#Strong anticancer properties discovered in soybeansproteins found in soybeans could inhibit the growth of colon liver and lung cancers.
The study looked at the role soybeans could have in the prevention of cancer. Using a variety of soybean lines
The study showed that peptides derived from soybean meal significantly inhibited cell growth by 73%for colon cancer 70%for liver cancer
and 68%for lung cancer cells using human cell lines. This shows that the selected high oleic acid soybean lines could have a potential nutraceutical affect in helping to reduce the growth of several types of cancer cells.
and can be delivered by simply eating the plant said senior author Dr. Alan M. Fogelman executive chair of the department of medicine
and director of the atherosclerosis research unit at the David Geffen School of medicine at UCLA. There was no need to isolate
but not in the blood suggesting that targeting the small intestine may be a new strategy to prevent diet-induced atherosclerosis the plaque-based disease of the arteries that can lead to heart attacks and strokes.
Scientists fed the tomatoes to mice that lacked the ability to remove low-density lipoprotein (LDL or bad cholesterol) from their blood and readily developed inflammation and atherosclerosis when consuming a high-fat diet.
decreased lysophosphatidic acid a tumor-promoter that accelerates plaque build up in the arteries in animal models;
which positively impacts cholesterol said the study's corresponding author Srinavasa T. Reddy a UCLA professor of medicine and of molecular and medical pharmacology.
and other researchers around the world in animal models of disease have suggested that a large number of conditions with an inflammatory component--not just atherosclerosis--might benefit from treatment with an apoa-1 mimetic peptide including Alzheimer's disease ovarian
and colon cancer diabetes asthma and other disorders. The immune system normally triggers an inflammatory response to an acute event such as injury or infection
which is part of the natural course of healing. But with many chronic diseases inflammation becomes an abnormal ongoing process with long-lasting deleterious effects in the body.
If the work in animal models applies to humans said Fogelman who is also the Castera Professor of Medicine at UCLA consuming forms of genetically modified foods that contain apoa-1-related peptides could potentially help improve these conditions.
The peptide would be considered a drug if given by injection or in a purified pill form but when it is a part of the fruit of a plant it may be no different from a safety standpoint than the food in which it is contained
--and it may be tolerated better than a drug Fogelman said. He noted that one possibility could be the development of the peptide into a nutritional supplement.
The current study and findings resulted from years of detective work in searching for an apoa-1 peptide that could be produced practically.
Peptides prior to the current 6f version have required additions that can only be made by chemical synthesis. The 6f peptide does not require these additions
This is one of the first examples in translational research using an edible plant as a delivery vehicle for a new approach to cholesterol said Judith Gasson a professor of medicine and biological chemistry director of UCLA
's Jonsson Comprehensive Cancer Center and senior associate dean for research at the Geffen School of medicine.
and future studies may yield important and fundamental knowledge about the role of the intestine in diet-induced inflammation and atherosclerosis.
The study was supported in part by U s. Public health Service Research Grants HL-30568 and HL-34343 and by the Laubisch Castera and M. K. Grey funds at UCLA. Studies on the determination of 6f in intestinal contents and plasma were funded partially by a Network Grant from the Leducq Foundation.
The above story is provided based on materials by University of California Los angeles (UCLA) Health Sciences. Note:
study findsthe American Academy of Pediatrics and the American Heart Association recommend that all children drink low fat
Researchers asked the parents/primary caregivers of almost 11000 children about their milk consumption--skimmed 1%semi-skimmed 2%milk fat full fat
which is tracking the long term health of a representative sample of US children born in 2001.
Milk fat may increase a feeling of fullness so reduce the appetite for other fatty/calorie dense foods they say.
The above story is provided based on materials by BMJ-British Medical Journal. Note: Materials may be edited for content and length.
The author team led by Dr. Roberge from the Department of Wildlife Fish and Environmental Studies at the Swedish University of Agricultural Sciences (SLU) calls for studies addressing cost-effectiveness of different retention and agroforestry systems in relation to biodiversity conservation argues for a stronger
and encourages increased collaboration between researchers and practitioners across the two fields. Story Source: The above story is provided based on materials by Pensoft Publishers.
#Chemical trickery explored to help contain potato pestthe pale cyst nematode Globodera pallida is one bad roundworm.
However the eggs are encased in cysts that can resist fumigation according to Navarre who works at the ARS Vegetable and Forage Crops Research Laboratory in Prosser Wash.
