Trying to control deer without a robust understanding of their true numbers can be like sleepwalking into disaster.
A team led by Rice physicist Ching-Hwa Kiang found that shear forces like those found in small arteries of patients with atherosclerosis cause snippets of nonclotting VWF to change into a clot-forming shape for hours at a time.
and it's stored there until the cells get signals that the vessels are in danger of injury Moake said.
which prevents people from bleeding to death when blood vessels are damaged by cuts and wounds. The body recognizes
when clotting must stop --when there are too many strings too much sticking too many platelet clumps
Sometimes as in SD flies there are no apparent ill effects but when the selfish genes come in the form of viruses
and governance as was witnessed during the 2003 SARS threat. Similar action focused on curbing ivory demand is key
not only health but the harm tobacco places on their economy by passing laws to reduce use;
Avoidable and unnecessary tobacco-linked illnesses strike people in their prime hit the poorest hardest inhibit country productivity burden already weak healthcare systems
Cancer Society and the Institute of Global Tobacco Control at Johns hopkins university. Meeting attendees were warned by speaker after speaker that
unless there is a concerted international effort now the plague of tobacco smoking that has claimed 100 million lives in the Developed Nations will claim a billion in the Developing Nations where smoking has yet to take hold as it did during the last century in the U s. and other Developed nations.
mysterious disease syndrome as key factors in bee colony deathsa new long-term study of honey bee health has found that a little-understood disease study authors are calling idiopathic
brood disease syndrome (IBDS) which kills off bee larvae is the largest risk factor for predicting the death of a bee colony.
The paper Idiopathic brood disease syndrome and queen events as precursors of colony mortality in migratory beekeeping operations in the eastern United states is published in the February issue of Preventive Veterinary medicine.
The global poaching crisis for elephants is at epidemic proportions said WCS Executive vice president for Conservation and Science John Robinson.
A weapon in the fight against kidney disease caused by high-fat dietsnew insight into grape seed extract as a therapeutic and preventative measure to fight obesity-induced kidney damage is presented in a new study.
In our research obesity-induced leaky kidney and proteinuria are shown to be prevented by GSSE which suggests the use of GSSE as a preventive nutriceutical for high-risk patients said co-author Kamel Charradi a researcher with the Laboratory of Bioactive Substance at the Center of Biotechnology of Borj-Cedria (CBBC) in Tunisia.
This research group has published previously work showing the benefits of GSSE in combating obesity heart dysfunction brain lipotoxicity and kidney cancer.
which is characterized by frequent diarrhea and abdominal pain. IBD actually refers to two conditions--ulcerative colitis and Crohn's disease--in
which the intestines become red and swollen and develop ulcers probably as the result of the body having an immune response to its own tissue.
While there is currently no cure for IBD there are drug therapies aimed at reducing inflammation and preventing the immune response.
While maize is grown in the area today they were able to rule out modern day contamination
and others to study how livestock diet affected the transport of pathogens in field runoff from manure-amended soils.
Results from these studies have been published in Foodborne Pathogens and Disease Applied and Environmental Microbiology and Transactions of the ASABE.
#Modifying infants diet may reduce celiac disease risk, Swedish study suggestsceliac disease is much more common in Sweden than in the rest of Europe
Celiac disease also known as gluten intolerance is a chronic disease whose only treatment is a lifelong strict gluten-free diet
Until the 1970s celiac disease was unusual and was diagnosed in only 0. 001%of all children.
Between 1984 and 1996 however Sweden was hit by an epidemic of celiac disease in children under 2 years of age.
A fourfold increase in incidence of clinically detected disease followed by a comparable decrease decade later was conï rmed through the National Swedish Childhood Celiac disease Register.
Through further investigation of the epidemic researchers have shown now that celiac disease currently affects up to 3%of all young people.
and in the United states. We now have proven this way of introducing gluten reduces the risk of getting celiac disease says Dr. Anneli Ivarsson.
which is part of the Preventcd European project ETICS is a screening study conducted in 2005-2011 among 12-year-olds born during the epidemic (1993) and after (1997).
The blood samples were analysed for celiac disease and the children who had elevated levels were called to the nearest pediatric clinic for a small intestinal biopsy to check for disease suspicion.
In summary for a twelve year period starting in 1984 Sweden experienced a unique epidemic of celiac disease in the youngest children.
and Sweden has by far the highest incidence of celiac disease in Europe and the United states. It is estimated that there are upwards of 150000 people with celiac disease in Sweden
of which about 100000 have not yet received proper diagnosis and treatment. Increased attention is needed at all for so many victims as possible to get the proper diagnosis
Celiac disease also known as gluten intolerance is a chronic disease whose only treatment is a lifelong strict gluten-free diet
Until the 1970s celiac disease was unusual and was diagnosed in only 0. 001%of all children.
