inexpensive test to screen people at high risk of developing the disease. A team at Barts Cancer Institute, Queen Mary University of London, has shown that the three-protein'signature'can both identify the most common form of pancreatic cancer
when still in its early stages -and distinguish between this cancer and the inflammatory condition chronic pancreatitis,
which can be hard to tell apart. The study, published today, 03 august in the journal Clinical Cancer Research, was funded by the UK charity, the Pancreatic cancer Research Fund.
It looked at 488 urine samples: 192 from patients known to have pancreatic cancer, 92 from patients with chronic pancreatitis and 87 from healthy volunteers.
A further 117 samples from patients with other benign and malignant liver and gall bladder conditions were used for further validation.
while patients suffering from chronic pancreatitis had significantly lower levels than cancer patients. When combined, the three proteins formed a robust panel that can detect patients with stages I-II pancreatic cancer with over 90 per cent accuracy.
With few specific symptoms even at a later stage of the disease, more than 80 per cent of people with pancreatic cancer are diagnosed
when the cancer has already spread. This means they are not eligible for surgery to remove the tumour-currently the only potentially curative treatment.
The five-year survival rate for pancreatic cancer in the UK is the lowest of any common cancer
people at higher risk of developing the disease include those with a family history of pancreatic cancer, heavy smokers, the obese and people over 50 years with new-onset diabetes.
if the 3-biomarker signature is present during the latency period-the time between the genetic changes that will cause the cancer to develop and the clinical presentation."
"For a cancer with no early stage symptoms, it's a huge challenge to diagnose pancreatic cancer sooner,
"says co-author and Director of Barts Cancer Institute, Professor Nick Lemoine.""With pancreatic cancer, patients are diagnosed usually
when the cancer is already at a terminal stage, but if diagnosed at stage 2,
Early diagnosis is an important part of our overall efforts against this aggressive cancer, alongside developing new treatments to tackle the disease once diagnosis is made.
It underlines the importance of increased research efforts to help improve survival rates.""Many of the urine samples from healthy individuals tested by Tanja's team were donated from the charity's own supporter community,
The results are reported in the Journal of Neurotrauma. hese findings tell us we have to look at spinal cord injury in a new way
he now believes that it is possible to significantly improve quality of life for patients with severe spinal cord injuries,
because youe not going to recover function below the lesion,?he said. hey have been told that for decades,
The finding led Edgerton to believe the same approach could be effective for people with complete paralysis. In the new research,
a drug often used to treat anxiety disorders. Researchers placed electrodes at strategic points on the skin
stepping and voluntary control of movements after paralysis. t was remarkable. Edgerton said most experts,
including himself, had assumed that people who were paralyzed completely would no longer have had neural connections across the area of the spinal cord injury.
and when the subjects see their legs moving for the first time after paralysis, they say it a big deal.
their injuries were suffered during athletic activities or, in one case, in an auto accident. All have been paralyzed completely for at least two years.
the Walkabout Foundation and the Russian Scientific Fund. hese encouraging results provide continued evidence that spinal cord injury may no longer mean a lifelong sentence of paralysis
but not complete, paralysis. heye likely to improve even more, he said. The scientists can only work with a small number of patients, due to limited resources,
Almost 6 million Americans live with paralysis, including nearly 1. 3 million with spinal cord injuries. person can have hope, based on these results,
Edgerton said. n my opinion, they should have hope s
#Artificial blood Vessels Become Resistant To Thrombosis, Study Scientists from ITMO University developed artificial blood vessels that are not susceptible to blood clot formation.
The achievement was made possible by a new generation of drug-containing coating applied to the inner surface of the vessel.
Surgery, associated with cardiovascular diseases, such as ischemia, often require the implantation of vascular grafts-artificial blood vessels,
#Real-time Data For Cancer Therapy, MIT Study Biochemical sensor implanted at initial biopsy could allow doctors to better monitor
and adjust cancer treatments. In the battle against cancer, which kills nearly 8 million people worldwide each year,
doctors have in their arsenal many powerful weapons, including various forms of chemotherapy and radiation.
Magnetic resonance imaging and other scanning technologies can indicate the size of a tumor, while the most detailed information about how well a treatment is working comes from pathologistsexaminations of tissue taken in biopsies.
Yet these methods offer only snapshots of tumor response and the invasive nature of biopsies makes them a risky procedure that clinicians try to minimize.