#Community approach effective in fight against diabetesnew research from Wake Forest Baptist Medical center shows that a diabetes prevention program led by community health workers is effective at reducing blood glucose
and potentially reducing diabetes over the long term. This is the largest program to successfully replicate the results achieved by the Diabetes Prevention Project (DPP) a research study led by the National institutes of health
and supported by Centers for Disease Control and Prevention which demonstrated several years ago that lifestyle weight-loss interventions can reduce the incidence of diabetes by 58 percent.
The study is published in the March 18 issue of the American Journal of Preventive medicine. We wanted to take this intervention out to people in the community rather than having them have to come to us in a clinical setting said the study's lead author Jeff Katula Ph d. assistant professor of health and exercise sciences at Wake Forest University and joint
assistant professor of epidemiology and prevention at Wake Forest Baptist. Given the high prevalence of obesity and metabolic syndrome and risk for diabetes our study shows we can provide an effective program in a community setting.
Latest estimates indicate that almost 26 million people in the U s. have diabetes and another 79 million adults have prediabetes a condition in
which blood glucose levels are higher than normal but not yet high enough to be diagnosed as diabetes.
Despite improved treatment the overall public health burden continues to increase which highlights the critical importance of prevention Katula said.
Because the DPP involved substantial amounts of resources and specialized personnel the goal of the Wake Forest Baptist study was to test a translation of the DPP model in community settings.
The lifestyle weight-loss interventions were conducted by community health workers in parks and recreation centers rather than by health care professionals in clinical settings.
The research team examined the effects of a 24-month lifestyle weight-loss program in 301 overweight or obese participants with elevated fasting blood glucose a common indicator of prediabetes.
The study was conducted in and around Forsyth County N c. from 2007 through 2011 with the volunteers representing the racial composition of the county's population.
Fasting blood glucose insulin insulin resistance body weight body mass index (BMI) and waist circumference were assessed every six months for 24 months.
Overweight and obese volunteers with elevated fasting blood glucose were assigned randomly to either a group-based lifestyle weight-loss intervention (LWL) or an enhanced usual care comparison (UCC.
which might include a doctor advising a patient to lose weight and to exercise. In this study the enhanced UCC provided participants with two meetings with a registered dietitian and monthly newsletters.
Results indicated that the significant reductions in body weight BMI waist circumference fasting blood glucose insulin and insulin resistance achieved during the first year of the program by the LWL group largely were maintained in the second year as compared to the usual care group.
This project was supported by award R18dk069901 from the National Institute of Diabetes and Digestive and Kidney diseases.
Co-authors of the study are Mara Vitolins Dr. PH. Timothy Morgan Ph d. Caroline Blackwell B. S. Scott Isom M. S. Carolyn Pedley M d. of Wake
M d. Ph d. of the University of Colorado School of Public health; and Michael Lawlor Ph d. of Wake Forest University.
The above story is provided based on materials by Wake Forest Baptist Medical center. Note: Materials may be edited for content and length.
what is believed to be a first of its kind study a research member at The Cancer Institute of New jersey
The Cancer Institute of New jersey is a Center of Excellence of the University of Medicine and Dentistry of New jersey-Robert Wood Johnson Medical school.
which is supported by The Cancer Institute of New jersey the UMDNJ-School of Public health and the UMDNJ-Robert Wood Johnson Medical school and provides help on quitting tobacco use through treatment education research and advocacy.
but there is more to the story according to Michael Steinberg MD MPH FACP a member of The Cancer Institute of New jersey
Despite those engaging in the relighting practice smoking fewer cigarettes there is no estimated reduction in their exposure to toxins says Steinberg.
In fact smokers who relight cigarettes may be at higher risk of lung cancer and chronic bronchitis. That is something of which policy makers need to be aware he notes.
and lack of employment would be related to a higher level of relighting says Dr. Steinberg who is also an associate professor of medicine at UMDNJ-Robert Wood Johnson Medical school and an associate professor of health education and behavioral science at UMDNJ
-School of Public health. We were surprised however that women are more likely to engage in this practice than men.
Steinberg and colleagues suggest key components of tobacco dependence treatment that could be affected by these findings include the dosage of medicines prescribed
and Michelle T. Bover-Manderski MPH UMDNJ-School of Public health. The study is supported by pilot funding through The Cancer Institute of New jersey.
Story Source: The above story is provided based on materials by Cancer Institute of New jersey. Note: Materials may be edited for content and length h
#Catastrophic loss of Cambodias tropical flooded grasslandsaround half of Cambodia's tropical flooded grasslands have been lost in just 10 years according to new research from the University of East Anglia.
The research has been led by Dr Charlotte Packman from UEA's school of Environmental sciences in collaboration with the Wildlife Conservation Society Cambodia Program and Birdlife International.
