or structural changes in mammary glands can lead to the breakdown of tissue architecture associated with tumors that metastasize,
and an international team of colleagues report that a misfolded version of a protein called alpha-synuclein seems to act in a similar way to transmit MSA from diseased human brain tissue to mice and to human cell cultures.
Woerman led a research team in the development of a rapid new method to test prion transmission using human cell cultures.
Human culture stems from knowledge acquired through society's shared experience. Cultural transmission enables new members of society to quickly learn from this accumulated experience.
Then they challenged these cultures with the parasite E. histolytica.""We do this all the time in cancer research,
E. histolytica decimated many thousands of these independent cell cultures. However, a small number of cells seemed to resist the parasite.
Over these generations of selection, we saw the cultures becoming more and more enriched for cells lacking specific genes."
a postdoctoral research associate in the Franklin College of Arts and Sciences.""But with rampant oxidative stress leading to uncontrolled cellular death,
The quantum lab on tour through Austria Currrently, a light version of the virtual lab can be experienced as an interactive exhibit in the special exhibition"Das Wissen der Dinge"in the Natural history Museum Vienna.
-H in cell lines, primary neuron cultures and zebrafish using molecular genetics, protein biochemistry and high speed imaging.
-H in cell lines, primary neuron cultures and zebrafish using molecular genetics, protein biochemistry and high speed imaging.
The paper outlines the overall architecture and server-side deployment model the design of Safepay, prototype implementation and security analysis. Here's how it works:
They showed that silicone elastomers can be printed seamlessly into gradient architectures composed of soft and rigid regions.
The application of the CRISPR-Cas9 system for mammalian genome editing was reported first in 2013, by Zhang and separately by George Church at Harvard.
Virginia--a liquid-cooled FPGA was operated using a custom processor architecture provided by Altera. With a water inlet temperature of approximately 20 degrees Celsius and an inlet flow rate of 147 milliliters per minute
Bakir's group has demonstrated the fabrication of copper vias that would run through the silicon columns that are part of the cooling structure fabricated on the FPGAS.
fabricated high aspect ratio copper vias through the silicon columns, reducing the capacitance of the connections that would carry signals between chips in an array."
From River Besòs sediments, after three years'research, the researchers have obtained a stable bacterial culture
"The metamaterial consists of silicon pillar arrays embedded in a polymer matrix and clad in gold film.
if you're crafting devices with complex architectures, such as customized miniature biomedical devices. Within a single patient-specific device, the corners, the curves,
"These are the sorts of architectures that we are now producing synthetically, "says Erb, who has received a $225,
With this technology, we're finally scratching the surface where we can theoretically determine that a particular fiber architecture leads to improved mechanical properties
and we can also produce those complicated architectures
#3-D printed'building blocks'of Life scientists have developed a 3-D printing method capable of producing highly uniform'blocks'of embryonic stem cells.
Previous work in this realm relied on"growing the cell cultures in a Petri dish, which tends to deform the structure,
"And, borrowing from previous cell culture work done by our group, our high-frequency ultrasound method detects changes within the stiffness of cells with high accuracy.
Everyone who ever tried to listen to music, whether in tiny earphones or big expensive cans, knows that
the music leaking out in the room around him. urn down the volume or youl go deaf!
he realized the danger of hearing loss by listening to music too loudly isn just something parents say
because they can stand your music. According to data by the World health organization and the American Academy of Audiology
Most devices we use today to listen to music, however, can crank the volume up to more than 100db.
Along with serial entrepreneur Anthony Lye, the startup they co-founded, Aegis Acoustics, is on a mission to prevent further hearing loss among kids who love consuming their music with headphones.
The sound of music At first glance the Aegis Pro headphones don look like a particularly revolutionary product.
because there is a growing literature that shows discrimination is actually harmful for people health, particularly among African american adults,
meaning that all the cells in the culture are quite similar to each other in the way they express their genetic information. reviously,
Now that they have a reliable human beige fat cell culture system, Kajimura said, his team will be able to use the system as a screening platform to identify
and characterization methods together with our previous knowledge to create this thin films architecture. The use of thin film technology for Bi oxide is not trivial and required long and hard studies.
and amount of TMPRSS2 in these cancer cell cultures stood in exact correlation with the known level of pain each cancer causes. t was exactly
said Wyss Core Faculty member George Church, Ph d, . who is a pioneer in the converging fields of synthetic biology, metabolic engineering, and genetics.
