#Circular RNAS throw genetics for a loop Behold the latest curio in the cabinet of RNA oddities:
The UK funding agencies plan to finance this gold open-access route by diverting some 1%of the national research budget
"We maintain our belief that the gold route is the best means of promoting openness
and its cargo, into the cell the macrophage is guarding. The work of Discher and his team is published today in Science1.
The synthetic protein shells simply fall apart during transport and dissemination, rendering the product useless. The team got around the problem by engineering the vaccine to have disulphide bonds cross-linking the protein triangles together.
one of a class known as multidrug and toxic compound extrusion transporters (MATES) that are found in cell membranes.
Previous efforts to identify compounds that block MATE transporters have been unsuccessful partly because researchers had a poor understanding of how these proteins work.
But in the past three years scientists have made some progress mapping the transporters detailed architecture. Two different labs have revealed already the structures of two bacterial MATE proteins,
But he is working to identify blocking peptides for MATE transporters found in human cells and in V. cholerae."
The sudden ballooning also amplified quantum fluctuations into clumps of matter that went on to seed the first stars,
Personalis, down the road in Menlo Park, offers sequencing services and interpretation for clinicians and pharmaceutical and biotechnology companies.
#Swallows may be evolving to dodge traffic Roadside-nesting cliff swallows have evolved shorter, more manoeuvrable wings, which may have helped them to make hasty retreats from oncoming vehicles,
They suggest that the two findings provide evidence of roadway-related adaptation.""I m not saying that it s all because of wing length,
Together with Mary Bomberger Brown, a ornithologist at the University of Nebraska-Lincoln, Brown tracked roadside populations of cliff swallows (Petrochelidon pyrrhonota) in western Nebraska for 30 years, mostly to study the birds social
but have taken also to living under bridges and highway overpasses. As the two researchers checked the roadside colonies, Brown, an amateur taxidermist,
collected dead swallows for skinning and stuffing#gathering 104 vehicle-killed adults and 134 adults killed accidentally in nets used for the study.
That would help the birds to dodge traffic as they exit or enter their nesting sites,
It is hard to definitely prove that animals are adapting to living around roads, says behavioural ecologist Colleen St clair at the University of Alberta in Edmonton, Canada.
Weaning the nation off fossil fuels entirely for its transportation needs may not be practical or realistic.
Lever is convinced that the microbes are not hitchhikers from the surface, but genuine residents of the crust."
Tom Milliken, who works for the wildlife trade monitoring group TRAFFIC, which is headquartered in Cambridge, UK and has been involved heavily in the debates about elephant poaching,
and research scientist Arnold Heynen, in collaboration with scientists at Cold Spring Harbor Laboratory and Roche pharmaceuticals.
created by Alea Mills at Cold Spring Harbor Laboratory. Using electrophysiological biochemical, and behavioral analyses, the MIT team compared this 16p11.2 mouse with
A summary of their work in human tumor cells and mice will be published on Feb 9 in the journal Nature Communications. y laboratory research on cargo transport inside the cells of patients with autism has led to a new strategy
and making them race to remove cargo from the cell membrane, destroying proteins prematurely. To better understand NHE9,
This slows down the hipping rateof cancer-promoting cargo and leaves them on the cell surface for too long.
Research from other laboratories suggested that one such cargo protein is EGFR, which maintains cancer-promoting signals at the cell surface
Protein complexes, molecules that transport payloads in and out of cells, and other cellular activities are organized all at the nanoscale.
"Duru wrote in a description of a Youtube video of the hoverboard's record-breaking flight.
Should Jets Be rerouted to Avoid Warming Contrails? Pennsylvania State university geography professor Andrew M. Carleton and graduate student Jase Bernhardt studied April data from two weather stations, one in the South and the other in the Midwest,
when commercial jets were grounded, suggested that the absence of contrails had an effect upon weather. But it took the longer recent study to show that the effect could be observed over a longer period as well.
whether that through GPS navigation or Carplay. How more connected can we get? What about a vehicle that's connected to your heart?
when tubes were placed in patients'airways for mechanical ventilation, a procedure that can cause the virus to become aerosolized.
