"said Jonathan Kipnis, Phd, professor in the UVA Department of Neuroscience and director of UVA's Center for Brain Immunology and Glia (BIG)."
Harris, a Phd, is an assistant professor of neuroscience and a member of the BIG center.
"In Alzheimer's, there are accumulations of big protein chunks in the brain, "Kipnis said.""We think they may be accumulating in the brain
a team of biomedical engineering undergraduates has developed a kit to teach front-line health care workers in developing countries how to implant contraceptives.
however, these simple procedures often must be done by frontline providers who have minimal training. Sometimes, the cylindrical toothpick-shaped implant may be inserted inadvertently into the woman's fat tissue instead of just under the outer skin layer.
a team of Johns hopkins university biomedical engineering undergraduates has developed a teaching set called the Contraceptive Implant Training Tool kit or CITT Kit, for short.
The medical simulator includes two training models: a stand-alone replica arm and a layered band that can be worn by health workers who act as"patients"during practice sessions."
The student inventors say their new system better mimics anatomical textures, resulting in a more realistic representation than current training tools that use materials such as Styrofoam and latex.
The Johns Hopkins students instead used silicone layers of different densities to more closely represent the physiology of skin,
The CITT Kit's components also feature landmarks that can help the students identify the correct placement site for a cylindrical implant
the students say their kit provides more advanced training in how to safely and easily remove an implant,
With this kit, the students say, health workers will be able to make practice incisions through replaceable silicones layers that respond more like human skin."
While working on their training kit, the student inventors were advised by physician Ricky Lu, technical director for reproductive health and family planning at Jhpiego,
a nonprofit Johns hopkins university affiliate that focuses on global health issues involving women and families.""The student inventors came up with a novel and exciting idea of using replaceable training pods,
"Lu said.""These pods have embedded placebo implants to simulate a range of removal challenges, from easy pop outs to deeply located and adherent implants requiring additional skills to extract them.
This is critical to have in clinical training where removal cases for practice may be limited during a short training course."
"The student inventors showcased their device recently at the annual Johns Hopkins Biomedical engineering Design Day event, organized by the university's Center for Bioengineering Innovation and Design.
The CITT Kit was developed within the yearlong undergraduate design team program, directed by Robert H. Allen, a lecturer in the Department of Biomedical engineering,
which is shared by the university's Whiting School of engineering and its School of medicine. Allen also is a lecturer in the School of medicine's Department of Gynecology and Obstetrics.
Working with Johns Hopkins Technology Ventures, the students have obtained a provisional patent covering their invention.
They say their invention aligns with voluntary contraception programs supported by philanthropic global health organizations such the Bill and Melinda Gates Foundation.
The students say support from one of these groups could help move their prototype out of the lab and into the field-testing and eventual clinical use s
#X-ray scanning to guarantee meat tenderness Arraypackaged meat products can be found today on fresh food counters with labels declaring their level of tenderness and tenderization process.
Moreover, many large-scale experiments have been carried out at Liverpool John Moores University in collaboration with the rest of the project group.
however, researchers at Hiroshima University revealed the mechanisms by which CCDC26 controls the receptor tyrosine kinase KIT expression.
Dr. Tetsuo Hirano from the Graduate school of Integrated Arts and Science at Hiroshima University found that knockdown of the CCDC26 gene in cells results in significant upregulation of the KIT gene,
Dr. Hirano and his collaborators at the School of medicine in Juntendo University showed that CCDC26 transcript levels are high in the nuclear fraction of human myeloid leukemia cell lines.
Researchers at the University of Bonn and the German Center for Infection Research (DZIF) have discovered two new groups of viruses within the Bunyavirus family in the tropical forest of Ivory coast.
"says the researcher from the University of Bonn Hospital. Simplified test to test novel viruses for risk of human infection Triggered by epidemics such as SARS and Ebola,
in association with Montpellier Regional University Hospital and Stanford university, have transformed bacteria into"secret agents"that can give warning of a disease based solely on the presence of characteristic molecules in the urine or blood.
