#Solar cooling system keeps water at 9 degrees Celsius for up to three months Maintaining food in places where high temperatures prevail,
The early establishment of bifidobacteria has been shown to be associated with improved immune response to vaccines, development of the infants'immature immune system,
She recently received a grant from the Pediatric Medical device Consortium at the Children's Hospital of Philadelphia to research this possibility i
"This will improve vaccine development, lead to better treatment outcomes and ultimately benefit cancer patients
"Right now, those at the lowest incomes must rely on health care that is highly subsidized by county and state tax dollars,
or get by without needed health care.""The 31 percent decrease in the rate of uninsured Texans was similar to drops in other states that did not expand Medicaid coverage,
#Breast cancer vaccines may work better with silicon microparticles Model studies showed that microparticles loaded with an antigen, HER2,
"We could completely inhibit tumor growth after just one dose of the cancer vaccine in the animal model,
"Cancer vaccines are designed to turn a patient's own immune system more strongly against cancer cells, and have been an area of recent and intense interest among oncologists.
Since 2010, the FDA has approved vaccines and other immunotherapy drugs for melanoma, prostate cancer, and lung cancer.
There are currently dozens of active clinical trials evaluating vaccines for cancer therapy. Approximately 235,000 new diagnoses of breast cancer were made last year,
As yet, there are no FDA-approved vaccines for breast cancer. Such a vaccine might target HER2 a cell surface hormone receptor that is overexpressed in the tumor cells of 15 to 30 percent of breast cancer patients.
Such cells are called HER2+or HER2 positive. In this case, HER2 is both a naturally occurring hormone receptor and an antigen target for therapy.
A vaccine against HER2 would train the immune system's more destructive agents to recognize the cancer cells overproducing HER2
But so far, vaccines against HER2 have seen only moderate success."Vaccines targeting the HER2 oncoprotein have been tried,
"But these vaccines have mostly not been very potent because of inefficient vaccine delivery, a poor immune response at the site of the tumor,
We have shown that the PSM-mediated vaccine is not only potent enough to trigger tumor cell killing,
and that the PSMS could be loaded with multiple antigens for a single vaccine target, or multiple antigens for several targets, possibly enhancing the approach's effectiveness further."
"Besides developing a highly potent breast cancer vaccine, we have demonstrated also that PSMS are said versatile, "Shen."
"This is a technology platform that can be applied by other scientists to develop vaccines for other types of cancers, ultimately helping,
but mass public health campaigns to administer the medication have been stalled because of potentially fatal side effects for patients co-infected with Loa loa,
inexpensive technologies that can be applied to a wide range of health care problems and settings.""Testing for HIV-1 in whole bloodcurrent tests for HIV infection detect antibodies to HIV in the individual's blood.
What exactly does the team's medical device detect?""In our pilot study, we were able to identify Escherichia coli (more commonly known as E coli)
The team will continue toward its goal of developing an easy-to-use spectroscopy-based point-of-care medical device for fast and reliable diagnostics."
"We hope this project will be useful to treat serious public health problems such as diabetes and obesity,"concludes the specialist s
"said the trial's co-primary investigator, Craig R. Cohen, MD, MPH, UCSF professor in the Bixby Center for Global Reproductive health in the department of obstetrics, gynecology and reproductive sciences.
The discovery that alpha-synuclein prions can transmit MSA raises a public health concern about treatments
The researchers also pointed out that this technique does not pose any serious health risks. Since this technique is intended for applications in ultra low power communication systems
whether blood transfusion from young individuals to older ones confers benefits.""The results of this work may provide additional evidence that eotaxin plays a role in the deleterious effects of aging,
particularly when there are flu vaccine shortages or limitations.""A therapy based on these inhaled drugs may help deal with new viral and bacterial strains that are resistant to conventional vaccines
and treatments and could be a game changer in terms of our preparedness for future pandemics and seasonal flu outbreaks because it's focusing on host immunity,
150, were associated with inpatient stays in health care facilities, according to the Active Bacterial Core surveillance report by the Centers for Disease Control and Prevention.
stating that it"represents a serious threat to public health and the economy.""In March, a National Action Plan outlined critical next steps for key federal agencies and departments.
antibiotic resistance is a problem that adds around $20 billion annually to health care costs in the U s."The biggest question scientists have to ask to tackle antibiotic resistance is,
In both the U s. and Europe, the spread of MRSA is a major threat to people in hospitals and other health care facilities.
