And more recently, Sundar Pichai took over as chief executive of Google-a role many said had been years coming.
"We decided to systematically test why it was that truncating guides too much caused Cas9 to no longer cut the intended genomic site,
We envision future uses for the technology that can help decipher the tangled web of interactions underlying for example cancer drug resistance and stem cell differentiation,
Kleiner and their colleagues zeroed in on the sites in chromosomes where DNA repair happens. Specifically
This process, called phosphorylation, occurs at sites of broken DNA as a way to mediate interactions between key proteins.
This interaction helps bring 53bp1 to the site of DNA damage, where it mediates the repair of double-stranded breaks in DNA by encouraging the repair machinery to glue the two ends back together."
since to phase II trials at multiple test sites. Results have not yet been released. The published findings come from AD patients who participated in safety trials from March 2001 to October 2012 at UC San diego Medical center.
and then attacks a previously unknown binding site on STAT3, disrupting its disease-promoting effects.
and modifies an inhibitor-binding site on the protein coiled coil literally protein coils coiled around each other
to the modified site. his is the confluence of two ideas wee been working on around
The human proteome (the entire set of expressed proteins) is estimated to be phosphorylated at more than 100,000 unique sites,
The reagents are fluorescent detection analytes that competitively bind to a key cofactor binding site of enzymes that catalyze methylation of histones, DNA, and RNA.
Cayman is poised to expand on the technology with a patent pending second-generation SAM mimic-based probe designed to competitively bind to SAM-binding sites of a different set of methyltransferases.
including new cancers at other sites or in the opposite breast.""These patients who had low risk scores by Oncotype did extraordinarily well at five years,
not only attack the main tumor site, but are more likely to find and attach themselves to tumor cells circulating in the bloodstream essentially attacking new tumors before they start,
which the platelet membrane could help us target relevant sites in the body. i
#An Accessible Approach to Making a Mini-brain If you need a working miniature brain say for drug testing, to test neural tissue transplants,
you could use these to measure dissolved oxygen or ph from a lot of different sites all over a pond or a lake,
leading viruses to binding sites that allow infections to spread at the molecular level. They serve as a key of sorts that gives viruses entry into the host to begin spreading.
which cells are transplanted into the injury site, "says research supervisor Dr James St john, from Griffith's Eskitis Institute for Drug Discovery.
and better integrate into the injury site. In turn, this will help the spinal cord to regenerate more effectively."
Fans remain largely confused as to why Tidal even exists it offers streaming music at twice the price of Google, Apple, and Spotify.
Aspirothe Aspiro website in 2001. Aspiro grew quickly thanks to partnerships with European phone manufacturers such as Ericsson and Nokia.
Flickr/sigurdgaaspiro partnered with a Norwegian music store to launch its streaming site. Aspiro focused on WAP for years,
"a company he had set up with the sole purpose of buying a music-streaming site.
Entertainment news site Showbiz 411 heard about the secret meeting and published a list of names that were in attendance.
and Jay z's streaming site would be called Tidal. The March 30 press conference was meant to be the opportunity for Tidal to reboot its public image and present itself as a major player in the world of music streaming. ew York
The relaunched streaming site would be based around exclusive music and video content, as well as special live events for subscribers.
the site encompasses high quality sound, video, exclusive editorial but there are more features on the way. In time, TIDAL will be not just a streaming service but a platform with enhanced experiences.
and his music is now available to stream on the site. The backlash against Tidal began in earnest after the New york press conference.
and Swedish news site Breakit claimed that 25 employees in Aspiro's Norway office had also been forced to leave."
I take my respectpharrell even told me go with the safest betjimmy Iovine on for the safety netgoogle dig around a crazy checki feel like Youtube is the biggest culpritthem n---pay you a 10th of what you supposed to getyou know I came in this game independent right?
they ain say s---Jay z suggested that Google offered him money to partner with its own streaming service,
but hinted that he was upset with music appearing on Youtube (and the diminished revenue he receives from it).
The site doesn't have any kind of item on hand to sell you. Instead, it acts as a middleman between manufacturers, enthusiasts, and would-be customers."
the site now has over one million monthly users. To keep up with that demand, Massdrop's employees have ballooned from 14 just over a year ago to 70 today.
El-Hage says that the company's unique relationship with vendors sets it apart from other failed flash sale websites.