Church is the Robert Winthrop Professor of Genetics at Harvard Medical school and Professor of Health Sciences and Technology at Harvard and MIT.
Now, Wyss Institute researchers led by Church have developed a new suite of such sensors, reported in Nucleic acids Researchjournal,
said Church. ee trying to control biological processes and we need new ways to get our hands in at the molecular level wee now reaching in deeper than wee previously been able to,
we were astounded to see exquisite fine-scale fibre architectures, which are completely different from those known in any other contemporary gel materials,
SEM images (false colour) depicting the intricate gel fibre architecture They then discovered that intertwined amongst these microscopic fibres were a profusion of nanoparticles around 100 nanometres in size.
to the best of our knowledge this is the first example of its kind reported in the literature.
because once you have that architecture, then you can ask fundamental biological questions. Kilian said these questions range from the basic how macrophages signal to the breast cells to the more long-term:
using them to measure activity in the larger culture population, which can include as many as a million cells. ecause we have all those electrodes,
and then compare the amount of activity being expressed by the culture to a target rate,
The optoclamp can be used to control cell cultures grown atop electrode arrays as well as in living animal models in
allowing experiments to focus stimulation on specific areas of the brain or brain cell cultures. The light signals now affect an entire culture
or brain region. e want to precisely control where photons are being sent to activate different cells, Newman said. ptogenetics allows genetic specification
Each silicon stump, or pillar has an elliptical cross section, and by carefully varying the diameters of each pillar
and rotating them around their axes, the scientists were able to simultaneously manipulate the phase and polarization of passing light.
or structural changes in mammary glands can lead to the breakdown of tissue architecture associated with tumors that metastasize,
assistant professor of mechanical engineering and a faculty member in the Penn State Materials Research Institute. ur surfaces combine the unique surface architectures of lotus leaves
the researchers etched micrometer scale pillars into a silicon surface using photolithography and deep reactive-ion etching,
and then created nanoscale textures on the pillars by wet etching. They then infused the nanotextures with a layer of lubricant that completely coated the nanostructures,
The paper outlines the overall architecture and server-side deployment model the design of Safepay, prototype implementation and security analysis. Here how it works:
The application of the CRISPR-Cas9 system for mammalian genome editing was reported first in 2013, by Zhang and separately by George Church at Harvard university.
due to apparent activation of blind pores within the carbon architectures as the cell charges and discharges over time,
Nanocarbon architectures derived from biological materials such as mushrooms can be considered a green and sustainable alternative to graphite-based anodes,
The nanoribbon-like architectures transform upon heat treatment into an interconnected porous network architecture which is important for battery electrodes
because such architectures possess a very large surface area for the storage of energy, a critical component to improving battery performance.
But now, in a landmark study by George Church and his team at the Wyss Institute for Biologically Inspired Engineering at Harvard university and Harvard Medical school, the gene editing system known as CRISPRAS9 has been used to genetically engineer pig DNA
Church is the Robert Winthrop Professor of Genetics at Harvard Medical school and a Wyss core faculty member.
The advance, reported by Church and his team, including the study lead author, Luhan Yang, a research fellow at HMS and the Wyss, was published in the October 11 issue of Science.
or PERVSROUGHT more than a billion dollarsworth of pharmaceutical industry investments in developing xenotransplant methods to a standstill by the early 2000s, said Church.
Church and his team have inactivated all 62 repetitive genes containing a PERV in pig DNA,
and is currently collaborating with Church on further genetic modifications of his pigs. f Church and his team are able to produce pigs from genetically engineered embryos lacking PERVS by the use of CRISPR-Cas9,
Then scientists placed the cells into culture conditions containing certain cytokines and soon saw that their efforts were continued successful cells to divide as stem cells instead of undergoing differentiation into B-cells.
