thus aiding in reducing global disease burden. The technique was found to be safe and effective in lab testssingapore:
thus aiding in reducing global disease burden. Through this technology, vaccines are delivered simply by laying a tiny patch onto a person's finger,
linical study and stability assessment of a novel transcutaneous influenza vaccination using a dissolving microneedle patch,
Similar to the approaches used to develop vaccines for polio, influenza, rabies and Hepatitis a, the vaccine is the first based on a genetically modified,
A green fluorescent protein was added to a gene from rhesus macaque monkeys that is known to restrict the feline and human form of the disease.
The real news here is the potential for developing disease resistant genetic lines. And maybe just maybe we#re one step closer to effectively combating this terrible disease b
#State Deficits to Shrink & Taxes Drop-Good News for Biotech Forecasters at the National Conference of State Legislatures2011 Legislative Summit expect a dramatic reduction of state deficits in the coming years,
The farmers went through a tough spot about a year ago, fighting disease. They got their crops to where they were ready to pick.
a rare hereditary disease in which a mutation of the MEN1 gene on chromosome 11 makes patients susceptible to developing both benign
and malignant tumors on hormone-producing organs such as the parathyroid gland, the pancreas and the pituitary gland. Animal studies previously linked this gene mutation with breast cancer;
Researchers concluded that the average age of diagnosis of breast cancer with this gene abnormality was 48 years old,
Besides skin cancer, it is the most commonly diagnosed cancer; breast cancer is also the 2nd deadliest type of cancer, right behind lung cancer.
About 85%of breast cancers occur in women who have no family history of breast cancer. Even though this study does not offer a cure,
it may provide future scientists with information that can help defeat this devastating disease and it may provide patients the chance to perform early action treatment. t is important that women with the MEN1 syndrome now know that they have to be aware that they run the risk of developing breast cancer,
because early treatment is always better, said Prof. Dr. Elsken van der Wall, a medical oncologist working for the UMC Utrecht Cancer Center e
#A Better Way to Make Unnatural Amino acids Discovered by Yu Certain amino acids that are not found in nature are highly sought after by pharmaceutical manufacturers.
and drugs that inhibit the formation of amyloid aggregates seen in Alzheimer, Parkinson and other diseases.
For many indications, such as Alzheimer and autism, the need for new treatments is enormous, yet investment in these areas is declining due to recent high profile failures.
along with academic institutions and disease foundations. These collaborations are defined coming together, in re-competitivespaces, to generate tools
In the field of autism, stakeholders such as academic researchers, pharma companies, and patient advocacy groups are coming together to better understand the inner workings of the disease in hopes to increase the development and approval of effective therapeutics.
A unified effort in Europe is named underway EU-AIMS a $40 million multi-year collaborative program to develop the infrastructure underpinning new treatments for autism.
These are just two instances of industry coming together to achieve a mutually beneficial goal and tackle challenges that no one organization can tackle alone.
Addressing chronic and complex diseases in kids can improve health outcomes, quality of life and reduce future medical spending
and biotech companies to develop better treatments most recently with Shire around rare diseases. These alliances leverage Boston Children research expertise and companiesdevelopment and commercialization capabilities.
The latest call for hospital-acquired infections closed recently with 35 applications. Back in September 2011, Roche global innovation program, called EIN (Expanding the Innovation Network,)
Roche agreed to support a new BIO-X project run by Karolinska Institutet spin out Liquid Biopsy in cancer diagnostics.
including circulating tumor cells from blood, paving the way for better cancer treatments. The project will get access both to the BIO-X process support
and Roche global R&d capabilities, offering access to equipment, services, reagents and know-how, as well as financial support for the project for up to two years f
Two patients with beta-thalassemia, a genetic disorder which normally requires regular blood transfusions, have been able to forgo transfusions for at least five months following a gene therapy treatment from bluebird.
including pests and pathogens, reduced habitat, lack of nutritional resources and exposure to pesticides. gripulse noted that The Washington post reported that the EPA will announce that it will accelerate a review of the effects of neonicotinoid pesticides on pollinators
#A paper microscope that costs only 50 cents can detect malaria from just a drop of blood
they remain an integral part of detecting disease and analyzing blood samples. Yet despite their necessity, theye expensive.
Practically, the Foldscope can help doctors correctly diagnose deadly diseases such as malaria, schistosomiasis, and African sleeping sickness.
In a TED Talk, Prakash explains that identifying these infections is as simple as adding dye to a single drop of blood.
