Dystrophy drug hope The experimental drug eteplirsen may help patients with Duchenne muscular dystrophy (DMD), a clinical trial of 12 boys with the condition reported on 3 october.
which makes the drug, revealed that four boys who had taken a high dose of eteplirsen for nearly a year were able to walk an average of 21 metres farther in six minutes than at the start of the trial.
The company plans to file for regulatory approval with the US Food and Drug Administration.
and a six-year drug war. Enrique Pe  a Nieto will have his hands full
After the fungus was injected along with the drug into the epidural space the space between the dura mater,
The fungus's confinement to just three lots of the drug also remains unexplained. If the facility's water or air supplies in general were contaminated,
Another pathway could be the drug itself: Although the water used for making up the final doses was allegedly sterile,
the steroid drug ingredient was not. Using nonsterile components for injection in somebody's spine?
about safety data from clinical trials of a drug for Alzheimer s disease before the results were made public.
and senior vice-president at the UK-based drug firm Pfizer, died on 22 Â January. Cox s research group at Pfizer aimed to find a way to arrange clinical-trial participants on the basis of their genetic make-up.
US food safety On 4 january, the US Food and Drug Administration released the first of its long-awaited proposals for protecting food safety.
Pharma split Abbott laboratories has spun off its drug-discovery business into an independent company called Abbvie,
The findings are likely to add urgency to efforts to ensure that infected mothers without access to formula take antiretroviral drugs throughout
Patent blocked India s Supreme court ruled on 1 Â April against an attempt by Swiss drug company Novartis to patent the anticancer drug Gleevec (imatinib mesylate.
India s patent law limits the ability of drug firms to make minor modifications to drugs to extend their patent life, a tactic known as evergreening.
The nation s support for cheap generic drugs has reduced prices, notably those of anti-HIV medicines.
Diabetes drug US regulators have given the green light to the first in a new class of drugs to treat diabetes.
On 29 march, the Food and Drug Administration approved canagliflozin (Invokana), which was developed by Johnson & johnson, headquartered in New brunswick, New jersey.
last year regulators shot down another such drug, dapagliflozin, citing cancer concerns. Source: US National Snow and Ice Data Centera record low in the extent of sea ice in the Arctic last September has been followed by a record refreezing of uncovered ocean surface,
Hepatitis drug A new hepatitis-C drug sofosbuvir, has been found to be highly effective in clinical trials.
the drug is one of several in development that could replace existing hepatitis-C treatments,
On 26 april, the US Food and Drug Administration (FDA) closed a public consultation on its finding that the engineered fish pose no significant environmental concern.
Last week marked the end of the public s opportunity to weigh in on a US Food and Drug Administration (FDA) draft assessment of the salmon.
Aquabountythe US Food and Drug Administration (FDA) has been slow to approve a genetically modified (GM) salmon made by Aquabounty of Maynard, Massachusetts.
Drug application with the FDA. 2001 â Aquabounty submits its first regulatory study to the FDA. 2009 â The FDA releases guidance for its evaluation of genetically engineered animals as veterinary drugs;
and physicians to boost GSK drug sales, funnelling the money through travel agencies. The executives are suspected of giving 3 Â billion renminbi (US$489 Â million) in bribes since 2007
would ban research involving addictive drugs or transplants of living cells from other species. It would also stop the breeding of dogs, cats and primates in Italy for research,
Indiana, announced on 12 Â July that it will focus on patients with mild Alzheimer s disease in a forthcoming clinical trial of the drug solanezumab.
The antibody-based drug, which targets the amyloid-Ã Â protein, will be tested in a large-scale phase III trial.
But secondary analysis hinted that the drug might help patients with mild forms of the disease.
Lead author Hana Golding, a microbiologist at the US Food and Drug Administration in Bethesda, Maryland, agrees
The authors have called on the US Food and Drug Administration to bar the practice. See go. nature. com/jqccur and page 253 for more.
the Food and Drug Administration and the National institutes of health (NIH) announced on 19 september. More than $273 Â million may be invested over the next five years to help the programme to develop
In October, the US Food and Drug Administration (FDA) is expected to issue a rule that affirms it has the authority to regulate e-cigarettes,
Many researchers think that widespread use of antibiotics to encourage growth in farm animals fuels the proliferation of MRSA and other drug-resistant bacteria.