Between 1984 and 1996 however Sweden was hit by an epidemic of celiac disease in children under 2 years of age.
A fourfold increase in incidence of clinically detected disease followed by a comparable decrease decade later was conï rmed through the National Swedish Childhood Celiac disease Register.
Through further investigation of the epidemic researchers have shown now that celiac disease currently affects up to 3%of all young people.
and in the United states. The researcher team led Dr. Anneli Ivarsson at the Department of public health and Clinical Medicine speculate that there may be a window of opportunity in which an infanwe now have proven this way of introducing gluten reduces the risk of getting celiac disease says Dr
which is part of the Preventcd European project ETICS is a screening study conducted in 2005-2011 among 12-year-olds born during the epidemic (1993) and after (1997).
The blood samples were analysed for celiac disease and the children who had elevated levels were called to the nearest pediatric clinic for a small intestinal biopsy to check for disease suspicion.
In summary for a twelve year period starting in 1984 Sweden experienced a unique epidemic of celiac disease in the youngest children.
and Sweden has by far the highest incidence of celiac disease in Europe and the United states. It is estimated that there are upwards of 150000 people with celiac disease in Sweden
of which about 100000 have not yet received proper diagnosis and treatment. Increased attention is needed at all for so many victims as possible to get the proper diagnosis and treatmentstory Source:
A University of Colorado Cancer Center review published in this month's issue of the journal Current Opinion in Gastroenterology shows that resistant starch also helps the body resist colorectal cancer through mechanisms including killing pre-cancerous cells
and reducing inflammation that can otherwise promote cancer. Resistant starch is found in peas beans
But consumed correctly it appears to kill pre-cancerous cells in the bowel says Janine Higgins Phd CU Cancer Center investigator and associate professor of Pediatrics at the University of Colorado School of medicine.
and sizes of lesions due to colorectal cancer and an increased number of cells that express the protein IL-10 which acts to regulate the body's inflammatory response Resistant starch may also have implications for the prevention
of breast cancer Higgins says. For example if you let rats get obese get them to lose the weight
This effect on obesity may help to reduce breast cancer risk as well as having implications for the treatment of colorectal cancer.
There are a lot of things that feed into the same model of resistant starch as a cancer-protective agent Higgins says.
which benefits exactly will pan out as mechanisms of cancer prevention one thing is clear: resistant starch should be on the menu.
and were successful in doing So long-term smokeless tobacco use is associated with cardiovascular disease and cancer.
The study was funded by the National Cancer Institute (R01 CA121165. Story Source: The above story is provided based on materials by Mayo Clinic.
Advantages of using plants to produce therapeutic proteins include the ability to produce large quantities quickly and cheaply the absence of human pathogens the stability of the proteins and the ease with
Instead the scientists say they should be grown under clearly defined and enforced conditions to keep the food and animal feed chain'contamination free'.
They chose the first plant-derived anti-HIV monoclonal antibody to be tested in humans. It was isolated purified
of which regulate plant responses to microbial infections. To study the expression of citrus srnas in response to HLB we grafted 19 greenhouse-grown healthy sweet orange plants with HLB-positive bark or leaf pieces.
Both donor and receptor trees tested negative for other graft-transmissible pathogens of citrus. As controls five plants were mock-inoculated with pathogen-free healthy tissue.
Samples were collected at 10-and 14-week post inoculation/grafting for small RNA profiling. Leaves were collected also continuously at later points to ensure that the tissue used for srna libraries was from the diseased trees. srnas ranging from 18 to 28 nucleotides were isolated cloned
In particular mir399 which is induced by P starvation in other plant species was discovered to be induced by HLB infection in the diseased citrus trees.
and in older adults slower walking speed is a predictor of disability nursing home admission and even death.
As the burden of disability becomes increasingly common and expensive identification of modifiable contributors to functional decline in older adults is emerging as a significant priority of public health research Beavers said.
A leafy plant related to a common weed known as lamb's quarter was infected also with a virus that caused a local infection.
The infection was enough to boost the plant's drought tolerance and may mean that the virus does not have to actively replicate in the cells where the resistance to drought occurs according to Roossinck.
and grow them better and more tolerant of environmental stress like heat and drought or pathogens?