With cheap, easy-to-use microscopes, any lab technician can learn to detect malaria, potentially revolutionizing healthcare in areas where these diseases run rampant.
While the generic Foldscope serves as a one-size-fits-all microscope, Prakash and his team have developed also specialized versions,
such as a malaria-centric one, that make identifying diseases even easier. TEDTHE completed Foldscope fits any standard microscrope slide.
Prakash vision of"frugal science"didn stop at the microscope, however. He built a $5 microfluidic chemistry lab that is able to test
More than just helping combat disease Prakash also hopes his"frugal science"movement will make science education and research accessible across the globe.
"My Phd supervisor, she found her melanoma when she was designing the device, just testing the image quality,"said Sadeghi."
The Brazilian neurobiologist was part of a team of researchers who created a mind-controlled robotic exoskeleton worn by Juliano Pinto as the paraplegic man took part in the kickoff for the 2014 World cup in Sao paulo o
#Smartphones tested as tools for medical research Jody Kearns doesn't like to spend time obsessing about her Parkinson's disease.
"The thing with Parkinson's disease is there's not much you can do about it, "she said of the nervous-system disorder,
and doctors together online, applying massive computing power to analyze DNA and even developing ingestible"smart"pills for detecting cancer.
Smartphone Medicine Dr. Michael Mcconnell, a cardiologist who's using an app to study heart disease,
who's using an app to study heart disease.""It's one thing that people have with them every day."
Apple launched its Researchkit program in March with five apps to investigate Parkinson's, asthma, heart disease, diabetes and breast cancer.
Elizabeth Ortiz, a 48-year-old New york nurse with asthma, measures her lung power each day by breathing into an inexpensive plastic device.
She types the results into the Asthma Health app which also asks if she's had difficulty breathing or sleeping,
and there's a high rate of asthma in my community, "said Ortiz, who said she already used her iphone"constantly"for things like banking and email."
and anyone else who suffers from asthma.""None of the apps test experimental drugs or surgeries.
Instead, they're designed to explore such questions as how diseases develop or how sufferers respond to stress, exercise or standard treatment regimens.
Stanford's Mcconnell said he also wants to study the effect of giving participants feedback on their progress,
while it is kept at a consistent warmth of 101.5°F (38°C). The three-plus weeks the manure is kept at that temperature is to guarantee any pathogens would be killed off,
#Lab-grown human muscle is a medical breakthrough The new kind of lab-grown muscle will allow the study of disease
"There are a some diseases, like Duchenne Muscular dystrophy for example, that make taking muscle biopsies difficult. If we could grow working, testable muscles from induced pluripotent stem cells,
or disorders particularly individuals who have become paralysed following spinal cord injury. EPFL The flexible silicon implant is covered in cracked gold conduction tracks that stretch with the silicon
#New martinsulin Patch Could Change Everything For Diabetics A new martinsulin patch could do away with painful injections
and revolutionize the way diabetics keep their blood sugar levels in check. For people affected by diabetes,
monitoring and regulating insulin levels can be a tedious and dangerous task. I remember my own grandmother,
a type II diabetic, would have a sugary snack on her at all times in case her blood sugar levels suddenly dropped,
but looking back now I see how her quality of life was compromised by one of today most shockingly prevalent diseases.
showed promising results in a mouse model of type 1 diabetes. Researchers hope to see similar success in subsequent clinical trials in humans. he whole system can be personalized to account for a diabetic weight
and sensitivity to insulin, said co-senior author Zhen Gu in a statement, o we could make the smart patch even smarter.
researchers suggest the patch can have a longer-lasting effect in diabetic patients. The patch emulates beta cells
sending insulin into the bloodstream. he hard part of diabetes care is not the insulin shots,
#Mutebutton can train your brain to ignore tinnitus By Roger Dobson for the Daily mail Published:
23:02 GMT, 18 may 2015 A new device that stimulates the tongue may be a new way to tackle tinnitus.
Clinical trial results suggest it can reduce tinnitus loudness by an average of about 40 per cent.
Tinnitus is the perception of sound in the ear usually a ringing noise, although it can be pitched a high whistling or buzzing, ringing, or hissing.
although in some cases it is linked to hearing loss-one theory is that when some sounds can no longer be heard,
although treatments such as maskers (ear-plugs that generate white noise to try to block out tinnitus noise), antidepressants,
or think differently about their tinnitus, can help. However, the Mutebutton is designed to gradually re-train the brain (via the nerves in the tongue)
in order to reduce the loudness of tinnitus. The stimulator is held between the lips and creates a mild current to stimulate nerves in sync with the sound played through the earphones.
