because they are more anatomically similar to humans than other animals such as mice and rats Prather said.
Physically pigs are much closer to the size and scale of humans than other animals and they respond to health threats similarly.
Cook-Mills had done previous allergy research in mice showing alpha-tocopherol decreased lung inflammation protecting healthy lung function and gamma-tocopherol increased lung
Small and fast-growing Arabidopsis thaliana is used widely as the lab mouse of plant biology. The plant grows in Europe from Spain to Scandinavia
When the researchers applied some of these cultures to mouse colon cells in the lab dish the cells were stimulated to release PYY hormone.
The study supported by The british Heart Foundation used mice to investigate the process by which these nitro fatty acids lower blood pressure looking at
Mice genetically engineered to be resistant to this inhibitory process were found to maintain their high blood pressure
However nitro fatty acids were found to lower the blood pressure of normal mice following the same diets.
#Transgenic mice produce both omega-3, omega-6 fatty acids on carbohydrate dietmassachusetts General Hospital (MGH) investigators have developed a transgenic mouse that synthesizes both the omega-3 and omega-6 essential
Our study also provides a mouse model for addressing research questions about the true health impacts of these essential fatty acids.
and in 2004 Kang's group reported that mice transgenic for a c. elegans gene called fat-1 converted omega-6s into omega-3s in their tissues.
The current study describes how crossbreeding the fat-1 mouse with another strain transgenic for the c. elegans gene fat-2
which converts monosaturated fats into omega-6s can produce mice expressing both c. elegans genes.
The crossbreeding protocol produces four different strains within the same litter--Omega mice that express both fat-1 and fat-2 strains that express only one of the c. elegans genes
Since our 2004 report on the fat-1 mouse our lab and many others have been working towards the generation of larger omega-3-producing animals--including pigs sheep
and supplements and the new Omega mouse model will help us better understand the true importance of the omega-6/omega-3 ratio for human health.
I am fascinated about the possibility of using imaging methods developed for mice and rats to see what is going on inside a shrimp or a snail.
I am convinced that imaging the chemical distribution inside aquatic species in general holds great promise to better understand their sensitivity to pesticides and other chemicals.
I am fascinated about the possibility of using imaging methods developed for mice and rats to see what is going on inside a shrimp or a snail.
I am convinced that imaging the chemical distribution inside aquatic species in general holds great promise to better understand their sensitivity to pesticides and other chemicals.
The same method might be used for the black-tailed prairie dog--removed from the endangered species list
Knutie says permethrin-treated cotton has been used in the Northeast to get mice to incorporate it in their nests to kill Lyme disease-carrying ticks.
In laboratory experiments Zhang and her colleagues were able to restore Nrf2 levels in cirrhotic liver tissue by inactivating Hrd1 effectively reversing liver cirrhosis in mice.
Their next step was to add tomatidine to the diet of mice. They found that healthy mice supplemented with tomatidine grew bigger muscles became stronger
and could exercise longer. And most importantly they found that tomatidine prevented and treated muscle atrophy.
Interestingly although mice fed tomatidine had larger muscles their overall body weight did not change due to a corresponding loss of fat suggesting that the compound may also have potential for treating obesity.
what we gave the mice. We also don't know if such a dose of tomatidine will be safe for people
or if it will have the same effect in people as it does in mice Adams says.
#What bank voles can teach us about prion disease transmission and neurodegenerationwhen cannibals ate brains of people who died from prion disease many of them fell ill with the fatal neurodegenerative disease as well.
bank voles appear to lack a species barrier for prion transmission and their universal susceptibility turns out to be both informative and useful for the development of strategies to prevent prion transmission.
Trying to understand the unusual susceptibility of bank voles to prions from other species Stanley Prusiner Joel Watts Kurt Giles
and colleagues from the University of California in San francisco USA first tested whether the susceptibility is an intrinsic property of the voles'Prp
or whether other factors present in these rodents make them vulnerable. The scientists introduced into mice the gene that codes for the normal bank vole prion protein thereby generating mice that express bank vole Prp but not mouse Prp.
When these mice get older some of them spontaneously develop neurologic illness but in the younger ones the bank vole Prp is in its normal benign folded state.
The scientists then exposed young mice to toxic misfolded prions from 8 different species including human cattle elk sheep and hamster.
They found that all of these foreign-species prions can cause prion disease in the transgenic mice
and that the disease develops often more rapidly than it does in bank voles. The latter is likely
because the transgenic mice express higher levels of bank vole Prp than are naturally present in the voles.
