the discovery opens new lines of inquiry about the Ash1l gene's potential role in cancers known to involve other members of the same gene family,
The Ash1l (Absent, small or homeotic 1-like) gene is part of a family of genes that includes MLL1 (Mixed Lineage Leukemia 1),
#Shape-shifting molecule tricks viruses into mutating themselves to death A newly developed spectroscopy method is helping to clarify the poorly understood molecular process by
"The researchers used summary statistics from genome-wide association studies of more than 200,000 individuals, looking for overlap in single nucleotide polymorphisms (SNPS) associated with clinically diagnosed AD and CRP and the three components of total cholesterol:
They found up to a 50-fold enrichment of AD SNPS for different levels of association with CRP, LDL, HDL and TG, which then lead to identification of 55 loci--specific locations on a gene,
#New transitional stem cells discovered Preeclampsia is a disease that affects 5 to 8 percent of pregnancies in America.
Complications from this disease can lead to emergency cesarean sections early in pregnancies to save the lives of the infants and mothers.
meaning that all the cells in the culture are quite similar to each other in the way they express their genetic information."
human health or quality of life are generated, "said the Mexican firm. The corporation has a pilot plant in their offices that was used to demonstrate the purification process,
and Ludwig Memorial Sloan Kettering (MSK)' s Jedd Wolchok has found that the combination of two immunotherapies for first-line treatment of advanced melanoma induces better responses
and nivolumab against ipilimumab alone in previously untreated patients, were presented today at the 2015 Annual Meeting of the American Association for Cancer Research
Notably, three of the deaths in the combination group were determined to have been combined related to the therapy."
The disease is the most common chronic neurological disorder among young adults, and results from aberrant immune cells destroying the protective coating, called myelin, around nerve cells in the brain and spinal cord.
or their families feel they cannot wait for the development of specific approved medications, "Tesar said,
gaming systems, and televisions may all be connected to the internet, increased bandwidth would eliminate problems like video streaming that stalls and buffers.
being presented as part of a poster presentation at the Annual Meeting of the American Association for Cancer Research (AACR) being held in Philadelphia,
#Researchers add a new wrinkle to cell culture Using a technique that introduces tiny wrinkles into sheets of graphene,
"We've shown that you can make textured environments for cell culture fairly easily using graphene."
"Traditionally, cell culture in the lab has been done in petri dishes and on other flat surfaces. But in the body, cells grow in considerably more complex environments.
that were obtained from local fertility clinics. However the work is very controversial, with some warning it could be the start of a slippery slope towards designer babies.
Then, combining that tissue-specific functional signal with the relevant disease's DNA-based genome-wide association studies (GWAS),
the researchers were able to identify statistical associations between genes and diseases that would otherwise be undetectable.
which they called a'network-guided association study, 'or Netwas, thus integrates quantitative genetics with functional genomics to increase the power of GWAS
and pathways, permitting discovery of novel associations. SCDA director Leslie Greengard says, "Olga and her collaborators have demonstrated that extraordinary results can be achieved by merging deep biological insight with state-of-the-art computational methods,
#New material for creating artificial blood vessels Arteriosclerotic vascular disorders are one of the most common causes of death in industrialized countries.
A new report published in the Journal of the American Association for Pediatric Ophthalmology and Strabismus (AAPOS) describes the effectiveness of a new computer-based vision-screening test, the Jaeb Visual acuity Screener (JVAS),
With them, it's like finding a needle in the fountain outside the Nebraska Union.
One-shot learning was apparent in cases where participants made an association between an image and an outcome after a single pairing.
and stimulate cell death if the damage cannot be repaired. Moffitt researchers found that SIRT1 is modified by a process called ubiquitination, in
leading to either DNA repair or cell death. The researchers performed studies to determine how ubiquitin modification changes SIRT1 function.
If cells are exposed to a drug called etoposide, SIRT1 ubiquitination blocks cell death. However, if cells are exposed to oxidative stress,
SIRT1 ubiquitination promotes cell death. These results are important because they increase scientists'understanding of how proteins and cells function,
#Percentage of Texans without health insurance drops dramatically The report found that from September 2013 to March 2015, the percentage of uninsured adult Texans ages 18-64 dropped from 25 to 17 percent."
and age groups, including younger adults.""Despite this improvement, Texas remains the state with the highest percentage of people without health insurance,
since 2013 primarily because the ACA Marketplace allows households above the federal poverty level to buy health insurance using subsidies.
The Health Reform Monitoring Survey (HRMS) is a quarterly survey of adults ages 18-64 that began in 2013.