STIS of viral origin constitute a major public health concern, notably in women from low-income countries who were shown to be infected with HIV-1 early in their sexual live,
This is a crucial step in creating a new generation of foldable electronics--think a flat-screen television that can be rolled up for easy portability--and implantable medical devices.
indicating it is a good material for implantable medical devices. Fatigue is a common problem for researchers trying to develop a flexible, transparent conductor,
and totally redesigned its core to repurpose its infectious capabilities into a safe vehicle for delivering vaccines
they would hang vaccine tags on the spikes. If on the other hand, they wanted the capsid to deliver medicines to a sick cell,
#Antimicrobial film for future implants The implantation of medical devices is not without risks. Bacterial or fungal infections can occur
Other frequently used medical devices that cause numerous infectious problems, such as catheters, may also benefit. These results are published in the journal Advanced Healthcare Materials.
Implantable medical devices (prosthesis/pacemakers) are an ideal interface for microorganisms, which can easily colonize their surface.
The challenge presented by implanting medical devices in the body is preventing the occurrence of these infections
or medical devices within a few years to control the complex microenvironment surrounding implants and to protect the body from infection n
and Matthew Gurka, Phd, of West virginia University's School of Public health. The test relies on an evaluation of metabolic syndrome,
#New approach toward a broad spectrum malaria vaccine Malaria affects millions of people worldwide. Plasmodium falciparum enolase participates in parasite invasion of host red blood cells and mosquito midgut epithelium.
A vaccine based on this motif could confer protection against all malaria parasites. In a recent breakthrough to combat malaria, a collaboration of Indian and American scientists have identified a malarial parasite protein that can be used to develop antibodies
The finding points towards developing a powerful malaria vaccine in the hope of eradicating this debilitating and often fatal disease.
Development of an antimalarial vaccine is an integral part of an effort to counter the socioeconomic burden of malaria.
and this conjugated system was used to vaccinate mice. Interestingly, a subsequent challenge with a lethal strain of mouse malaria parasite in these vaccinated animals showed considerable protection against malaria.
Says Prof. Dassarma, Phd, a professor of microbiology and immunology at the school,"GVNPS offer a designer platform for vaccines
and this work is a significant step forward towards a new malaria vaccine.""This study is a significant advance in the field,
since most other vaccine candidate molecules tested so far confer protection against only a single species of parasite, due to the species and strain specific nature of these molecules."
"The small segment of five amino acids that forms a protective epitope is present in all human malaria causing species of Plasmodium and hence,
Efforts are focused now at developing this into an effective vaccine against malaria a
#Turning up the heat: Holey metamaterials enhance thermal energy harvesting It's estimated that the U s. fails to use more than half of the energy it generates--mostly
While this old, simple technique may seem a quaint throwback in the age of high-technology health care tools like genetic sequencing
we also want to bring health care to the low-income population, helping to make and early detection before it can lead to more problems
#Researchers develop 3-D printing method for creating patient-specific medical devices A team of researchers at Northeastern University has developed an innovative 3-D printing technology that uses magnetic fields to shape composite materials
Besides the possibility of treatment, the study also raises hopes for an HIV vaccine. If researchers can induce an uninfected person immune system to generate potent antibodies such as 3bnc117
and we look forward to commercializing this technology with one or more leading medical device companies that can benefit by making it easier and painless for diabetics to measure glucose,
and could ultimately lead to the design of a vaccine to prevent transmission of the virus. This innovative approach could also be part of the solution for one day eradicating the virus. Despite recent advances,
For decades, scientists have been trying to devise a vaccine to block HIV infection, which causes AIDS.
The discovery by Finzi team could help develop a two-part vaccine to prevent HIV infection:
but mass public health campaigns to administer the medication have been stalled because of potentially fatal side effects for patients co-infected with Loa loa,
#Ebola Vaccine Demonstrates 100%Protection in Latest African Trial According to an unusual new study, published last week in the world most prestigious medical journal Lancet, the deadly outbreak
might finally come to an end a vaccine, developed by the Public health Agency of Canada and manufactured by the American pharmaceutical company Merck Sharp & Dome, was shown just to confer 100%protection against the disease,
starting mere 10 days after receiving a single shot. his will go down in history as one of those hallmark public health efforts,
said Michael Osterholm, Director of the Center for Infectious disease Research and Policy in Twin cities, Minnesota,
who wasn involved in the study. e will teach about this in public health schools. he vaccine,
the researchers opted for a design called ring vaccination, whereby only the contacts, and the contactscontacts, of new Ebola patients were vaccinated.