Dr Packman said: Tropical and flooded grasslands are among the most threatened ecosystems globally. The area around the Tonle Sap lake is the largest remaining tropical flooded grassland in Southeast asia.
Dr Packman added: Between 1995/1996 and 2005 the encroachment of scrubland was the major cause of grassland loss due to a reduction in traditional low intensity agricultural practices in the grasslands.
and help identify new crops that might be at risk says Dr. Hannah Burrack an assistant professor of entomology at NC State
#For smokers, low levels of Vitamin d may lead to cancernew research appearing online today in Clinical Chemistry the journal of AACC shows that decreased levels of Vitamin d may predispose smokers to developing tobacco-related cancer.
This study illustrates that simple Vitamin d blood tests and supplements have the potential to improve smokers'health.
In the U s. alone cigarette smoking accounts for more deaths annually than HIV illegal drugs alcohol motor vehicle injuries suicides and murders combined.
It is the primary causal factor for at least 30%of all cancer deaths and can lead to multiple kinds of cancer including bladder cervical esophageal head and neck kidney liver lung pancreatic and stomach as well as myeloid leukemia.
According to the Centers for Disease Control and Prevention the healthcare expenditures and productivity losses due to smoking cost the economy approximately $193 billion per year.
In this paper Afzal et al. measured plasma Vitamin d levels in blood samples collected in 1981-1983 from 10000 Danes from the general population.
Researchers then followed the study participants for up to 28 years through the Danish Cancer Registry.
Of the participants 1081 eventually developed a tobacco-related cancer. The authors determined that the median Vitamin d concentration among these participants was only 14.8 ng/ml
versus the higher 16.4 ng/ml median concentration found for all participants together. These results show for the first time that the risk of tobacco-related cancers as a group is associated with lower concentrations of Vitamin d.
The data also indicate that tobacco smoke chemicals may influence Vitamin d metabolism and function while Vitamin d may conversely modify the carcinogenicity of tobacco smoke chemicals.
If further research confirms this it would be consistent with previous studies demonstrating the anti-tumorigenic effects of Vitamin d derivatives as well as the correlation of Vitamin d deficiency with favorable cancer-forming conditions and increased susceptibility to tobacco smoke carcinogens.
Interestingly though low Vitamin d levels were connected not with risk of other cancer types. Our analyses show that the association between lower concentrations of plasma Vitamin d
and higher risk of cancer may be driven by tobacco-related cancer as a group which has not been shown before stated author Børge G. Nordestgaard MD DMSC in the paper.
This is important for future studies investigating the association between plasma Vitamin d and risk of cancer.
The above story is provided based on materials by American Association for Clinical Chemistry (AACC. Note: Materials may be edited for content and length.
#High-fat dairy products linked to poorer breast cancer survivalpatients who consume high-fat dairy products following breast cancer diagnosis increase their chances of dying from the disease years later according to a study by Kaiser permanente researchers.
The study published in the Journal of the National Cancer Institute is the first to examine the relationship between high-fat and low-fat dairy consumption following a diagnosis of breast cancer and long-term breast cancer survival.
Previous studies have shown that higher lifetime exposure to estrogen is a causal pathway to breast cancer.
The researchers studied a cohort of women who were diagnosed with early-stage invasive breast cancer between 1997 and 2000 primarily from Kaiser permanente's Northern California region (83 percent) and the Utah Cancer Registry (12 percent.
Those consuming larger amounts of high-fat dairy (one serving or more per day) had higher breast cancer mortality as well as higher all-cause mortality
and higher non-breast cancer mortality wrote lead author Candyce H. Kroenke Scd MPH staff scientist with the Kaiser permanente Division of Research
and a 49 percent increased risk of dying from their breast cancer during the follow-up period said Kroenke.
The study found an association between high-fat dairy and breast cancer mortality but no association with low-fat dairy products and breast cancer outcomes.
Women entered into the cohort approximately two years after their breast cancer diagnosis. At the beginning of the study 1893 women completed a self-administered food-frequency questionnaire
Of the total sample 349 women had a recurrence of breast cancer and 372 died of any cause 189 (50.8 percent) of them from breast cancer.
