and carry payloads of pharmaceutical drugs to targeted tissues. However, when usual methods to produce carbon nanoparticles are rather complex
They used spectroscopy to confirm the formulation as well as visualize the delivery of the particles and drug molecules.
The experiment showed that the carbon nanoparticles did not release the drug payload at room temperature
They began to release the anticancer drug only at body temperature. Scientists also found that they can alter the infusion of the particles into melanoma cells by adjusting the polymer coatings.
Study showed that cancer cells were affected positively by drugs delivered by these carbon nanoparticles. These carbon nanoparticles,
They can be used to carry a variety of different drugs into a human body. It is a very versatile platform to treat melanoma, other kinds of cancers and other diseases.
as well as to make it carry several different drugs at the same time to allow for a multidrug therapy with the same particles.
and tune them to release the drugs in the presence of the cellular environment. This is a great achievement,
which will eventually lead to innovative drug therapies for cancer and other diseases i
#Access to electricity and artificial light shortened time of our sleep Science knows that nowadays people tend to sleep less than they used to before modern times.
#Nanowire implants offer remote-controlled drug delivery A team of Purdue University researchers developed a new implantable drug-delivery system using the nanowires,
which can be controlled wirelessly to release small amounts of a drug payload. A team of researchers has created a new implantable drug-delivery system using nanowires that can be controlled wirelessly.
The nanowires respond to an electromagnetic field generated by a separate device, which can be used to control the release of a preloaded drug.
The system eliminates tubes and wires required by other implantable devices that can lead to infection and other complications,
Purdue University Mari Hulman George Professor of Applied Neuroscience and director of Purdue Center for Paralysis Research. his tool allows us to apply drugs as needed directly to the site of injury,
but it is our hope that this could one day be used to deliver drugs directly to spinal cord injuries, ulcerations, deep bone injuries or tumors,
or chemotherapy. he team tested the drug-delivery system in mice with compression injuries to their spinal cords
The nanowires can be loaded with a drug and when the correct electromagnetic field is applied, the nanowires release small amounts of the payload.
The magnitude and wave form of the electromagnetic field must be tuned to obtain the optimum release of the drug
and the precise mechanisms that release the drug are understood not yet well, she said. The team is investigating the release process.
The electromagnetic field is likely affecting the interaction between the nanomaterial and the drug molecules, Borgens said. e think it is a combination of charge effects
and release drugs, he said. t is a reversible process. Once the electromagnetic field is removed, the polymer snaps back to the initial architecture
and retains the remaining drug molecules . or each different drug the team would need to find the corresponding optimal electromagnetic field for its release,
Gao said. This study builds on previous work by Borgens and Gao. Gao first had to figure out how to grow polypyrrole in a long vertical architecture,
which allows it to hold larger amounts of a drug and extends the potential treatment period.
Functional Drug Delivery Using Electromagnetic field-Responsive Polypyrrole Nanowires, was published in the journal Langmuir. Other team members involved in the research include John Cirillo,
In addition, the concentration of drug maintained during treatment is known not because it is below the limits of systemic detection,
very small dose of a drug to effectively serve as a big dose right where you need it,
Borgens said. y the time the drug diffuses from the site out into the rest of the body it is in amounts that are undetectable in the usual tests to monitor the concentration of drugs in the bloodstream. olypyrrole is an inert and biocompatable material,
which the drug delivery device will work. The current system appears to be limited to a depth in tissue of less than 3 centimeters
Human calcineurin is already a proven target for drugs treating other illnesses including adult rheumatoid arthritis and lupus,
John Laporte Given Professor of Immunology and Infectious diseases. s drug resistance is a major problem for malaria control and eradication,
it is critical that that we continue to develop new antimalarials that act against previously unexploited targets in the parasite to keep priming the drug pipeline.
said lead author Aditya Paul, a postdoctoral researcher at the Harvard Chan School. n addition to a possible drug target,
The fifth column is implanted an bit of genetic code that sits idle until a certain drug enters the cell.