Director of the Sbarro Institute for Cancer Research and Molecular Medicine, at Temple University, Philadelphia a
#New test predicts sudden cardiac death in hemodialysis patients ICNC is organised by the Nuclear Cardiology
and Cardiac CT section of the European Association of Cardiovascular Imaging (EACVI), a registered branch of the European Society of Cardiology (ESC), the American Society of Nuclear Cardiology (ASNC),
and the European Association of Nuclear medicine (EANM). ICNC 12 is held 3 to 5 may 2015 in Madrid, Spain.
"Hemodialysis patients are increased at risk of sudden cardiac death because they often have latent ischaemic heart disease
to predict the risk of sudden cardiac death in hemodialysis patients. All 3 methods were performed at rest.
20 sudden cardiac deaths occurred. Patients who suffered sudden cardiac death were more likely to have abnormal BMIPP scintigraphy,
abnormal Q wave and a greater C reactive-protein protein level compared to patients who did not experience sudden cardiac death.
There were no differences between the 2 groups in other clinical, laboratory or hemodialysis parameters. Taken on their own, patients with a BMIPP score greater than 16 had an 11-fold increased risk of sudden cardiac death,
while an abnormal Q wave conferred an 18-fold increased risk, and A c-reactive protein level greater than 2. 38 mg/dl predicted a 7-fold increased risk.
Patients with 2 or 3 of the predictors had a sudden cardiac death risk that was 145 times greater than patients with normal levels on all 3 measures.
"The most powerful way to predict sudden cardiac death was to combine the measures. Hemodialysis patients who had 2
In hemodialysis patients, abnormal uptake of BMIPP has an independent and incremental value in the prediction of sudden cardiac death in combination with C reactive-protein protein and Q wave.
"For the first time there is a way to predict sudden cardiac death in hemodialysis patients. In a clinical setting, BMIPP scintigraphy can be used in hemodialysis patients who are identified as high risk by abnormal Q wave and increased C reactive-protein protein.
which could be an effective therapeutic target for preventing sudden cardiac death.""He concluded:""Further diagnostic tests should be considered in high risk patients with abnormal BMIPP scintigraphy.
and help physicians select a prophylactic therapeutic strategy against sudden cardiac death in hemodialysis patients."
#New test predicts sudden cardiac death in hemodialysis patients ICNC is organised by the Nuclear Cardiology
and Cardiac CT section of the European Association of Cardiovascular Imaging (EACVI), a registered branch of the European Society of Cardiology (ESC), the American Society of Nuclear Cardiology (ASNC),
and the European Association of Nuclear medicine (EANM). ICNC 12 is held 3 to 5 may 2015 in Madrid, Spain.
"Hemodialysis patients are increased at risk of sudden cardiac death because they often have latent ischaemic heart disease
to predict the risk of sudden cardiac death in hemodialysis patients. All 3 methods were performed at rest.
20 sudden cardiac deaths occurred. Patients who suffered sudden cardiac death were more likely to have abnormal BMIPP scintigraphy,
abnormal Q wave and a greater C reactive-protein protein level compared to patients who did not experience sudden cardiac death.
There were no differences between the 2 groups in other clinical, laboratory or hemodialysis parameters. Taken on their own, patients with a BMIPP score greater than 16 had an 11-fold increased risk of sudden cardiac death,
while an abnormal Q wave conferred an 18-fold increased risk, and A c-reactive protein level greater than 2. 38 mg/dl predicted a 7-fold increased risk.
Patients with 2 or 3 of the predictors had a sudden cardiac death risk that was 145 times greater than patients with normal levels on all 3 measures.
"The most powerful way to predict sudden cardiac death was to combine the measures. Hemodialysis patients who had 2
In hemodialysis patients, abnormal uptake of BMIPP has an independent and incremental value in the prediction of sudden cardiac death in combination with C reactive-protein protein and Q wave.
"For the first time there is a way to predict sudden cardiac death in hemodialysis patients. In a clinical setting, BMIPP scintigraphy can be used in hemodialysis patients who are identified as high risk by abnormal Q wave and increased C reactive-protein protein.
which could be an effective therapeutic target for preventing sudden cardiac death.""He concluded:""Further diagnostic tests should be considered in high risk patients with abnormal BMIPP scintigraphy.
and help physicians select a prophylactic therapeutic strategy against sudden cardiac death in hemodialysis patients
The comparison involved the normal and tumor genomes from 43 children and adults with brain tumors, leukemia, melanoma and the pediatric eye tumor retinoblastoma."
