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www.npr.org 2015 0000181.txt

#Researchers Create Artificial Organs That Fit in Your Hand Great balls of cells! Scientists are developing mock human organs that can fit in the palm of your hand. These organs-on-a-chip are designed to test drugs and help understand the basics of how organs function when they are healthy and when they are diseased. For instance, you have your gut-on-a-chip being developed at the Johns Hopkins School of medicine. It's a high-tech approach to dealing with a scourge of the low-tech world.""I'm interested in solving a worldwide problem of diarrheal diseases, "says Dr. Mark Donowitz, who runs this lab. He says 800,000 children a year die from these diseases notably cholera, rotavirus and certain strains of E coli.""We've failed so far to find drugs to treat diarrhea using cell culture models and mouse intestine, "Donowitz says. Mice simply don't react the way we do to these germs, so they aren't very helpful for studying diseases of the gut. So Donowitz's team is building what it hopes will be a much better way to study these diseases: the gut-on-a-chip. Truth be told, there's not a lot to see. Postdoctoral researcher Jennifer Foulke-Abel holds one in the palm of her hand. It's a thin sheet of glass, topped with a plastic microscope slide and a tiny cavity inside. Half a dozen spaghetti-size tubes bristle from the device.""The reason there are so many tubes is we have a vacuum chamber that will cause the membrane to stretch, the way the intestine stretches as it moves food along, "Fouke-Abel explains. Cells plucked from a human intestine will be put into a tiny chamber around that membrane, and they will divide, grow and even organize themselves much as you would find them in human guts. The device, when operating, might hold 50,000 gut cells. Step 1 in this research is to see whether cells in the ersatz organ react the same way to diseases as do cells in the human gut.""And in all three of the diseases I mentioned, we've been able to take that first step, "Donowitz says.""So we know that these appear to be really good models of the human disease.""Still, it's a work in progress. The guts-on-a-chip produce digestive enzymes, hormones and mucus, but they don't yet incorporate other parts of the human intestine, such as blood vessels or nerve cells.""They all have to be incorporated if you want to move from a simple to a more complex system, which I think you need to do if you are going to reproduce intestinal biology, "Donowitz says. This lab is moving in that direction. And once it has a complete system built, one use will be to test potential drugs for the diseases being studied.""We think this could be a real step forward in terms of reducing waste-of-time drug development, "Donowitz says. While this lab at Johns Hopkins is working to develop the gut, other labs scattered around the country are working on other organ systems e

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