In a culture without these cytokines the cells differentiated into various immune cells. Team wanted to test
The carbonic anhydrase would be immobilized with solvent inside a reactor vessel that serves as a large purification column.
Each company was formed around the discovery of unique identifying protein features within the cellular architecture of sperm and egg cells.
he CPM+LPCS that we have derived from human ipscs can be transferred from one medium to another for continuous culture
and smuggle cancer signals their neighbors New research in The FASEB Journal suggests that an in vitro co-culture system robustly quantifies the transfer of fluorescent proteins between cells
#Study reveals the architecture of the molecular machine that copies DNA DNA replication is essential to all life,
and Stony Brook University has revealed that vital complex molecular architecture. And to their surprise, it does not look as they had expected. ur finding goes against decades of textbook drawings of
Harvard university scientist George Church and his former student, Farren Isaacs, of Yale, held a press conference to announce a breakthrough of their own.
Isaacs and Church described how, in separate experiments, they created what they called a enomically reordered organism, or GRO.
Church and Isaacs recently announced they had formed a Boston-based company, enevolv, to supply such GROS for use by industry to,
Church declared that e are aiming at modifying plant and animal cells, and maybe plants and animals. potential objection to the technology is already apparent:
Church likewise argues that his GROS are safe because they depend upon unnatural amino acids that are supplied only in the lab. Withhold these and the bacteria die.
Both Romesberg and Church reported a tiny fraction of the bacteria managed to slip the genetic handcuffs via mutation.
"In nature, a great number of microorganisms, like diatoms, can assemble biominerals into intricate hierarchical three-dimensional architectures with great structural control,
Black silicon consists of clusters of microscopic vertical pillars or nanowires. Incoming light bouncing between individual silicon nanowires cannot escape the complex structure,
They then seeped a polymer between the silicon nanowire pillars. After the plastic support solidified, they etched away the silicon backing, leaving bull-eye patterned black silicon embedded in supple plastic.
digital music has matched and will likely soon surpass physical formats in the money it generates,
The drops contributed to the overall picture for the global music industry revenue of $14. 97bn in 2014, down a modest 0. 4%from a year earlier.
CDS are still far more popular than digital music in Japan which nonetheless saw revenue decline by 5. 5%in 2014,
and other sites to license music consistently. Youtube, owned by search engine giant Google, enjoys so-called afe harbourstatus under US law that lets it avoid liability for copyright infringement as it is considered an internet service provider.
The IFPI, in data released in the report, said that more than half of all internet users accessed music through video sites such as Youtube in the past six months.
It hovered thanks to"Magnetic field Architecture"(MFA), a fancy name for what the company's founder,
#Dr dre's new album streamed 25 million times on Apple Music in its first week Compton,
the new album from hip-hop mogul and Apple employee Dr dre, was streamed 25 million times in its first week on Apple Music.
only available for stream on Apple Music and digitally through itunes. Beats cofounder Jimmy Iovine was positive about the results,
saying that it constituted a good start for Apple Music.""We're beginning to show what we can do in terms of communicating music to a worldwide audience and helping artists at the same time,
"he told The New york times . But where Iovine says Apple is started just getting getting music to the world,
hip-hop's current kings are already old hands at disseminating their music to a huge and internet-literate fanbase.
The article also touches upon the misogyny that possibly exists within the modern dating culture.
"but rather in the midst of reviving the dating culture by building something that is changing the world"and leading to"meaningful relationships."
"While reading the recent Vanity fair article about today's dating culture, we were saddened to see that the article didn't touch upon the positive experiences that the majority of our users encounter daily,
Turkey's journey towards a new startup culture While far from the levels of Greece, Spain,
and service oriented architecture, the lines between software providers and software consumers have blurred, almost to the point in
because the app will red-flag the issue, the doctor can intervene, and the doctor and patient can work on solutions together.
In fact, Carme Ruscalleda, the Catalan chef behind the three Michelin starred restaurant Sant Pau, used it to make an edible model of one of the stained-glass windows of Santa maria del Mar, a gothic church in Barcelona."