"In this study of the tumor and normal genomes of 43 patients, CONSERTING identified copy number alterations in children with 100 times greater precision and 10 times greater precision in adults."
and have immediate practical application in associations of farmers and agrifood companies m
#Sensor detects spoilage of food VTT has developed a sensor that detects ethanol in the headspace of a food package.
#3d'organoids'grown from patient tumors could personalize drug screening Three-dimensional cultures (or'organoids')derived from the tumors of cancer patients closely replicate key properties of the original tumors,
These'organoid'cultures are amenable to large-scale drug screens for the detection of genetic changes associated with drug sensitivity
In recent years, scientists have developed organoid cell culture systems as an alternative approach to grow normal and diseased tissue in a dish.
whether these cultures could potentially bridge the gap between cancer genetics and patient outcomes. In the new study, the researchers grew 22 organoids derived from tumor tissue from 20 patients with colorectal cancer
and then sequenced genomic DNA isolated from these cultures. The genetic mutations in the organoid cultures closely matched those in the corresponding tumor biopsies and agreed well with previous large-scale analyses of colorectal cancer mutations.
These findings confirm that the cultures faithfully capture the genomic features of the tumors from
which they are derived as well as much of the genomic diversity associated with colorectal cancer. To link drug sensitivity to genetic changes,
In validation of the approach, the researchers identified previously reported associations between specific mutations and resistance to particular drugs.
The organoids also revealed a novel gene-drug association, indicating that the subset of cancer patients with RNF43 mutations would strongly benefit from a drug that inhibits a protein called porcupine."
people at higher risk of developing the disease include those with a family history of pancreatic cancer, heavy smokers, the obese and people over 50 years with new-onset diabetes.
The team discovered that the gene coding for the MOCOS (Molybdenum Cofactor Sulfurase) enzyme was expressed under in stem cells from nine out of eleven of the ASD adults studied.
which has frequently been observed in autistic children, its association with gastrointestinal diseases --which often accompany autistic disorders
"Nusse's lab at Stanford focuses on a family of proteins of called Wnts, which are key regulators of stem cell fate.
lips and eyes--to alter their facial expressions in a variety of social situations. The findings, published in PLOS ONE today (05 august 2015),
and it was seen by some as a black sheep of the transition metal dichalcogenides TMD) family and purposefully ignored.
See fabricated a novel 1mm device (aka Robot Man) made of yellow photonic crystal-enhanced QDS.
"Until our study, we didn't really know how sulfur atoms are incorporated into a natural product--now we have discovered a new family of enzymes
"The study links a family of enzymes--molecules that act as biological catalysts--known as polyketide synthases (PKS) directly to a complex series of chemical reactions that ultimately add sulfur to leinamycin, a member of the polyketide family of natural products."
one of the co-first authors of the study and a member of the Shen lab."Since polyketide synthases are a large family of enzymes that have been proven amenable for polyketide structural diversity and drug discovery,
#Device may detect urinary tract infections faster Sepsis is a major killer and accounts for about half of the hospital deaths in the US by some estimates.
Bukau, the co-chaperones of the so-called J-protein family are key, in that they"lure"the Hsp70 folding helpers to the protein aggregates
A preliminary test of the assay on blood samples and some skin samples from 29 participants from families with inherited heart disease validated the clpp approach
We also find that several of his family members have similar heart conditions. So if we run the new genetic test
and find the man's illness has a genetic cause, such as dilated cardiomyopathy, we now have both a cause and a diagnosis,
and family with whom they live and work and readily distinguish those allies from strangers.
and an impressive collection of odorant receptors--ants have the largest odorant receptor gene family known in insects,
Scripps Family Chair Professor of Chemistry, described such a feat. But Lerner's team reasoned that a selection-based design of these junctions would be a more general approach to making useful protein-in-protein molecules.
exactly what will become of these new families of 2-D materials we've discovered,
and preventing HIV more difficult, leading to sicker patients and more deaths. In turn, once someone is infected with HIV,
The trial, conducted over one year at two Family AIDS Care & Education Services (FACES) health facilities in the Nyanza region in Kenya, enrolled 72 participants at one facility for the intervention
The study found that patients who received the device had significantly lower mortality than heart valve patients who underwent open-heart surgery.