Now, researchers at MIT Koch Institute for Integrative Cancer Research are closing that information gap by developing a tiny biochemical sensor that can be implanted in cancerous tissue during the initial biopsy.
Making cancer treatments more targeted and precise would boost their efficacy while reducing patientsexposure to serious side effects. e wanted to make a device that would give us a chemical signal about what happening in the tumor,
says Michael Cima, the David H. Koch (1962) Professor in Engineering in the Department of Materials science and engineering and a Koch Institute investigator who oversaw the sensor development. ather than waiting months to see
if the tumor is shrinking, you could get an early read to see if youe moving in the right direction.
on-demand data concerning two biomarkers linked to a tumor response to treatment: ph and dissolved oxygen.
you can see the response chemically before you see a tumor actually shrink, Cima says.
and the inflammation will make the tumor appear to be growing, even while the therapy is effective.
since tumors thrive in low-oxygen (hypoxic) conditions. t turns out that the more hypoxic the tumor is,
could let you see how hypoxia was changing in the tumor, so you could adjust the radiation accordingly.
so we can use them to monitor tumor response, Cima says. e did a little bit of that in these experiments,
While the primary application of these sensors would be cancer care, Cima is also eager to collaborate with researchers in other fields, such as environmental science. or example,
and demonstrate for opioid pain relievers can be adapted to produce many plant-derived compounds to fight cancers, infectious diseases and chronic conditions such as high blood pressure and arthritis.
#Minimally Invasive Robotic Surgical Tool Feels For Tumors, Study Tumors often look identical to healthy nearby tissue,
but they tend to feel different. Surgeons often use their fingers to feel the size and shape of
Michigan State university Study Researchers at Michigan State university were part of a team to discover a new natural defense against HIV infection.
that comprise similar building blocks of the host the pathogens are trying to infect. On the surface of the envelope, there are viral glycoproteins, known as Env spikes,
leading viruses to binding sites that allow infections to spread at the molecular level. They serve as a key of sorts that gives viruses entry into the host to begin spreading.
The number of infections is rising, though overall the country still has a low rate of infection.
Currently, there is no cure for HIV-1; once patients have it, they have it for life.
but they cannot cure the disease. Current drug treatments have to be taken for a lifetime,
"We see a way to treat this disease by helping the body protect itself, "he said."
to dedicate our work to fighting this disease
#Twin Study Suggests Genetic Factors Contribute To Insomnia In Adults, Virginia Commonwealth University Reveals DARIEN,
IL-A new study of twins suggests that insomnia in adults is explained partially by genetic factors,
and this heritability is higher in females than in males. Results show that the genetic influences on insomnia symptoms in adults were substantial and largely stable over time while differing significantly by sex.
In the longitudinal model, the estimated heritability of insomnia was 59 percent for females and 38 percent for males."
"This study indicates that genes may play a larger role in the development of insomnia symptoms for women than for men,
providing some of the first formal evidence for sex differences in an adult sample, "said first author Mackenzie Lind, a doctoral candidate at the Virginia Institute for Psychiatric and Behavioral Genetics at Virginia Commonwealth University in Richmond."
According to the American Academy of Sleep Medicine, transient insomnia symptoms occur in 30 to 35 percent of the population.
Chronic insomnia, which occurs at least three times per week for at least three months, affects about 10 percent of adults.
Insomnia is more common in women than men and involves difficulty falling asleep or staying asleep
Insomnia symptoms were evaluated via self-report questionnaire at two non-overlapping time points. According to the authors, this is the first study to examine the genetic and environmental influences on insomnia symptoms in adults in a longitudinal, representative twin sample.
The authors also noted that in addition to the substantial heritability estimates, unique environmental factors continue to account for a large amount of variance in insomnia symptoms s
#Self-propelled Powder To Stop Bleeding Created, University of British columbia Researchers UBC researchers have created the first self-propelled particles capable of delivering coagulants against the flow of blood to treat severe bleeding,
a potentially huge advancement in trauma care. leeding is the number one killer of young people,
and maternal death from postpartum hemorrhage can be as high as one in 50 births in low resource settings so these are extreme problems,
Traditional methods of halting severe bleeding are not very effective when the blood loss originates inside the body like the uterus,
gas-generating calcium carbonate micro-particles that can be applied in powder form to stop critical bleeding.