For decades, the local cattle have been prime suspects behind the country s outbreaks of drug-resistant,
when global epidemics of drug-resistant salmonella infections began to arise. Livestock was assumed to be the source of the epidemics
The authors therefore suggest that local livestock are not the source of drug-resistant human salmonella outbreaks in Scotland.
Mark Woolhouse, an epidemiologist at the University of Edinburgh, UK, says that the study clarifies how pathogens and drug-resistance genes spread."
"It s not just multi-bug, multi-drug, he says, "but multi-country. Scotland imports most of its red meat,
Brain implant Patients with epilepsy who fail to respond to medications could benefit from a newly approved brain implant.
California, received a green light from the US Food and Drug Administration on 14 Â November.
and Drug Administration (FDA) approved on 13 Â November a breakthrough therapy to treat a rare blood cancer called mantle-cell lymphoma.
California, is only the second drug to be approved under the FDA s Breakthrough Therapy Designation programme a pipeline launched last year to fast-track regulatory approval of particularly promising treatments.
PLOS ONE 8, e77142 (2013) The number of potential drug leads disclosed in patents each year has plummeted over the past seven years.
the US Food and Drug Administration (FDA) proposed eliminating most artificial trans-fats forms of fat associated with increased heart risk from processed foods.
Viropharma develops drugs for rare diseases. The bulk of its roughly $400 Â million in annual sales revenue comes from a drug used to treat a rare blood condition known as hereditary angioedema.
Source: ethan perlsteinscience projects seeking crowdfunding in the past two years have included a glow-in-the-dark plant that raised US$484,
Bioensure has been approved for use by the US Food and Drug Administration and the Department of agriculture and independent tests have shown the mixture to be nontoxic.
to stymie drug-patent reform in South africa. The country is considering loosening patent protections to improve access to cheaper, generic drugs,
in line with moves in India and Brazil in recent years (see Nature 500, 266; 2013.
and Drug Administration to test therapies involving embryonic stem cells. See Nature http://doi. org/q8f (2014) for more.
Advertisements for the best-selling drug relied on studies showing that it also reduced the risk of stroke and heart attack.
which receives about US$6 Â billion per year to distribute antiretroviral drugs and medical care in countries affected by AIDS (see Nature 457,254-256;
which also examined the United kingdom s stockpiling programme for the influenza drug Tamiflu (oseltamivir), the authors say that evaluation of the efficacy of Tamiflu
and other medicines has been hampered by drug manufacturers withholding data. The report follows recent European and US initiatives to increase data sharing and transparency in clinical trials.
Although the drug remains illegal under national laws, the US government has said that it will not interfere with state industries kept under strict local controls.
New drug approvals The US Food and Drug Administration approved 27 Â new drugs in 2013, down from a 15-year high of 39 Â drugs the year before,
The agency told reporters that it had received fewer drug applications for review in 2013 and that the number of approvals was in line with the average of 28 new drugs approved annually over the past five years.
US ICEFOSSIL felony A fossil retailer from Eagle, Colorado, pleaded guilty on 2 january to conspiracy to smuggle dinosaur bones and other fossils into the United states from China and Mongolia.
The buyout will create a company with annual sales of $15 billion from drugs targeting disorders of the heart, digestive system and central nervous system, among other areas.
The expanded company will have combined a investment in new drug development of $1 billion per year. Holt retires Physicist and congressman Rush Holt (Democrat,
7 13 february 2014sharing drug data Ten major pharmaceutical companies have agreed to share data from early-stage trials with each other and with academic researcher,
is designed to speed up identification of biomarkers and promising drug targets for four diseases: Alzheimer s, rheumatoid arthritis, lupus and diabetes.
Stem-cell ruling Certain types of stem-cell treatment should be regulated as drugs, a US appeals court decided on 4 Â February.
is a medical procedure that does not require regulation by the Food and Drug Administration. The court decided that processing the cells for use in the therapy made the end product a drug.
The company has completed not clinical trials on the treatment so cannot market the product in the United states. It does sell it in the Cayman islands (see Nature 488
a Food and Drug Administration advisory panel examined the science behind the technologies on 25-26 Â February.
I don't think massive amounts of intoxicating drugs would make Dan's writing any better.