#Links between ozone levels and cardiac arrest analyzedresearchers at Rice university in Houston have found a direct correlation between out-of-hospital cardiac arrests and levels of air pollution and ozone.
if there is a link between ambient ozone levels and cardiac arrest. Ensor is a professor and chair of Rice's Department of Statistics and Raun is a research professor in Rice's Department of Statistics.
and more than 11000 concurrent out-of-hospital cardiac arrests (OHCA) logged by Houston Emergency Medical Services (EMS).
Early intervention is seen as critical as the chance of survival for a person suffering cardiac arrest drops 10 percent for every minute he
and death such as the AIDS virus Roossinck said. However on a research trip in Costa rica a biodiversity hot spot in Central america she noticed that unmanaged wild plants looked healthier than managed agricultural fields.
#Researchers find potential new therapeutic target for treating non-small cell lung cancerresearchers at Moffitt Cancer Center have found a potential targeted therapy for patients with tobacco-associated non-small cell lung cancer.
IKBKE overexpression has been associated with breast and prostate cancers. However it had not been linked to environmental carcinogen such as tobacco smoke until now.
Tobacco smoke is documented the strongest initiator and promoter of lung cancer. The traditional model holds that tobacco components promote carcinogenesis through a process that leads to DNA damage.
Recent studies have shown that tobacco smoke can also promote lung cancer through changes in the pathways that regulate cell proliferation and survival.
in order to find potential drug targets to treat non-small cell lung cancer. In this study IKBKE was found to be induced by two tobacco carcinogens:
Their findings suggest that IKBKE is a key molecule related to tobacco-induced lung cancer. Since IKBKE kinase is induced by tobacco small molecular inhibitors of IKBKE could have a therapeutic drug potential for lung cancer explained lead author Jin Q. Cheng Ph d. M d. senior member
of the Molecular Oncology Department at Moffitt. Current treatments for non-small cell lung cancer include surgery radiotherapy and chemotherapy.
However patients eventually develop resistance to treatment. There is a great need to better understand the molecular mechanism of resistance
According to the researchers STAT3 is activated frequently in various types of human cancers and when activated STAT3 increases IKBKE overexpression and protein levels.
In non-small cell lung cancer nicotine-induced IKBKE depends on STAT3. The authors noted that the activation stage of STAT3 represents an attractive therapeutic potential
and IKBKE levels increase in response to nicotine and nicotine-derived nitrosamine ketone this evidence can be used potentially to develop a non-small cell lung cancer intervention strategy that targets IKBKE concluded Cheng.
The work was supported by National Cancer Institute Grants CA137041 and P50 CA119997 and James & Esther King Biomedical Research Program 1kg02 1kd04 and 1kn08.
The above story is provided based on materials by H. Lee Moffitt Cancer Center & Research Institute.
The first project was launched in 2009 by the Department of energy at a corn ethanol production facility in Decatur Ill. operated by the Archer daniel midlands Company.
Another 8. 6 million people suffer from a serious smoking-related illness. Annually costs associated with smoking-related illness account billions in medical expenses
and lost productivity and 5. 1 million years of potential life lost in the United states the CDC reports.
The research was supported by TRDRP Grant 18st-0201 and National Cancer Institute Grant CA-61021.
The new study focused on two of the most widespread mycotoxin contaminants of grain crops--deoxynivalenol (DON) and zearalenone (ZEN.
Coffee rust spores are spread by the wind and the rain from lesions on the underside of leaves.
Long-term exposure can lead to the development of different types of cancer as well as serious cardiovascular neurological and other health problems.
Although the yield of aromatic rice is lower the farmers will not need to spend much money on applying chemicals that could pollute the environment and harm their own health.#
It could also benefit people suffering from celiac disease who consume rice-based foods on a regular basis. Therefore it is essential that further research on aromatic rice from different parts of Bangladesh
Alvarez contended that confined animal feeding operations (CAFOS) are potential sources of environmental contamination by antibiotics
which can cause allergic reactions in some humans. Asian needle ants also appear to be driving out native ant populations in forests--including native species that play important roles in ecosystem processes such as dispersing seeds.
when cholera had been ravaging the capital Dr Wickstead explained. A garden on a site like this might tell us more about the people who lived
and vegetables to the diet may help protect the kidneys of patients with chronic kidney disease (CKD) with too much acid build up according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN).
#¢Urine measurements of kidney injury were lower after one year in both groups.#¢#¢Although fruits and vegetables are rich in potassium
and vegetables patients had a favorable response by reduction of urinary kidney injury markers said Dr. Wesson.
