would it be possible to deliver the mesh electronics by syringe needle injection, a process common to delivery of many species in biology and medicine-you could go to the doctor
and you inject this and you're wired up.'"'"Though not the first attempts at implanting electronics into the brain-deep brain stimulation has been used to treat a variety of disorders for decades-the nano-fabricated scaffolds operate on a completely different scale."
and administered like any other injection. After injection, the input/output of the mesh can be connected to standard measurement electronics
so that the integrated devices can be addressed and used to stimulate or record neural activity.""These type of things have never been done before, from both a fundamental neuroscience and medical perspective,
"Lieber said.""It's really exciting-there are a lot of potential applications.""Going forward, Lieber said, researchers hope to better understand how the brain
#Innovative Hand-held Tool and App to Monitor for Signs of Skin cancer Unveiled at World Dermatology Conference Sadeghi,
#Once people take high-quality, high-resolution images of suspicious moles or skin abnormalities, they can archive images
Molescope#is expected to provide healthcare benefits in communities without access to medical specialists and in those with long waitlists,
and a more expensive professional version to be presented at the World Congress of Dermatology meeting.
and is registered FDA as a Class 1 medical device in the U s a CE mark in the EU
The company is initiating an early adopter program with qualified dermatologists and receiving strong interest from potential distributors and channel partners throughout the world.
Hugh Macnaught, is now chair of the company board of directors. t was obvious from the outset that Maryam had identified an unmet medical need
It was released in June 2011 and donated to the BC Cancer Agency at Vancouver General Hospital.
Sadeghi Phd research on skin cancer prevention and analyzing dermoscopic images for early skin cancer diagnosis using intelligent computer technologies was recognized with a 2012 Innovation Challenge Award from the Natural sciences and Engineering Research Council
and Toxic Gases RMIT University researchers have created wearable sensor patches that detect harmful UV radiation and dangerous, toxic gases such as hydrogen and nitrogen dioxide.
stretchy electronic sensors are also capable of detecting harmful levels of UV radiation known to trigger melanoma.
#Ultracompact Highly sensitive Nanomechanical Sensor Can Detect Viral Disease Markers Two young researchers working at the MIPT Laboratory of Nanooptics and Plasmonics,
such as viral disease markers, which appear when the immune system responds to incurable or hard-to-cure diseases,
including HIV, hepatitis, herpes, and many others. The sensor will enable doctors to identify tumor markers,
whose presence in the body signals the emergence and growth of cancerous tumors. The sensitivity of the new device is characterized best by one key feature:
according to its developers, the sensor can track changes of just a few kilodaltons in the mass of a cantilever in real time.
One Dalton is roughly the mass of a proton or neutron, and several thousand Daltons are the mass of individual proteins and DNA molecules.
So the new optical sensor will allow for diagnosing diseases long before they can be detected by any other method,
If you place antibodies to certain viruses on the cantilever, it'll capture the viral particles in the analyzed environment.
#Nanoparticles Arrest Destruction of Beta Cells and Avoid Diabetes Development This work led to more studies with the support of the Spanish Government, Catalan Government and private patrons with a keen interest in it.
Thanks to this, the article published today in PLOS ONE describes a new step towards the creation of a vaccine,
and even curing the disease in humans. Initially the researchers avoided the destruction of the insulin-producing pancreatic cells (beta cells) in the body by modifying the individual's immune cells, known as dendritic cells.
This important step requires the extraction of the subjects'dendritic cells for their subsequent manipulation and re-injection.
and avoid Diabetes development. This technique could be a much better candidate for a human vaccine.
The invention is protected commercially and an international patent has been applied for. Droplets of fat and water which can be produced on a large scaleliposomes have been used in several medical treatments.
They are not cells, but droplets with an external fat membrane, similar to cell membranes. They can be made using a very specialized process,
The Catalan researchers are the first group in the world to use liposomes that imitate naturally dying cells to fight against Diabetes.
Next stepsafter showing that liposomes prevent the onset of Type 1 Diabetes in mice, the next steps are to test it in human cells in vitro,
to start clinical trials on human candidates for preventive vaccination and to cure the disease by combining the vaccine with regenerative therapies.
The Germans Trias Institute plans to carry out these steps with patients at the hospital and to optimize the product by dosage and guideline studies.
It is planned also to optimize the product for personalization. To achieve these objectives more competitive funding will be necessary from public agencies.