The idea is that the brain gradually begins to play down the illusory sounds of tinnitus
In a trial at the National University of Ireland, the system was tested on 60 people who'd had tinnitus for longer than six months.
Tinnitus volume reduced by 42 per cent on average. The Mutebutton is likely to be available in the UK later this year.
senior audiologist at charity Action On Hearing loss, says:''We welcome all new research, as the mechanisms behind this debilitating condition are still not fully understood
'More evidence is needed on the effectiveness of this device before it can offer real hope to the millions of tinnitus sufferers across the UK.'
'Meanwhile, researchers have identified now the areas of the brain thought to be involved in tinnitus-with the hope that this new understanding could trigger new treatments.
Scientists at Newcastle University and the University of Iowa, in the U s.,have shown that more areas of the brain are involved in tinnitus than just the sound centre-the auditory cortex-which was thought previously to be responsible.
which lit up during times of loud and quiet tinnitus. Their findings might explain why the condition can be difficult to treat,
enabling people with physical disabilities to play the piano, as we demonstrated with our Eye Play the Piano project.'
#The HEADPHONES that detect brain damage: Pioneering device tracks changes in pressure caused by injury and infection Doctors have developed a brain pressure test using a special set of headphones that can detect life-threatening head injuries and infections.
The technique involves a patient wearing the headphones with an ear plug linked to a computer.
This enables doctors to measure fluid pressure in the skull-known as intracranial pressure (ICP)- without the need for surgery or painful spinal procedures.
when the brain swells as a result of an injury or infection and prevents blood flow, depriving the brain of the oxygen it needs to function.
The headphones are set to be used in the diagnosis and treatment of conditions such as meningitis and head trauma injuries
it is also being adapted by Nasa to analyse brain pressure levels in astronauts to help tackle space-related visual problems and sickness.
And doctors said they believe it could be used to distinguish between head injuries and post traumatic stress disorder in soldiers returning from combat zones.'
'We know that high pressure inside the skull resulting from injuries and infections can be fatal,
so it is essential it is detected as early as possible to avoid exacerbating symptoms and ensure treatment can begin promptly'explained Dr Robert Marchbanks, a consultant clinical scientist.'
'Current methods for testing ICP require procedures to be carried out under sedation or anaesthetic, which means they are limited to the most severe cases
'And he continued it was'as painless and gentle'as cataract surgery. Visual acuity-or the ability to see fine spatial details-is measured typically with a Snellen chart used by optometrists globally.
The chart displays letters that get progressively smaller in size. The benchmark, and vision that is considered healthy and'normal,
Legal blindness is categorised as 20/200. On the opposite scale, 20/15 offers enhanced vision.
The lens-glasses combination was designed to help restore the sight of people suffering from age-related macular degeneration, or blindness.
In particular, they were designed to restore the sight of people suffering from age-related macular degeneration, or blindness.
In the body peripheral nervous system, neuromodulation monitors the status of organs and manages how they respond to disease.
it can cause people to become more ill as the body fails to fight the infection.
and public anxiety around having such sensitive data captured, stored, and accessed. We have researched this area by presenting people with potential future scenarios that involved biometrics.
sex trafficking and the spread of diseases. According to Nasa, scientists could also use it to search for images and data from spacecraft.
#Flawed science triggers U-turn on cholesterol fears For decades they have been blacklisted as foods to avoid, the cause of deadly thickening of the arteries, heart disease and strokes.
'London-based cardiologist Dr Aseem Malhotra, science director of campaign Group action On Sugar, wrote in The british Medical Journal that it was time to'bust the myth of the role of saturated fat in heart disease'.
'He added that the food industry had contributed effectively to heart disease by lowering saturated fat levels in food and replacing it with sugar.
and saturated fat in food to heart disease were tinged with scandal'.
#NSA testing smartphones that can tell who you are by the way you write: Handwriting recongition system The NSA is set to begin using smartphone software that can recognise a person by the way they write.
'The 60,000 Britons who have lost a limb due to illness, accident or warfare have a choice of prosthetic replacements,
Exploding cells captured on film for first time-shedding light on how our immune system works A key component of the body defence against disease has been captured on film for the first time.
If a disease or infection causes white blood cells to die, they can then warn others nearby to mount an immune response.
'It could be that we've identified the mechanics of how dying white blood cells go about alerting neighbouring cells to the presence of disease
or infection. lternatively we may have discovered the transportation mechanism for a virus to infect other parts of the body.
could now help scientists develop new ways of harnessing the power of the immune system to fight off disease.