Their RNASCOPE and DNASCOPE were able to distinguish cells that harbor the provirus, VIRAL RNA, or even viruses outside of cells much more clearly than any previous in situ technique. ee convinced that we can see individual virions
A system that lets rovers handle more of their own navigation could spell more speed for interplanetary explorers.
and the system figures out the route using stored satellite images of the terrain. Along the way the rover's onboard cameras scan for rocks that are too small for the satellites to catch.
If any are spotted Seeker automatically adjusts the route to skirt around them. The system also uses the cameras and satellite images to monitor progress.
This article appeared in print under the headline Rover navigation system feels the need for Martian spee e
A system that lets rovers handle more of their own navigation could spell more speed for interplanetary explorers.
and the system figures out the route using stored satellite images of the terrain. Along the way the rover's onboard cameras scan for rocks that are too small for the satellites to catch.
If any are spotted Seeker automatically adjusts the route to skirt around them. The system also uses the cameras and satellite images to monitor progress.
This article appeared in print under the headline Rover navigation system feels the need for Martian spee e
and return to Earth using a parachute to slow its decent through the atmosphere about 8 days later.
and the jets are not always active exploring them remotely is challenging. The more the spacecraft can do without waiting for communication with Earth the better they can explore especially
if the Canadian space agency selects their ISS-MRI for a life science berth on a rocket flight in 2016.
Five years down the road I expect really portable MRIS based on TRASE to be everywhere Sarty says.
In cases where images with greater resolution are needed the pair plan to use aerial imagery from drones provided local aviation and privacy laws permit.
A new project proposing that galaxy-spanning alien civilisations should generate detectable heat has turned up a few dozen galaxies that hold promise as harbours for life.
Predicting retail activity a key economic indicator could be done by counting vehicles in the car parks of supermarkets and malls.
#Spacex unveils sleek reusable Dragon crew capsule First cargo now crew the uber-modern space taxi known as the Dragon V2 is ready for passengers.
NASA is already using an unpiloted version of Dragon to send cargo to the International space station and return valuable gear and scientific experiments.
The new vehicle has simple silvery walls seats for up to seven passengers and a set of flatscreen control panels.
But the most radical aspect of the redesign is the landing gear which will allow astronauts to set the spacecraft down on solid ground.
The current version of Dragon deploys a parachute as it descends and splashes down in the ocean.
You'll be able to land anywhere On earth with the accuracy of a helicopter Musk said during the event at Spacex headquarters in Hawthorne California.
and flown again much like commercial airplanes. As long as we continue to throw away rockets and spacecraft we will never have true access to space says Musk.
Like passengers in today's commercial aeroplanes riders of the Dragon V2 won't get much leg room in the capsule's tight quarters.
Passengers on the Dragon V2 won't get much leg room (Image: Spacex) NASA ASTRONAUTS are not set to ride in the Dragon V2 until 2017.
However a colony of mice and rats will make the journey on the next Spacex cargo launch becoming the private company's first mammalian passengers.
or the air flows that make aeroplane flights bumpy. Now Sandra Chapman of the University of Warwick UK and her colleagues have examined the solar wind's behaviour using NASA's twin STEREO spacecraft.
This is not a trailer for an alien invasion movie NASA is gearing up to conduct the first test flight of a disc-shaped spacecraft designed to safely land heavy loads
Until recently NASA had used parachutes and airbags for most robotic landings on Mars starting with the Viking mission in 1976.
which combined parachutes with landing gear powered by retrorockets that could lower the rover to the surface on tethers.
Such weight can't be slowed adequately by parachutes in the Martian air which is just 1 per cent as dense as Earth's. Unfortunately rocket-powered landings are out of the question too as the atmosphere is still just thick enough to buffet incoming spacecraft with more turbulence than thrusters can accommodate.
and a giant parachute twice the size of Curiosity's. The decelerator would attach to the outer rim of a capsule-like entry vehicle.
and moments later the parachute will fire. The saucer should gently splash down in open water.
NASA has three more test flights in Hawaii planned for the LDSD and mission managers will review the results before deciding on next steps.
Then after spending decades building the ISS the US cancelled the space shuttle the vehicle originally intended for transport to the ISS as part of its post-Apollo programme.
After the shuttle's last flight in 2011 though the US became dependent on Russia for transport to the ISS using Soyuz at a cost of nearly $71 million for each seat it requires.
Whether that for-the-camera useless blame game can translate into much needed political will to accelerate backup plans for ISS transport remains to be seen
accelerating the diversification of ISS transport options and rethinking the propensity of using space as a foreign policy surrogate.
