#Discovery: cells unwillingly help adenoviruses Various viruses claim many lives every day and cause other nonlethal infections that can lead to serious complications.
but they are used also in sciences adenoviruses are used widely in gene therapy. Scientists found out that cells unwillingly provide lipids,
New knowledge should also help with using adenoviruses in vaccination and gene therapy e
#Scientists discover first NA ambulanceu of T researchers have discovered how severely damaged DNA is transported within a cell
because DNA contains the instructions for all our genetic information. While the repaired DNA can still replicate,
but at a great cost, said Mekhail. he cell has compromised a genome, but it stable
when our chromosomes break and are said misrepaired Durocher. his work teaches us that the location of the break within the cell nucleus has a big impact on the efficiency of repair. he implications of the research could extend to a large number of developmental
The examination of epigenomes requires mapping DNA interactions with a certain protein in the entire genome.
At one point, the study of in vivo genome-wide protein-DNA interactions and chromatin modifications required approximately 10 million cells for an individual test.
scientists have devised a new strategy to precisely modify human T cells using the genome-editing system known as CRISPR/Cas9.
and inexpensively edit genetic information in virtually any organism. T cells, which circulate in the blood, are an obvious candidate for medical applications of the technology,
But in practice, editing T cell genomes with CRISPR/Cas9 has proved surprisingly difficult, said Alexander Marson, Phd, a UCSF Sandler Fellow,
and allows new genetic sequences to be inserted, has generally been introduced into cells using viruses or circular bits of DNA called plasmids.
so there increasing clinical infrastructure that we could potentially piggyback on as we work out more details of genome editing,
differing by specific changes in the genetic material of the leukemia cells, but also by their response to therapies.
which occurs due to breakage and aberrant fusion of genetic material in the tumour cells, resulting in the formation of a new oncogenic protein encoded by parts of the genes TCF3 and HLF, respectively (TCF3-HLF-positive leukemia cells).
An international group of clinicians and scientists from different universities and research institutions, among them the Berlin-based Max Planck Institute for Molecular genetics (Department of Vertebrate Genomics, Hans Lehrach, group
With the aim of identifying therapeutic entry points for this incurable form of ALL THE consortium team decoded both the genome and the transcriptome of the cancer cells,
and an altered gene expression program leads to a reprogramming of leukemic cells to an early, stem-cell like, developmental stage,
but the researchers expect expenses to drop over time (as has been the case with genome sequencing).
Jewett. ur new protein-making factory holds promise to expand the genetic code in a unique and transformative way, providing exciting opportunities for synthetic biology and biomolecular engineering,
and Canadian researchers has managed to successfully sequence the full genome of a living organism using a machine the size of a smartphone called the Minion.
and get a genetic sequence right there.""The drawbacks identified so far revolve around accuracy-the data it produces is currently less accurate than the data produced by a larger machine,
and develop ways to reconstruct complete genomes off this tiny sequencer, "he said. Once proven, it's hoped that the device could be used to sequence tumour genomes,
giving the option of more personalised diagnosis and treatment to cancer patients.""It's not ready for prime time yet,
and look at their genomes we can recognize many equivalences, said molecular biologist Edward Marcotte of the University of Texas at Austin who led the new study. n fact,
#Optogenetics Meets CRISPR The CRISPR gene-editing system just got even better: a new light-activated Cas9 nuclease could offer researchers greater spatial and temporal control over the RNA-guided nuclease activity,
using its Magnet proteins to create a photoactivatable Cas9 nuclease (pacas9) for light-controlled genome editing. he existing Cas9 does not allow to modify genome of a small subset of cells in tissue, such as neurons in the brain,
We have been interested in the development of a powerful tool that enables spatial and temporal control of genome editing.
Sato said. he new study makes use of the split Cas9 architecture to enable light-activated genome editing,
Sato group now plans to expand the colors of light that can activate the pacas9 nuclease o make genome editing more flexible
hotoactivatable CRISPR-Cas9 for optogenetic genome editing, Nature Biotechnology, doi: 10.1038/nbt. 3245,2015 d
#Tasty Visuals To help those with visual impairments make out the shape and movement of objects, a company has developed a device that takes visual information
#White house unveils $215 million plan to develop patient-specific medical treatments The White house unveiled a"Precision Medicine Initiative"today a $215 million investment that will go toward building a database containing genetic information
The investment, one that part of President Obama 2016 budget proposal, will also go toward pioneering new models for patient-specific medical research research that caters to a specific patient needs based on their genetics instead of relying on a one-size-fits-all
or more volunteers"whose genetic information will be stored in a series of databases. About $70 million will go to the National Cancer Institute, a subsection of the NIH,
The Genetic information Nondiscrimination Act was signed into law in 2008 to prevent genetic discrimination from happening,
says Michael Eisen, a geneticist at the University of California, Berkeley.""I worry that this $200 million will ultimately come from basic research funding,
"The mosquito genome is like an unfinished puzzle""Jake and his students found a way to look in those pieces
what's referred to as the"black hole"of the genome regions full of duplicate information that are extremely hard to sequence.
and eventually exploit this male-determining factor by using transgenics, essentially changing this specific gene in mosquitoes on a deep enough cellular level that they pass it on to any offspring."
researchers detail how sequencing genetic information in sperm can show whether a man is infertile. The scientists looked at the sperm RNA,
which carries essential genetic information. But around 20 years ago, Krawetz and his research team discovered that sperm also house RNA
Since sperm RNA correspond to genes in a child genome, the researchers may be able to study these sequences to see
Finette, 58, is a professor of pediatrics, microbiology and molecular genetics at the University of Vermont College of Medicine and director of the Global Health and Humanitarian Opportunity Program.
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