#Medical cannabis DOESN'T ease pain, nausea, vomiting, sleep disorders or Tourette's By Lizzie Parry for Mailonline Published:
Medicinal cannabis has been legalised in 23 US states as a therapy to treat disease or alleviate symptoms,
And weaker evidence still that the drug eased nausea and vomiting in chemotherapy patients, sleep disorders,
and Tourette syndrome. Dr Penny Whiting, from the University of Bristol, and her team evaluated the evidence for benefits and adverse events, related to medicinal cannabis use.
Moderate-quality findings suggest that cannabinoids may be beneficial for the treatment of chronic neuropathic or cancer pain,
and muscle contractions due to multiple sclerosis. But researchers discovered weak evidence that medical marijuana was associated with improvements in nausea and vomiting due to chemotherapy
weight gain in HIV, sleep disorders and Tourette syndrome. And there was very-low quality evidence the drug eased anxiety.
In addition, Dr Whiting and her team found weak evidence to support the claim that medicinal cannabis has no effect on psychosis,
and very little evidence in defence of the idea it had no effect on depression.
Meanwhile, the drug was linked with several adverse effects. Notably, cannabinoids were found to cause dizziness, dry mouth, nausea, fatigue, euphoria, vomiting, disorientation, drowsiness, confusion, a loss of balance and hallucination.
The study authors said:''Further large, robust, randomised clinical trials are needed to confirm the effects of cannabinoids, particularly on weight gain in patients with HIV/AIDS, depression, sleep disorders, anxiety disorders, psychosis, glaucoma,
and Tourette syndrome are required.''Further studies evaluating cannabis itself are required also because there is very little evidence on the effects and adverse effects of cannabis.'
'In an editorial linked to the study, Dr Deepak Cyril and Dr Mohini Ranganathan, of Yale university, said:'
a cough-suppressant that may also fight cancer, as well as improved plant strains with higher yields of morphine.
'The scientists hope that understanding how this type of memory is formed could someday help patients suffering from certain neurological disorders, such as Alzheimer's disease e
'We're also very interested in addressing stress in working dogs, such as guide dogs for the blind,'sayssean Mealin,
and mitigate stress for the dogs, improving the length and quality of a dog's life,
and trained not to display signs of stress in their behavior.''In addition to disaster response research, the research team has done already work that uses the platform to assist in dog training.
#Have scientists found a cure for deafness? Gene therapy that restores hearing in mice could be used on humans in just five years By Ellie Zolfagharifard For Dailymail. com and Reuters Published:
01:22 GMT, 9 july 2015 Gene therapy to treat hereditary human deafness could be available within five years.
Research revealed today shows the revolutionary technique is capable of fixing faulty DNA to let genetic deaf mice hear again.
Separately, a similar Novartis gene therapy trial is under way to help restore hearing in people who have become deaf through damage or disease.
The latest study found that mice with genetic hearing loss could sense noises after receiving healthy copies of their faulty genes.
Scientists say the mice mutated genes are similar to those responsible for some hereditary human deafness
The technique has had positive clinical results recently in conditions ranging from blood diseases to blindness.''We are somewhat late in the auditory field but
In the case of deafness, this involves injecting a gene-carrying engineered virus into the inner ear.
There are currently no approved disease-modifying treatments for disabling hearing loss, which affects some 360 million people,
Much of the hearing loss in older people is noise-induced or age-related but at least half of deafness that occurs before a baby learns to speak is caused by defects in one of more than 70 individual genes.
It is these infants Swiss and U s. researchers hope to help, after showing that replacing a mutated gene improved the function of hair cells of the inner ear and partially restored hearing in deaf mice.
Scientists from The swiss Federal Institute of technology in Lausanne and the Boston Children's Hospital, tested hearing in newborn mutant mice by seeing how high they jumped
which is a common cause of human genetic deafness, accounting for 4 to 8 percent of cases.
or AAV1, This virus infected the hair cells in ears of deaf baby mice, giving them working genes.
Scientists say other forms of hereditary deafness could also be fixed using the same strategy. Work at Novartis is advanced more,
disease or exposure to certain drugs, including some antibiotics. But it will not help the one to three babies per 1
000 born with severe genetic hearing loss in both ears.''There are a big range of deafness types needing different approaches,
'said Moser
#Behold the PENTAQUARK! Large hadron collider discovers new particle that has eluded scientists since the 1960s A new particle called the pentaquark has been discovered by scientists at the Large hadron collider (LHC).
who is co-senior author of the study with Dr. Bruce Conklin, a senior investigator at the Gladstone Institute of Cardiovascular disease and a professor of medical genetics and cellular and molecular pharmacology at UC San francisco.'