One of the alternative models was just little pockets of water driving the jets and in that model you wouldn't have much in the way of life
The fist-sized robot, a product of Virtual Incision in Lincoln, Nebraska, will have its first zero gravity test in an aircraft flying in parabolic arcs in the next few months.
Charged particles can flow along these lines into Earth's atmosphere leading to dazzling auroras as well as geomagnetic storms that can wreak havoc on navigation systems and power grids.
Virgin galactic's Spaceshiptwo is a six passenger two pilot suborbital craft designed to give wannabe astronauts a few minutes in space.
The first flights were initially set for 2008 but have since been delayed repeatedly. Founder Richard Branson announced a 2014 date last month.
which will see celebrities compete for a flight to space aboard an XCOR AEROSPACE Lynx craft.
the Lynx is yet to perform a single test flight. For those looking beyond low Earth orbit Mars One is also continuing with its plans to send humans on a televised one-way mission to the Red planet by 2023.
Advances in pre-flight automation mean that the rocket dubbed Epsilon can be ready to lift off in about a week with fewer people in mission control helping to slash costs to about $38 million per launch much cheaper than its heavier labour-intensive predecessors.
But perhaps the most exciting aspect of the inaugural launch will be Epsilon's cargo: the world's first space telescope designed to study the planets from afar.
Kepler was designed to spot transits the periodic dips in a star's brightness indicating that a planet has passed in front of it.
When a planet transits a star the amount of light it blocks is used to calculate its size.
while the two lobes on the horizontal plane consist of slower-moving particles (watch a NASA video of the tail in action).
Instead the smaller cheaper machine might help labs around the world study deep-space objects such as powerful radiation jets squirted out by black holes.
so that it crashes into metal atoms releasing a jet of electrons and positrons. These particles are separated into two beams with magnets (Physical Review Letters doi. org/m2n.
whereas our jet is a hundred times narrower and remains pencil-like as it propagates he adds.
After a few delays due to weather and a technical glitch the Antares launch vehicle lifted off on its maiden flight on 21 april.
Since the space shuttles retired in 2011 NASA has been contracting with private firms to deliver cargo and soon hopefully astronauts to the space station.
Its Falcon 9 rocket lifted off from Cape canaveral in Florida carrying a Dragon capsule filled with cargo and science experiments.
Antares was designed to deliver the company's Cygnus cargo craft to the ISS. For the test flight the rocket climbed high into a clear blue sky carrying a mock cargo ship with the same mass
and dimensions as Cygnus to avoid putting the real thing at risk. About 10 minutes into the mission the Cygnus dummy successfully separated from the rocket
When the real Cygnus flies it will carry about 2 tonnes of cargo per trip.
But while Dragon can return from its missions loaded with cargo no Cygnus craft will ever make it back to Earth.
If all goes well the company is contracted to make a total of eight cargo missions to the station over the next three or four years y
If not we'll get on the road. In the immediate future Curiosity will be going temporarily silent.
an alternative route to customers via satellites will be invaluable. It's not the only reason."
Solving transport problems The Keystone system value lies in skirting wind turbine transportation constraints that have plagued the industry for years.
so trucks can safely haul them on highways and under bridges. This means that in the United states, most towers for 2-or 3-megawatt turbines are limited to about 260 feet.
at developing advanced drivetrain controls and rotor designs. ut out of that study we spotted tower transport as one of the biggest bottlenecks holding back the industry,
but to do so with considerable mobility, enabling immediate transport to a construction site, streamlining delivery and increasing construction efficiency.
then choose the optimal route to avoid a close encounter. As the robot considers its options,
Lines, each representing a possible route for the robot to take, radiate across the room in meandering patterns and colors,
with a green line signifying the optimal route. The lines and dots shift and adjust as the pedestrian and the robot move.
and other autonomous, route-planning vehicles. s designers, when we can compare the robot perceptions with how it acts,
such as a robot possible routes, and its perception of an obstacle position. They projected this information on the ground in real time,
If all midsized carrier networks were to replace current radio amplifiers with Eta Devices technology he says the reduction in greenhouse gases would be equivalent to taking about 5 million cars off the road.
and we can start having traffic back and forth, Reis says. This research was funded in part by the National Science Foundation
and everything is defined in planes. In many applications you want the three-dimensionality: 3-D printing is going to make a big difference in the kinds of systems we can put together
This is a finding of fundamental importance in the biology of pancreatic cancer says David Tuveson a professor at the Cancer Center at Cold Spring Harbor Laboratory who was involved not in the work.
and giving them the chance to jettison their cargo. It s very expensive for port security to use traditional robots for every small boat coming into the port says Sampriti Bhattacharyya a graduate student in mechanical engineering who designed the robot together with her advisor Ford Professor of Engineering
If I turn on the two jets at one end it won t go straight. It will just turn.