Growing incidence and complex consequencestype 1 Diabetes is an illness where the body does not recognize the beta cells of the pancreas as its own
The most serious is that in the long term hyperglycemia provokes retinal damage that can lead to blindness renal insufficiency, destruction of nerve fibers or
what is called"Diabetics Foot"where ulcers form, leading eventually to the need to amputate. The causes of the disease are unknown,
although there are both genetic and environmental factors involved. About 0. 3%of the population is affected
This immunotherapy presents a possible solution for Type 1 Diabetes. Source: http://www. uab. es e
. a professor of chemistry at Tufts and senior author on the paper, worked with iodine-125 radioactive isotope that is routinely used in cancer therapies.
Gold-Plated Cancer Fighters? Then Alex Pronschinske, Ph d.,first author on the paper and a postdoctoral researcher in Sykeslab, suggested that they measure the electrons emitted by the sample without prodding from X-rays in the photoelectron spectrometer.
which have been shown to be very effective in radiation oncology because they break cancer cellsdna into pieces.
Because these electrons can travel only 1 to 2 nanometers human hair is about 60,000 nanometers widehey do not affect healthy tissue and organs nearby.
you get this big flux of low energy electrons coming out. he finding suggests a new avenue for radiation oncology:
then affix the nanoparticles to antibodies targeting malignant tumors and put them in a liquid that cancer patients could take via a single injection.
Theoretically, the nanoparticles would attach to the tumor and emit low energy electrons, destroying the tumor DNA.
The gold-based nanoparticles would be flushed out of the body, Sykes says, unlike free iodine-125,
which can accumulate in the thyroid gland and cause cancer. If proven, this approach could be a potential improvement over current radiation therapy protocols, in
which doctors treat some cancers by putting radioisotopes, including iodine-125, into tiny titanium capsules and implanting them in tumors.
Instead of emitting large amounts of low energy electrons as the gold-bound iodine does, the titanium capsules inhibit radiation,
Sykes says, making such therapies less effective than they could be. He has applied for a patent on the new technique.
Researchers in Sykes'lab are now assessing precisely how the low energy electrons travel through biological fluids.
#Scientists Demonstrate Intrinsic Chirality in Ordinary Nanocrystals By Stuart Milnethese findings have opened new possibilities in medicine,
which could be medical benefits, while the other form, which is its antipode, would be useless.
while the other is toxic and does not relieve pain. The optical activity is considered to be an important indicator of chiral environment.
published online in the Journal of Maternal-Fetal & Neonatal Medicine, was conducted by an interdisciplinary team of researchers from the NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the University of Pennsylvania, Wayne State university/Detroit Medical center
, Seoul National University and Asan Medical center in South korea.""We believe that this technology may be used to address questions that are difficult to answer with current placenta model systems
and help enable research on pregnancy and its complications,"said Roberto Romero, M d.,chief of the NICHD's Perinatology Research Branch and one of the study authors.
#Polymer Nanobrushes Grab Selected Bacteria for Pathogen Detection A Texas A&m Agrilife Research engineer and a Florida colleague have developed a biosensor that can detect listeria bacterial contamination within two
The same technology can be developed to detect other pathogens such as E coli O157: H7, she said.
But listeria was chosen as the first target pathogen because it can survive even at freezing temperatures.
It is also one of the most common foodborne pathogens in the world and the third-leading cause of death from food poisoning in the U s."It can grow under refrigeration,
but it will grow rapidly when it is warmed up as its optimum growth temperature ranges from 30 to 37 degrees Celsius--86 to 98 degrees Fahrenheit,
000 National Science Foundation grant to continue their work on nanobrushes for pathogen detection n
#Nano-Packaged Drug Can Halt and Reverse Progression of Atherosclerosis in Rodents In what may be a major leap forward in the quest for new treatments of the most common form of cardiovascular disease,
scientists at Johns Hopkins report they have found a way to halt and reverse the progression of atherosclerosis in rodents by loading microscopic nanoparticles with a chemical that restores the animals'ability to properly handle cholesterol.
known as atherosclerotic vessel disease, is the leading cause of heart attacks and strokes that claim some 2. 6 million lives a year worldwide, according to the World health organization.
That earlier study showed that animals feasting on high-fat foods remained free of heart disease if pretreated with a man-made compound
and clear out D-PDMP was a major hurdle in efforts to test its therapeutic potential in larger animals and humans.
but not potent enough to stop the disease from advancing. Perhaps, most importantly, the team says,
and pumping dysfunction, the hallmarks of advanced disease.""Our experiments illustrate clearly that while content is important,
"says lead investigator Subroto Chatterjee, Ph d.,a professor of medicine and pediatrics at the Johns hopkins university School of medicine and a metabolism expert at its Heart and Vascular Institute."
and its ability not merely to prevent disease but to mitigate some of its worst manifestations."