"We have to establish a culture of food machine usage. Cooks are keen to do demonstrations
For this study the research team also worked with Tony Heinz David M. Rickey Professor of Optical Communications at Columbia Engineering and professor of physics at Columbia's Graduate school of Arts and Sciences.
One step further along the researchers also determined the molecular architecture of the final double-ring structure left behind after the ORC leaves the system offering a number of key biological insights.
Furthermore it is applicable to a broad range of documents from school textbooks children's stories and literature.
or not the new finding spells trouble for modern civilization it likely will help researchers understand how
The Capflank-method is suited even for heavily fragmented ancient DNA extracted from animal bones from museum collections.
Greenwood's colleagues successfully applied Capflank to samples from koalas kept in museums. Capflank is at its most efficient though with fresh DNA.
Scientific literature on Bre1 had been mixed. Some studies indicated that Bre1 had a role as a tumor suppressor Strahl said.
and practice cultures across our health system increases the generalizability of our findings to other health care settings.
Of the 25 genes previously identified in the literature 19 (76 percent) were identified by DIGGIT,
Alpha-helix rods and folded beta-sheet constructions were clearly visible within the 20 subunits of the APC/C defining the overall architecture of the complex.
#Painting robot lends surgeons a hand in the operating room Would you let an artist perform lifesaving surgery on you?
if the artist is a painting robot. Timothy Lee built a robotic painting arm that can replicate the lines
I never really thought you could do music with robots he said. That got me thinking'What else can you do with robots that most people wouldn't think about
'I thought I could do something with painting and that prompted the idea of robotic surgery.
Lee said painting and surgery have more in common than initially meets the eye. A painter has to be nimble and precise with his brushstrokes much like a surgeon must be nimble and precise with a scalpel.
More than painting by numberslee ordered parts online and assembled his contraption. His invention took an artistic turn
You can think of a painting canvas as a body and the brush as a surgeon's knife.
This year the event will take place at the University of Pittsburgh where Lee will demonstrate his robot's painting abilities.
The researchers studied the squeezed B cells in culture and found that they could expand antigen-specific T cells at least as well as existing methods using antibody-coated beads.
On either face of a silicon wafer, they etch dense arrays of tiny rectangular columns tens of micrometers across
thicker electrodes, the system reduces the conventional battery architecture number of distinct layers, as well as the amount of nonfunctional material in the structure, by 80 percent.
and a little bit more comprehensive than some of the other designs that might be reported in the literature.
and architecture by prioritizing the process over the built form.""To this extent we are integrating the service,
while producing a piece of architecture as another equally important outcome. It is neither strictly service design or architecture,
but an integrated hybrid with aspects of each.""Mapping the user journey Elsewhere, Melbourne's Huddle has launched recently Smart Blocks, a collaboration with the Australian government.
The task force turned to crowdsourcing to develop a design for the memorial to the passengers and crew of Flight 93.
and digital storage for music and movies--all#decedents#of technologies that he pioneered and championed.
richest companies abandoned this idea as a red flag. Not Feedly, Digg, AOL, Newsblur, and others,
We try to play good music for them. It s a matter of having the right temperature, right moisture levels and not too much light.
where the length of the mercury column in a capillary is controlled by the thermal expansion of the mercury in a reservoir connected to the capillary.
Tuning the voltage allowed them to control the length of the metal column in the capillary.
because speech and music are compressed in different ways. Voice compression typically relies on algorithms called code-excited linear prediction (CELP),
containing algorithms for both voice and music, and it switches between them as needed. The new voice algorithms are substantially more complex than those of the decade-old 7, 000-Hz codec.
the resulting material preserved the natural architecture found in the reeds. After 200 cycles of charging
but let them experience the hacker culture, and collaborate with really different thinkers of this world,
The Sony hack has displayed a lot about the failing of our modern, wired corporate culture. Like just how casual internal company HR employees treat email communication, for example.
but also raise red flags, it makes more sense than ever for tech startups to adopt a policy of radical openness:
A company that starts out with a closed paradigm and later chooses to open up will have a tough time rerouting company culture
and director David Fincher and actress Robin Wright both brought home a statue for their work.
television hasn been as quick to have been disrupted by the Internet as other industries, like music or books.
music, shopping lists and more. It offers a basic music player as well that lets you see what playing,
what youe played recently and what in your queue, while also offering player controls that let you play,
it also planting the flag for an entire ecosystem of startup companies engaged in overturning the ways in
Exit Music In the following years attention and capital turned to payments companies like Braintree (acquired by Paypal), Stripe or Square as the hope for fintech biggest home runs.
and contributes weekly to art & culture magazine Beautiful/Decay. With online sales up 17%and physical retail down 11%,it no wonder retailers large and small are increasingly living online.
and has defined both the controller architecture and use cases for SDNS through open APIS and standards-based protocols.