Aortic stenosis can lead to heart failure and death. About 100,000 people in the United states have aortic stenosis a
Chemical analysis of these insoluble deposits reveals that they are made up of a family of short protein fragments,
An international team of researchers led by Christian Haass (Professor of Metabolic Biochemistry at LMU and Speaker for the German Center for Neurodegenerative Diseases in Munich) and Dr. Michael Willem (LMU) has made now a discovery
and an international team of colleagues report that a misfolded version of a protein called alpha-synuclein seems to act in a similar way to transmit MSA from diseased human brain tissue to mice and to human cell cultures.
Both MSA and PD can arise sporadically in families with no history of the disease,
Woerman led a research team in the development of a rapid new method to test prion transmission using human cell cultures.
Arrayin 2004, professor Petter Strømme examined a child with congenital cataract, growth delay and symptoms from the brain, the peripheral nervous system,
#Completely paralyzed man voluntarily moves his legs, scientists report A 39-year-old man who had had been paralyzed completely for four years was able to voluntarily control his leg muscles
In addition to the robotic device, the man was aided by a novel noninvasive spinal stimulation technique that does not require surgery.
me, having spent my whole adult life before breaking my back as an athlete.""Even in the years since he lost his sight,
and quality of life,"said V. Reggie Edgerton, senior author of the research and a UCLA distinguished professor of integrative biology and physiology, neurobiology and neurosurgery.
he now believes it is possible to significantly improve quality of life for patients with severe spinal cord injuries,
a disease that the World health organization estimates was responsible for 584,000 deaths in 2013, along with an estimated 198 million new cases in that span of time.
sequenced the genomes of more than 100 members of a Colombian family affected with early-onset Alzheimer's.
when the mutation so powerfully determines the early age at onset in most of the family members?
Human culture stems from knowledge acquired through society's shared experience. Cultural transmission enables new members of society to quickly learn from this accumulated experience.
which infects 50 million people and causes 40,000-110,000 deaths via severe diarrhea worldwide.""Chelsea is a fearless experimenter.
Then they challenged these cultures with the parasite E. histolytica.""We do this all the time in cancer research,
E. histolytica decimated many thousands of these independent cell cultures. However, a small number of cells seemed to resist the parasite.
Over these generations of selection, we saw the cultures becoming more and more enriched for cells lacking specific genes."
A follow-up experiment showed that new intestinal cells treated with E. histolytica showed potassium efflux--the flow of potassium from inside a cell out through the cell wall--directly before cell death."
"The parasite was causing potassium efflux right before cell death and cells that happened to be unable to transport potassium didn't die."
"This is a major finding with translational implications for this infection that causes so many deaths worldwide, but also proof that this cancer-science approach can be used to explore genetic mechanisms of resistance in the field of infectious disease,
mortality due to disease can be prevented by manipulating characteristics of the host t
#Super-stretchable metallic conductors for flexible electronics Washington state University researchers have discovered how to stretch metal films used in flexible electronics to twice their size without breaking.
#New molecule found to prevent preterm birth Premature births are linked intimately with inflammation of the uterine tissue, a biological response
which is the world's leading cause of infant death and the origin of potentially severe,
The research team is looking forward for tests to be able in a near future that will be able to predict the preterm delivery risk of a woman,
937 deaths in the U s. Although current infection rates are declining, the majority of these deaths, about 8,
but showed extensive association with microglia--mobile cells that surround and protect neurons. Another example of Scales's practical application came from examining the 3d positions of active microglial cells and amyloid beta plaques.
a detailed 3d reconstruction and analysis using Scales clearing showed that association with active microglial cells occurs early in plaque development,
and seriously improve the quality of life by reducing carbon emissions from fossil fuels and encourage efficient use of resources."
and prevents cellular death. The authors first discovered that an enzyme related to HSD10, Csga, produces energy during sporulation in the bacterium Myxococcus xanthus.
or cell death. HSD10 activity is inhibited strongly when bound to the amyloid beta peptide so prevalent in Alzheimer's disease."
"But with rampant oxidative stress leading to uncontrolled cellular death, you end up with diseases such as Alzheimer's and Parkinson's.
Mooney--who is also the Robert P. Pinkas Family Professor of Bioengineering at the Harvard John A. Paulson School of engineering
As of now, transplanted cell death remains a major challenge. To improve the therapeutic ability of transplanted stem cells,
Cancer cachexia impairs quality of life and response to therapy, which increases morbidity and mortality of cancer patients.
Currently, there is no approved treatment for muscle wasting but a new study from the Research Institute of the Mcgill University Health Centre (RI-MUHC) and University of Alberta could be a game changer for patients, improving both quality of life and longevity.
The research team discovered a new gene involved in muscle wasting that could be a good target for drug development.