Our study suggests that these interventions will help maintain kidney health in those with kidney disease added Dr. Goraya.
and without dietary intervention in patients with chronic kidney disease is needed urgently. Study co-authors include Jan Simoni Phd and Chan-Hee Jo Phd.
and alternatives to traditional combustible tobacco says Robin Mermelstein director of the UIC institute and principal investigator of the National Cancer Institute-funded study.
The project is supported by the National Cancer Institute one of the National institutes of health under award number P01ca098262.
#Zinc helps against infection by tapping brakes in immune responsenew research suggests that zinc helps control infections by gently tapping the brakes on the immune response in a way that prevents out-of-control inflammation that can be damaging and even deadly.
and animal studies that a protein lures zinc into key cells that are first-responders against infection.
The zinc then interacts with a process that is vital to the fight against infection and by doing
if there is not enough zinc available at the time of infection the consequences include excessive inflammation.
In this research zinc's activity was studied in the context of sepsis a devastating systemic response to infection that is a common cause of death in intensive care-unit unit patients.
But scientists say these findings might also help explain why taking zinc tablets at the start of a common cold appears to help stem the effects of the illness.
We do believe that to some extent these findings are going to be applicable to other important areas of disease beyond sepsis said Daren Knoell senior author of the study and a professor of pharmacy and internal medicine at Ohio State.
Without zinc on board to begin with it could increase vulnerability to infection. But our work is focused on
what happens once you get an infection --if you are deficient in zinc you are at a disadvantage
While this study and previous work linking zinc deficiency to inflammation might suggest that supplementation could help very sick ICU patients it's still too early to make that leap.
We predict that not everybody in the ICU with sepsis needs zinc but I anticipate that a proportion of them would Knoell said.
Usually if there is zinc deficiency we would expect to see other nutrient deficiencies too. Zinc deficiency affects about 2 billion people worldwide including an estimated 40 percent of the elderly in the United states--who are also among the most likely Americans to end up in an ICU.
The research is published in the journal Cell Reports. Knoell's lab previously showed that zinc-deficient mice developed overwhelming inflammation in response to sepsis compared to mice on a normal diet.
Zinc supplementation improved outcomes in the zinc-deficient mice. Until now the beneficial effects of zinc in combating infection have not been understood fully at the molecular level.
This is because zinc has numerous complex jobs in the body and interacts with thousands of proteins to sustain human life.
Of all the zinc contained in our bodies only about 10 percent of it is readily accessible to help fight off an infection said Knoell also an investigator in Ohio State's Davis Heart and Lung Research Institute.
We believe that our findings help to narrow an important gap that has existed in our understanding of how this relatively simple metal helps us defend ourselves from infection he said.
In experiments using human monocytes--cells involved in the first line of defense against an invading pathogen--the researchers examined
When a pathogen is recognized a series of molecules wake up from dormancy to create a process that activates the innate immune response.
A major part of this process involves the NF-Î B pathway named for a highly active protein that is known to play an important role in the immune response to infection.
not only attacks the pathogen but can also cause much more collateral damage. The researchers knew from previously published experiments that
When researchers allowed this protein to function unchecked in mice with zinc deficiency the animals developed excessive inflammation in response to sepsis--confirmation that IKKB was zinc's target to turn off the inflammatory pathway.
His lab is continuing to study the NF-Î B pathway inflammation and zinc deficiency in other disease processes.
#Scientists identify genetic mechanism that contributed to Irish Faminewhen a pathogen attacks a plant infection usually follows after the plant's immune system is compromised.
A team of researchers at the University of California Riverside focused on Phytophthora the pathogen that triggered The irish Famine of the 19th century
The Genus phytophthora contains many notorious pathogens of crops. Phytophthora pathogens cause worldwide losses of more than $6 billion each year on potato (Phytophthora infestans) and about $2 billion each year on soybean (Phytophthora sojae.
The researchers led by Wenbo Ma an associate professor of plant pathology and microbiology focused their attention on a class of essential virulence proteins produced by a broad range of pathogens including Phytophthora called effectors.
The effectors are delivered to and function only in the cells of the host plants the pathogens attack.
The researchers found that Phytophthora effectors blocked the RNA silencing pathways in their host plants (such as potato tomato
Its effectors are the first example of proteins produced by eukaryotic pathogens--nucleated single -or multicellular organisms--that promote infection by suppressing the host RNA silencing process.
Our work shows that RNA silencing suppression is a common strategy used by a variety of pathogens--viruses bacteria
and Phytophthora--to cause disease and shows too that RNA silencing is an important battleground during infection by pathogens across kingdoms.
