Unlike other drugs that target cancer cells from the outside often injuring normal cells as a side effect this therapy consists of multiple drugs chemically bonded to a nanoplatform that functions as a transport vehicle.
but it appears that the nanobioconjugate may represent a new generation of cancer therapeutics in
Pig receiving chemotherapy for lymphoma successfully recoveringplayful as a puppy even at 730 pounds Nemo a rescued black-and-white Hampshire pig became a porcine pioneer after lymphoma struck.
These he says are feed additives in given routinely without a prescription at lower than therapeutic concentrations for purposes such as growth promotion
#Survey shows increase in resistance to drug therapies among bovine respiratory disease casesa survey of records of bovine respiratory disease cases at the Kansas State Veterinary Diagnostic Laboratory showed that drug resistance in one of the primary
However the contribution of multidrug resistance to limited or failed therapy in veterinary patients has received much less attention.
Dr Wenxin Wang is trying to uncover therapies for diseases such as diabetic ulcers and Epidermolysis Bullosa
GNVS can efficiently deliver a variety of therapeutic agents including DNA RNA (DIR-GNVS) proteins
and the subtropical fruit may revolutionize how medical therapies like anticancer drugs are delivered to specific tumor cells.
The researchers demonstrated that GNVS can transport various therapeutic agents including anticancer drugs DNA/RNA and proteins such as antibodies.
Our GNVS can be modified to target specific cells--we can use them like missiles to carry a variety of therapeutic agents for the purpose of destroying diseased cells he said.
The therapeutic potential of grapefruit derived nanoparticles was validated further through a Phase 1 clinical trial for treatment of colon cancer patients.
It made sense for us to consider eatable plants as a mechanism to create medical nanoparticles as a potential nontoxic therapeutic delivery vehicle.
At Wake Forest Baptist we are now fighting cancer with state-of-the-art therapies including immunotherapeutics Powell said.
#Identification of stem cells two separate roles raises possibility of therapies that could inhibit fat formation,
which could point the way to potential therapies. The findings are published in the April 27 online edition of Stem Cells and Development.
This is important because now we have the potential to develop therapies that can block the activity of Type 1 pericytes to form fat
We suggest that Type 1 pericytes could be used as a cellular target for therapy to diminish fat accumulation in the muscle.
and destroy only the abnormal cells sparing healthy tissue from the damage that triggers side effects with existing cancer chemotherapy.
The whole situation is bedevilled by this primitive old-fashioned attitude that Schedule 1 drugs could never have therapeutic potential
The first session will be a low dose to check there are no adverse responses the second session will give a higher therapeutic dose
While they are under the influence of the drug the patients will have guided talking therapy to enable them to explore their negative thinking
This advancement will in principle allow us to track the genomic evolution of prostate cancer after we initiate a therapy
We hope the comprehensive understanding of cancer biology at the individual level will ultimately lead to better therapy choice for patients suffering from advanced cancer.
and may help doctors personalize therapies to a patient's unique cancer. To date CTC capture technologies have been able to do little more than count the number of CTCS which is informative but not very useful from a treatment planning perspective.
which was on par with their tests of p53 activity caused by a chemotherapy drug called etoposide.
#Functional ovarian tissue engineered in laba proof-of-concept study suggests the possibility of engineering artificial ovaries in the lab to provide a more natural option for hormone replacement therapy for women.
-or cell-based hormone therapy--essentially an artificial ovary-to deliver sex hormones in a more natural manner than drugs said Emmanuel C. Opara Ph d. professor of regenerative medicine and senior author.
The loss of ovarian function can be due to surgical removal chemotherapy and radiation treatments for certain types of cancer and menopause.
and postmenopausal hormone replacement therapy use a factor that may negatively affect lung cancer prognosis. In addition the overall soy food intake is higher in Chinese women than in Western women.
and a member of the Advanced Diagnostics & Therapeutics initiative (AD&T) at the University of Notre dame. And for these flies it can sometime turn out to be a difficult thing to do.
for patients during and after radiation therapy and beyond. Radiation treatment of organs with cancer is designed to give enough of a dose to be toxic to the cancer tumor with minimal impact to the surrounding tissue
This discovery might lead to useful therapeutic interventions to fight disease according to Krummel. Results of the study were published online March 10 in Nature Immunology.
and makes it more likely that therapeutic interventions can be designed more rationally. To study the problem Kiang's lab worked closely with Moake's team at Rice's Bioscience Research Collaborative
and provide more clues about potential therapies. The research was supported by the National institutes of health the National Science Foundation the Alliance for Nanohealth the Welch Foundation the Mary R. Gibson Foundation and the Everett Hinkson Fund.