In this new work, the teams led by Jérôme Bonnet (CBS, Inserm U1054, CNRS UMR5048, Montpellier University), Franck Molina (Sysdiag, CNRS FRE 3690),
in association with Professor Eric Renard (Montpellier Regional University Hospital) and Drew Endy (Stanford university), applied this new technology to the detection of disease signals in clinical samples.
"says Alexis Courbet, a postgraduate student and first author of the article. As a proof of concept, the authors connected the genetic transistor to a bacterial system that responds to glucose,
The research team at Tohoku University turned its attention to iron selenide (Fese which is a member of iron-based superconductors*2
This work was supported by grants from the Japan Society for the Promotion of Science (JSPS) and Japan's Ministry of Education
A master clock in the brain, tuned to the daily cycle of light and dark, sends out signals that synchronize the molecular clocks ticking away in almost every cell and tissue of the body.
a professor of chemistry and biochemistry at UC Santa cruz and corresponding author of the paper, the connection between clock disruption and cancer is still unclear."
The new study focused on a protein called PASD1 that Partch's collaborators at the University of Oxford had found was expressed in a broad range of cancer cells,
. associate professor in the Tumor Microenvironment and Metastasis Program at The Wistar Institute and lead author of the study."
the researchers found that pre-treatment with Intralipid reduced the accumulation of the platinum-based drug by 20.4 percent in the liver, 42.5 percent in the spleen and 31.2 percent in the kidney.
Professor Thomas said the treatment targeted the underlying cause of rheumatoid arthritis.""Current therapies only treat the symptoms
"Professor Thomas said.""We have designed a vaccine-style treatment or'immunotherapy'specifically for individuals carrying high-risk rheumatoid arthritis genes and specific rheumatoid arthritis antibodies, called anti-CCP."
"Professor Thomas said a single injection of the patient's own immune-modified dendritic cells was found to be safe
Professor Thomas is working on a delivery technology with Dendright Pty Ltd (a Uniquest start-up company) in collaboration Janssen Biotech Inc,
and Phillip Messersmith, Phd (University of California, Berkeley).""We discovered that the HIF-1a pathway--an oxygen regulatory pathway predominantly used early in evolution
a professor at LIMR who heads the Laboratory of Regenerative medicine. The discovery is the latest development in a long investigation sparked by a chance observation in an unusual mouse strain.
shape and orientation, said the paper's senior author, Michael Levin, Ph d.,Vannevar bush professor of biology and director of the Tufts Center for Regenerative and Developmental biology."
Dr. Oliver Eickelberg and Dr. Claudia Staab-Weijnitz of the Comprehensive Pneumology Center (CPC) at Helmholtz Zentrum München and their colleagues at LMU University Hospital in Munich and Yale university
School of medicine have discovered now a new therapeutic target for IPF. The main focus of their research was to identify causative mechanisms involved in the disease.
This cooperative project is a direct result of the research stay of Professor Kaminski (Yale) at the CPC through the support of a Helmholtz International Fellow Award (HIFA.""
has already been tested on a small sample of patients at the La paz University Hospital and in ex vivo tissues of animal models.
This means it can be used without having to undergo specialised training, and as it is portable, it can be made available to any intensive care or accident and emergency unit and observation or hospital room."
"says Dr. Xiaodong Yang, an assistant professor at Missouri S&t, who leads the Nanoscale Optics Laboratory in the university's mechanical and aerospace engineering department."
"We chose the athletic logo to fill that need.""""Unlike the printing process of an inkjet or laserjet printer, where mixed color pigments are used,
an assistant professor of mechanical and aerospace engineering at Missouri S&t and a co-author of the paper.