Without urgent action now more patients will be thrust back to a time before we had effective drugs.
Clostridium difficile and drug-resistant enterobacteriaceae are generally infections people get while they are in hospitals from their catheters breathing machines and other invasive equipment.
and try to develop new drugs. Most importantly it will need to change how people use antibiotics.
The claim of breach of ethics for withholding vaccines is not a valid argument as drug companies have no problem testing every other drug on participants
and Drug Administration is asking veterinary drug companies to voluntarily agree to make it illegal to feed healthy animals some antibiotics.
If the antibiotic is on the FDA s list of drugs that are used related to drugs to fight infections in people including everything from bronchitis to urinary tract infections to Lyme disease to infections after surgeries then the agency is asking companies to stop their use for fattening up pigs chickens
âÂ#Âoeeven if it were observed by the industry there s no guarantee that the usage profile for these drugs would changeã¢Â# Keeve Nachman who studies food production at the Johns Hopkins Bloomberg School of Public health tells Popular Science.
Paradoxically using drugs to kill off the Loa loa larvae can be dangerous because when large numbers of the larvae die in and around the brain they can block capillaries and cause encephalopathy a condition that can cause cognitive losses memory problems personality changes and more.
No doctor would treat me thought I was lying only wanting drugs forced me to see a psychiatrist mocked
Specific drugs that were found to cause harm and were banned subsequently did not trigger a blanket ban on ALL OF the same kind of medication.
For example while thalidomide was banned there was never a blanket ban on all anti-nausea medication. And the FDA never approved its use in the U s. at any time during the 5 years it was available.
It is possible that specific GMO foods in the future--ones not studied and certified yet--may turn out to be more harmful than their non-GMO counterparts.
Organovo's first biological product will be liver tissue for drug testing. Every year the pharmaceutical industry spends more than $39 billion on R&d.
According to the Food and Drug Administration liver toxicity is the most common reason for a drug to be pulled from clinical trials as well as from the marketplace after it's been approved.
There's still no reliable way to evaluate how a drug will affect the human liver before it's ingested not even animal trials.
A study published in October showed the mice predicted how well a drug for treating hepatitis C would be metabolized by humans.
Every drug taken orally whether a painkiller an anti-inflammatory or a new cancer pill must pass a liver tox.
People normally do a reaction purify the chemicals take the drug add it to cells look at the response formulate maybe do animals
If bioprinted assays provide pharmaceutical researchers with better quicker data the entire drug-discovery process will accelerate.
But what guarantee is there that their âÂ#Âoeassurancesã¢Â# of vaccines now are any better than the now admitted risky alternatives back then that were peddled as âÂ#Âoemiracle drugs with no drawbacksã¢Â#Â?
and doctors offices due to her stay) but my oldest one is on daily medications to control her asthma and allergies.
Popular science should do a lot more research not just listen to the drug and pharmaceutical industry.
Most specifically the GSK paxil case wherein they used a ghostwriter to say the drug was safe.
In a letter to the U s. Food and Drug Administration the Center for Science in the Public interest used Long John Silver's as an example to lobby for a ban on partially hydrogenated oils
In addition the human form of one protein is blocked by the lipid-lowering drug clofibrate perhaps linking this and related compounds to the rising global incidence of human infertility...
No births yet but some planed anti-rejection drugs will likely make this happen. Even still this is the same problem as resurrecting the Thylacine
Dr. Dela Cruz's probiotic treatmentwhat makes Dr. Dela Cruz s treatment system unique is that it s not a drug in the traditional sense.
#How To Detect Counterfeit Drugs Growing up in Pakistan in the 1980s Muhammad Zaman and his family always knew which pharmacy to trust
The crisis of poor quality drugs is worst in the developing world where regulatory oversight is weak
The bogus-drug trade isn't just a problem for the world's poorest patients:
Last year the Food and Drug Administration (FDA) warned consumers about fakes of Adderall the attention-deficit-disorder drug which contained a powerful painkiller.
Now new technology verification systems and researchers like Zaman are working to make sure that the drugs people take are
Detecting dangerous or substandard drugs is generally difficult. Verifying a medication's manufacturing origin is simple only when it comes from a big international company with a tracking system in place and that's often not the case.