The results show that the universal susceptibility of bank voles to cross-species prion transmission is an intrinsic property of bank vole Prp.
Because the transgenic mice develop prion disease rapidly the scientists propose that the mice will be useful tools in studying the processes by
which toxic prions convert healthy Prp and thereby destroy the brain. And because that process is similar across many neurodegenerative diseases better understanding prion disease development might have broader implications.
Story Source: The above story is provided based on materials by PLOS. Note: Materials may be edited for content and length.
They found that one particular type of antioxidant in cocoa prevented laboratory mice from gaining excess weight
The scientists fed groups of mice different diets including high-fat and low-fat diets and high-fat diets supplemented with different kinds of flavanols.
They found that adding one particular set of these compounds known as oligomeric procyanidins (PCS) to the food made the biggest difference in keeping the mice's weight down
In studies with mice the researchers found that the administration of the elafin molecule protects the intestinal lining of the upper gut that is damaged by gluten.
and protect mice against a lethal dose challenge of West Nile virus--even as late as 4 days after the initial infection.
and protect mice from exposure. MABS target proteins found on the surface of West Nile virus
and neutralize West Nile virus. Mice were infected with a lethal dose of West Nile virus and increasing amounts of a MAB therapeutic were delivered as a single dose the same day of infection.
In each case they protected up to 90 percent of the mice from lethal infection. This is the first instance of such an effect
#Peaches inhibit breast cancer metastasis in micelab tests at Texas A&m Agrilife Research have shown that treatments with peach extract inhibit breast cancer metastasis in mice.
Cancer cells were implanted under the skin of mice with an aggressive type of breast cancer cells the MDA-MB-435 and
when the mice were consuming the peach extract said Dr. Luis Cisneros-Zevallos a food scientist for Agrilife Research in College Station.
Furthermore after determining the dose necessary to see the effects in mice it was calculated that for humans it would be equivalent to consuming two to three peaches per day.
The study reveals that ants reduce seed predation by rodents and increase germination success --which confirms the importance of this ecosystem function for forest regeneration.
To quantify the effect of rodents in addition to the impact of ants half of the depots where equipped with wire exclusion cages.
Under the leaf litter the seeds were less likely to be detected by rodents or other seed predators and benefited from the humid conditions favorable for germination.
if the less is more effect also occurs in less socially organized species such as rats or non-mammalian species such as birds.
and say we need to develop a better mouse trap--to develop better storage. Our point is that
and economic incentives the best mouse trap still won't help. Story Source: The above story is provided based on materials by University of Illinois College of Agricultural Consumer and Environmental sciences (ACES.
In places where the only grazers were small animals like rabbits voles and gophers the grazers'effect was weak and variable.
Story Source: The above story is provided based on materials by University of Maryland. Note: Materials may be edited for content and length.
and wild boar--the boar is also a nest predator--but also corvids rodents bears and other species of nest predators
#How evolution shapes the geometries of lifewhy does a mouse's heart beat about the same number of times in its lifetime as an elephant's
although the mouse lives about a year while an elephant sees 70 winters come and go?
It's used to calculate the correct human dosage of a medicine tested on mice among many other things.
and in different contexts then perhaps model organisms--such as bees and mice--can provide insights into the biological basis of aggression in all animals including humans the researchers said.
and mice and found a few genes that are associated consistently with aggression. This suggests that even after hundreds of millions of years of evolution some genes may retain their ancestral roles in similar forms of behavior like aggression.
The team then compared the wasp results to gene expression data already available in honey bees fruit flies and mice.
In solitary species like fruit flies and mice the same set of aggression genes controls fighting between males over territory.
and mice--can be used to study aggression in humans because they share some of the same genes that regulate aggression behaviors
and control-group mice and all 21 humans whose stool was tested. Crannell said the method requires little equipment
and her colleagues studied the behavior of the toxin in mice specifically which cells it targeted.
#Lingonberries halt effects of high-fat dietlingonberries almost completely prevented weight gain in mice fed a high-fat diet a study at Lund University in Sweden has found--whereas the'super berry'aã
Some of the mice were fed a low-fat diet while the majority of the animals were fed a diet high in fat.
When the mice were compared after three months it could be observed that the lingonberry group had by far the best results.
The mice that had eaten lingonberries had not put on more weight than the mice that had eaten a low-fat diet
--and their blood sugar and insulin readings were similar to those of the'low-fat'mice.