This research was part of the Life After Cancer Epidemiology (LACE) study one of several efforts by investigators with the Kaiser permanente Division of Research to consider the role of lifestyle factors such as nutrition exercise
and social support on long-term breast cancer survival and recurrence. While hundreds of studies have examined the role of lifestyle factors in cancer risk
and prevention this study is one of a small but growing number that focus on the role of lifestyle factors after a breast cancer diagnosis For example the Pathways study of breast cancer survivorship based at the Division of Research is collecting
and analyzing data about women's genetic background tumor characteristics and lifestyle choices immediately after diagnosis. Findings from this study along with the LACE study are providing objective information to help guide women as they make decisions following a breast cancer diagnosis;
among these findings are that soy decreases the risk of breast cancer recurrence quality of life after diagnosis influences outcomes
and physical activity is beneficial. Susan E. Kutner MD chair of the Kaiser permanente Northern California Regional Breast Care Task force said that the new study bolsters the counseling that Kaiser permanente gives breast cancer survivors about the importance of a low-fat diet as well as exercise
and weight management in preventing recurrence of the disease. Women have been clamoring for this type of information Dr. Kutner said.
They're asking us'Tell me what I should eat?''With this information we can be more specific about recommending low-fat dairy products.
Authors of the study in addition to Dr. Kroenke and Caan were Marilyn L. Kwan Phd and Adrienne Castillo MS RD of the Kaiser permanente Division of Research;
and Carol Sweeney Phd of the University of Utah Division of Epidemiology. The National Cancer Institute of the National institutes of health funded this study (grant R01ca129059.
Story Source: The above story is provided based on materials by Kaiser permanente. Note: Materials may be edited for content and length h
#Predicting hotspots for future flu outbreaksthis year's unusually long and rocky flu season would be compared nothing to the pandemic that could occur
if bird flu became highly contagious among humans which is why UCLA researchers and their colleagues are creating new ways to predict where an outbreak could emerge.
Using surveillance of influenza cases in humans and birds we've come up with a technique to predict sites where these viruses could mix
and generate a future pandemic said lead author Trevon Fuller a UCLA postdoctoral research fellow at the Institute of the Environment and Sustainability's Center for Tropical Research.
The researchers'models revealed that coastal and central China and Egypt's Nile Delta are danger zones where bird flu could combine with human flu to create a virulent kind of super-flu.
Governments can prioritize these zones --and use the researchers'models to identify other hotspots--for increased monitoring of flu in humans livestock poultry and wild birds.
That could help detect a novel flu virus before it spreads worldwide the researchers said.
The research paper Predicting Hotspots for Influenza Virus Reassortment was published March 13 in the peer-reviewed public health journal Emerging Infectious diseases.
Previous pandemics such as the 1957 and 1968 influenzas that each killed more than a million people or the 2009 H1n1 swine flu outbreak that killed 280000 worldwide developed
when viruses from humans and animals exchanged genes to create a new virus in a process called reassortment.
Recent research using mice confirms that genes from bird flu and human flu can combine to create dangerous new flu strains.
Swine which are susceptible to both bird and human flu could serve as a mixing vessel for reassortment between the two viruses.
The mixing of genetic material between the seasonal human flu virus and bird flu can create novel virus strains that are more lethal than either of the original viruses said senior author Thomas Smith director of the Center for Tropical
Research and a professor at UCLA's Institute of the Environment and Sustainability and the UCLA Department of Ecology and Evolutionary Biology.
These findings predicting potential outbreak sites can help decision-makers prioritize the most important areas where people poultry
and livestock should be vaccinated and animals should be monitored for novel viruses which could help predict
and prevent the next pandemic he said. The researchers looked for locations where bird flu outbreaks human flu outbreaks
and swine populations overlapped to predict hotspots where reassortment is more likely using a $1. 3 million grant from the Fogarty International Center at the National institutes of health.
The research focused on two flu strains that studies in mice have shown can combine with lethal results:
the seasonal H3n2 human flu and the H5n1 strain of bird flu that has crossed occasionally over into humans.
Currently H5n1 has a 60 percent mortality rate in humans but is known not to spread between humans frequently.
While the World health organization has identified six countries as hosts to ongoing widespread bird flu infections in poultry in 2011--China Egypt India Vietnam Indonesia
and Bangladesh--the UCLA researchers and their colleagues had limited data to work with. Not all flu outbreaks whether bird or human are tracked.
The scientists had to identify indicators of flu outbreaks such as dense poultry populations or rain and temperatures that encourage flu transmission.
For each type of flu we identified variables that were predictive of the various virus strains Fuller said.
We wanted a map of predictions continuously across the whole country including locations where we didn't have data on flu outbreaks.
Although the researchers had bird flu data for parts of both China and Egypt other countries such as Indonesia don't have full reporting systems in place.
Even in China and Egypt accurate reporting is hampered by farmers who may conceal flu outbreaks in order to sell their livestock.
If we provide incentives for better reporting we could more precisely predict future outbreaks Fuller said.
Story Source: The above story is provided based on materials by University of California-Los angeles. The original article was written by Alison Hewitt.