A weapon in the fight against kidney disease caused by high-fat dietsnew insight into grape seed extract as a therapeutic and preventative measure to fight obesity-induced kidney damage is presented in a new study.
#Research supports promise of cell therapy for bowel diseaseresearchers at Wake Forest Baptist Medical center and colleagues have identified a special population of adult stem cells in bone marrow that have the natural ability to migrate to the intestine
While there is currently no cure for IBD there are drug therapies aimed at reducing inflammation and preventing the immune response.
Because these therapies aren't always effective scientists hope to use stem cells to develop an injectable cell therapy to treat IBD.
Our hope is that a mixture of these cells could be used as an injectable therapy to treat IBD.
Advantages of using plants to produce therapeutic proteins include the ability to produce large quantities quickly and cheaply the absence of human pathogens the stability of the proteins and the ease with
#Researchers find potential new therapeutic target for treating non-small cell lung cancerresearchers at Moffitt Cancer Center have found a potential targeted therapy for patients with tobacco-associated non-small cell lung cancer.
Since IKBKE kinase is induced by tobacco small molecular inhibitors of IKBKE could have a therapeutic drug potential for lung cancer explained lead author Jin Q. Cheng Ph d. M d. senior member
Current treatments for non-small cell lung cancer include surgery radiotherapy and chemotherapy. However patients eventually develop resistance to treatment.
and develop new gene-targeted therapies that can circumvent resistance said the authors. In this study the researchers also reported for the first time that IKBKE is a target of STAT3 a transcription factor that plays a key role in many cellular processes such as cell growth
The authors noted that the activation stage of STAT3 represents an attractive therapeutic potential because IKBKE is a STAT3 target.
While IKBKE induces chemotherapy resistance knocking down IKBKE sensitizes cancer cells to chemotherapy and reduces cancer cell survival.
Alkali supplementation therapy such as bicarbonate is used to treat CKD patients with severe metabolic acidosis but simply adding more fruits and vegetables
There might be therapeutic implications about giving supplemental zinc in a strategic manner to help improve some people with certain conditions.
Simply put finding new therapies is akin to troubleshooting a broken mechanical assembly line -if you know all the steps in the manufacturing process it's much easier to identify the step where something went wrong.
But researchers at the University of Georgia have made a discovery that may soon lead to new therapies for this critically neglected disease that cause neither the risks nor the pain associated with traditional treatments.
Now that we better understand this critical pathway we may begin thinking about new therapies for sleeping sickness.
We hope that potential therapies will be equally applicable to animals and that it will have a positive impact on the area's economic outlook.
which may lead to new therapies for uncontrollable bleeding and trauma. These are fundamental discoveries about cell life
and in the lives of other organisms and we hope that these will lead to new therapies for a variety of disorders.
We offer a monthly post-op support group--group therapy so to speak --and most of those patients do really well''Fernandez said.
A smaller radiation field combined with modern treatment techniques like newer chemotherapy agents and radiation technologies provides physicians with more options.
and for developing therapeutic approaches to diseases caused by EEHV. Elephant populations have been plummeting. African elephants declined roughly from 10 million to half a million during the 20th century due largely to habitat destruction
and breast-milk sources of postnatal CMV infection in VLBW infants says first author Cassandra Josephson MD from the Center for Transfusion and Cellular Therapies Department of Pathology and Laboratory
While mortality from heart disease has declined in recent decades with much of the reduction attributed to medical therapies the authors said prevention through a healthy lifestyle avoids potential side effects of medication
#Artificial liver tested as potential therapy for patients with alcohol-related organ failurecedars-Sinai physicians and scientists are testing a novel human cell based bioartificial liver support system
and effectiveness of the ELADÂ bioartificial liver system which is designed by Vital Therapies Inc. the sponsor of the clinical trials.
The research at Cedars-Sinai involves patients with liver disease caused by acute alcoholic hepatitis a group with few therapeutic options.
when Manuka honey is prescribed for esophagitis pain during radiation therapy (RT) it is not more effective than standard medical care according to research presented today at the American Society for Radiation Oncology's (ASTRO's) 56th Annual Meeting.
The randomized phase II trial enrolled 163 lung cancer patients at 13 cancer centers who were undergoing concurrent chemotherapy and RT.