In all of these chronic conditions, muscle wasting predicts earlier death.""Cancer patients often present with muscle wasting even prior to their initial cancer diagnosis,
not only can we potentially improve the quality of life of patients, but also allow them to better tolerate their oncological treatments, to stay at home for a longer period of time,
The quantum lab on tour through Austria Currrently, a light version of the virtual lab can be experienced as an interactive exhibit in the special exhibition"Das Wissen der Dinge"in the Natural history Museum Vienna.
-H in cell lines, primary neuron cultures and zebrafish using molecular genetics, protein biochemistry and high speed imaging.
#Novel role of mitochondria identified in immune function Scientists at The Scripps Research Institute (TSRI) have discovered a new role for an enzyme involved in cell death.
Talking to the Immune system Previous studies have shown RIPK3 controls the induction of a type of programmed cell death, called necroptosis,
Patricia A. Martin-Deleon, a reproductive biologist at the University of Delaware, has witnessed this behavior many times in her studies of fertility in mice, the closest genetic model to humans (and with a much faster reproductive cycle.
The research, supported by the National institutes of health-National Institute of Child Health and Human Development and the Delaware INBRE program, is published in the Journal of Biological Chemistry.
disappointing reality that they can't have a child of their own. Even when the process works, a high sperm-to-egg ratio is required, the opposite of
"That gives us hope they can be used as vehicles for improving fertility and the chances of producing healthy embryos and offspring."
-H in cell lines, primary neuron cultures and zebrafish using molecular genetics, protein biochemistry and high speed imaging.
and then trigger a specific response, such as cell death. This system can be customized to detect any DNA sequence in a mammalian cell
and then produce transcription factors that would activate the cells'own programmed cell death pathways. Research tool The researchers are now adapting this system to detect latent HIV proviruses
Cells that did not receive the new gene could be induced to undergo cell death creating a pure population of the desired cells.
The Canadian Diabetes Association reports that more than 20 Canadians are diagnosed newly with the disease every hour of every day.
It is also the seventh leading cause of death in Canada, with associated health-care costs estimated at nearly $9 billion a year.
"Without access to this critical tissue through the Alberta Diabetes Institute Isletcore and the generosity of organ donors and their families, we would not have been able to carry out this study,
an aging population and heightened awareness of the disease stemming from the 2011 death of Apple Inc. cofounder Steve jobs. Zajac-Kaye's group discovered that a single protein is behind the process that allows pancreatic neuroendocrine tumors to thrive.
and induced the death of pancreatic cancer cells. Researchers then tested its effectiveness on human pancreatic cells that had been implanted in mouse models.
Metastases cause the vast majority of cancer deaths, but their tiny seeds are so difficult to track that few researchers have managed to study them.
despite the fact that it causes virtually all breast cancer deaths. Previous work by Werb's group had found a subset of cells at the edges of breast cancer tumors that seemed primed to metastasize.
undifferentiated state and relatively immune to cell death, which the researchers surmised might help metastatic colonies survive in new and hostile environments.
Also, each family of bacteriophages can have a different genome organization and life cycle, making it difficult to engineer them
The MIT team began with a phage from the T7 family that naturally kills Escherichia coli.
and characterization of atomically thin 2d hybrid perovskites and introduces a new family of 2d solution-processed semiconductors for nanoscale optoelectronic devices, such as field effect transistors and photodetectors."
The application of the CRISPR-Cas9 system for mammalian genome editing was reported first in 2013, by Zhang and separately by George Church at Harvard.
or death in the cabozantinib arm as compared with the everolimus arm. Regaining tumour control after prior targeted therapy may reduce symptoms related to kidney cancer
Bakir's group has demonstrated the fabrication of copper vias that would run through the silicon columns that are part of the cooling structure fabricated on the FPGAS.
fabricated high aspect ratio copper vias through the silicon columns, reducing the capacitance of the connections that would carry signals between chips in an array."
"The findings are particularly significant in the light of improving life expectancies and the associated increase in cases of ARMD.
Risk Factors for Cardiovascular disease Approximately 610,000 people die from heart disease every year in the United states--that's one of every four deaths.
These modifiable risk factors include high blood pressure, high cholesterol, obesity, physical inactivity, diabetes, unhealthy diets and smoking.
or the size and position of the fetus in a pregnant woman, to mention a few examples.
Trib1 is part of the protein family Tribbles which play diverse roles in cell signalling and development.
From River Besòs sediments, after three years'research, the researchers have obtained a stable bacterial culture
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