Multiple sources confirm that Google Wallet saw a jump in payment volume following the launch of Apple Pay.
and why the fledgling mobile payments feature is sure to be a success. Provides a quarterly update on the mobile payments industry including analysis of Softcard, Google Wallet, Currentc, Paypal, and Looppay.
a popular social coding site for programmers, is fighting a days-long cyberattack that reportedly originates in China.
The U s. coding site Github said on Sunday it was deflecting most of the traffic from the cyberattack that had caused intermittent outages.
The attackers paralyzed the site at times by using distributed denial of service, or DDOS, attacks, a technique commonly used to disrupt websites and computer networks,
according to the Wall street journal. They pushed massive amounts of traffic to Github by redirecting overseas users of the popular Chinese search engine Baidu Inc,
according to the Wall street journal. The newspaper said they targeted two Github pages that link to copies of websites banned in China-a Mandarin-language site from the New york times Co and Greatfire. org,
which helps Chinese users circumvent government censorship. A Beijing-based Baidu spokesman said a thorough investigation had determined it was neither a security problem on Baidu's side nor a hacking attack."
"We have notified other security organizations and are working to get to the bottom of this, "the spokesman said.
and involved"every vector we've seen in previous attacks as well as some sophisticated new techniques that use the web browsers of unsuspecting, uninvolved people to flood github. com with high levels of traffic.
including a provision that allows the government to block websites without announcing or explaining its decision to do so.
The web is about to exhaust its supply of Internet Protocol (IP ADDRESSES. Now, technology companies are scrambling to get onto a new system to route internet traffic to the right place.
Under the web's current system, there are billions of them. 3 billion to be exact.
#India orders clampdown on internet porn websites India has ordered Internet service providers to block access to more than 850 adult websites in
users may still view the sites through virtual private networks and proxy servers. He said the move would protect children.
dated last Friday, orders Internet service providers to block access to the 857 sites on grounds of morality and decency.
The Supreme court said earlier in July that ordering a ban on adult websites was not its job
In the past, India has tried to control social media sites like Facebook and Twitter and ask them to take down offensive material.
It also blocked access to a homegrown soft-porn website in 2009. Kaul said more websites may be added to the list of those to be blocke e
#Airbus patents plane that could fly from New york to London in 1 hour A rocket-plane that could fly from Vancouver to Tokyo in three hours instead of 10 has been patented by Airbus. The U s. patent for an"ultra-rapid air vehicle
along with a Youtube video. The feat was accomplished using a system allowing the brain to bypass the injured spinal cord
Building and maintaining offshore wind technology is compared expensive with onshore wind projects because of challenges such as transporting equipment and workers to the sites
Google patents a way for autonomous vehicles to understand hand signals A Google patent has revealed that the firm self-driving cars will be able to detect
Google announced its self-driving cars would be capable of doing this last year, but the latest patent reveals new details about how it would work.
Google algorithms can then decide whether a cyclist is present, and then identify parts of his or her body.
HOW DOES GOOGLE'S AUTONOMOUS CAR WORK? Google's prototype two-seater'bubble'cars have buttons to begin and end the drive,
but no other controls. An onboard computer uses data from sensors, including radar, a laser and cameras,
Under the vision unveiled by Google, passengers might set their destination by typing it into a map
and the ability to self-drive will depend on specifically designed Google road maps tested on the company's current fleet of vehicles.
and will be able to use Google's extended maps service, using GPS technology to locate the vehicle's exact position on an electronic map.
leaving open different possibilities for exactly how Google self-driving cars could work. Google says it begun discussions with most of the world's top automakers in a bid to get self-driving cars on the road by 2020.
In March, a separate patent revealed that Google's self driving car could have airbags both inside and out.
It shows an external airbag system in action that inflates if the car hits a pedestrian or other object.
The head of self-driving cars for Google expects real people to be using them on public roads in two to five years.
and Google would collect data on how they interact with other vehicles and pedestrians. Google is working on sensors to detect road signs and other vehicles,
and software that analyzes all the data. The small, bulbous cars without steering wheels or pedals are being tested at a Google facility in California.
Urmson wouldn't give a date for putting driverless cars on roads en masse saying that the system has to be safe enough to work properly.
He told reporters at the Automotive News World Congress in Detroit that Google doesn't know yet how it will make money on the cars.