Evidence of persistent carriage of this new livestock-associated strain and its drug resistance has led to restrictions on the non-therapeutic use of antibiotics in livestock overseas.
and the chemotherapy agent calicheamicin said the complicated new molecule offered a challenge he couldn't resist.
The researchers also plan to develop the vaccine into the type of antibody serum therapy used in the first U s. recipients in a platform that could deliver at least 2000 doses of potentially lifesaving serum per month.
But for those patients who already have the disease antibody-based therapies could be the best treatment--it's a way to give the body's own defenses time to ramp up.
The experimental therapy that humanitarian aid workers Kent Brantly and Nancy Writebol received was purified based on a monoclonal antibodies from mice genetically engineered to produce humanlike antibodies against the Ebola virus.
Therefore it provides more hope for developing therapeutic agents he said. Such agents could lead to a universal flu vaccine that would last a lifetime.
and make therapeutic applications a reality. The possibilities for this reengineered protein are considerable. Montclare explained that
in addition to therapeutic formulations which could prevent nerve damage in the event of a gas attack
Plans are under way to begin developing therapeutic applications for this modified phosphotriesterase and the research team believes that its methodology--using computational biology to identify potentially beneficial modifications to proteins--could point the way to future breakthroughs in engineered proteins.
and grains in pet food. 8. 53 percent of dogs and 58 percent of cats are overweight causing the need for functional and therapeutic pet food (APOP 2013). 9. 51 percent
Originally we thought that biological pacemaker cells could be a temporary bridge therapy for patients who had an infection in the implanted pacemaker area Marbã¡
Originally we thought that biological pacemaker cells could be a temporary bridge therapy for patients who had an infection in the implanted pacemaker area Marbã¡
#How gardens could help dementia carea new study has revealed that gardens in care homes could provide promising therapeutic benefits for patients suffering from dementia.
The optical imaging exam appears to detect changes that occur 15-20 years before clinical diagnosis. It's a practical exam that could allow testing of new therapies at an earlier stage increasing our chances of altering the course of Alzheimer's disease said Shaun
This knowledge could help develop customized therapies like training the body's immune system to respond to certain proteins found in foods.
and other autoimmune disorders trying to figure out a way for parasite-derived therapies. Li Hu Project Manager from BGI said The constructed pig whipworm genome sequence provides us a genetic resource for deeply investigating the mechanisms underlying human autoimmune diseases.
grown in pigsone of the biggest challenges for medical researchers studying the effectiveness of stem cell therapies is that transplants
By establishing that these pigs will support transplants without the fear of rejection we can move stem cell therapy research forward at a quicker pace.
Hopefully this means that we are one step closer to therapies and treatments for a number of debilitating human diseases.
Promising drug therapies for fatal lung disease foundresearchers in separate clinical trials found two drugs slow the progression of idiopathic pulmonary fibrosis a fatal lung disease
which there is currently no therapy approved by the Food and Drug Administration. Paul W. Noble MD chair of the Department of Medicine at Cedars-Sinai and director of the Women's Guild Lung Institute is the senior author of the multicenter study that found that the investigational drug pirfenidone
These IPF drug therapy findings by Dr. Noble and his colleagues exemplify the dedication and hard work required to find treatments for a group of patients who have so few therapeutic options
because there have been approved no drugs by the Food and Drug Administration specifically targeted for treating this fatal disease said Shlomo Melmed MD senior vice president and dean at Cedars-Sinai and the Helene A. and Philip E. Hixon Chair in Investigative Medicine.
#Radiotherapy: Novel lung cancer treatment meets with successan old idea of retreating lung tumors with radiation is new again especially with the technological advances seen in radiation oncology over the last decade.
Two complementary papers published back-to-back recently in the journal Radiotherapy and Oncology and the Journal of Thoracic Oncology outline the treatment success at Wake Forest Baptist. â#oeone of the toughest challenges of lung cancer is
â#Urbanic said the overall findings of the study suggest that there are some patients with recurrent lung cancers who can be treated with another definitive course of radiation therapy
and still have a chance at a cure. â#oeat many cancer treatment centers these patients only get chemotherapy
Eighty-six patients were identified who received at least two courses of thoracic radiotherapy. Of that number 33 were treated with repeat thoracic radiotherapy using stereotactic body radiation therapy (SBRT) or accelerated hypofractionated radiotherapy (AHRT) as a component of their treatment.