"says Washburn's co-researcher and advisor, Michael J. Richardson, an associate professor of psychology. The researchers say the discovery could also impact future research into areas such as the development of robotics,
#Crossing a critical threshold in optical communications Researchers from Lehigh University, Japan and Canada have advanced a step closer to the dream of all-optical data transmission by building
The coauthors are Himanshu Jain, professor of materials science and engineering, and Volkmar Dierolf, professor of physics, both at Lehigh,
and researchers from Kyoto University in Japan and Polytechnique Montreal in Canada. The group says its achievement will boost ongoing efforts to develop photonic integrated circuits (PICS) that are smaller, cheaper, more energy-efficient and more reliable than current networks that use discrete optoelectronic components--waveguides, splitters, modulators, filters
, amplifiers--to transport optical signals.""A major trend in optics,"the researchers write, "has been a drive toward...
"After conducting experiments at Lehigh and at Kyoto University and Polytechnique Montreal, the group built a single crystal in glass,
a Donald B. Willett Professor of Engineering and head of the Department of Materials science and engineering at Illinois."The physics of separating spins with heat currents is related to the operation of thermocouples and the thermoelectric generators that power deep space
and Kyung-Jin Lee, Department of Materials science and engineering and KU-KIST Graduate school of Converging Science and Technology, Korea University, Seoul l
Schwab, an assistant professor at NYU Langone and its Skirball Institute of Biomolecular Medicine, says similar laboratory test plans are underway for more potent CXCR4 antagonists, most likely in combination with established chemotherapy regimens.
"said co-senior author Kumar Sharma, MD, a professor of medicine and director of the Center for Renal Translational Medicine at UC San diego School of medicine."
"Catherine Godson, Phd, co-senior author and director of the UCD Diabetes Complications Research Centre in UCD School of medicine and UCD Conway Institute, said the study's findings demonstrate the value
when he was a graduate student. The work combines his expertise in manipulating droplet fluid dynamics with a fundamental element of computer science--an operating clock."
Arrayarrayfor nearly a decade since he was in graduate school, an idea has been nagging at Prakash:
and in the early stages of the project, Prakash recruited a graduate student, Georgios"Yorgos"Katsikis,
"said graduate student and co-author Jim Cybulski.""That lends itself very well to a variety of applications."
#How a gut feeling for infection programs our immune response An unexpected finding by an international team of scientists based at The University of Manchester
"Dr Grainger and his team are now working with other groups at The University of Manchester to carry out further studies on monocytes, particularly from patients with inflammatory conditions,
'said senior author Dr. Richard Wang, assistant professor of dermatology and a member of UT Southwestern's Harold C. Simmons Comprehensive Cancer Center.'
Choi, who joined Binghamton's faculty less than three years ago as an assistant professor of electrical and computer engineering, earned a doctorate from Arizona State university after doing undergraduate work and a master's degree in South korea.
a former Binghamton undergraduate and co-author of the new journal article. Choi recalls an actual"lightbulb moment
Han Tan, Professor Luca Comai and colleagues were studying centromeres, the handles by which chromosomes are moved
"says Professor Veerle Baekelandt from the Research Group for Neurobiology and Gene therapy.""You could compare it to the construction of a house,
In 2013, Professor Ronald Melki and his colleagues from CNRS isolated several forms of fibres called'strains'.
because it creates a new class of devices for controlling X-rays,"added Paul Evans, a professor of materials science at the University of Wisconsin-Madison."
specialised labs or expensive reagents, has been developed at Uppsala University, Sweden. The technique could be developed further to be used in point of care devices, for instance for diagnostic purposes.
and often requires special training to handle. In order to use protein detection for diagnostic purposes, e g. in a clinic, new, less complicated methods to study proteins are needed.
#New mechanism that attacks viral infections discovered An innovative mechanism that the innate immune system uses to control viral infections has been uncovered by researchers at the University Medical centers in Mainz and Freiburg.
"explained Professor Andreas Diefenbach of the Department of Medical microbiology and Hygiene of the Mainz University Medical center.
from the University's Department of Engineering Mathematics, have designed a smart materials system, inspired by biological chromatophores,
#Bacteria could help clean groundwater contaminated by uranium ore processing A team of Rutgers University scientists
"said Lee Kerkhof, a professor of marine and coastal sciences in the School of Environmental and Biological sciences."