This type of approach has never been used in a formal vaccine study ever before. The rings, also called clusters, were randomized such that 48 of them received the vaccine right after a new Ebola case sprung up in their community,
while the other 42 received a shot only three weeks afterwards. Of the 2, 380 people who were assigned to the latter group,
16 got infected. In the second group consisting of 2 014 people the count of new Ebola cases was zero,
The Director-General of THE WHO Margaret Chan called for further studies to clear up any lingering doubts about the vaccine efficacy,
#Could flu someday be prevented without a vaccine? Researchers have discovered a way to trigger a preventive response to a flu infection without any help from the usual players the virus itself or interferon, a powerful infection fighter.
but prevent infection altogether. he flu vaccine needs to change every year because the virus is constantly mutating.
but the scientistslong-term goal is to develop a vaccine-independent method to prevent flu infections. f we were to have an outbreak of some pandemic influenza virus similar to
The device is expected to make a difference in medical treatments, preventive health care and sports p
Secondly, these new findings may be very helpful developing vaccines with more effective adjuvants. Adjuvants are used compounds in vaccines that activate innate immunity they are necessary ingredient of efficient vaccines.
For a long time scientists thought that the effect of adjuvant can be maintained a several days only. But this new research shows that it is not necessarily true.
which would make for much more effective vaccines. As much as human immune system still remains not completely clear for science
Knowing how to form these memories may hide the key to creating better, more effective and long-lasting vaccines a
#Team develops quick way to determine bacteria antibiotic resistance Bacteria ability to become resistant to antibiotics is a growing issue in health care:
indwelling medical devices, and surgically implanted prostheses provide suitable environments for Staphylococcus epidermidis to propagate and form biofilms.
This separation has significant potential implications for health care, as rapid and early detection will significantly improve therapeutic outcomes.
claims Chiu. nbiased point-of-care testing for pathogens by rapid metagenomic sequencing has the potential to radically transform infectious disease diagnosis in both clinical and public health settings.
#Medical device Breakthrough: UV-light enabled catheter fixes holes in the heart without invasive surgery Researchers from Boston Children Hospital, the Wyss Institute for Biologically Inspired Engineering at Harvard university,
While medical devices that remain in the body may be jostled out of place or fail to cover the hole as the body grows,
lack of link to autism New research finds no evidence that thimerosal-containing vaccines cause negative behaviors or result in neuropathology in infant primates,
In the study, infant rhesus macaques received several pediatric vaccines containing thimerosal, a mercury-based preservative,
Other animals received just the measles-mumps-rubella (MMR) vaccine, which does not contain thimerosal,
or an expanded vaccine schedule similar to that recommended for U s. infants today. Control animals received a saline injection.
Regardless of vaccination status all animals developed normal social behaviors; the administration of vaccines to rhesus macaques did not result in neuropathological abnormalities or aberrant behaviors such as those often observed in autism.
Cellular analysis of the cerebellum, amygdala and hippocampus three brain regions known to be altered in autism was vaccinated similar in
and unvaccinated animals. his comprehensive study included many physiological measures and behavioral measures. Fundamentally the vaccines had no ill effects,
said Gene Sackett, UW professor emeritus of psychology and director of the lab work at the Washington National Primate Research center. o the extent that macaques mirror human physiology,
These vaccines are safe. n
#New technology enables people to take own blood samples at home A world-first prototype for taking accurate blood samples at home has been developed by a Tasmanian-led research partnership.
and Matthew Gurka of West virginia University School of Public health developed the new diagnostic test. The test relies on an evaluation of metabolic syndrome,
however, the door is now open on the possibility that humans could one day receive lifesaving organ transplants from pigs.
professor of neuroscience in Penn School of veterinary medicine and Perelman School of medicine, provides important clues for understanding how a father life experiences may affect his children brain development and mental health through a purely biological and not behavioral means. t remarkable to
has direct implications for our climate and public health. Seismic Research/Disaster Prevention: Keys to hazard management for major earthquakes, hurricanes,
the researchers showed their system was effective in mice with equine encephalitis virus and with strains of influenza virus relevant to public health,
says Jean Robillard, M d.,interim president of the University of Iowa and vice president for medical affairs, University of Iowa Health care s
and Health Conference, being held this week at the University of North carolina School of Global Public health.