Study results appeared online Feb 3 in Nature Genetics. What is RNA silencing and what is its significance?
The discovery by Ma's lab is the first to show that RNA silencing regulates plant defense against eukaryotic pathogens.
A similar motif is found in effectors of animal parasites such as the malaria pathogen Plasmodium suggesting an evolutionarily conserved means for delivering effectors that affect host immunity.
Next her lab will work on extensively screening other pathogens and identifying their effectors'direct targets
so that novel control strategies can be developed to manage the diseases the pathogens cause. Ma was joined in the study by UC Riverside's Yongli Qiao Lin Liu Cristina Flores James Wong Jinxia Shi Xianbing Wang Xigang Liu Qijun Xiang
and geriatric medicine at Wake Forest Baptist Medical center and research director of its Sticht Center on Aging is the principal investigator in a National institutes of health-funded study into the effectiveness of insulin administered through the nose in treating individuals with mild cognitive impairment
or mild Alzheimer's dementia. But the $7. 9 million nationwide study involving 30 institutions--one of two projects selected by the NIH to be part of its National Alzheimer's Plan
which aims to find an effective way to prevent or treat the disease by 2025--won't be able to attain its goal without a sufficient number of subjects.
#Breast milk reduces risk of sepsis and intensive care costs in very-low-birth-weight infantsfeeding human breast milk to very-low-birth-weight infants greatly reduces risk for sepsis
and significantly lowers associated neonatal intensive care unit (NICU) costs according to a study by Rush University Medical center researchers.
days of life decreased the odds of sepsis by almost 20 percent. A daily dose of 25 to 49.99 milliliters of human milk per kilogram cut NICU costs by more than $20000 while 50 milliliters per kilogram per day lowered NICU costs by nearly $32000.
The research which was led by Dr. Aloka L. Patel is the first report of an economic impact of an average daily dose of human milk for days 1 to 28 of life on risk of infection
Of 175 very-low-birth-weight infants 23 (13 percent) developed sepsis from gram-positive bacteria such as staphylococci Streptococcus and Enterococcus species and gram-negative bacteria such as Escherichia coli
Late-onset sepsis commonly occurs in about 22 percent of very-low-birth-weight babies the United states
and later neurodevelopmental disabilities sepsis significantly raises NICU costs due to increased use of ventilation and longer lengths of stay.
#No clear evidence more gluten in new wheat is responsible for increase in celiac diseaseno clear evidence exists to support the idea that celiac disease is increasing in prevalence
Donald D. Kasarda cites evidence that the incidence of celiac disease increased during the second half of the 20th century.
Also known as gluten intolerance celiac disease occurs when gluten a protein in wheat barley and rye damages the lining of the small intestine causing a variety of symptoms.
This may prove difficult given the risks of bias and ethical strictures of studying the use of an illegal substance he said.
and result in emphysema heart attack and now stroke he said. Co-authors are: Heidi Pridmore M d.;
and so are likely to be sensitive to modern agrochemical contamination of the environment. They may play an important role in organic rice farming.
or symptoms we know from the latest laboratory studies the potency some have in terms of infiltrating our cells and tissue and causing harm.
#Exposure to pesticides in food, air and water increases risk of type 2 diabetes, study findsa study led by the University of Granada reveals that there is a direct relationship between the presence of Persistent Organic Pollutants
in the body and the development of type 2 diabetes regardless of the patient's age gender or body mass index.
A study conducted at the University of Granada has revealed that there is a direct relationship between exposure to pesticides (Persistent Organic Pollutants CPOS) in food air and water and prevalence of type 2 diabetes in adults regardless
and they might be one of the reasons why obese people are more likely to develop diabetes since the more fat the higher the COP concentrations in the body.
In a paper recently published in the journal Environmental Research researchers demonstrate that people with higher concentrations of DDE-the main metabolite in the pesticide DDT-are four times more likely to develop type 2 diabetes than other people.
In addition the risk of type 2 diabetes is associated also with exposure to Î-HCH (beta-Hexachlorocyclohexane)
According to professor Arrebola the mechanism of action by which COPS increases the risk of diabetes is still unknown.
The prevalence of diabetes in the world has increased significantly in the last decades. It is estimated that by 2030 4. 4%of the world population have this metabolic disorder.
The factors causing such increase in the prevalence of diabetes are not still clearly understood.
Overtext Web Module V3.0 Alpha
Copyright Semantic-Knowledge, 1994-2011