'said Simon Gayther, Ph d.,professor in preventive medicine, Keck School of medicine of USC, corresponding author of the international genome-wide association study (GWAS).'
D.,associate professor and researcher at the Hollings Cancer Center at the Medical University of South carolina,
#New type of gecko-like gripper created Researchers at the University of Pennsylvania are developing a new kind of gripper,
The research was conducted by Kevin Turner, the Gabel Family Term Associate professor in the School of engineering and Applied science's Department of Mechanical engineering and Applied Mechanics,
and Helen Minsky, a graduate student in his lab. Array"When it comes to tunable adhesion,
plasmids and other mobile genetic elements, says Rodolphe Barrangou, associate professor of food science at NC State and a co-corresponding author of the paper.
mechanical engineering professor Carolyn Conner Seepersad.""We believe that this technology, when constructed in future helmets
"said Nina Jablonski, Evan Pugh Professor of Anthropology, Penn State, who led the research. One hundred healthy young individuals divided between those of Xhosa ancestry
#Violence by teachers almost halved in primary schools An innovative program of activities used in Ugandan primary schools has succeeded in reducing violence by teachers against children by 42 percent, according to new research.
An innovative programme of activities used in Ugandan primary schools has succeeded in reducing violence by teachers against children by 42,
They found that the Toolkit produced a large reduction in physical violence from school staff--42%--as reported by primary school students.
results suggested that the Toolkit was more effective for male students. Students in intervention schools reported improved feelings of well-being and safety at school
suggesting that the Toolkit succeeded in changing the school environment. Study lead author, Dr Karen Devries from the London School of Hygiene & Tropical Medicine, said:"
"What's notable about these results is that we found a very large reduction. We don't normally see a shift of such magnitude.
levels of physical violence in the intervention schools remained high, with 30%and 60%of students reporting violence in the past week and past term respectively.
While school staff (unlike students) might be expected to emphasise an improvement, their reports show very similar effect sizes
and direction to those of the students'reports, lending weight to the results. Students in Ugandan primary schools are slightly older than those in higher income countries
a factor to consider when generalising the results to primary school populations with different age profiles.
The international team of researchers co-led by Dr Natalie Borg from the Department of Biochemistry and Molecular biology at Monash University,
Dr Borg's team at Monash University were able to visualise the crystal structure of the Anapn1 protein for the first time, providing valuable insights.
Experts at Monash University monitored people participating in a range of extreme endurance events, including 24-hour ultra-marathons
especially in the heat and with little training, put their bodies under enormous strain above the body's protective capacity.
rather than jumping straight into a marathon, for example, with only a month's training, "he said.
But if you haven't done the training and you're unfit--these are the people who can get into trouble,
#Key to quick battery charging time University of Tokyo researchers have discovered the structure and transport properties of the"intermediate state"in lithium-ion batteries--key to understanding the mechanisms of charge
Now Professor Atsuo Yamada's research group at the University of Tokyo Graduate school of Engineering have developed a novel technique to stabilize the intermediate state.
Dr. Samuel Asfaha, a clinician-scientist at Lawson and an assistant professor of medicine at the Schulich School of medicine & Dentistry, Western University,
and his colleagues at Columbia University (New york), have identified a previously unknown, long-lived radiation-resistant stem cell population in the colon.
#Sediment makes it harder for baby Nemo to breathe easy Researchers from the ARC Centre of Excellence for Coral reef Studies at James Cook University have discovered that suspended sediment damages fish gills
"says study lead author, Phd Student Sybille Hess.""Sediment-exposed fish also increased the number of protective cells on their gills,
and accumulation of sediment, may trigger the development of fish diseases, "says co-author Dr Tracy Ainsworth."
"says Labrique, Phd, an associate professor in the Bloomberg School's departments of international health and epidemiology."
#Researchers develop pioneering new method to map enzyme activity Researchers from Cardiff University have pioneered a new technique that will enable scientists to precisely pinpoint the areas on an enzyme that help to speed up chemical reactions.