The control algorithm constantly adjusts the velocity of the water pumped through each of the six jets to keep the robot on course.
and routing of maritime traffic. The MIT research was funded by the National Science Foundation n
or underwatered. hey don have to know the flight algorithms, or underlying hardware, they just need to connect their software or piece of hardware to the platform,
A five-year stretch at Boeing as an engineer for the U s. military A160 Hummingbird UAV and as a commercial pilot put Downey in contact with drone manufacturers, who,
#Ride sharing could cut cabs road time by 30 percent Cellphone apps that find users car rides in real time are exploding in popularity:
and even as it faces legal wrangles a number of companies that provide similar services with licensed taxi cabs have sprung up.
What if the taxi-service app on your cellphone had a button on it that let you indicate that you were willing to share a ride with another passenger?
How drastically could cab-sharing reduce traffic fares and carbon dioxide emissions? Authoritatively answering that question requires analyzing huge volumes of data
and the Italian National Research Council s Institute for Informatics and Telematics present a new technique that enabled them to exhaustively analyze 150 million trip records collected from more than 13000 New york city cabs over the course of a year.
If passengers had been willing to tolerate no more than five minutes in delays per trip almost 95 percent of the trips could have been shared.
if the passengers are using cellphone apps. So the researchers also analyzed the data on the assumption that only trips starting within a minute of each other could be combined.
In analyzing taxi data for ride sharing opportunities Typically the approach that was taken was a variation of the so-called traveling-salesman problem Santi explains.
and the travel times between them there is a route that would allow a traveling salesman to reach all of them within some time limit.
First they characterize every taxi trip according to four measurements: the time and GPS coordinates of both the pickup and the dropoff.
if it ran on a server used to coordinate data from cellphones running a taxi-sharing app.
whereas the GPS data indicated that on average about 300 new taxi trips were initiated in New york every minute.
Finally an online application designed by Szell Hubcab allows people to explore the taxi data themselves using a map of New york as an interface.
David Mahfouda the CEO of the car-and taxi-hailing company Bandwagon whose business model is built specifically around ride sharing says that his company hired analysts to examine the same data set that Santi
We did analysis of rides from Laguardia Airport and were able to build really detailed maps around where passengers were headed from that high-density departure point he says.
But he adds we definitely simplified the problem in order to focus on a particular real-world problem that we thought we could solve.
Mahfouda says that his company is founded on the assumption that a very significant number of taxi rides are shareable.
But he says it also saved passengers time. Something that doesn t get mentioned a lot in this space is the amount of time that gets saved through ride consolidation he says.
the rotor of a helicopter may actually move detectably between the reading of one row and the reading of the next.
this didn t change#until companies began bringing Wireless internet access into hotel lobbies libraries airports and other public places.
You can have a charging surface wherever you go from a kitchen counter to your workplace to airport lounge
A navigation application might for instance be authorized to identify the subway stop or parking garage nearest the user.
Down the road, as technology to monitor houses such as automated thermostats and other sensors begins to nlock the data in the residential scale,
flat-screen TVS, gaming consoles, laptops, electric bikes, and air conditioners, while reducing the cost of manufacturing.
if you take the area of the plane and the solid angle of light coming out from that plane, that is fixed,
Cossairt says. hat that means is that if you take the 3-D image size
With his new colleagues at Lincoln Lab Krieger has performed experiments at radar frequencies using a one-dimensional array of sensors deployed in a parking lot
when you re walking through the airport and you hit the moving walkway. When you get off
and transport are important processes in solar-cell devices so understanding what limits these may well help the design of better materials
These illicit products which include electronics, automotive and aircraft parts, pharmaceuticals, and food can pose safety risks and cost governments and private companies hundreds of billions of dollars annually.