Gene therapy is not a drug, but a transfer of human genes. Gene therapy refers to the incorporation of new DNA into cells,
CEO of Nightstarx. e have been granted orphan drug designation for the product in the United states and Europe,
a drug that affects the genetic material of cells and inhibits cell division when administered in high doses,
then by using special methods of drug delivery you can program the death of the affected cells Vasily Studitsky concluded,
adding that the process of development and testing of such drugs, of course, requires considerable time n
and a drug-screening tool to make pregnancies safer. In experiments to be published Tuesday, July 14, in the journal Nature Communications,
a senior investigator at the Gladstone Institute of Cardiovascular disease and a professor of medical genetics and cellular and molecular pharmacology at UC San francisco. his technology could help us quickly screen for drugs likely to generate cardiac birth defects,
which drugs are dangerous during pregnancy. Screening for drug toxicity To test the potential of the system as a drug-screening tool,
the researchers exposed the differentiating cells to thalidomide, a drug known to cause severe birth defects.
They found that at normal therapeutic doses the drug led to abnormal development of microchambers, including decreased size,
problems with muscle contraction and lower beat rates compared with heart tissue that had not been exposed to thalidomide. e chose drug cardiac developmental toxicity screening to demonstrate a clinically relevant application of the cardiac microchambers,
as many as 280,000 pregnant women are exposed to drugs with evidence of potential fetal risk. The most commonly reported birth defects involve the heart,
and the potential for generating cardiac defects is of utmost concern in determining drug safety during pregnancy.
and other UC Berkeley researchers publicly debuted a system of beating human heart cells on a chip that could be used to screen for drug toxicity.
and antiviral drugs, represent the primary barrier to a cure. n important component in this process is a group of proteins collectively called type 1 Interferons,
#Futuristic brain probe allows for wireless control of neurons Scientists used soft materials to create a brain implant a tenth the width of a human hair that can wirelessly control neurons with lights and drugs.
minimally invasive device for controlling brain cells with drugs and lighta study showed that scientists can wirelessly determine the path a mouse walks with a press of a button.
Typically, scientists who study these circuits have to choose between injecting drugs through bulky metal tubes
and can simultaneously deliver drugs and lights. e used powerful nanomanufacturing strategies to fabricate an implant that lets us penetrate deep inside the brain with minimal damage,
or cannulas, scientists typically use to inject drugs. When the scientists compared the implant with a typical cannula they found that the implant damaged
The scientists tested the device drug delivery potential by surgically placing it into the brains of mice.
In other experiments, they made mice walk in circles by injecting a drug that mimics morphine into the ventral tegmental area (VTA
when the scientists directed the device to simultaneously inject a drug that blocks neuronal communication.
It has room for up to four drugs and has four microscale inorganic light-emitting diodes. They installed an expandable material at the bottom of the drug reservoirs to control delivery.
When the temperature on an electric heater beneath the reservoir rose then the bottom rapidly expanded
and pushed the drug out into the brain. e tried at least 30 different prototypes before one finally worked,
and roads while conducting a study to see what role they might play in causing cancer. e expect that this may allow us to identify targets for a new class of anticancer drugs.?
#Scientists determine structure of important drug target using groundbreaking X-ray laser approach Using the brightest X-ray laser in the world,
Researchers at Arizona State university Biodesign Institute Center for Applied Structural Discovery collaborated with an international team of researchers from 19 institutions working to develop a roadmap for more selectively targeting pathways for drug treatment.
GPCR drugs that selectively modulate one pathway are preferred often as they can have better therapeutic benefits with fewer undesirable side effects than non-selective drugs. rrestin
who led the study. n the realm of drug development, a detailed understanding of the structure,
The more specific the interaction, the better the drugs tend to work while also lowering the chance of side effects.
and account for about 40 percent of current drug targets. Researchers have been trying to determine the structure of a GPCR with arrestin for more than two decades,
controling its function. etermining the atomic structures of proteins in their active states is critical for developing effective drugs with far fewer side effects,
and provides an excellent guide for developing new drugs with fewer side effects. esearchers at the Center for Applied Structural Discovery helped to pioneer a new technique called femtosecond crystallography,
and cancer as well as to use this structure to screen for drug compounds that are designed to treat these diseases with far fewer side effects,
including prolonged drug delivery, electronic monitoring, and weight-loss intervention. However, these devices, often created with nondegradable elastic polymers, bear an inherent risk of intestinal obstruction as a result of accidental fracture or migration.