Google may face state regulatory hurdles depending on where it chooses to test the cars in public.
Under legislation that Google persuaded California lawmakers to pass in 2012, self-driving cars must have a steering wheel and pedals.
'Computer users who see the message are directed then to a website that shows them how to buy Bitcoins to pay the hackers.
A Youtube video is opened in the background featuring a song used in a fictional radio station in the game Grand Theft Auto V.'We believe that the crypto ransomware uses social engineering techniques as a means of infecting victims'
when a user visits a website, including well-known ones with good security systems, according to technology consultant Greg Miller of CMIT Solutions of Goshen, New york. Once inside the computer,
#Audi, Mercedes and BMW hit back at Google and Appple: Firms buy Nokia's map business in bid to beat tech firms with self driving cars and navigation German carmakers BMW,
known as HERE, clubbing together to keep the assets away from Internet rivals such as Uber of Silicon valley and China's Baidu and Tencent.
their parts suppliers and software rivals like Uber, Google or Apple.''With the joint acquisition of HERE, we want to secure the independence of this central service for all vehicle manufacturers,
'There is a risk that the other automakers will be pushed further into the arms of Google, 'said Richard Windsor an independent financial analyst who tracks major tech players.
'It comes just weeks after Google has admitted it's self driving cars are being hit'surprisingly often'by other drivers
'said Google's Chris Urmson. The three Google employees on board complained of minor whiplash, were checked out at a hospital
and cleared to go back to work following the July 1 collision, Google said. The driver of the other car also complained of neck and back pain.
The simulation shows Google's car being rear ended at 17mph at a junction in Mountain view after stopping at a red traffic lightin a blog post
he says the problem has been common.''Our self-driving cars are being hit surprisingly often by other drivers who are distracted and not paying attention to the road.'
'New data released by Google reveals other drivers have hit the firm's cars 14 times since the start of our project in 2009,
It comes as the latest version of Google's self-driving car-a pod-like two-seater that needs no gas pedal
Google says. The technology giant's mission is to have driverless cars available to consumers in the next five years.'
'Google said.''They're ultimately designed to work without a steering wheel or pedals, but during this phase of our project we'll have safety drivers aboard with a removable steering wheel, accelerator pedal,
And the pod can only drive in areas that have been mapped thoroughly by Google. At first it will likely even have a steering wheel
But Google is lobbying for more flexible regulations. Google will initially build and test 25 pods,
mostly in neighborhoods surrounding its Mountain view headquarters. It will eventually build between 50 and 100,
and will broaden testing to sites that are hillier and rainier. The ultimate goal, says Google cofounder Sergey Brin,
is controlled computer cars that can eliminate human error, which is a factor in an estimated 90 percent of the 1. 2 million road deaths that occur worldwide each year.
Google shocked the auto industry in 2010 with its announcement that it was working on a driverless car.
Brin insists Google doesn't aspire to be a car company, but wants its technology to be adopted by automakers.'
Chris Urmson, who directs Google's self-driving car project, says the slow-moving, friendly looking prototype-his young son thinks it looks like a koala because of the nose-like black laser on the front-is a good bridge between the company's current test fleet of 20 specially outfitted Lexus SUVS
Earlier this week, in response to questions from The Associated press, Google acknowledged 11 minor accidents in the six years it has been testing autonomous cars.
and notes that Google's vehicles have completed more than 1. 7 million miles of testing. He says all but one of the accidents were caused by drivers in other cars;
in the only incident caused by a Google car, a staffer was driving in manual mode.
Urmson says Google needs to do a better job of educating people about self-driving technology and updating them on Google's progress.
and the site will feature a monthly report that will include details of any accidents involving Google cars.
The site will also have a section where people can send feedback when they interact with the cars.
The prototype cars-assembled in suburban Detroit by Roush Industries-have the same array of radars, lasers and cameras as Google's fleet of Lexus SUVS,
the head of software for the self-driving car project, says Google's software has gotten much better over the last year at classifying objects, like trees and mailboxes,
For example, Google's cars will slow down if they sense that a car in the next lane is speeding up to cut in front of them.
And in one recent test, a Google car paused when a cyclist ran a red light.
one of Google's Lexus SUVS seemed momentarily confused when a mail truck partially blocked its path.