The median age was 66 and the majority of patients (88 percent) were treated for primary lung cancer.
or woman who got treated with either chemotherapy and radiation or radiation alone for a lung cancer that couldnâ##t be removed surgically.
We also need to develop targeted therapies to support lactation success in women with a history of glucose intolerance.
Determining the exercise intensity of gardening tasks should be useful information for developing garden exercise programs based on physical activity recommendations for health benefits the researchers said adding that the data will also be valuable for designing horticultural therapy program based on
and evolution of the disease opening up the possibility of identifying new therapeutic targets to combat lentiviral infections.
#Critical end-stage liver disease discovery madea team of researchers in the University of Arizona's College of Pharmacy has discovered a molecular pathway that could be key to creating new therapeutics that would slow or even reverse
The discovery could change the way scientists develop therapeutics as it provides a new target for future drugs.
and this could increase because of the rising acceptability of natural therapies. The study published in the scientific journal Forests Trees
There are other forms of medicinal nicotine replacement therapy (NRT) that have been used for 17 years to help smokers quit.
New therapies possibleresearchers at Mcmaster University have discovered a key molecule that could lead to new therapies for people with celiac disease an often painful and currently untreatable autoimmune disorder.
School of medicine. â#oethere is need a great for a therapy that will protect patients with celiac disease from these accidental contaminations. â#Verdu says the results raise the possibility of elafin administration
or replacement as a new adjuvant therapy to the gluten free diet. â#oethis would add flexibility to a restrictive lifelong diet
Development of new therapies such as this one could help in the management of common gastrointestinal disorders such as irritable bowel syndrome that could be triggered also by wheat containing food.
and drilling medical therapy and diagnosis biopharmaceuticals air conditioning fuel cells power transmission systems solar cells micro-and nanoelectronic mechanical systems and cooling systems for everything from engines to nuclear reactors.
An international research group led by Arizona State university professor Qiang Shawn Chen has developed a new generation of potentially safer and more cost-effective therapeutics against West Nile virus and other pathogens.
The therapeutics known as monoclonal antibodies (MABS) and their derivatives were shown to neutralize and protect mice against a lethal dose challenge of West Nile virus--even as late as 4 days after the initial infection.
First we wanted to show proof-of-concept demonstrating that tobacco plants can be used to manufacture large and complex MAB-based therapeutics.
Secondly we've wanted to improve the delivery of the therapeutic into the brain to combat West Nile virus at the place where it does the greatest harm.
Chen's group has been a pioneer in producing MABS as therapeutic candidates in plants including tobacco and lettuce plants.
One approach to tackle this challenge is to program into the therapeutic antibodies the capability of binding to receptors that can help the MABS to cross into the brain.
and increasing amounts of a MAB therapeutic were delivered as a single dose the same day of infection.
whether the therapeutic called Tetra phu-E16 could be effective after infection. In this case the therapeutic was administered 4 days after West Nile virus infection
when the virus has already spread to the brain. In each case they protected up to 90 percent of the mice from lethal infection.
and clinical trials may reach around $1 billion per each therapeutic candidate. Therapeutic MABS are made typically in animal host cells
and assembled into Y-shaped complexes. Until now tetravalent MABS had never been made in a plant system before.
To make the potential therapeutics the group is able to use young tobacco plants and a protein expression system to make
It is our hope that these results may usher in new age of cost-effective MABS therapeutics against WNV
which yield nicotine tar and a bewildering array of carcinogens and'stop smoking devices'in the form Nicotine Replacement Therapies (NRTS) such as patches gum lozenges throat sprays and inhalators
Professor Hughes argues future legislation that positions e-cigarettes as'therapies'which require tight regulation may drastically diminish their appeal.
and treating very rare diseases--used three innovative tools to detect a previously unknown gene mutation test potential therapies in the lab
Several researchers have shown that this therapy works on a single food allergen but it had not been tested on multiple food allergens.
Future research will also determine the most effective way to conduct the therapy. Nadeau's team is now planning a phase-2 trial at Stanford and possibly four other research institutions across the country.
and may be useful for antibody based therapies or diagnostics explained Ekiert. It turns out that cows make a very unusual kind of antibody different from anything scientists have seen ever before
and activate targets that have thus far been intractable for antibody-based therapies. Story Source: The above story is provided based on materials by Biophysical Society.
#Grape seed promise in fight against bowel canceruniversity of Adelaide research has shown for the first time that grape seed can aid the effectiveness of chemotherapy in killing colon cancer cells as well as reducing the chemotherapy's side effects.