including orally delivered capsules that can release drugs over a number of days, weeks, or potentially months following a single administration.
or extended-release drug-delivery systems that could last for weeks or months after a single administration. his delivery system provides a flexible and smooth external covering that slowly disintegrates,
which could release drugs or small devices for monitoring and imaging the GI TRACT, says Edith Mathiowitz,
In particular, the authors say they are excited for the drug-delivery applications of this technology. With further work in adjusting the polymer composition or the design of the system
they say that they could tailor devices to release drugs over a specific timeframe of up to weeks or months at a time.
MIT is negotiating an exclusive license agreement with Lyndra, an early-stage biotechnology company developing novel oral drug-delivery systems,
as scientists have shown that using drugs to block PD-1 coaxes T cells to attack tumors.
and deliver drugs and vaccines, a olar spongethat can capture and release carbon dioxide emissions andplastic material that gets better with age.
and drug discovery The liver plays a critical role in human metabolism. As the gatekeeper of the digestive track, this massive organ is responsible for drug breakdown
and is therefore the first to be injured due to overdose or misuse. Evaluating this drug-induced liver injury is a critical part of pharmaceutical drug discovery
and must be carried out on human liver cells. Regretfully, human liver cells, called hepatocytes, are in scarce supply as they can only be isolated from donated organs.
embryonic and genetic engineered stem cells. his is quite a revolution for pharmaceutical drug discovery, said Prof.
and could not be used reliably for drug discovery. In fact, up until now stem cell-derived hepatocytes showed little ability to predict clinical outcome.
The limited availability of functional hepatocytes for drug testing is a major bottleneck bringing pharmaceutical companies to spend $1 billion/year on liver cells alone. ur ability to produce an unlimited supply of functional liver
and bile acids that activate the fetal liver dormant drug metabolism program. The groundbreaking work further demonstrated that liver cells produced from either embryonic stem cells
can detect the toxic effect of over a dozen drugs with greater than 97%accuracy. he implications for liver biology
and drug discovery are said quite staggering Prof. Oren Shibolet, Head of the Liver Unit at the Tel-aviv Sourasky Medical center, who was involved not in this study. he method provides access to unlimited amounts of functional liver cells
and is likely to critically improve our ability to predict drug toxicity, which was limited previously by the unavailability of liver cells.
and drug metabolism in their children to develop quiet differently. n
#Nonsurgical approach helps people with paralysis voluntarily move their legs In a study conducted at UCLA,
a drug often used to treat anxiety disorders. Researchers placed electrodes at strategic points on the skin, at the lower back and near the tailbone and then administered a unique pattern of electrical currents.
By establishing a umanized mouse model they provided an invaluable tool for testing the therapeutic response of the leukemic cells to different drugs.
The Zürich Group tested close to one hundred drug substances, and demonstrated exquisite response of the mouse model TCF3-HLF-positive cells to the drug Venetoclax,
a drug targeting the protein BCL2, which has shown already efficiency in other type of cancers.
Source: MP s
#Paralyzed men move legs with new noninvasive spinal cord stimulation Five men with complete motor paralysis were able to voluntarily generate step-like movements thanks to a new strategy that non-invasively delivers electrical
For the final four weeks of the study, the men were given the pharmacological drug buspirone
The engineered ribosome may enable the production of new drugs and next-generation biomaterials and lead to a better understanding of how ribosomes function.
or that drug. hose are the kind of experiments that this study now tells us are conceptually possible,
Last week (June 18), the US Food and Drug Administration gave the company permission to begin selling its device,
or one that can be used to mass produce a new drug. This"sets the stage for the production of entirely new classes of exotic molecules.""
Early results from a trial in Guinea show that the drug protected 100 percent of the people who received it against Ebola.
Among the 2, 014 people who received the drug immediately, no cases of Ebola were reported, starting 10 days after the initial vaccination,
it faces hurdles such as approval from the Food and Drug Administration, which may mean a clinical trial.
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