Note: Materials may be edited for content and length. Journal Reference e
#College kids who dont drink milk could face serious consequencescollege-age kids who don't consume at least three servings of dairy daily are three times more likely to develop metabolic syndrome than those who do said a new University of Illinois study.
And only one in four young persons in the study was getting the recommended amount of dairy said Margarita Teran-Garcia a U of I professor of food science and human nutrition.
That alarming finding means that three-fourths of the 18-to 25-year-old college applicants surveyed are at risk for metabolic syndrome the researcher said.
Metabolic syndrome occurs when a person has three of the following risk factors: abdominal obesity high blood pressure high blood sugar and unhealthy cholesterol and lipid levels.
Having this disorder greatly increases a person's chances of developing heart disease and type 2 diabetes she said.
Although scientists believe that dairy products guard against obesity and the health problems that accompany extra weight they aren't sure how it happens.
It may be the calcium it may be the proteins. Whatever the mechanism evidence suggests that dairy products are effective in attaining
and maintaining a healthy weight she said. In the study 339 Mexican college applicants filled out a food frequency questionnaire
and were evaluated then for metabolic syndrome risk factors. The analysis controlled for sex age family history of cardiovascular disease and type 2 diabetes and physical activity.
The study is part of the Up Amigos project a collaboration between scientists at the U of I and the Universidad Autã noma de San luis Potosî in Mexico.
and eating and exercise habits affect the students'health over time. The research is important to Hispanics in the United states
And obesity is now a more serious public health problem in Mexico than in the United states. According to new data from a national Mexican survey 72 percent of adults are overweight
because persons in this age group don't visit the doctor often and they may not know they have problems with their weight blood pressure lipids
Adopting the USDA dairy recommendation as a young person is a low-cost approach to maintain health
and decrease future disease risk she said. And in a few years when our survey participants are parents they'll be able to model good nutrition for their children.
or a few whales because of sickness or disorientation triggers a chain reaction in which healthy individuals are drawn into the shallows in an effort to support their family members.
and kinship even when considering only the location of nursing calves and their mothers who were separated often widely
One research direction being pursued in Johnson's lab is to induce viral pneumonia in piglets at the point in the postnatal period
They are also looking at effects of prenatal infections in the mother to see if that alters the trajectory of normal brain growth in the offspring.
The risk for behavioral disorders and reduced stress resilience is increased by pre-and postnatal infection
and Sickkids Research Institute announced today that they have mapped successfully the genes in the fungus that causes Dutch elm disease.
Essentially Dutch elm disease is caused by a fungus that prevents the normal distribution of nutrients in the tree by blocking the flow of sap said Alan Moses an Assistant professor with the University of Toronto's department of Cell & Systems Biology one of the authors of the study.
Relatively little is known about the fungus that causes Dutch elm disease and it's a very distant relative of the fungi that are studied more often by researchers like bread mould or beer yeast.
Dutch elm disease is believed to have originated in The himalayas travelling to Europe from the Dutch east indies in the late 1800s.
It emerged in Holland shortly after the First world war earning the name Dutch elm disease. It is the most destructive elm tree disease in North america and typically kills most trees within two years of infection.
Dutch elm disease is a problem in many parts of the world particularly Scotland Spain Italy Western Canada and New zealand.
Story Source: The above story is provided based on materials by University of Toronto. Note: Materials may be edited for content and length.
#Tobacco industry appears to have evaded FDA ban on light cigarette descriptorsnew research from Harvard School of Public health (HPSH) shows that one year after the federal government passed a law banning word descriptors such as light mild
The tobacco industry was found guilty by a federal court in 2006 for deceptively promoting'light'cigarettes as safer after countless smokers who switched to lights died prematurely thinking they had reduced their health risks.
and Drug Administration approval for these products as required by law said study co-author Gregory Connolly director of the Center for Global Tobacco Control at HSPH and professor of the practice of public health in the Department of Social and Behavioral
After the U S. Surgeon general's 1964 report found that cigarette smoking causes disease tobacco companies began marketing light cigarettes with ventilation holes that allowed air to mix with smoke
However a 2001 National Cancer Institute (NCI) report found that smokers compensate for the lower smoke yield in light cigarettes
In 2006 a U s. federal court ruled that tobacco companies should be banned from any future use of descriptive words that convey a false health message.
manufacturers'annual reports filed with the Massachusetts Department of public health; national cigarette sales data; and the results of a 2011 national public opinion survey that included questions about smokers'perceptions of their brands being light or regular.
The above story is provided based on materials by Harvard School of Public health. Note: Materials may be edited for content and length.
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