Lead author of the study Professor Rudolf Allemann, Distinguished Research Professor and Head of Cardiff University's School of Chemistry, said:"
"Enzymes are not only central to living systems, but also to many industrial processes, such as the production of food, textiles, detergents, pharmaceuticals and other chemicals where environmentally friendly methods are of ever increasing importance."
the research team, consisting of researchers at Cardiff University's School of Chemistry, the University of Valencia and Jaume
I University in Spain, investigated the physical movements of the enzyme dihydrofolate reductase (DHFR). DHFR is a small enzyme that plays an essential role in the building of genetic material and proteins,
antibodies and growth factors while lending itself to many different mechanically robust formats, said Fiorenzo Omenetto, Ph d.,senior author on the paper and associate dean for research and Frank C. Doble Professor
The researchers, who included collaborators from the University of Illinois at Urbana-Champaign, foresee wide potential for future investigation and application of this technology.
Benedetto Marelli, Miaomiao Yang and Bo An, of the Department of Biomedical engineering at Tufts University;
Serdar Onses and John Rogers, of the University of Illinois at Urbana-Champaign; and David Kaplan, of the Department of Biomedical engineering and Department of Chemical and Biological engineering at Tufts University.
Omenetto and Kaplan are pioneers in the use of silk as an alternative to plastics. Omenetto's 2011 TED Talk called silk a"new old material"that could have a profound impact in many technical fields.
and her research group in the University's School of Oral and Dental Sciences, Pertinax is a new formulation of chlorhexidine.
'said Barbour, Senior Lecturer in Biomaterials in the School of Oral and Dental Sciences.''Our initial focus will be in the dental market,
'said Professor Bill Bonfield, chairman of the Armourers and Brasiers Venture Prize judging panel.''Our prize looks to encourage scientific entrepreneurship in the UK
"says Professor Christof Wöll, Director of KIT Institute of Functional Interfaces (IFG).""This new application of metal-organic framework compounds is the beginning only.
Computations made by the group of Professor Thomas Heine from Jacobs University Bremen, which is involved also in the project,
atomically-thin layered material at room temperature could lead to novel nanoelectronic circuits and devices, according to researchers at Penn State and three other U s. and international universities.
"says Joshua Robinson, a Penn State assistant professor of materials science and engineering whose student, Yu-Chuan Lin, is first author on a paper appearing online today, June 19, in the journal Nature Communications.
"says Datta, a coauthor on the paper and Penn State professor of electrical engineering.""Resonant tunneling diodes with NDR can be used to build high frequency oscillators.
"Coauthor Robert Wallace of the University of Texas at Dallas says this collaborative work represents an important achievement in the realization of useful 2d integrated circuits."
and Lain-Jong Li, at King Abdullah University of Science and Technology, Saudi arabia. The work was performed in conjunction with the Center for Two-dimensional and Layered Materials (2dlm) at Penn State and supported by the Semiconductor Research Corporation and DARPA through the Center for Low energy Systems Technology.
#Supercomputers surprisingly link DNA crosses to cancer Supercomputers have helped scientists find a surprising link between cross-shaped (or cruciform) pieces of DNA and human cancer, according to a study at The University of Texas at Austin (UT Austin.
Vasquez is the James T. Delucio Regents Professor in the Division of Pharmacology and Toxicology at The University of Texas at Austin.'
Support is acknowledged also from the Alexander Von humboldt Foundation, the NASA Office of the Chief Technologist's Space technology Research Fellowship, the AFOSR Quantum memories Multidisciplinary University Research Initiative,
and the National Science Foundation Integrative Graduate education and Research Traineeship Program, Interdisciplinary Quantum Information science and Engineering (iquise
Dr. Hesham Sadek, Assistant professor of Internal medicine and with the Hamon Center for Regenerative Science and Medicine.