Published in the journal PLOS ONE the researchers say that combining grape seed extracts with chemotherapy has potential as a new approach for bowel cancer treatment--to both reduce intestinal damage commonly caused by cancer chemotherapy
This is the first study showing that grape seed can enhance the potency of one of the major chemotherapy drugs in its action against colon cancer cells says Dr Cheah researcher in the School of Agriculture Food and Wine.
and tissue damage caused by chemotherapy in the small intestine and had no harmful effects on non-cancerous cells.
Unlike chemotherapy grape seed appears to selectively act on cancer cells and leave healthy cells almost unaffected.
â#¢significantly decreased intestinal damage compared to the chemotherapy control; â#¢decreased chemotherapy-induced inflammation by up to 55%â#¢increased growth-inhibitory effects of chemotherapy on colon cancer cells in culture by 26%Our experimental studies have shown that grape
seed extract reduced chemotherapy-induced inflammation and damage and helped protect healthy cells in the gastrointestinal tract says Dr Cheah.
While this effect is very promising we were concerned initially that grape seed could reduce the effectiveness of the chemotherapy.
In contrast we found that grape seed extract not only aided the ability of chemotherapy to kill cancer cells
but was also more potent than the chemotherapy we tested at one concentration. Co-author and project leader Professor Gordon Howarth says:
Grape seed is showing great potential as an anti-inflammatory treatment for a range of bowel diseases and now as a possible anticancer treatment.
The group found that lead intoxication can impair the therapeutic effectiveness of the antibiotic amoxicillin in goats.
while the amoxicillin levels helped to demonstrate how much of the antibiotic was absorbed for therapeutic purpose.
therefore need more frequent administrations of amoxicillin administration for the antibiotic therapy to be as effective as it is in the control group of healthy goats.
and thus presents a plausible target for future therapeutics aimed at these serious infections of both humans and animals.
and suggests that therapies modulating ALDH enzyme activity or otherwise eliminating toxic aldehydes should be developed
They added that the data can also be useful information when designing garden-based therapeutic interventions for children with low levels of physical ability.
or destroyed a tumor will continue to return despite the use of existing cancer-killing therapies.
and to highlight new therapeutic targets for preventing or treating diabetes and obesity. Story Source:
and tips from a Saint louis University physical therapist for those who want to join the running revolution.#
or destroyed a tumor will continue to return despite the use of existing cancer-killing therapies.
or chemotherapy or both we see it as an ideal target for immunotherapy. We have found at least two fragments of the protein that can be targeted to trigger an immune response to kill tumor cells.
and chemotherapy median length of survival is 15 months for patients diagnosed with glioblastoma multiforme.
The dendritic cell vaccines are produced by the biotechnology company Immunocellular Therapeutics Ltd . which funded this study.
and certain rights in the vaccine technology and corresponding intellectual property have been licensed exclusively by Cedars-Sinai to Immunocellular Therapeutics.
James Bender Phd MPH a co-author is Immunocellular Therapeutics'vice president for product development and manufacturing.
and the therapeutic value of observing these fascinating creatures in action. Is this design a viable method for home-friendly beekeeping?
and farming is good occupational therapy. Image credits: Lufa Farms) Tomato plants grow over 20'high within the greenhouse (s). It's like a jungle in there,
The enzyme-replacement therapy costs $300 000 to $500, 000 per year for children and much higher for adults.
People who were benefited chronically mentally ill more from poverty strategies than formal psychiatric therapies. I started working on improved housing and other opportunities for the chronically mentally ill.
Radiation serves us broadly in the medical field, both as a diagnostic and therapeutic tool.
The typically poor longevity effects of single compounds argue against the use of drug-like therapeutics directed to a single target for longevity treatments.
and have been a major therapeutic supplement in Europe since the 1980s. Most of the research and commercial success with proanthocyanidins has come from extracts of a French maritime pine bark called Pycnogenol (65 to 75%proanthocyanidins) and various grape seed extracts (80-90%proanthocyanidins.
Therapy wasn needed t often. Having different crops with different life cycles made it harder for weeds to grow.
medical drugs and devices, over-the-counter medicine, clinical therapies, etc. This field has taken on a life of its own due to economic incentives:
and cell therapies, enable regenerative medicine, or make cancer cells self-destruct. The potential seems limitless.
< Back - Next >
Overtext Web Module V3.0 Alpha
Copyright Semantic-Knowledge, 1994-2011