D-PDMP treatment improved heart function in mice with advanced forms of atherosclerotic heart disease, marked by heart muscle thickening
#Encapsulated, Nanobody-Targeted Drugs Cold Help Treat Sleeping sickness Sleeping sickness, or African trypanosomiasis, is caused by trypanosome parasites transmitted by tsetse flies
The disease is considered fatal if untreated, but as it affects mostly poor people in low-income countries,
A study published on June 25th in PLOS Pathogens reports a new way to circumvent drug resistance
a high-tech approach with potential applications to other infectious diseases. Current treatment of sleeping sickness relies primarily on four drugs.
Three of these drugs get into the interior of the parasite cells via the trypanosome's transport proteins that normally supply the parasite with nutrients,
The researchers developed a drug carrier that consists of polymeric nanoparticles coated with specialized antibodies that target a small conserved (i e.
which is why the chances of developing an effective vaccine have been deemed low.)They show that this new formulation reduces the minimal curative dose in a disease model, based on infections in mice, by 100-fold and,
most importantly, circumvents drug resistance in a cell line that is resistant as a result of mutations in the transporter that mediates drug uptake.
minimizing the toxicity and circumventing resistance mechanisms caused by mutations in surface transporters.""The implication of this proof-of-concept study of a novel technology for reversing transporter-related drug resistance,
#Nanotechnology Drug in Droplets for Painless Treatment of Secondary Blindness The Mexican company"Medical and Surgical Center for Retina"created a way to transport drugs,
in order to avoid risks and painful treatments in people with secondary blindness due to chronic degenerative blindness such as diabetic retinopathy and degeneration of the eye.
The innovative formula results eliminates the need to administrate the drug by intraocular injection. It is a nanotechnology product,
or antibody fragments and allow its passage into the eye. Once inside it releases the drugs.
"With this technology hospitals that have no resources can apply the needed drugs, without requiring a a specialist or a particular facility for the administration.
"The doctor Juan carlos Altamirano Vallejo, medical director of the Medical and Surgical Center for Retina, mentions that the conditions that originate in the retina are caused mostly by chronic degenerative diseases such as diabetes (diabetic retinopathy
Patients with this conditions usually require one injection per month which comes at a very high cost
and Innovation and plans to conclude the Clinical Research regulated by the Federal Commission for Protection Against Health risks (COFEPRIS) next year.
The idea is for the medicine to be distributed in state and private health institutions. So far
the achieved results are the same as the ones obtained with intraocular injection, but without the inherent risks of this procedure, such as infection or retinal detachment.
Current talks are being held with COFEPRIS to conduct a study within several diseases and increase its use for different conditions.
In the United states, patients who have followed the treatment have had positive results. The Medical and Surgical Center for Retina provides medical care
and a specialized retina Ophthalmology Clinic provides consultation, which also has an area of`Biotechnology and Drug Research of Biomedical engineering, Diagnosis and Treatment Equipment.
Altamirano Vallejo says that receiving the award opens the doors to reach more people and prevent blindness."
"It is the most important prize delivered by the Presidency of the Republic in the area of`technology and innovation.
For us, to have an entity such as the award foundation to guide us and allows us to learn,
and prevent blindness. Source: http://www. invdes. com. mx
#MEMS Innovations Enable Commercialization of Implantable Microchips for Drug-Delivery An implantable, microchip-based device may soon replace the injections
and pills now needed to treat chronic diseases: Earlier this month, MIT spinout Microchips Biotech partnered with a pharmaceutical giant to commercialize its wirelessly controlled, implantable,
microchip-based devices that store and release drugs inside the body over many years. Invented by Microchips Biotech cofounders Michael Cima, the David H. Koch Professor of Engineering,
each capped with a metal membrane, that store tiny doses of therapeutics or chemicals. An electric current delivered by the device removes the membrane,
for example, diabetes, cancer, multiple sclerosis, and osteoporosis. Now Microchips Biotech will begin co-developing microchips with Teva Pharmaceutical, the world largest producer of generic drugs,
to treat specific diseases, with licensing potential for other products. Teva paid $35 million up front, with additional milestone payments as the device goes through clinical trials before it hits the shelves. bviously,
this is a huge validation of the technology, Cima says. major pharmaceutical company sees how this technology can further their efforts to help patients.
to $289 billion annually in unnecessary health care costs from additional hospital visits and other issues.
Failure to follow prescriptions, the study also found, causes around 125,000 deaths annually and up to 10 percent of all hospitalizations.