"said Dr. Joseph Hill, Chief of the Division of Cardiology and Professor of Internal medicine at UT Southwestern,
The Max Planck researchers, together with colleagues from the High-Field magnet Laboratories at the Helmholtz-Zentrum Dresden-Rossendorf and at the Radboud University in The netherlands
as well as the High-Field magnet Laboratory at Radboud University in Nijmegen, Netherlands, and the Diamond Light source in Oxfordshire, England.
'said Professor Shankar Balasubramanian of the Department of chemistry and the Cancer Research UK Cambridge Institute, who led the research.'
as well as in mouse embryonic stem cells--the body's master cells which can become almost any cell type in the body.
#New formula expected to spur advances in clean energy generation Researchers from the University of Houston have devised a new formula for calculating the maximum efficiency of thermoelectric materials, the first new formula in more than a half-century,
who is also M d. Anderson Chair professor of physics at UH.""If the engineering ZT is not high enough,
was carried out by an international team led by scientists at Imperial College London and clinicians at Imperial College Healthcare NHS Trust.
Researchers from UCL (University college London), Keele University Medical school, Heyrovsky Institute of Physical chemistry and Academy of Sciences of the Czech republic were involved also in the study.
Professor George Hanna lead author of the study and Director of NIHR-Diagnostic Evidence Cooperatives at Imperial College London, said:"
"Esophageal and gastric cancers are on the rise in the UK with more than 16,000 new cases diagnosed each year.
The researchers used breath samples of patients with esophageal and gastric cancer at Imperial College Healthcare NHS Trust from 2011 to 2013.
an exciting world-record performance,'said study co-author Yi Cui, an associate professor of materials science and engineering at Stanford and of photon science at the SLAC National Accelerator Laboratory.
for both electrodes,'said graduate student Haotian Wang, lead author of the study.''This bifunctional catalyst can split water continuously for more than a week with a steady input of just 1. 5 volts of electricity.
'Other Stanford co-authors of the study are postdoctoral scholar Hyun-Wook Lee, visiting student Zhiyi Lu,
and graduate students Yong Deng, Po-Chun Hsu, Yayuan Liu and Dingchang Lin. Arra a
#New mechanism that regulates tumor initiation, invasion in skin basal cell carcinoma Researchers at the Université libre de Bruxelles,
Cédric Blanpain, MD/Phd, professor and WELBIO investigator at the IRIBHM, Université libre de Bruxelles
which--like many neurodegenerative diseases--is characterized by an accumulation of misfolded mutant proteins that interfere with brain function.
"said study leader Dr. Steven Potkin, UCI professor of psychiatry & human behavior.""This assay that reflects a pathological process can play a key role in more rapidly developing an effective treatment.
"says Yet-Ming Chiang, the Kyocera Professor of Ceramics at MIT and a cofounder of 24m (and previously a cofounder of battery company A123).
and colleagues including W. Craig Carter, the POSCO Professor of Materials science and engineering. In this so-called"flow battery,"the electrodes are suspensions of tiny particles carried by a liquid
Venkat Viswanathan, an assistant professor of mechanical engineering at Carnegie mellon University who was involved not in this work, says the analysis presented in the new paper"addresses a very important question of
"In addition to Chiang, the Power Sources paper was authored co by graduate student Brandon Hopkins, mechanical engineering professor Alexander Slocum,
and Kyle Smith of the University of Illinois at Urbana-Champaign. The work was supported by the U s. Department of energy's Center for Energy storage Research,
#Biomanufacturing of Cds quantum dots A team of Lehigh University engineers have demonstrated a bacterial method for the low-cost, environmentally friendly synthesis of aqueous soluble quantum dot (QD) nanocrystals at room temperature.
and material science students present this novel approach for the reproducible biosynthesis of extracellular, water-soluble QDS in the July 1 issue of the journal Green Chemistry.
supplied by Lehigh's Faculty Innovation Grant (FIG) and Collaborative Research Opportunity Grant (CORE) programs.
Researchers from the University of Cambridge have developed a simple'recipe'for combining multiple materials with single functions into a single material with multiple functions:
rather than functional things,"said Dr Stoyan Smoukov of the University's Department of Materials science and Metallurgy,
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