Smith said. e are actively raising additional capital to help us bring this innovative public health product to people in need around the world. adidrop PBC administrative office is located on Allied Street in Charlottesville
and eggs has lead to numerous breakthroughs in reproductive health, and now he believes his team has discovered a revolutionary strategy to treat cancer. he focus of my work has always been to define the signature molecules that are on
or to the sperm gives you opportunities to create small-molecule drugs for female and male contraception, contraceptive vaccines,
#Researchers Smash Records with Pig-to-Primate Organ transplants A biotech company is genetically engineering pigs so that their organs might work in people.
or between-species organ transplants. The researchers say they have kept a pig heart alive in a baboon for 945 days
including new vaccines. It might be possible, for instance, to make a tuberculosis virus with unnatural DNA in it.
but also benign, that would be the perfect vaccine, says Schultz. Synthetic life forms have implications far beyond new products.
And once synthetic biology leads to a new drug or vaccine, he thinks, wel get used to the idea of inventing life for our own good. ne has to pick the most near-term applications of this technology to show what it can really do for the good of mankind,
was tested for four weeks by 22 participants with a schizophrenia diagnosis. Schizophrenia is a long-term mental health condition
The health care and liability costs associated with infections are astronomical, and despite increasingly rigid policies and best practices designed to keep hospitals sterile,
but some hospital administrators have come to view them as the first must-have robot tech in a health care industry that's bracing for big changes with the imminent arrival of robot cleaners, diagnosticians, surgeons, and nurses."
"The acquisition of this technology is simply another way that we're working to protect the integrity of our health care environment,
meaning it integrates well into a new health care paradigm centering around data collection and analysis."With rising issues around health care-associated infections,
and Vaccine Production Facility with a gene transfer technique that teaches the T cells to target
which are thought to provide long-term vaccine-like activity preventing tumor recurrence. Since B cells play a role in helping fight infection patients typically receive immunoglobulin replacement to maintain healthy immune function.
and power wearable sensors or medical devices or perhaps supply enough energy to charge your cell phone in your pocket says James Hone professor of mechanical engineering at Columbia and co-leader of the research.
and can be collected easily in places where public smoking is allowed it could be part of a low-cost solution for a serious public health issue they say.
The team lead by Professor Lester Kobzik at the Harvard university School of Public health introduced Streptococcus pneumoniae into the lungs of mice to mimic the inhalation of bacteria that occurs naturally as we breathe.
The structural knowledge may help others engineer small molecules that inhibit DNA replication at specific moments leading to new disease prevention
and social inclusion of the users as they gain better access to education employment health care and social activities she adds.
#Defective gene renders diarrhea vaccine ineffective Acute diarrheal illnesses cause nearly one-fifth of all child deaths in developing countries.
Today vaccination is considered the most important method for reducing mortality. Unfortunately several studies have shown that the two available living vaccines Rotarix and Rotateq
which are recommended by bodies including the World health organization are not sufficiently effective in developing countries. In many African countries protection has been as low as 20-50%.
%The current study to be published in the Journal of Clinical Infectious diseases by Johan Nordgren from Professor Lennart Svensson's research group shows that up to four of ten children in Burkina faso are genetically resistant to the virus strains found in the vaccines.
The researchers found that children who can not express a particular sugar molecule in the small intestine called the Lewis molecule do not become infected by the rotavirus types found in existing vaccines.
This means that these children do not get the desired immunological protection from the vaccine.
and can greatly impact the evaluation of the rotavirus vaccines now being introduced in several developing countries.
The results could lead to a review of the vaccine composition and the development of vaccines better suited to the populations most affected by rotavirus.
Story Source: The above story is provided based on materials by Linköping University. Note: Materials may be edited for content and length.
and their families says Weiss leader of the university's Brain and Mental health strategic research priority.
This ground-breaking study was set up under the leadership of Brigitte Eisenwort together with Thomas Niederkrotenthaler and Benedikt Till (both from the Institute for Social medicine at the Meduni Vienna's Centre for Public health) as well as Barbara Hinterbuchinger from the University
#Bioinspired coating for medical devices repels blood, bacteria From joint replacements to cardiac implants and dialysis machines medical devices enhance
or save lives on a daily basis . However any device implanted in the body or in contact with flowing blood faces two critical challenges that can threaten the life of the patient the device is meant to help:
They developed a new surface coating for medical devices using materials already approved by the Food and Drug Administration (FDA.