Up to 20%of our mice's diet was lingonberries. It isn't realistic for humans to eat such a high proportion.
However the goal is not to produce such dramatic effects as in the'high-fat'mice
and the production of glucose by the intestine the researchers subjected rats and mice to diets enriched with fermentable fibers or with propionate or butyrate.
They then observed a strong induction of the expression of genes and enzymes responsible for the synthesis of glucose in the intestine.
Mice fed a fat -and sugar-rich diet but supplemented with fibers became less fat than control mice
and were protected also against the development of diabetes thanks to significantly increased sensitivity to insulin.
The researchers repeated the experiment with mice whose intestine's ability to produce glucose had been suppressed by genetic engineering.
these mice became fat and developed diabetes like those fed a fiber-free diet. It is therefore the production of glucose by the intestine from propionate and butyrate that is behind the positive effects of fermentable fibers on the organism.
In the case of the Mara-Serengeti ecosystem this would be the migratory wildebeest herds
Data were collected from GSM-GPS telemetry devices attached to three species of vultures in Mara-Serengeti ecosystem of East Africa.
Studies in lab mice showed that the resulting vaccine was able to stimulate an immune response against the CD133 proteins without causing side effects such as an autoimmune reaction against normal cells or organs.
A team of researchers led by Benjamin Marsland from Lausanne University Hospital (CHUV) has shown in experiments with mice that the lack of fermentable fibers in people's diet paves the way for allergic inflammatory reactions in the lungs.
either put mice on a standard diet with four percent fermentable fibers or gave them low-fiber food with merely 0. 3 percent fermentable fibers.
When the researchers exposed the mice to an extract of house dust mites the mice with the low-fiber food developed a stronger allergic reaction with much more mucus in the lungs than the mice with the standard diet.
Conversely a comparison between mice on a standard diet and mice who received food enriched with fermentable fibers likewise showed that these dietary fibers have a protective influence.
because the share of plant fibers in Western diets is comparable to the low-fiber food of the mice
but also because the examined aspects of the immune system are virtually indistinguishable in mice and humans.
as a result of the discoveries The traditional vision of some mass of hapless lemmings--scrounging for whatever they can pinch from the side of a street
You might have long grasses that attract mice and a bird that eats mice. You have to know how to manage it.
The old way of doing it was getting pot from your dealer down the street who maybe got it from a source that grew it in a relatively unsavory environment like a garage where you're dealing with chemicals, molds, mice.
In the deserts of the American Southwest, native people studied how thick the mud walls of prairie dog chambers were to determine the best way to stay cool in that environment.
They're building a computer model that unlike other AI projects does not mimic the brains of human, monkeys or mice.
what would become an early Apple computer mouse, they cobbled together a roller ball (from a bottle of Ban deodorant) and a butter dish.
Meats that are considered pre-Hispanic include venison, duck, boar, armadillo or a squirrel-like rodent called tepezcuintle.
We talked about mice and spiders in space and why she wouldnt be a good candidate for space flight.
There is an Amgen bone-loss experiment with a mouse; There is a microbe experiment; One is looking at virulents of salmonella to develop a salmonella vaccine;
Dissolving fruit stickerstraditional fruit stickers seem destined to go the way of the mouse pad.
Even if British utilities were to hit a 2020 goal of generating more electricity from renewable sources, consumers compulsion to view screens, click mice,
Still, rats can be a menace. So why go through all this trouble? For Mathur, it s been a lifelong dream to spend her time growing flowers and vegetables.
With Studio Visualizer, the 3-D bottle is turned from side to side and upside down with the move of a computer mouse.
the scientists has managed to successfully utilise IPS cells to grow a brown rat's pancreas inside of a white mouse,
and mice for the purpose of adding bite marks to pieces. Instead of relying on a quick dirt rub for faked pottery,
The mtor inhibition has extended mouse mean lifespan by 33%.%In traditional Chinese medicine astragalus is considered a true tonic that can strengthen debilitated patients and increase resistance to disease in general.
promote peripheral nerve regeneration in rats, and inhibit mtor (a major longevity gene shown by extensive government studies to extend lifespan in mice).
In looking for the best herb in the Indian Ayurvedic medicinal tradition, I soon focused on the potent antidiabetic herb, Pterocarpus marsupium.
Theanine may also have positive effects on serotonin levels to promote restful Sleep in rats, theanine is neuroprotective.
Like humans and other mammals (e g. mice), it is quite difficult to increase their lifespan significantly.
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