and transport it through wounds and deep into the damaged tissue. After studying and modeling the movement of the particles in vitro,
the particles proved highly effective in stopping the bleeding. While much more rigorous testing and development is needed to bring the agent to market
from sinus operations to treating combat wounds. he area wee really focusing on is postpartum hemorrhage:
and clinical data to help predict the effects of disease on brain anatomy. In experiments, they trained a machine-learning system on MRI data from patients with neurodegenerative diseases
and found that supplementing that training with other patient information improved the system predictions. In the cases of patients with drastic changes in brain anatomy, the additional data cut the predictionserror rate in half,
Common denominator In their experiments, the researchers used data from the Alzheimer Disease Neuroimaging Initiative, a longitudinal study on neurodegenerative disease that includes MRI scans of the same subjects taken months and years apart.
and those displaying evidence of either Alzheimer disease or mild cognitive impairment, and one in which they trained it only on data from healthy subjects.
The brains of healthy subjects and subjects in the early stages of neurodegenerative disease change little over time,
But they instead used it to predict what the brains of Alzheimer patients would have looked like had they not been disfigured by disease.
Some promising experimental Alzheimer drugs require early determination of how the disease is likely to progress,
Rosen says. f machine-learning tools can help avoid the need for PET scans in evaluating patients early in the disease course,
bring researchers closer to creating an implantable intestine as replacement therapy for a range of devastating disorders-including infections, cancer and trauma-that result in loss or death of gut tissue.
Chief among them is a condition that affects 12 percent of premature newborns, called necrotizing enterocolitis (NEC),
Doing so further amplified the growth and differentiation of new gut cells, specifically the growth of Paneth cells responsible for production of infection-fighting proteins that guard against intestinal infections
the result is a potentially fatal arrhythmia. Now, a team of researchers from Oxford and Stony Brook universities has found a way to precisely control these waves-using light.
'When there is scar tissue in the heart or fibrosis, this can cause part of the wave to slow down.
which cells are transplanted into the injury site, "says research supervisor Dr James St john, from Griffith's Eskitis Institute for Drug Discovery.
"In Australia, more than 12,000 people live with spinal cord paralysis and there is at least one new occurrence every day,
the current outcome for patients is permanent paralysis, with an overall cost to the community of $2 billion a year."
"In light of the overwhelming impact of spinal cord injury, new therapeutic interventions for drug discovery and cell therapy are needed urgently."
"What is needed now is to make the transplantation therapy more effective and suitable for patients with a range of different spinal cord injuries."
and better integrate into the injury site. In turn, this will help the spinal cord to regenerate more effectively."
An abnormally high or low white blood count, for instance, might indicate a bone marrow pathology or AIDS.
The rupturing of white blood cells might be the sign of an underlying microbial or viral infection.
Strangely shaped cells often indicate cancer. While this old, simple technique may seem a quaint throwback in the age of high-technology health care tools like genetic sequencing
and Genistein, the compound found in soybean which has been suggested to play a role in prevention of steroid-hormone related cancers, particularly breast cancer.
The development of a new method to grow three-dimensional organoid cultures of pancreatic tumors directly from patients'surgical tissue offers a promising opportunity for testing targeted therapies
'mini tumors'in a culture dish,"explains the study's corresponding author Senthil Muthuswamy, Phd, Director of the Cell biology Program in the Cancer Research Institute at Beth Israel Deaconess Medical center
or traits that are seen in the patient tumor from which they came and, therefore, can serve as an innovative platform for both cancer research and for cancer treatment."
"Scientists have been growing cells in 3d culture for decades. These models are used to help understand various biological processes such as tissue development and cancer growth,
and Muthuswamy's laboratory has spent the past 15 years growing normal and cancer-derived cells from human breast tissue as 3d organoids.
This new paper provides an innovative new direction for this technology.""We have developed now a new methodology to grow human pancreatic tumor cells from surgical tissues
and have demonstrated that these tumor organoids recreate both morphology and biology of the cancer tissue in the patient,
"says Muthuswamy, who conducted this research while at the University of Toronto. The research team also demonstrated that these clonally derived organoids could be used to identify patient-specific sensitivities to novel therapeutic agents."