--so we further adapted our approach by capitalizing on the natural roughness of chemically modified surfaces of medical devices said Aizenberg who leads the Wyss Institute's Adaptive Materials platform.
The Wyss team developed a super-repellent coating that can be adhered to existing approved medical devices.
While most of the team's demonstrations were performed on medical devices such as catheters and perfusion tubing using relatively simple setups they say there is a lot more on the horizon.
What emerged could become a new paradigm for implantable medical devices extracorporeal circuits and more. Story Source:
and child care centers to report illnesses to local public health departments could improve the detection of disease outbreaks
and improve public health response to outbreaks during a presentation at 2: 09 p m. PDT in Marina Ballroom Salon E at the San diego Marriott Marquis."For example,
Previously some public health departments have found that school absenteeism as a marker for illness was delayed imprecise
Most public health departments do not electronically track influenza or stomach illnesses in preschools and child care centers settings."
"Most illness reporting methods used by many public health departments are based slow, paper and inefficient, "says Hashikawa.
Researchers sent data electronically to the public health department weekly or more frequently if spikes in illness cases were seen.
and practice cultures across our health system increases the generalizability of our findings to other health care settings.
or biological contaminants with far-reaching implications for public health including homeland security concerns. Applying world class research to water quality has to be viewed as a critical component for sustaining society as a whole says Clarkson University President Tony Collins. As healthy water becomes increasingly scarce establishing real-time data as the new standard for understanding water quality around the globe
and tax base needed to fund pensions health care and other benefits for the elderly it is typically families that bear the brunt of the cost of having children the study found.
and a positive step towards addressing the major public health issue of antibiotic overuse.""Investors seem to agree.
like substance use disorders, mental health issues and unemployment. At community courts, the criminal case management process itself involves providing access to treatment and social services.
and why it is challenging for researchers to develop vaccines targeting the HIV envelope proteins,
Dry powder inhaler formulation Despite advances in vaccination and antimicrobial therapy, community-acquired pneumonia remains a leading cause of morbidity and mortality, even in highly developed countries.
is always deadly for those unable to obtain vaccines in time. Some 55,000 people die from rabies every year.
#Cell-Squeezing Device Opens New Possibilities for Cell-Based Vaccines A newly published study details how researchers from MIT developed a new microfluidic cell-squeezing device, opening new possibilities for cell
-based vaccines. MIT researchers have shown that they can use a microfluidic cell-squeezing device to introduce specific antigens inside the immune system B cells,
and implementing antigen-presenting cell vaccines. Such vaccines, created by reprogramming a patient own immune cells to fight invaders,
hold great promise for treating cancer and other diseases. However, several inefficiencies have limited their translation to the clinic
While most of these vaccines are created with dendritic cells, a class of antigen-presenting cells with broad functionality in the immune system,
A new vaccine-preparation approachdendritic cells are the most naturally versatile antigen-presenting cells. In the body, they continuously sample antigens from potential invaders,
when for cell-based vaccines: They have a short lifespan, they do not divide when activated,
which has limited options for B-cell-based vaccine programming. Using Cellsqueeze circumvents this problem, and by being able to separately configure delivery and activation,
researchers have greater control over vaccine design. Gail Bishop a professor of microbiology at the University of Iowa Carver School of medicine and director of the school Center for Immunology and Immune-Based Diseases, says that this paper presents a reative new approach with considerable potential in the development
of antigen-presenting cell vaccines.?The antigen-presenting capabilities of B cells have often been underestimated, but they are being appreciated increasingly for their practical advantages in therapies,
in this new study, demonstrates promise as a versatile platform for creating more effective cell-based vaccines. ur dream is to spawn out a whole class of therapies
Future stepsthe researchers say they now plan to refine their B-cell-based vaccine to optimize distribution and function of the immune cells in the body.
A b-cell-based approach could also reduce the amount of patient blood required to prepare a vaccine.
patients receiving cell-based vaccines must have drawn blood over several hours each time a new dose must be prepared.
and cost required to engineer cell-based vaccines. e envision a future system, if we can take advantage of its microfluidic nature,
run it through a bedside device that has the antigen you want to vaccinate against, and then you have the vaccine,
Szeto says. This research was funded by the Kathy and Curt Marble Cancer Research Fund through the Koch Institute Frontier Research Program, the National Cancer Institute, the National Institute of General medicine Sciences
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