When health-care providers in the developing world can afford only drugs that don't have a built-in security network it takes valuable time
The liquid then runs onto a microfluidic chip the size of a postage stamp where it combines with a molecule designed to bind solely with the drug in question.
The process reveals how much of the drug is present and how quickly it dissolves and takes 15 minutes or less.
Some drugs are entirely fake snake oil sawdust chalk. But others particularly those in developing countries might contain an ineffective amount of medicine or release the right amount in the wrong way;
Pharmacheck is designed to recognize these drugs as well. Too strong a signal right away could mean that the medicine wasn't made properly
Too weak a signal means there might not be enough of the active ingredient to be effective (in antibiotics low doses could lead over time to drug-resistant microbes.
Some drugs are entirely fake. Others contain an ineffective amount of medicine. Meanwhile the FDA is ramping up deployment of its own handheld scanners
which detect changes in a drug's ingredients and packaging to help determine its provenance.
The FDA has about 30 CD-3 devices deployed at international mail facilities where counterfeit drugs slip into the country and more at other points of entry.
or how it's released in the body FDA officials say the device is great for screening lots of drugs.
Its convenient and still-unnamed product a lab on a piece of paper the size of a business card directly detects a drug's ingredients.
Each paper can detect one type of drug. Rub some crushed Tylenol or antimalarial on it for example dip it in water
Some USA pharmacies do over charge for drugs where some people look else way in other countries for cheaper equal type drugs.
I do hope this helps those who buy overseas to receive safer correct drugs because the local pharmacies manufactures will not lower their prices
and Drug Administration's recommended daily values for all the different nutrients we need everything from carbohydrates
#Which Drugs Actually Kill Americans Infographic Death reporting in the U s. requires an underlying cause the event or disease that lead to the death.
The subcategories are limited in their detail many drugs are lumped together like MDMA and caffeine which are listed together as psychostimulants.
And while cocaine heroin and alcohol are all responsible for enough deaths to warrant their own stripes on the chart many popular illegal drugs including marijuana
if a person had listed multiple drugs on their death certificate they're being counted twice here.
when its got Marijuana lumped in with all of the truly dangerous drugs. MARIJUANA has caused NEVER a single case of overdose in all of human history.
Tobacco kills more Americans than all of these drugs+pharma=COMBINED!**400000 Americans killed by Tobacco each year.
Drug laws are divorced from reality. They only serve to support the drug trade. We cannot continue to lie to drug users
and expect them to take us seriously. They know better than anyone that all drugs are not bad and all pharmaceuticals are not safe either.
Why would our children listen to us if they think we are fools? Looks like Alcohol overdoses have doubled in the last few years as well.@
Taylorjusher That is because people are believing the lie that legal drugs are safe and illegal ones are dangerous.
while the reckless outlaws using overpriced contaminated incorrectly dosed illegal drugs are still alive and partying.
The elderly obese man had drugs in his system as he stepped in front of the bus that squished him running away from his angry wife with that machete.
More proof that the war on drugs is a wasteful fallacy. Absolute BS. I don't know where they got these statistics but
Alcohol and opioids like heroin have got to be the drugs causing the most death..The graph is anything but clear.
Auroria I agree that sugar is a drug and that is extremely unhealthy (I avoid it).
In that same time green pharma related drug deaths increased from 2. 7 to 9. 9 per 100000 per year (1. 8cm by ruler to 6. 6cm where 25%=16. 6cm
Something like Deaths by Drug Overdose Group by Drug would have been a billion times better. Please be more responsible.
That being said there are healthier methods of ingestion such as vaporizing tinctures and edibles. Those methods still can't yield a toxic response
1. This chart shows deaths caused by drug overdose. It does not show deaths from chronic health problems caused by drug use nor accidents (car crashes falls) nor suicides while intoxicated.
If all these other deaths were shown the death count for alcohol would be much much greater. 2. Overdose deaths from cannabis LSD magic mushrooms
People concentrate on illegal drugs when legal drugs kill many times more. In France Alcool is third biggest killer.
Here government encourage to drink wine
#Dear President Obama: When Will You Stop Talking About Climate Change And Actually Do Something?
Often Popsci writes articles of drugs and alchol and at other times sexual type aricles.
Do you know of any other preventative medication or mineral that is intended for human consumption that comes from a smoke stack?
