more than four million Americans and causes over 750,000 hospitalizations and 130,000 deaths per year in the United states alone.
disease and cell death. eat shock genes and their heat shock proteins are expressed highly during stress and are very critical to protect cells;
and release the drug payload, triggering changes that result in cell death within a few days.
or death, can take as little as two weeks. That may not leave enough time for the immune system to mount an effective response.
#Transplant Surgeons Revive Hearts After Death Transplant surgeons have started using a device that allows them to eanimatehearts from people who have died recently,
Transplant surgeons recognize two major categories of death. People can be brain dead, or they die
what they now call irculatory death. But by the time it stops on its own, a person heart is starved of oxygen
Eventually he thinks it might be possible to recover livers as much as an hour after death.
unlike in the U s. There are more than twice as many heart donors per capita in the U s as in the U k. Large believes taking hearts from circulatory-death donors could expand the supply in the U k. by almost a third,
This way the team effectively turns a circulatory death into a brain dead eating heartdonor. With the heart pumping,
Cancers in this system the oesophagus, stomach, intestines and rectum are major causes of death and difficult to investigate,
so this is obviously not something that is going to be used to draw the Millennium Falcon into the Death Star any time soon.
As a result, one type of resistant staph bacteria called MRSA causes over 80,000 infections and 11,285 deaths occur every year.
That's one death every seven seconds. 52 million Europeans are living with diabetes, and in Germany alone, there are 6 to 8 million documented cases.
and complications arising from those infections lead to nearly 100,000 deaths annually. The health care and liability costs associated with infections are astronomical,
This is important because the death of photoreceptor cells is known to cause retinal degenerative diseases in humans that lead to blindness.
of a study published Oct 15 2014 in Cancer Research a journal of the American Association of Cancer Research.
Overtext Web Module V3.0 Alpha
Copyright Semantic-Knowledge, 1994-2011