Opflex was designed to offer a highly scalable architecture that works across a broad range of hardware devices to enable multivendor innovation.
As part of this, part of Bittorrent team from Bundles Bittorrent paid content service covering different kinds of media from books to music
and a robust arts culture and one day we hope to be able to bring their work to our global audience of over 57 million members.
More importantly, deep fragmentation between language and cultures meant humans from different backgrounds were unable to effectively communicate with each other.
Wide adoption of a set of unicode ideograms helped people of different cultures to communicate with one another
Nevertheless with a population of 144 million people and a strong tech culture the country represents a lot of emerging market opportunity for Apple (and others.
which you apply to your temple and neck. When you open Thync app, it quickly connects to the module
Instead, it uses tiny pulses of electricity to stimulate the skin at your temple, which then activates the instinctual fight-or-flight response in your brain to indirectly affect emotional response.
and I really wanted a simple way to send donations to our local church, which typically collected cash
I note that I into music and fashion related categories. You then browse reams of products that each show their typical retail price.
Next is designing the high-level system architecture to minimize patient risk and ensure that it is usable.
Next is designing the high-level system architecture to minimize patient risk and ensure that it is usable.
Our architecture draws on and potentiates this work say Alex Graves Greg Wayne and Ivo Danihelka at Deepmind which is based in London.
An associate professor of media arts and sciences and leader of the Biomechatronics Group in MIT's Media Lab Herr is sophisticated building devices that aid human movement by mimicking nature.
Our culture is trained to think about a person with an unusual body or mind as weak Herr says.
What itunes Did for Music? The point-of-sale terminal at the CVS drugstore in Palo alto, California, can accept payments through a quick tap from a smartphone.
While some features have already been built a long list of them are still to come such as the ability to block other users from seeing your profile to post music
Alnylam looked everywhere for solutions scouring the scientific literature collaborating with other companies considering novel approaches of its own.
Three Pillars of the Networked Economysap has identified three main areas where the Networked Economy is having
The Synapse chip breaks with a design known as the Von neumann architecture that has underpinned computer chips for decades.
and scalability of this architecture are really unique. One downside is that IBM chip requires an entirely new approach to programming.
a Dutch social psychologist who developed ways to measure a set of cultural dimensions for comparing cultures.
It shows that differences in culture affect the dynamics of social spreading processes in a measurable way.
whose cultures differ in how they value individualism versus collectivism, say Lang and co. What more,
scientists from Harvard university, led by George Church, say theye created big advances to the method which people need to start worrying about.
Google aims to change that by creating search results that take you somewhere specific within an app or trigger a function like playing music by a specific artist.
In museums it could pull up Wikipedia articles when focused on a piece of art (Amazon says that it will add image-recognition for artwork to Firefly later in the year).
would allow people to make music with facial expressions: raise or lower eyebrows to make a tone rise or fall,
or smile or frown to make music that sounds happy or sad. Affectiva grew out of emotion-detecting research at MIT Media Lab. The company software,
Higher quality music seemed to come from a fake hi-fi speaker. And a stuffed bird high off the ground produced realistic chirps.
As a practical matter, it will also offer museum restoration artists and others a way to put faces to long-dead victims
. or museums, there is no other way to do itou aren going to ship a 2, 000 year old Egyptian mummy in the mail,
Dipasquale has dabbled in using multipeer connectivity himself creating an experimental app that streams music from one device to several others nearby.
That fountain of variability could be key to finding ways to push our fermenting friends to more efficiently create biofuels and other chemicals f
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