Later, during a demonstration drive in Google's parking lot, the prototype-without a wheel or pedal-braked
like the time a Google SUV stopped and waited while a woman in a wheelchair chased a duck with a broom.
Google isn't alone in developing self-driving cars. Mercedes-benz Infiniti and other brands already have advanced driver assistance systems, like lane keeping and adaptive cruise control,
Unlike Google, automakers think self-driving cars will arrive feature-by-feature instead of all at once, giving people plenty of time to adapt to autonomous driving.
says Google's'moon shot'strategy is difficult and riskier than just adding features to existing cars.
Google could make self-driving urban pods for universities or urban centers, for example, or sell its technology to automakers.
can be ordered pre on Neuroon's website for $299 (£195) and will be shipped internationally after the initial run is processed.
'The Neuroon website also lets users calculate when they should seek and avoid light during their stay by using their origin location,
Both Google and Nasa have been developing a quantum computer as part of their artificial intelligence work. However their D-Wave quantum computer needs to be kept at temperatures of around-273°C(-459°F). The latest research by Professor Dzurak and his colleagues,
They have applied their new technique to two super-eruption sites and a pair of very large eruptions and found that it took them no more than 500 years to move from formation to eruption.
We found the toothbrush for as low as $35 on ebay and for only $14 on Amazon.
Researchers at Switzerland Ecole Polytechnique Federal de Lausanne are also testing a low-carbon cement that could reduce the carbon footprint of construction sites by 40 percent, Forbes reported last year s
and designed to meet stringent groundwater standards at contaminated sites. Regenesis says the substrate reduces harmful chemicals and toxins,
This includes reducing chlorinated solvents at industrial dry cleaning sites as well as petroleum cleanup projects. Plumestop is composed of very fine particles of activated carbon (1-2 m) suspended in water through the use of unique organic polymer dispersion chemistry.
to identify the sites in the alpha-B-crystallin that attach to the beta-amyloid. It is the first direct structure analysis of a complete heat shock protein during interaction with a bonding partner,
which binds to an amino acid sequence of the prion protein, known as'fifth copper binding site,
opening the way for the development of new drugs targeting this copper binding site, and thus for new potential treatments".
which cells are transplanted into the injury site, "says research supervisor Dr James St john, from Griffith's Eskitis Institute for Drug Discovery.
and better integrate into the injury site. In turn, this will help the spinal cord to regenerate more effectively."
In the early 2000s, Maria's group had pioneered the single-atom approach for metals anchored on oxide supports as the exclusive active sites for the water-gas shift reaction to upgrade hydrogen streams for fuel cell use.
While an Apple patent for wireless earbuds with bone conduction popped up recently on the USPTO website
they only attach at certain putative sites. On the other hand, ubiquitins have a subtle trick up their sleeves they can tag other tags.
not just FX,"said the head of Travelex's new digital team, former Google and e-Harmony executive Sean Cornwell."
Ola due to high encryption codes, say ISPS Dot had issued a letter to Internet service providers (ISPS) asking them to block websites of taxi operators Uber,
However, websites are still accessible to all. ISPS now say they are unable to block taxi aggregator websites Ola and Uber due to high encryption codes.
ISPS can only block http sites and not https as the latter have higher encryption. This means they can block Taxiforsure,
but not Ola and Uber. hese sites can not be blocked because of technical issues. We have given already representation to government earlier.
This was a general representation. We are giving compliance except in https sites, Internet Service Providers Association of India (ISPAI) President Rajesh Chharia said.
He added that Dot had accepted itself that there was a need to set up a committee to discuss modalities around blocking of https sites around 3-4 months back.
The Delhi government had written to the Department of Electronic & Information technology (Deity) in March that despite the ban, Uber,
Among the other feasible applications for the transistors is better power electronics for data centres run by Google
#Google Project Ara modular smartphone delayed to 2016 Google had announced earlier this year, that it will unveil the modular smartphone in Puerto rico as part of a pilot program that will allow people to choose their own hardware based on their needs and interests.
Looks like, amidst the all new structuring happening at Google, the modular device will have to wait until next year.
on day 2 of the Google I/O developers conference, at the ATAP keynote, Google engineer Rafa Camargo assembled a Project Ara phone as part of a live demo,
Google, known by its employees for frequent eorgs announced a major shake up with the holding company Alphabet.
Google, Google X and other products now become subsidiary of the parent company. Toshiba has teamed up with Gujarat-based Einfochips to provide chips for Google Project Ara.