While its first partnership is for treating chronic diseases, Microchips Biotech will continue work on its flagship product, a birth-control microchip, backed by the Bill and Melinda Gates Foundation,
sees this hormone-releasing microchip as one of the first implantable rtificial organsbecause it acts as a gland. lot of the therapies are trying to chemically trick the endocrine systems Cima says. e are doing that with this artificial organ we created.
and somewhat fantastical, applications beyond drug delivery, including disease diagnostics and jewelry that could emit scents. e were trying to find the killer application.
and researchers from Microchips, conducted the microchipsfirst human trials to treat osteoporosis this time with wireless capabilities.
In that study, published in a 2012 issue of Science Translational Medicine, microchips were implanted into seven elderly women,
Results indicated that the chips delivered doses comparable to injections and did so more consistently with no adverse side effects.
of life-a cellular recycling unit with a role in many diseases. The proteasome complex is present in all multicellular organisms,
and plays a critical role in cancer by allowing cancer cells to divide rapidly. Researchers used a technique called electron cryo-microscopy,
Scientists from The Institute of Cancer Research, London, and the Medical Research Council (MRC) Laboratory of Molecular biology in Cambridge were able to visualise the proteasome complex down to a resolution of around 3. 5 Angstroms,
and was funded by Cancer Research UK and the MRC. The research could help other scientists to use CRYO EM in structure-based drug design studies-in which researchers build the best possible drugs starting from a molecule which already binds to the active site of a target protein.
Blocking the proteasome prevents this regulated recycling of amino acids and triggers controlled cell death, particularly in fast-dividing cells typical of cancer.
Senior study author Dr Edward Morris, Team Leader in Structural Electron microscopy at The Institute of Cancer Research, London, said:"
"Dr Emma Smith, senior science communications officer at Cancer Research UK, said:""Revealing the molecule's detailed shape could be the first step towards designing more precise drugs to block it.
This molecule plays an important role in some cancers and drugs that block it are already available to patients
unsafe drinking water and the inadequate supply of water for hygiene purposes contribute to almost 90%of all deaths from diarrheal diseases
#Smart Sensor Chip with Nanocavities for Early Prostate Cancer Diagnosis Researchers at the University of Birmingham believe that the novel technology will help improve the process of early stage diagnosis. Glycoprotein molecules,
Because of their essential role in our immune response, they are useful clinical biomarkers for detecting prostate cancer and other diseases.
In doing so, they developed a more accurate and efficient way of diagnosing prostate cancer than the current tests
which rely heavily on antibodies. These antibodies are expensive to produce, subject to degeneration when exposed to environmental changes (such as high temperatures
or UV LIGHT) and more importantly, have a high rate of false-positive readings. Professor Paula Mendes said,
so could feasibly be kept on the shelf of a doctors'surgery anywhere in the world.
Problematically for diagnosis, the protein part of glycoproteins does not always change if the body is diseased.
The findings, published in the journal Chemical science, show how the rate of false readings that come with antibody based diagnosis can be reduced by the smart technology that focuses on the carbohydrate part of the molecule.
the team wanted to identify the presence of disease by detecting a particular glycoprotein which has specific sugars in a specific location in the molecule.
and so we need technology that can discriminate between these subtle differences-where antibodies are not able to."
the sugar part of the prostate cancer glycoprotein is reacted with a custom-designed molecule that contains a boron group at one end (the boron linkage forms a reversible bond to the sugar).
and the only key that will fit is the specific prostate cancer glycoprotein that we're looking for.
"Dr John Fossey added,"It's estimated that one in eight men will suffer from prostate cancer at some point in their life,
so there's a clear need for more accurate diagnosis. By focussing on the sugar, we appear to have hit the'sweet spot'for doing just that.
and collaboration with commercial partners, will open the door to adapting the current technology for other diseases.
Lots of diseases produce specific glycoproteins, so there are a number of possible avenues to improve the accuracy of our diagnoses."
where they create clothing that kills bacteria, conducts electricity, wards off malaria, captures harmful gas and weaves transistors into shirts and dresses. otton is one of the most fascinating and misunderstood materials,
which could help in warding colds, flu and other diseases. Two of Hinestroza students created a hooded bodysuit embedded with insecticides using metal organic framework molecules,
Malaria kills more than 600,000 people annually in Africa. While insecticide-treated nets are common in African homes
Other students have used MOFS to create a mask and hood capable of trapping toxic gases in a selective manner.