or consumers. conomists tend to think what drives international price differences are things like transportation costs, information costs, tariffs, cultural differences, and other factors,
In an incubator at the University of Massachusetts at Boston, the renamed Sample6 tailored the product for the food industry before relocating to its current headquarters in Boston Seaport District,
Further down the road, he says, a goal is to transform diagnostics into something more accessible to the public perhaps even leading to at home diagnostics. undamentally,
and charging them requires plug-in infrastructure that s still sparse in the United states. Now MIT spinout XL Hybrids is upfitting (and retrofitting) gas and diesel commercial vans and trucks with fuel-saving add-on electric powertrains
The system s powertrain includes an electric traction motor a lithium-ion battery advanced power converters
and other connecting components that attach to the powertrains of traditional General motors and Ford cargo delivery and shuttle vans as well as cutaway trucks.
-and-go traffic of urban areas. Over the past year XL Hybrids co-founded by Clay Siegert SM 09
and other companies have started retrofitting vehicles with electric powertrains. But XL Hybrids innovation comes from targeting commercial fleet vehicles with a good value proposition all around Hynes says offering low-cost equipment quick installation savings on gas and oil and easy integration.
An XL Hybrids electric motor adds torque to an existing powertrain meaning a customer can reduce the size of the engine from say a 6-liter to a 4. 8-liter
and more than 95 percent of transportation fuel is oil. So he quit his job in 2008 with the aim of starting a company to cut oil consumption.
With rising innovations in batteries and advanced power inverters and motors Hynes backed into a technological solution with retrofitted electric powertrains.
the researchers took advantage of albumin function as a transporter of molecules called fatty acids. Albumin has binding pockets that can capture fatty, hydrophobic molecules,
and a bicycle-powered charging system for cellphones and lanterns. Davide Zaccagnini a vascular surgeon and program manager for the Science Monks and Technology Leadership Program says he was motivated to join because
It even being used in helicopter extraction and rescue missions. Finding steady success with its military customers, Atlas is now expanding its Charlestown, Mass.
Also, the APA can function as a backup for a helicopter if something goes awry with the primary hoist:
Instead of flying the helicopter back to base for a working hoist, rescuers can store the APA in a seat compartment,
when you get the chance to enable something you couldn do before like continue a helicopter rescue operation
In a conventional Time of Flight camera, a light signal is fired at a scene where it bounces off an object
and thus provides a promising alternative route for n demandmolecular sensing, says Cognet, who was not part of the research team.
For example, in trying to prevent the buildup of ice on an airplane wing, the contact time of raindrops is critical:
and quite sophisticated mechanism may open new routes for manipulating particles and cells in an elegant manner.
while resting and are unable to mentally replay a route they have just run as normal mice do.
and in no particular order indicating that the mice were not replaying the route they had just run.
#Finding blood clots before they wreak havoc Life-threatening blood clots can form in anyone who sits on a plane for a long time is confined to bed
including materials used in aircraft, oil wells, and other critical industrial applications. Metal fatigue, for example which can result from an accumulation of nanoscale cracks over time s probably the most common failure modefor structural metals in general
a research director at the MIT Center for Transportation and Logistics and a Morocrafts advisory board member. t provides not only more transparency but also a connection between consumers and artisans,
and research scientist Arnold Heynen, in collaboration with scientists at Cold Spring Harbor Laboratory and Roche pharmaceuticals.
created by Alea Mills at Cold Spring Harbor Laboratory. Using electrophysiological biochemical, and behavioral analyses, the MIT team compared this 16p11.2 mouse with
a bike-mounted maize sheller. Easily attached to a bike and powered by pedaling, the low-cost,
cast-iron sheller allowed farmers to process their corn 10 times faster in one day, as opposed to weeks when done by hand.
This machine resembles a stationary bike, with a wooden seat and a hand-cranked sheller at its side.
Moreover, it required dismantling used bikes, which are valuable commodities for Tanzanians. That when Wu engineered a solution. e were building this pedal-powered machine,
In D-Lab, she modified the sheller into a $30 dd-onfor a bike by constructing a bike stand
and gears on the upper part of the bike to attach and detach devices. Now not only could farmers process all their maize in one day,
but they also retained their bikes for other uses. In 2009, Wu continued developing the device
or a bike-powered butter churner that couldn find a market. But GCS is now furthering development on a motorized multicrop thresher eveloped by a team of students that the Bill
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