The camera modules will be made available in both 5mp and 13mp versions, and a 2mp front-facing module is also in the works.
Nestlé unveiled its first'zero water'manufacturing site in the"water-stressed"Mexican state of Jalisco in October 2014.
Nestlé immediately started to look for other sites where we would apply the technology, "the Nestlé spokesperson said."
For starters, there are more than 700 different crowdfunding sites online, providing platform-level support for whatever kind of campaign you might have in mind.
And the other authors are Di-Yan Wang (Stanford), Mingyun Guan (Stanford), Michael Angell (Stanford), Changxin Chen (Stanford), Jiang Yang (Stanford) and Bing-Joe
which is joint venture among NRG ENERGY, Google and Brightsource energy. That project takes 173,000 mirrors and focuses the sunlight to the plant solar receiver steam generator,
#EU Formally Accuses Google Of Market Abuse, Opens Probe Into Android The European union competition chief formally laid down the gauntlet to Google on Wednesday,
accusing it of market dominance in web searches, particularly around online shopping. It also opened a formal investigation into
whether its Android operating system unfairly favored its own apps. would like to hear what Google has to say for itself,
said Margarethe Vestager, the EU competition commissioner at a press conference in Brussels on Wednesday. he Statement of Objection is not the end.
Wel take in the response of Google and decide how to proceed. Wee not here to take the side of rivals.
Google wrangle with the EU over search results has been going on for five years, but the formal Statement of Objections is a landmark step.
who was criticized by some for not taking a stronger stance with Google. Almunia was replaced by Vestager late last year.
The next step is for Google to formally answer the EU Statement of Objection, which at its core accuses Google of favoring its own shopping services over those of third parties like Tripadvisor, Microsoft and Streetmap,
who filed their complaints with the EU back in 2010. If Google and the Commission cannot reach a settlement
and the case reaches the European High court, it could not only drag on for several more years
but see Google fined 10%of its annual revenues. At 2014 levels that would be $6. 6 billion.
Some might argue that Google as a private company should have the freedom to organize search results how it wants
who added that she considered Google to be lose to a monopoly. Google sent a memo to its employees yesterday showing charts from Comscore and its own internet analytics
saying the Statement of Objections was isappointing news. But, it added, e have a very strong case. t
#EU v. Google: What Each Side Is Saying The European union on Wednesday formally accused Google of abusing its dominant power in web search in violation of antitrust laws.
The action is potentially the most significant antitrust case in the tech industry since regulators on both sides of the Atlantic tangled with Microsoft beginning in the late 1990s
It could force Google to pay billions in fines or to alter the way it presents search results.
Specifically, the European commission said that Google's GOOGL+0. 35%promotion of its own comparison shopping search function may rtificially divert traffic from rival comparison shopping services
which has been investigating Google search practices for about 5 years, detailed its concerns, known as a Statement of Objections,
on Google comparison shopping service here. The accusations did not extend to other areas of search,
like reviews and travel that Google rivals like Yelp YELP+3. 14 %and Tripadvisor TRIP+0. 57%had complained about.
whether Google has violated European antitrust laws with its Android operating system and related mobile services. The commission said it is concerned that Google may have hindered market access to rival mobile apps by pushing Android phone makers to pre-install its suite of mobile services
which include search, maps, Google Drive and the Play store. It also said it is concerned Google may have hindered market access to makers of modified versions of Android.
The commission full concerns on Android are detailed here. Google put out a vigorous defense. In a blog post, Google search chief Amit Singhal said that people have more search choices today than ever before,
and that competition among shopping search engines is thriving. ndeed if you look at shoppingn area where we have seen a lot of complaints
and where the European commission has focused in its Statement of Objectionst clear that (a) there a ton of competition (including from Amazon and ebay EBAY+0. 58%,
%two of the biggest shopping sites in the world) and (b) Google shopping results have not the harmed the competition,
Singhal wrote. In a separate blog post, Hiroshi Lockheimer, an engineering vice president for Android, rebutted the commission concerns regarding Google mobile operating system. ndroid has been a key player in spurring this competition and choice, lowering
prices and increasing choice for everyone, Lockheimer wrote. Google will now has 10 weeks to respond to the commissions charges.
The commission will then evaluate those responses and potentially recommend remedies e
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