"From a research point of view, this organoid approach now provides us with a'live'biobank of tissue for discovery
""Pancreatic cancer is a terrible disease, "said Pier Paolo Pandolfi, MD, Phd, Director of the BIDMC Cancer Center."
"Patients diagnosed with locally advanced or metastatic pancreatic cancer have a survival rate of less than three percent.
These new pancreatic progenitor organoids and tumor organoids can be used to model pancreatic cancer and for drug screening to identify precision therapy strategies
US researchers have developed a new low-cost lab-on-a-chip device to aid analysis of sputum from patients with pulmonary diseases such as tuberculosis and asthma.
and provide alternate treatment approaches for patients with pulmonary diseases.""""Current analysis method has said several disadvantages
In addition, the council is worried that Europe G. M. O. phobia may slam the door on new technologies.
because cassava crops were wiped out by brown-streak disease. That was particularly painful because in neighboring Uganda
which is meant to identify everything in wheat's DNA sequences that can trigger a reaction in people suffering from celiac disease, an autoimmune disorder in
The only known treatment for celiac disease is a gluten free diet free of any foods that contain wheat, rye, and barley."
Though celiac disease is four to five times more common now than 50 years ago, only about 1 per cent of the world's population is believed to suffer from it,
Understanding the causes of celiac disease and gluten intolerance is the goal of a lot of research around the world;
An expert on celiac disease who reviewed Miller's plan online worries that it may prove"too simplistic,
Armin Alaedini, assistant professor of medical sciences at Columbia University and a researcher at the New york-based school's Celiac disease Center, said the project may end up with a less toxic wheat product that isn't completely safe for all celiac disease patients."
The medical advisory board for the Celiac disease Foundation, a nonprofit based in Woodland Hills, California, could not reach a consensus on the viability of Miller's research.
Her son had been sick his entire life before being diagnosed with celiac disease at age 15, Geller said,
If these research efforts can keep celiac disease in the public eye, more doctors will be aware of it and more federal research dollars may flow,
Many people with the disease would like to"eat actual wheat, with the properties of wheat that make the bread nice and fluffy,
which had assumed long that antibiotics would always be available to cure bacterial illness. The scientific community hopes to be able to develop a new range of antibiotics to replace those that are increasingly losing their ability to work against infections like tuberculosis.
A research team led by Markus Aebi Professor of Mycology at ETH Zurich (The swiss Federal Institute of technology in Zurich), believes it may have found the answer.
a class of small proteins produced by numerous organisms to counter disease-causing microorganisms. In fact, the human body produces defensins in the skin
and mucous membranes to protect itself against infections. Patent pending To yield larger amounts of the antibiotic,
because it kills pathogens such as Listeria, a type of bacteria that can cause severe food poisoning."
#Ubisoft offers new video game it says can treat lazy eye The Montreal-based gaming company Ubisoft has developed a video game it says could be used to treat amblyopia, also known as lazy eye.
Amblyopia is a condition in children where vision in one eye does not develop properly.
The company says it's the first video game based on a patented method for the treatment of amblyopia.
Ga.-based company that develops therapies for eye diseases. Game meant to be said engaging Ferland the game involves controlling moles on the tablet screen.
#Superfast blood tests devised in Montreal could revolutionize diagnosing A simple and fast chemical process developed by scientists in Montreal could allow family doctors to one day use equipment as straightforward and cheap as a diabetic's blood sugar tests to diagnose a range of diseases
but it could be useful for doctors treating autoimmune diseases, or for using the eshha technique to detect things like how much of a chemotherapy drug a patient is metabolizing
After that, they're also aiming to detect antibodies for syphilis and herpes. One of the big advantages of their method is its cost:
The electrodes used to detect the electrical current can be had for five to 10 cents each,
#Paralyzed man walks again using brain-computer link A brain-to-computer technology that can translate thoughts into leg movements has enabled a man paralyzed from the waist down by a spinal cord injury to become the first such patient to walk without the use of robotics,
The slow, halting first steps of the 28-year-old paraplegic were documented in a preliminary study published in The british-based Journal of Neuroengineering and Rehabilitation,
and spinal injury victims regain some mobility. Dr. An Do, a study co-author, said clinical applications were many years away.
brain-controlled walking after a complete spinal cord injury,"said biomedical engineer Zoran Nenadic, who led the research. 3. 6 metres The steps taken a year ago by the experiment's subject,
if someone will have a heart attack. Nguyen's concern for his mother's heart condition inspired him to create the device.