Do you know of any other drug that is not regulated in terms of content or medicinal purity that is allowed for human consumption?
or drug as a one size fit's all dose for everyone regardless of your age race frequency of consumption etc..
and we use rats to test out drugs we are starting to develop for human use...
and Drug Administration required trans fat labeling starting in 2006. By 2010 no trans fats was the fifth most popular nutrition claim on new packaged foods
People under the influence of drugs also experience temporary or in some cases permanent reorganization of cognitive process.
#Herd Of Secret Drug Goats Discovered At Biotech Ranchlet's say you're a giant biotech company in sunny California
or selling drugs to anyone. They're extracting antibodies for use in research by other companies.
At the time Thomas Platts-Mills and Scott Commins both allergy specialists at the University of Virginia Health System were trying to understand why some of their patients had developed a severe allergic reactions to cetuximab an intravenous cancer-fighting drug.
The doctors eventually learned that Immunoglobulin e (Ige) antibodies in their patients were reacting with a sugar in the drug called alpha-gal.
but not every patient reacted poorly to the drug. Commins and Platts-Mills discovered these strange reactions occurred in patients who all hailed from the same place:
This aspect of wildlife forensic science is supported by the United nations Office for Drugs and Crime and has already proved highly successful in tracking seizures and locating their source.
Human patients take immunosuppressant drugs when they get organ transplants so that's not unusual.)It seems
and immune system-suppressing drugs. In an abstract the team submitted to a meeting of heart
when it tried other drug regimens their baboons died in less than a year. Baboons who received hearts from un-genetically modified pigs rejected the hearts within a day.
The Food and Drug Administration is still determining its regulatory stance. It s sponsoring more research
which the scientists describe as a potential goldmine for drug discovery. It's not surprising on the face of it that sloths harbor some interesting microscopic fur-friends:
It also comes as no shock that fungi create chemicals of interest to drug developers as fungi have spawned drugs from penicillin to Lovastatin.
and the drugs currently used to treat it are discontinued often due to their negative side effects. A total of 20 of the chemicals isolated from these microbes were active against at least one bacterial strain
and Drug Administration-approved surgical glues in use today but they're either not strong enough to use on the heart
and to adopt better substitutes for the drugs such as vaccinations. Hollis also suggests that an international treaty could ideally be imposed.
According to the paper the sheep industry has become dependent on drugs to control these parasites. Over time these drugs are less effective as helminths become resistant to the drugs.
Therefore there is pressure on the industry to find alternate strategies. One such strategy is genetic selection.
Currently e-cigarettes are regulated not by the U s. Food and Drug Administration. Twenty-six states have regulations prohibiting sale to minors;
This research adds weight to calls for the increased use of drugs for primary prevention of cardiovascular disease as well as for persevering with policies aimed at improving the nutritional quality of UK diets they conclude.
and that both drugs and healthier living can make a real difference in preventing heart disease and stroke.
new drug-delivery technologies; transparent flexible displays for electronic devices; special filters for water purification; new types of sensors;
#Legislation to provide allergy medication in schools crucial to save livesan act recently signed by President Obama will make it easier to provide epinephrine to children with severe food allergies in schools even without a prescription.
and in some cases requiring that schools to have this medication available for all students
and trains school employees to administer the drug in an emergency. Additionally the bill provides civil-liability protection for those who administer epinephrine in an emergency.
Food and Drug Administration and the World Health Association. Whether from cows goats or sheep raw milk and milk products are a continuing source of bacterial infections that are especially dangerous to pregnant women fetuses the elderly young children
The work should be significant for pharmaceutical companies that design drugs through painstaking processes and at great cost by eliminating some of the trial and error in identifying new sites on proteins that could be manipulated more easily to treat disease said Rice biological physicist Jos Onuchic.
You can't design drugs in a vacuum he said. These simulations give us possible targets to subject to much more detailed simulations.
Since several FDA-approved drugs contain derivatives of isoxazole our findings may have potential clinical implications for repurposing these drugs to treat Parkinson's.
and Drug Administration (FDA) estimated the impact of graphic warning labels on U s. smoking rates based on Canada's experience.
and Drug Administration (FDA) was challenged successfully by the tobacco industry and the court cited the very low estimated impact on smoking rates as a factor in its judgment.
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