#Discovery of Mesh Cell Structure Could Help Understand Development of Cancer For the first time a structure called he meshhas been identified
which is found to change in certain cancers, such as those of the breast and bladder.
The finding was made by a team led by Dr Stephen Royle, associate professor and senior Cancer Research UK Fellow at the division of biomedical cell biology at Warwick Medical school.
and support from Cancer Research UK and North West Cancer Research. Dr Royle said: e had been looking in 2d
TACC3, is overproduced in certain cancers. When this situation was mimicked in the lab, the mesh and microtubules were altered
Dr Emma Smith, senior science communications officer at Cancer Research UK, said: roblems in cell division are common in cancer cells frequently end up with the wrong number of chromosomes.
and it might be a crucial insight into why this process becomes faulty in cancer
and whether drugs could be developed to stop it from happening. orth West Cancer Research (NWCR) has funded the research as part of a collaborative project between the University of Warwick and the University of Liverpool,
which could potentially better inform future cancer therapies. s a charity we fund only the highest standard of research,
award-winning scientists and pioneering professionals. arwick Medical school division of biomedical cell biology carries out fundamental molecular and cellular research into biomedical problems.
Major human diseases such as cancer inflammation, neurodegeneration and bacterial/viral infection are primarily diseases of cells.
Without a molecular understanding of the underlying cell biology, intelligent directed therapeutic intervention is impossible. The division research focuses on fundamental cell biology processes such as cell division and intracellular communication.
Source: http://www2. warwick. ac. uk m
#Scientists Discover New Chemical reaction Pathway on Titanium dioxide The reaction mechanism, reported in ACS Nano, involves the application of an electric field that narrows the width of the reaction barrier,
Technology areas of interest include cloud applications, analytics, social media, mobile, materials, medical devices, digital health, healthcare IT, instruments and cloud software infrastructure.
The nanoparticles infused with silver ions were utilized to attack Pseudomonas aeruginosa, disease-causing bacteria; E coli, a bacterial species that cause food poisoning;
Staphylococcus epidermis, bacteria that form toxic biofilms on plastics such as catheters in the human body; and Ralstonia, a genus of bacteria that contains various soil-borne pathogens.
All these bacteria were destroyed by the newly developed nanoparticles. Using this latest technique, researchers can easily modify the nanoparticle recipe to target certain microbes.
According to Alexander Richter, first author of the paper and a Ph d. candidate at NC State who received the 2015 Lemelson-MIT prize,
The method released the stress in the laminate layer and avoided stress to build up between the two stacked layers.
Yet, more traditional approaches to thermocompression bonding come with long cycle times(>1 minute per die),
rapid, data-rich biomedical imaging. By merging data simultaneously collected by thousands of microlenses optical elements each smaller than the width of a human hair this new multispectral microscope is able to produce a continuous series of datasets that essentially reveal how much of multiple colors
Multispectral Imaging Color and Data Combinemultispectral imaging is used for a variety of scientific and medical research applications.
Medical researchers are able to study these frequencies to learn about the composition and chemical processes that are taking place within a biological sample.
This is essential for pharmaceutical research particularly cancer research--to observe how cells and tissues respond to specific chemicals and experimental drugs.
which find application in cancer treatment, pollution reduction, renewable energy collection. Scientists from Harvard, Boston, and Princeton universities have played also a role in the development of this innovative technique, called D Structure Identification of Nanoparticles by Graphene Liquid Cell EM (SINGLE),
and observe and study the biological and medical significance of RNA misregulation. Details will be published the week of July 20 in the journal Proceedings of the National Academy of Sciences (PNAS.
"Mirkin is the George B. Rathmann Professor of Chemistry in the Weinberg College of Arts and Sciences and professor of medicine, chemical and biological engineering, biomedical engineering and materials science and engineering.
which was the first genetic-based approach that is able to detect live circulating tumor cells out of the complex matrix that is human blood.
a start-up company, has developed a proprietary nano-polymer additive that protects against any microbial infection
or implant-associated infection, improve clinical outcomes and increase device longevity. The nano-polymer additive's unique features are that they are activated only upon contact,
Antimicrobial resistance (AMR) is considered to be the most urgent and important challenge of all medical fields.
"Unless we take significant actions to improve efforts to prevent infections. the implications will be devastating."
"1 NIH (National institutes of health) estimates that"Infectious diseases are the second cause of death worldwide, more than13 millions deaths per year (mostly due to bacteria.
More than 60%of microbial infections proceed with involvement of biofilms.""Prof. Ervin Weiss inventor and one of the developers of the nano-polymer additive technology adds,
and heavy metals, will revolutionize medical device industry. s
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