#Cancer Patient Receives 3d printed Titanium Ribs & Sternum 3d printing continues to profoundly affect the modern world.
The latest incredible feat involves a 54 year old Spanish man suffering from a chest wall sarcoma a type of cancerous tumour.
Researchers believe the results could lead to new ways of using the hormone to treat psychological problems such as stress and speech disorders.
'It could be that these trigger settings in the embryo that affect the risk of obesity or diabetes in life.'
of which are known to play a role in protecting cells against infections. The placenta absorbs these molecules
and is used to diagnose epilepsy and sleep disorders. Kokoon's app gives detailed feedback based on the nightly EEG readings to help you improve your quality of kip, according to Antos.
The hollow particles also offer impact protection to the syntactic foam because each shell acts like an energy absorber during its fracture.
#Brain training app that could help schizophrenia sufferers live a normal life A new brain training app developed to help improve the memory of people with schizophrenia could save taxpayers thousands of pounds,
which found that schizophrenia patients who played the game regularly for a month were four times better at remembering these kinds of things than non-players.
Schizophrenia is estimated to cost £13. 1billion per year in total in the UK. The long-term mental health condition can cause a range of symptoms including hallucinations and delusions.
But current medications to treat these symptoms cause debilitating side effects including poor memory, which can stop sufferers being able to work or study.
and is aimed at people who suffer with poor episodic memory-one of the main side effects of schizophrenia drugs.
who had been given a diagnosis of schizophrenia, to either the cognitive training group or a control group at random.
which scientists say is important as lack of motivation is another common aspect of schizophrenia.
'We need a way of treating the cognitive symptoms of schizophrenia, such as problems with episodic memory,
this could help people with schizophrenia minimise the impact of their illness on everyday life.'
Breakthrough could lead to better treatment for brain disorders Scientists have created super-intelligent mice by altering a single gene.
but it also meant the they were less likely to feel anxiety or recall fear, researchers found.
They hope the discovery may help the search for treatments for disorders such as Alzheimer's, schizophrenia and post traumatic stress disorder (PTSD.
The experiments also showed that PDE4B-inhibited mice suffered less anxiety, choosing to spend more time in open, brightly lit spaces than normal mice,
whether the findings could have implications for Alzheimer's disease or other dementias.''We'd need to see how this gene could influence memory
'There is currently a lack of effective treatments for dementia and understanding the effect of genes can be a key early step on the road to developing new drugs.'
'With so many people affected by dementia, it is important that there is research into a wide array of treatment approaches to have the best chance of helping people sooner
trapped, frozen or absorbed in some material-from the surface that is triggered by tidal stress on the moon.
and fibres will prove to be a valuable research tool for non-animal testing of new drugs and investigating brain disorders such as Alzheimer's.
'We've struggled for a long time trying to solve complex brain disease problems that cause tremendous pain and suffering.'
Already the scientists have gone on to create brain organoid models of Alzheimer's and Parkinson's disease, and autism, in a dish.
With the addition of a blood circulation, which is currently lacking, they also hope to use the model to study stroke therapies.
Military applications include research on Gulf war syndrome, traumatic brain injury, and posttraumatic stress disorder. r
#Royal Navy could soon be using remote-controlled warships with'see-through'hulls Sleek and stealthy, it resembles something from Star wars. In fact,
this is what British warships could look like in as little as 35 years. With RAF jets already being replaced by drones piloted by men sitting at computer screens many miles away,
and prevent fatal injuries Fatal shootings by police and other law enforcement agencies could soon be avoided thanks to a device that acts like an'airbag'for a bullet.'
effectively slowing it down to result in less injury. Scroll down for video It is hoped the'airbag for a bullet'could reduce the number of civilians killed by police officers in potentially lethal situations.
but less injury to a body than a conventional bullet. In this way, it is'less lethal'than a regular bullet
#Scientists brew cannabis chemical THC for better drugs for cancer sufferers An active ingredient typically found in cannabis has been engineered genetically in the lab for the first time.
They believe the breakthrough will lead to more effective and easier-to-manufacture cancer and HIV drugs
It's often used to treat nausea associated with HIV or cancer therapies but this new process could offer a less expensive,
It's often used to treat nausea associated with HIV or cancer therapies, but this new process could offer a less expensive,
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