'This technology could help us quickly screen for drugs likely to generate cardiac birth defects, and guide decisions about
a drug known to cause severe birth defects. They found that at normal therapeutic doses, the drug led to abnormal development of microchambers, including decreased size,
The most commonly reported birth defects involve the heart, and the potential for generating cardiac defects is of utmost concern in determining drug safety during pregnancy.'
cells along the edge experienced greater mechanical stress and tension, and appeared more like fibroblasts,
which is an imperfect model for human disease
#Lexus builds car with human HEARTBEAT in connection between driver and vehicle Lexus has built a car that pulsates with light in time with the driver's heartbeat in order to display the connection between the driver and the car.
000 people in Britain, 85 per cent of them with the dry form of the disease.
and his brain now needs to get use to interpreting it. he Argus II retinal implant was used previously on 130 patients with the rare eye disease retinitis pigmentosa.
which is known as Stargardt disease. For Kathy, a blind spot takes up the majority of her vision.
and to read him stories at bed time. eing a person with a disability who has two children of her own,
Incredible Technology Our glasses are packed with sophisticated technology designed to support people with legal blindness. esight is hands-free, mobile,
am I at risk of heart disease? One day soon your mirror might actually be able to give you the answer.
Facial recognition software looks for telltale markers of stress or anxiety, while the gas sensors take samples of the user breath looking for compounds that give an indication of how much they drink or smoke.
like heart disease or diabetes. revention is the most viable approach to reduce the socioeconomic burden of chronic and widespread diseases,
such as cardiovascular and metabolic diseases, they write. Clinical trials of the device will begin next year at three sites in France
This means (cue maniacal laughter) attorneysfees accountantsfees and compliance costs. Raising $50 million under Regulation A is going to require your company to invest money in the process.
or complete eradication of all diseases and poverty is up for debate. But the fact is this is going to have an impact bigger than any other impact that man has seen before.
While medical injections are unpleasant and inconvenient, theye also necessary for people with illnesses like diabetes.
Schoellhammer sees this being helpful for the 1 million people in the United states who have irritable bowel syndrome (IBS) as well as other conditions.
#Powerful MRI SCANNERS could predict diseases Cutting-edge technology, designed to delve deeper into the human body, has arrived at a research centre in Portugal.
The ultra-high field MRI SCANNERS are around ten times more powerful than current models. hese new machines will allow scientists to make a very early diagnosis of cancer
In the future, diseases could be predicted in advance. n the normal scanners, the spinal cord is too blurry and we don distinguish too many fine details.
Champalimaud Foundation. here are some very important diseases of the spinal cord, like multiple sclerosis. So when the diseases begin,
there are some microstructural changes in the spinal cord. For example, the diameter of the cell can change,
if the person is going to have a disease or not, or if he is in an early stage.
to carry out comprehensive analysis of some brain diseases, the brain has to be cut and examined after death.
during depression. epression is a widespread disease. It one of the major causes of disability worldwide.
And one of the main problems of depression is that currently there is no way for clinicians to guide a treatment selection,
That upgrade may be a headache but system requirements on Windows haven budged in nine years.
or agic bulletto describe new drugs he was working on to cure syphilis and cancer. In theory, such drugs would leave healthy tissue intact
for example, and would have immediate applications in conditions like hydrocephalus, where proper flow through these chambers is disrupted.
Terapio can recognize possible allergies and potentially dangerous medication interactions. And naturally, when not displaying data,
could make flu shot obsolete Influenza is no longer the scourge it once was thanks to modern medicine,
Influenza mutates rapidly, which means a new vaccine formulation is needed every year. An international team of researchers has identified a new antibody that might give us the edge in this yearly arms race.
So why is influenza such a tricky virus to vaccinate against? The virus has a jumble of proteins on its surface called hemagglutinin
The pattern of these proteins is different in every strain of influenza, which allows it to evade your immune system
When your body has become sensitized to a pathogen, it can prepare an adaptive immune response.
As the immune response picks up, more antibodies are pumped out and other immune cells swing into action to clear virus-infested cells and combat the infection.
A vaccine provides a template of antigens to train the immune response to recognize the new strains of influenza each year.
This antibody was isolated from the blood of patients infected with the pandemic H1n1 influenza virus in 2009.
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